HUP0303174A2 - A terbinafin almasav addíciós sói, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények - Google Patents

A terbinafin almasav addíciós sói, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények

Info

Publication number
HUP0303174A2
HUP0303174A2 HU0303174A HUP0303174A HUP0303174A2 HU P0303174 A2 HUP0303174 A2 HU P0303174A2 HU 0303174 A HU0303174 A HU 0303174A HU P0303174 A HUP0303174 A HU P0303174A HU P0303174 A2 HUP0303174 A2 HU P0303174A2
Authority
HU
Hungary
Prior art keywords
preparation
malic acid
terbinafine
pharmaceutical compositions
acid addition
Prior art date
Application number
HU0303174A
Other languages
English (en)
Inventor
Danielle Giron
Stefan Hirsch
Jean-Louis Reber
Original Assignee
Novartis Ag.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag. filed Critical Novartis Ag.
Publication of HUP0303174A2 publication Critical patent/HUP0303174A2/hu
Publication of HUP0303174A3 publication Critical patent/HUP0303174A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/26—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
    • C07C211/30—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring the six-membered aromatic ring being part of a condensed ring system formed by two rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Emergency Medicine (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Surgery (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Seasonings (AREA)

Abstract

A találmány tárgyát az (I) képletű vegyület almasavval képzett sók,azok előállítása, az azokból készült gyógyszerkészítmények és azokgombaellenes szerekként történő előállítása képezi. Ó
HU0303174A 2001-02-07 2002-02-06 Malic acid addition salts of terbinafine, process for their preparation and pharmaceutical compositions containing them HUP0303174A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0103046.9A GB0103046D0 (en) 2001-02-07 2001-02-07 Organic Compounds
PCT/EP2002/001249 WO2002070455A1 (en) 2001-02-07 2002-02-06 Malic acid addition salts of terbinafine

Publications (2)

Publication Number Publication Date
HUP0303174A2 true HUP0303174A2 (hu) 2003-12-29
HUP0303174A3 HUP0303174A3 (en) 2008-03-28

Family

ID=9908301

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0303174A HUP0303174A3 (en) 2001-02-07 2002-02-06 Malic acid addition salts of terbinafine, process for their preparation and pharmaceutical compositions containing them

Country Status (28)

Country Link
US (2) US20040147603A1 (hu)
EP (1) EP1370513B1 (hu)
JP (1) JP4078206B2 (hu)
KR (2) KR100859609B1 (hu)
CN (1) CN1216034C (hu)
AT (1) ATE294154T1 (hu)
AU (1) AU2002238534C1 (hu)
BR (1) BR0207077A (hu)
CA (1) CA2437592A1 (hu)
CZ (1) CZ20032132A3 (hu)
DE (1) DE60203890T2 (hu)
DK (1) DK1370513T3 (hu)
EC (1) ECSP034713A (hu)
ES (1) ES2240698T3 (hu)
GB (1) GB0103046D0 (hu)
HK (1) HK1060876A1 (hu)
HU (1) HUP0303174A3 (hu)
IL (2) IL157241A0 (hu)
MX (1) MXPA03007072A (hu)
NO (1) NO20033473L (hu)
NZ (1) NZ527300A (hu)
PL (1) PL204812B1 (hu)
PT (1) PT1370513E (hu)
RU (1) RU2289570C2 (hu)
SI (1) SI1370513T1 (hu)
SK (1) SK9992003A3 (hu)
WO (1) WO2002070455A1 (hu)
ZA (1) ZA200306029B (hu)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004004700A1 (en) * 2002-07-02 2004-01-15 Novartis Ag Methods for the treatment of sinusitis
GB0503942D0 (en) * 2005-02-25 2005-04-06 Novartis Ag Purification process
WO2007104474A1 (en) * 2006-03-10 2007-09-20 Novartis Ag Antifungal compositions comprising (1) a salt of terbinafine with malic acid and (2) malic acid
US8431140B2 (en) 2006-06-14 2013-04-30 Dr. Reddy's Laboratories, Inc. Topical compositions
EA019959B1 (ru) 2009-01-16 2014-07-30 Экселиксис, Инк. Малатная соль n-(4-{[6,7-бис-(метилокси)хинолин-4-ил]окси}фенил)-n'-(4-фторфенил)циклопропан-1,1-дикарбоксамида и ее кристаллические формы для лечения рака
CN106106449A (zh) * 2016-06-21 2016-11-16 广西中烟工业有限责任公司 特比萘芬制剂及其在提高烟叶角鲨烯含量中的应用

