HUP0303174A3 - Malic acid addition salts of terbinafine, process for their preparation and pharmaceutical compositions containing them - Google Patents

Malic acid addition salts of terbinafine, process for their preparation and pharmaceutical compositions containing them

Info

Publication number: HUP0303174A3
Authority: HU; Hungary
Prior art keywords: terbinafine; preparation; pharmaceutical compositions; acid addition; addition salts
Prior art date: 2001-02-07

Application number

HU0303174A

Other languages

English (en)

Original Assignee

Novartis Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-02-07

Filing date

2002-02-06

Publication date

2008-03-28

2002-02-06 Application filed by Novartis Ag filed Critical Novartis Ag

2003-12-29 Publication of HUP0303174A2 publication Critical patent/HUP0303174A2/hu

2008-03-28 Publication of HUP0303174A3 publication Critical patent/HUP0303174A3/hu

Links

BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 title 1
BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 title 1
235000011090 malic acid Nutrition 0.000 title 1
239000001630 malic acid Substances 0.000 title 1
239000008194 pharmaceutical composition Substances 0.000 title 1
150000003839 salts Chemical class 0.000 title 1
DOMXUEMWDBAQBQ-WEVVVXLNSA-N terbinafine Chemical class C1=CC=C2C(CN(C\C=C\C#CC(C)(C)C)C)=CC=CC2=C1 DOMXUEMWDBAQBQ-WEVVVXLNSA-N 0.000 title 1
229960002722 terbinafine Drugs 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
- C07C211/26—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
- C07C211/30—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring the six-membered aromatic ring being part of a condensed ring system formed by two rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Emergency Medicine (AREA)
Epidemiology (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Surgery (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Seasonings (AREA)

HU0303174A 2001-02-07 2002-02-06 Malic acid addition salts of terbinafine, process for their preparation and pharmaceutical compositions containing them HUP0303174A3 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GBGB0103046.9A GB0103046D0 (en)	2001-02-07	2001-02-07	Organic Compounds
PCT/EP2002/001249 WO2002070455A1 (en)	2001-02-07	2002-02-06	Malic acid addition salts of terbinafine

Publications (2)

Publication Number	Publication Date
HUP0303174A2 HUP0303174A2 (hu)	2003-12-29
HUP0303174A3 true HUP0303174A3 (en)	2008-03-28

Family

ID=9908301

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HU0303174A HUP0303174A3 (en)	2001-02-07	2002-02-06	Malic acid addition salts of terbinafine, process for their preparation and pharmaceutical compositions containing them

Country Status (28)

Country	Link
US (2)	US20040147603A1 (hu)
EP (1)	EP1370513B1 (hu)
JP (1)	JP4078206B2 (hu)
KR (2)	KR100859609B1 (hu)
CN (1)	CN1216034C (hu)
AT (1)	ATE294154T1 (hu)
AU (1)	AU2002238534C1 (hu)
BR (1)	BR0207077A (hu)
CA (1)	CA2437592A1 (hu)
CZ (1)	CZ20032132A3 (hu)
DE (1)	DE60203890T2 (hu)
DK (1)	DK1370513T3 (hu)
EC (1)	ECSP034713A (hu)
ES (1)	ES2240698T3 (hu)
GB (1)	GB0103046D0 (hu)
HK (1)	HK1060876A1 (hu)
HU (1)	HUP0303174A3 (hu)
IL (2)	IL157241A0 (hu)
MX (1)	MXPA03007072A (hu)
NO (1)	NO20033473L (hu)
NZ (1)	NZ527300A (hu)
PL (1)	PL204812B1 (hu)
PT (1)	PT1370513E (hu)
RU (1)	RU2289570C2 (hu)
SI (1)	SI1370513T1 (hu)
SK (1)	SK9992003A3 (hu)
WO (1)	WO2002070455A1 (hu)
ZA (1)	ZA200306029B (hu)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU2003244633A1 (en) *	2002-07-02	2004-01-23	Novartis Ag	Methods for the treatment of sinusitis
GB0503942D0 (en) *	2005-02-25	2005-04-06	Novartis Ag	Purification process
WO2007104474A1 (en) *	2006-03-10	2007-09-20	Novartis Ag	Antifungal compositions comprising (1) a salt of terbinafine with malic acid and (2) malic acid
EP2043604A2 (en)	2006-06-14	2009-04-08	Dr. Reddy's Laboratories Ltd.	Topical compositions
CA2995880C (en)	2009-01-16	2021-01-05	Exelixis, Inc.	Processes for preparing n-(4-{[6,7-bis(methyloxy)quinolin-4-yl]oxy}phenyl)-n'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide
CN106106449A (zh) *	2016-06-21	2016-11-16	广西中烟工业有限责任公司	特比萘芬制剂及其在提高烟叶角鲨烯含量中的应用

