BR0108378A - Sal cristalino de um composto, composição farmacêutica, processo para a manufatura do dito sal, e, uso do mesmo - Google Patents

Sal cristalino de um composto, composição farmacêutica, processo para a manufatura do dito sal, e, uso do mesmo

Info

Publication number
BR0108378A
BR0108378A BR0108378-3A BR0108378A BR0108378A BR 0108378 A BR0108378 A BR 0108378A BR 0108378 A BR0108378 A BR 0108378A BR 0108378 A BR0108378 A BR 0108378A
Authority
BR
Brazil
Prior art keywords
salt
manufacture
compound
pharmaceutical composition
crystalline
Prior art date
Application number
BR0108378-3A
Other languages
English (en)
Inventor
Nigel Philip Taylor
Tetsuo Okada
Original Assignee
Astrazeneca Ab
Shionogi & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab, Shionogi & Co filed Critical Astrazeneca Ab
Publication of BR0108378A publication Critical patent/BR0108378A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

"SAL CRISTALINO DE UM COMPOSTO, COMPOSIçãO FARMACêUTICA, PROCESSO PARA A MANUFATURA DO DITO SAL, E, USO DO MESMO". A invenção refere-se a sais cristalinos do composto ácido (E)7-[4-(4-fluorofenil)-6-isopropil-2-[metil(metil-sulfonil)amino] pirimi-din-5il] -(3R,5S)-3,5-diidróxiept-6-enóico de fórmula (I), bem como a processos para sua manufatura, composições farmacêuticas contendo-os, e seus usos.
BR0108378-3A 2000-02-15 2001-02-12 Sal cristalino de um composto, composição farmacêutica, processo para a manufatura do dito sal, e, uso do mesmo BR0108378A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0003305.0A GB0003305D0 (en) 2000-02-15 2000-02-15 Pyrimidine derivatives
PCT/GB2001/000574 WO2001060804A1 (en) 2000-02-15 2001-02-12 Crystalline salts of 7-[4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl]-(3r,5s)-3,5-dihydroxyhept-6-enoic acid

Publications (1)

Publication Number Publication Date
BR0108378A true BR0108378A (pt) 2003-03-11

Family

ID=9885517

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0108378-3A BR0108378A (pt) 2000-02-15 2001-02-12 Sal cristalino de um composto, composição farmacêutica, processo para a manufatura do dito sal, e, uso do mesmo

Country Status (36)

Country Link
US (2) US6841554B2 (pt)
EP (2) EP1873148B1 (pt)
JP (1) JP4099333B2 (pt)
KR (1) KR100708262B1 (pt)
CN (1) CN1210266C (pt)
AR (1) AR029228A1 (pt)
AT (2) ATE382610T1 (pt)
AU (1) AU775569B2 (pt)
BG (1) BG65562B1 (pt)
BR (1) BR0108378A (pt)
CA (1) CA2397450C (pt)
CO (1) CO5280213A1 (pt)
CY (2) CY1107225T1 (pt)
CZ (1) CZ302136B6 (pt)
DE (2) DE60132178T2 (pt)
DK (2) DK1873148T3 (pt)
EE (1) EE05288B1 (pt)
ES (2) ES2298214T3 (pt)
GB (1) GB0003305D0 (pt)
HK (2) HK1051532A1 (pt)
HU (1) HU228422B1 (pt)
IL (2) IL150807A0 (pt)
IS (1) IS2592B (pt)
MX (1) MXPA02007819A (pt)
MY (1) MY129018A (pt)
NO (1) NO323770B1 (pt)
NZ (1) NZ520032A (pt)
PL (1) PL206729B1 (pt)
PT (2) PT1263739E (pt)
RU (1) RU2265599C2 (pt)
SA (1) SA01220166B1 (pt)
SI (2) SI1873148T1 (pt)
SK (1) SK287144B6 (pt)
UA (1) UA74567C2 (pt)
WO (1) WO2001060804A1 (pt)
ZA (1) ZA200205331B (pt)

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Also Published As

Publication number Publication date
ES2335542T3 (es) 2010-03-29
IS2592B (is) 2010-03-15
RU2265599C2 (ru) 2005-12-10
CA2397450C (en) 2009-11-17
CY1107225T1 (el) 2013-04-18
SK287144B6 (sk) 2010-01-07
KR20030011771A (ko) 2003-02-11
CN1210266C (zh) 2005-07-13
NO20023853L (no) 2002-08-14
DK1873148T3 (da) 2010-03-08
HK1055958A1 (en) 2004-01-30
PT1873148E (pt) 2010-01-20
DE60132178T2 (de) 2008-12-18
IL150807A0 (en) 2003-02-12
JP4099333B2 (ja) 2008-06-11
JP2003523334A (ja) 2003-08-05
SA01220166B1 (ar) 2006-11-25
CY1109756T1 (el) 2014-09-10
EP1873148A1 (en) 2008-01-02
BG65562B1 (bg) 2008-12-30
KR100708262B1 (ko) 2007-04-17
UA74567C2 (uk) 2006-01-16
IS6494A (is) 2002-08-09
SI1263739T1 (sl) 2008-04-30
MY129018A (en) 2007-03-30
NZ520032A (en) 2004-03-26
PT1263739E (pt) 2008-02-19
NO323770B1 (no) 2007-07-02
DE60140581D1 (de) 2009-12-31
NO20023853D0 (no) 2002-08-14
ES2298214T3 (es) 2008-05-16
IL150807A (en) 2007-07-04
US20030045718A1 (en) 2003-03-06
CZ20022754A3 (cs) 2002-11-13
HUP0204051A3 (en) 2003-07-28
HU228422B1 (en) 2013-03-28
CN1418198A (zh) 2003-05-14
EE05288B1 (et) 2010-04-15
EP1873148B1 (en) 2009-11-18
US6841554B2 (en) 2005-01-11
AU3208401A (en) 2001-08-27
WO2001060804A1 (en) 2001-08-23
US20060014766A1 (en) 2006-01-19
US7129352B2 (en) 2006-10-31
AR029228A1 (es) 2003-06-18
ZA200205331B (en) 2003-10-03
DK1263739T3 (da) 2008-03-17
ATE382610T1 (de) 2008-01-15
EE200200445A (et) 2003-12-15
AU775569B2 (en) 2004-08-05
GB0003305D0 (en) 2000-04-05
BG106969A (en) 2003-04-30
CA2397450A1 (en) 2001-08-23
CO5280213A1 (es) 2003-05-30
SK11742002A3 (sk) 2003-02-04
RU2002124621A (ru) 2004-01-10
CZ302136B6 (cs) 2010-11-10
ATE449079T1 (de) 2009-12-15
SI1873148T1 (sl) 2010-02-26
DE60132178D1 (de) 2008-02-14
HK1051532A1 (en) 2003-08-08
HUP0204051A2 (en) 2003-05-28
PL356472A1 (en) 2004-06-28
EP1263739B9 (en) 2008-10-29
PL206729B1 (pl) 2010-09-30
EP1263739A1 (en) 2002-12-11
MXPA02007819A (es) 2004-09-10
EP1263739B1 (en) 2008-01-02

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