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3507755A (en) * 1967-10-17 1970-04-21 Bayer Ag Process for the purification of acrylonitrile by distillation with side stream withdrawal and decantation
US4276125A (en) 1979-02-02 1981-06-30 Asahi Kasei Kogyo Kabushiki Kaisha Process for purification of crude olefinically unsaturated nitrile and condenser useful for same process
US4269667A (en) 1979-08-02 1981-05-26 Standard Oil Company Acrylonitrile purification by extractive distillation
EP0024587B1 (en) * 1979-08-22 1984-11-14 Sandoz Ag Propenylamines, processes for their production, pharmaceutical compositions containing them and their use as pharmaceuticals
KR850001603B1 (ko) 1980-12-03 1985-10-24 아사히 가세이 고오교오 가부시기가이샤 불포화 니트릴의 제조법
GB8608335D0 (en) 1986-04-04 1986-05-08 Pfizer Ltd Pharmaceutically acceptable salts
NZ227042A (en) * 1987-11-27 1991-05-28 Banyu Pharma Co Ltd Substituted alkylamine derivatives and pharmaceutical compositions
HU223343B1 (hu) * 1991-05-20 2004-06-28 Novartis Ag. Allil-amin-származékot tartalmazó gyógyászati készítmények és eljárás azok előállítására
US6005001A (en) * 1991-05-20 1999-12-21 Novartis Ag (Formerly Sandoz Ag) Pharmaceutical composition
HU219480B (hu) 1991-05-23 2001-04-28 Novartis Ag. Eljárás gombás körömmegbetegségek ellen helyileg alkalmazható, allil-amin-származékot tartalmazó gyógyászati készítmények előállítására
US5461068A (en) * 1993-09-29 1995-10-24 Corwood Laboratories, Inc. Imidazole derivative tincture and method of manufacture
DE4400770C1 (de) * 1994-01-13 1995-02-02 Lohmann Therapie Syst Lts Wirkstoffhaltiges Pflaster zur Abgabe von Estradiol mit mindestens einem Penetrationsverstärker, Verfahren zu seiner Herstellung und seine Verwendung
NZ280065A (en) * 1995-09-20 1998-04-27 Apotex Inc Preparation of n-alkyl-n-(1-naphthylmethyl)alk-2-en-4-ynylamine derivatives
HUP0001739A3 (en) * 1997-03-31 2001-04-28 Johnson & Johnson Consumer Solvent system for enhanced penetration of pharmaceutical compounds for topical use and the use of the buffer solvent system
WO1999049895A2 (en) 1998-03-31 1999-10-07 Johnson And Johnson Consumer Companies, Inc. Method for increasing the permeability of horny human tissue
US6231875B1 (en) 1998-03-31 2001-05-15 Johnson & Johnson Consumer Companies, Inc. Acidified composition for topical treatment of nail and skin conditions
AU758679B2 (en) * 1998-07-24 2003-03-27 Seo Hong Yoo Preparation of aqueous clear solution dosage forms with bile acids
JP2000053681A (ja) 1998-08-10 2000-02-22 Sankyo Co Ltd 三環性複素環化合物を含有する抗菌剤
DK1222160T3 (da) 1999-10-22 2003-11-17 Richter Gedeon Vegyeszet Fremgangsmåde til fremstilling af substituerede allylaminderivater og salte deraf
GB0014448D0 (en) 2000-06-13 2000-08-09 Novartis Ag Organic compounds
JP4899139B2 (ja) 2000-08-10 2012-03-21 株式会社ポーラファルマ 抗真菌医薬組成物
JP4803511B2 (ja) 2000-08-25 2011-10-26 株式会社ポーラファルマ 抗真菌医薬組成物
JP2002068975A (ja) 2000-08-25 2002-03-08 Pola Chem Ind Inc 抗真菌医薬組成物

Also Published As

Publication number Publication date
US20040147603A1 (en) 2004-07-29
JP2004523567A (ja) 2004-08-05
US7488759B2 (en) 2009-02-10
NZ527300A (en) 2005-02-25
KR20030077606A (ko) 2003-10-01
EP1370513B1 (en) 2005-04-27
KR100859609B1 (ko) 2008-09-23
PT1370513E (pt) 2005-08-31
JP4078206B2 (ja) 2008-04-23
US20070088084A1 (en) 2007-04-19
NO20033473L (no) 2003-09-17
HK1060876A1 (en) 2004-08-27
ATE294154T1 (de) 2005-05-15
CN1491206A (zh) 2004-04-21
IL157241A0 (en) 2004-02-19
WO2002070455A1 (en) 2002-09-12
IL157241A (en) 2009-06-15
PL204812B1 (pl) 2010-02-26
PL362554A1 (en) 2004-11-02
CZ20032132A3 (cs) 2003-10-15
DK1370513T3 (da) 2005-08-01
EP1370513A1 (en) 2003-12-17
RU2289570C2 (ru) 2006-12-20
SI1370513T1 (en) 2005-10-31
CA2437592A1 (en) 2002-09-12
GB0103046D0 (en) 2001-03-21
ZA200306029B (en) 2004-06-28
BR0207077A (pt) 2004-01-20
SK9992003A3 (en) 2004-01-08
DE60203890T2 (de) 2006-01-19
DE60203890D1 (de) 2005-06-02
ES2240698T3 (es) 2005-10-16
HUP0303174A3 (en) 2008-03-28
AU2002238534C1 (en) 2006-04-13
KR20080041756A (ko) 2008-05-13
AU2002238534B2 (en) 2005-09-29
ECSP034713A (es) 2003-09-24
CN1216034C (zh) 2005-08-24
RU2003126176A (ru) 2005-03-10
MXPA03007072A (es) 2003-11-18
NO20033473D0 (no) 2003-08-05

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Legal Events

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FD9A Lapse of provisional protection due to non-payment of fees