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3507755A (en) *	1967-10-17	1970-04-21	Bayer Ag	Process for the purification of acrylonitrile by distillation with side stream withdrawal and decantation
US4276125A (en)	1979-02-02	1981-06-30	Asahi Kasei Kogyo Kabushiki Kaisha	Process for purification of crude olefinically unsaturated nitrile and condenser useful for same process
US4269667A (en)	1979-08-02	1981-05-26	Standard Oil Company	Acrylonitrile purification by extractive distillation
DE19375084I2 (de) *	1979-08-22	2000-11-16	Novartis Ag	Propenylamine Verfahren zu ihrer Herstellung sie enthaltende pharmazeutische Zusammensetzungen und ihre Verwendung als Arzneimittel
KR850001603B1 (ko)	1980-12-03	1985-10-24	아사히 가세이 고오교오 가부시기가이샤	불포화 니트릴의 제조법
GB8608335D0 (en)	1986-04-04	1986-05-08	Pfizer Ltd	Pharmaceutically acceptable salts
NZ227042A (en) *	1987-11-27	1991-05-28	Banyu Pharma Co Ltd	Substituted alkylamine derivatives and pharmaceutical compositions
HU223343B1 (hu) *	1991-05-20	2004-06-28	Novartis Ag.	Allil-amin-származékot tartalmazó gyógyászati készítmények és eljárás azok előállítására
US6005001A (en) *	1991-05-20	1999-12-21	Novartis Ag (Formerly Sandoz Ag)	Pharmaceutical composition
HU219480B (hu)	1991-05-23	2001-04-28	Novartis Ag.	Eljárás gombás körömmegbetegségek ellen helyileg alkalmazható, allil-amin-származékot tartalmazó gyógyászati készítmények előállítására
US5461068A (en) *	1993-09-29	1995-10-24	Corwood Laboratories, Inc.	Imidazole derivative tincture and method of manufacture
DE4400770C1 (de) *	1994-01-13	1995-02-02	Lohmann Therapie Syst Lts	Wirkstoffhaltiges Pflaster zur Abgabe von Estradiol mit mindestens einem Penetrationsverstärker, Verfahren zu seiner Herstellung und seine Verwendung
NZ280065A (en) *	1995-09-20	1998-04-27	Apotex Inc	Preparation of n-alkyl-n-(1-naphthylmethyl)alk-2-en-4-ynylamine derivatives
HUP0001739A3 (en) *	1997-03-31	2001-04-28	Johnson & Johnson Consumer	Solvent system for enhanced penetration of pharmaceutical compounds for topical use and the use of the buffer solvent system
US6231875B1 (en)	1998-03-31	2001-05-15	Johnson & Johnson Consumer Companies, Inc.	Acidified composition for topical treatment of nail and skin conditions
AU3212099A (en)	1998-03-31	1999-10-18	Johnson & Johnson Consumer Companies, Inc.	Method for increasing the permeability of horny human tissue
CN1205922C (zh) *	1998-07-24	2005-06-15	柳署弘	制备含有胆汁酸的澄清水溶液剂型
JP2000053681A (ja)	1998-08-10	2000-02-22	Sankyo Co Ltd	三環性複素環化合物を含有する抗菌剤
DE69909848T2 (de)	1999-10-22	2004-04-15	Richter Gedeon Vegyészeti Gyár R.T.	Verfahren zur herstellung substituierter allylamin derivative und deren salze
GB0014448D0 (en)	2000-06-13	2000-08-09	Novartis Ag	Organic compounds
JP4899139B2 (ja)	2000-08-10	2012-03-21	株式会社ポーラファルマ	抗真菌医薬組成物
JP4803511B2 (ja)	2000-08-25	2011-10-26	株式会社ポーラファルマ	抗真菌医薬組成物
JP2002068975A (ja)	2000-08-25	2002-03-08	Pola Chem Ind Inc	抗真菌医薬組成物

