BR0207077A - Sais de adição do ácido málico da terbinafina - Google Patents

Sais de adição do ácido málico da terbinafina

Info

Publication number
BR0207077A
BR0207077A BR0207077-4A BR0207077A BR0207077A BR 0207077 A BR0207077 A BR 0207077A BR 0207077 A BR0207077 A BR 0207077A BR 0207077 A BR0207077 A BR 0207077A
Authority
BR
Brazil
Prior art keywords
malic acid
terbinafine
acid addition
addition salts
salts
Prior art date
Application number
BR0207077-4A
Other languages
English (en)
Inventor
Danielle Giron
Jean-Louis Reber
Stefan Hirsch
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of BR0207077A publication Critical patent/BR0207077A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/26—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
    • C07C211/30—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring the six-membered aromatic ring being part of a condensed ring system formed by two rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Emergency Medicine (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Surgery (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Seasonings (AREA)

Abstract

"SAIS DE ADIçãO DO áCIDO MáLICO DA TERBINAFINA". A invenção refere-se a sais de um composto da fórmula I com ácido málico, a preparação dos mesmos, as composições farmacêuticas correspondentes e o uso dos mesmos como antimicóticos.
BR0207077-4A 2001-02-07 2002-02-06 Sais de adição do ácido málico da terbinafina BR0207077A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0103046.9A GB0103046D0 (en) 2001-02-07 2001-02-07 Organic Compounds
PCT/EP2002/001249 WO2002070455A1 (en) 2001-02-07 2002-02-06 Malic acid addition salts of terbinafine

Publications (1)

Publication Number Publication Date
BR0207077A true BR0207077A (pt) 2004-01-20

Family

ID=9908301

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0207077-4A BR0207077A (pt) 2001-02-07 2002-02-06 Sais de adição do ácido málico da terbinafina

Country Status (28)

Country Link
US (2) US20040147603A1 (pt)
EP (1) EP1370513B1 (pt)
JP (1) JP4078206B2 (pt)
KR (2) KR100859609B1 (pt)
CN (1) CN1216034C (pt)
AT (1) ATE294154T1 (pt)
AU (1) AU2002238534C1 (pt)
BR (1) BR0207077A (pt)
CA (1) CA2437592A1 (pt)
CZ (1) CZ20032132A3 (pt)
DE (1) DE60203890T2 (pt)
DK (1) DK1370513T3 (pt)
EC (1) ECSP034713A (pt)
ES (1) ES2240698T3 (pt)
GB (1) GB0103046D0 (pt)
HK (1) HK1060876A1 (pt)
HU (1) HUP0303174A3 (pt)
IL (2) IL157241A0 (pt)
MX (1) MXPA03007072A (pt)
NO (1) NO20033473L (pt)
NZ (1) NZ527300A (pt)
PL (1) PL204812B1 (pt)
PT (1) PT1370513E (pt)
RU (1) RU2289570C2 (pt)
SI (1) SI1370513T1 (pt)
SK (1) SK9992003A3 (pt)
WO (1) WO2002070455A1 (pt)
ZA (1) ZA200306029B (pt)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005538067A (ja) * 2002-07-02 2005-12-15 ノバルティス アクチエンゲゼルシャフト 副鼻腔炎の処置方法
GB0503942D0 (en) * 2005-02-25 2005-04-06 Novartis Ag Purification process
WO2007104474A1 (en) * 2006-03-10 2007-09-20 Novartis Ag Antifungal compositions comprising (1) a salt of terbinafine with malic acid and (2) malic acid
WO2007147052A2 (en) * 2006-06-14 2007-12-21 Dr. Reddy's Laboratories Limited Topical compositions
CA2995880C (en) 2009-01-16 2021-01-05 Exelixis, Inc. Processes for preparing n-(4-{[6,7-bis(methyloxy)quinolin-4-yl]oxy}phenyl)-n'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide
CN106106449A (zh) * 2016-06-21 2016-11-16 广西中烟工业有限责任公司 特比萘芬制剂及其在提高烟叶角鲨烯含量中的应用