2001
- 2001-02-07 GB GBGB0103046.9A patent/GB0103046D0/en not_active Ceased
2002
- 2002-02-06 RU RU2003126176/04A patent/RU2289570C2/ru not_active IP Right Cessation
- 2002-02-06 ES ES02704689T patent/ES2240698T3/es not_active Expired - Lifetime
- 2002-02-06 IL IL15724102A patent/IL157241A0/xx unknown
- 2002-02-06 MX MXPA03007072A patent/MXPA03007072A/es active IP Right Grant
- 2002-02-06 HU HU0303174A patent/HUP0303174A3/hu unknown
- 2002-02-06 CA CA002437592A patent/CA2437592A1/en not_active Abandoned
- 2002-02-06 KR KR1020037010291A patent/KR100859609B1/ko not_active IP Right Cessation
- 2002-02-06 AU AU2002238534A patent/AU2002238534C1/en not_active Ceased
- 2002-02-06 NZ NZ527300A patent/NZ527300A/en unknown
- 2002-02-06 CZ CZ20032132A patent/CZ20032132A3/cs unknown
- 2002-02-06 CN CN028046080A patent/CN1216034C/zh not_active Expired - Fee Related
- 2002-02-06 EP EP02704689A patent/EP1370513B1/en not_active Expired - Lifetime
- 2002-02-06 JP JP2002569776A patent/JP4078206B2/ja not_active Expired - Fee Related
- 2002-02-06 BR BR0207077-4A patent/BR0207077A/pt not_active IP Right Cessation
- 2002-02-06 AT AT02704689T patent/ATE294154T1/de not_active IP Right Cessation
- 2002-02-06 SK SK999-2003A patent/SK9992003A3/sk not_active Application Discontinuation
- 2002-02-06 SI SI200230146T patent/SI1370513T1/xx unknown
- 2002-02-06 DK DK02704689T patent/DK1370513T3/da active
- 2002-02-06 PT PT02704689T patent/PT1370513E/pt unknown
- 2002-02-06 DE DE60203890T patent/DE60203890T2/de not_active Expired - Lifetime
- 2002-02-06 PL PL362554A patent/PL204812B1/pl not_active IP Right Cessation
- 2002-02-06 KR KR1020087010521A patent/KR20080041756A/ko not_active Application Discontinuation
- 2002-02-06 US US10/470,885 patent/US20040147603A1/en not_active Abandoned
- 2002-02-06 WO PCT/EP2002/001249 patent/WO2002070455A1/en active IP Right Grant
2003
- 2003-08-04 IL IL157241A patent/IL157241A/en not_active IP Right Cessation
- 2003-08-05 ZA ZA200306029A patent/ZA200306029B/en unknown
- 2003-08-05 NO NO20033473A patent/NO20033473L/no not_active Application Discontinuation
- 2003-08-06 EC EC2003004713A patent/ECSP034713A/es unknown
2004
- 2004-06-01 HK HK04103924A patent/HK1060876A1/xx not_active IP Right Cessation
2006
- 2006-11-29 US US11/606,268 patent/US7488759B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
EP1370513B1 (en)	2005-04-27
AU2002238534B2 (en)	2005-09-29
KR20080041756A (ko)	2008-05-13
DE60203890D1 (de)	2005-06-02
CN1216034C (zh)	2005-08-24
KR20030077606A (ko)	2003-10-01
ATE294154T1 (de)	2005-05-15
ZA200306029B (en)	2004-06-28
PL204812B1 (pl)	2010-02-26
HK1060876A1 (en)	2004-08-27
JP4078206B2 (ja)	2008-04-23
IL157241A (en)	2009-06-15
US20040147603A1 (en)	2004-07-29
CA2437592A1 (en)	2002-09-12
GB0103046D0 (en)	2001-03-21
EP1370513A1 (en)	2003-12-17
AU2002238534C1 (en)	2006-04-13
US7488759B2 (en)	2009-02-10
DE60203890T2 (de)	2006-01-19
PT1370513E (pt)	2005-08-31
MXPA03007072A (es)	2003-11-18
NO20033473D0 (no)	2003-08-05
HUP0303174A2 (hu)	2003-12-29
CZ20032132A3 (cs)	2003-10-15
KR100859609B1 (ko)	2008-09-23
US20070088084A1 (en)	2007-04-19
JP2004523567A (ja)	2004-08-05
PL362554A1 (en)	2004-11-02
IL157241A0 (en)	2004-02-19
SK9992003A3 (en)	2004-01-08
DK1370513T3 (da)	2005-08-01
ECSP034713A (es)	2003-09-24
CN1491206A (zh)	2004-04-21
BR0207077A (pt)	2004-01-20
SI1370513T1 (en)	2005-10-31
WO2002070455A1 (en)	2002-09-12
NO20033473L (no)	2003-09-17
ES2240698T3 (es)	2005-10-16
NZ527300A (en)	2005-02-25
RU2003126176A (ru)	2005-03-10
RU2289570C2 (ru)	2006-12-20

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Legal Events

Date	Code	Title	Description
2010-10-28	FD9A	Lapse of provisional protection due to non-payment of fees