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3507755A (en) * 1967-10-17 1970-04-21 Bayer Ag Process for the purification of acrylonitrile by distillation with side stream withdrawal and decantation
US4276125A (en) 1979-02-02 1981-06-30 Asahi Kasei Kogyo Kabushiki Kaisha Process for purification of crude olefinically unsaturated nitrile and condenser useful for same process
US4269667A (en) 1979-08-02 1981-05-26 Standard Oil Company Acrylonitrile purification by extractive distillation
ATE10272T1 (de) * 1979-08-22 1984-11-15 Sandoz Ag Propenylamine, verfahren zu ihrer herstellung, sie enthaltende pharmazeutische zusammensetzungen und ihre verwendung als arzneimittel.
KR850001603B1 (ko) 1980-12-03 1985-10-24 아사히 가세이 고오교오 가부시기가이샤 불포화 니트릴의 제조법
GB8608335D0 (en) 1986-04-04 1986-05-08 Pfizer Ltd Pharmaceutically acceptable salts
NZ227042A (en) * 1987-11-27 1991-05-28 Banyu Pharma Co Ltd Substituted alkylamine derivatives and pharmaceutical compositions
HU223343B1 (hu) * 1991-05-20 2004-06-28 Novartis Ag. Allil-amin-származékot tartalmazó gyógyászati készítmények és eljárás azok előállítására
US6005001A (en) 1991-05-20 1999-12-21 Novartis Ag (Formerly Sandoz Ag) Pharmaceutical composition
HU219480B (hu) 1991-05-23 2001-04-28 Novartis Ag. Eljárás gombás körömmegbetegségek ellen helyileg alkalmazható, allil-amin-származékot tartalmazó gyógyászati készítmények előállítására
US5461068A (en) * 1993-09-29 1995-10-24 Corwood Laboratories, Inc. Imidazole derivative tincture and method of manufacture
DE4400770C1 (de) * 1994-01-13 1995-02-02 Lohmann Therapie Syst Lts Wirkstoffhaltiges Pflaster zur Abgabe von Estradiol mit mindestens einem Penetrationsverstärker, Verfahren zu seiner Herstellung und seine Verwendung
NZ280065A (en) * 1995-09-20 1998-04-27 Apotex Inc Preparation of n-alkyl-n-(1-naphthylmethyl)alk-2-en-4-ynylamine derivatives
CN1252003A (zh) 1997-03-31 2000-05-03 强生消费者公司 增强药物化合物渗透作用的溶剂***
WO1999049895A2 (en) 1998-03-31 1999-10-07 Johnson And Johnson Consumer Companies, Inc. Method for increasing the permeability of horny human tissue
US6231875B1 (en) 1998-03-31 2001-05-15 Johnson & Johnson Consumer Companies, Inc. Acidified composition for topical treatment of nail and skin conditions
US6251428B1 (en) * 1998-07-24 2001-06-26 Seo Hong Yoo Preparation of aqueous clear solution dosage forms with bile acids
JP2000053681A (ja) 1998-08-10 2000-02-22 Sankyo Co Ltd 三環性複素環化合物を含有する抗菌剤
SK286804B6 (sk) * 1999-10-22 2009-05-07 Richter Gedeon Vegy�Szeti Gy�R Rt. Spôsob prípravy substituovaného derivátu alylamínu a jeho solí
GB0014448D0 (en) 2000-06-13 2000-08-09 Novartis Ag Organic compounds
JP4899139B2 (ja) 2000-08-10 2012-03-21 株式会社ポーラファルマ 抗真菌医薬組成物
JP2002068975A (ja) 2000-08-25 2002-03-08 Pola Chem Ind Inc 抗真菌医薬組成物
JP4803511B2 (ja) 2000-08-25 2011-10-26 株式会社ポーラファルマ 抗真菌医薬組成物

Also Published As

Publication number Publication date
KR20030077606A (ko) 2003-10-01
ZA200306029B (en) 2004-06-28
IL157241A (en) 2009-06-15
US20040147603A1 (en) 2004-07-29
DE60203890D1 (de) 2005-06-02
RU2289570C2 (ru) 2006-12-20
CZ20032132A3 (cs) 2003-10-15
ATE294154T1 (de) 2005-05-15
CA2437592A1 (en) 2002-09-12
DK1370513T3 (da) 2005-08-01
HUP0303174A3 (en) 2008-03-28
DE60203890T2 (de) 2006-01-19
NZ527300A (en) 2005-02-25
SK9992003A3 (en) 2004-01-08
PL204812B1 (pl) 2010-02-26
HK1060876A1 (en) 2004-08-27
CN1491206A (zh) 2004-04-21
AU2002238534C1 (en) 2006-04-13
US20070088084A1 (en) 2007-04-19
IL157241A0 (en) 2004-02-19
PL362554A1 (en) 2004-11-02
PT1370513E (pt) 2005-08-31
JP2004523567A (ja) 2004-08-05
HUP0303174A2 (hu) 2003-12-29
CN1216034C (zh) 2005-08-24
RU2003126176A (ru) 2005-03-10
ECSP034713A (es) 2003-09-24
US7488759B2 (en) 2009-02-10
MXPA03007072A (es) 2003-11-18
NO20033473D0 (no) 2003-08-05
EP1370513A1 (en) 2003-12-17
WO2002070455A1 (en) 2002-09-12
AU2002238534B2 (en) 2005-09-29
GB0103046D0 (en) 2001-03-21
SI1370513T1 (en) 2005-10-31
JP4078206B2 (ja) 2008-04-23
ES2240698T3 (es) 2005-10-16
KR20080041756A (ko) 2008-05-13
NO20033473L (no) 2003-09-17
KR100859609B1 (ko) 2008-09-23
EP1370513B1 (en) 2005-04-27

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 9A ANUIDADE(S).

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2103 DE 26/04/2011.