JPS56142236A - Ml-236a and mb-530a derivative - Google Patents

Ml-236a and mb-530a derivative

Info

Publication number
JPS56142236A
JPS56142236A JP4600480A JP4600480A JPS56142236A JP S56142236 A JPS56142236 A JP S56142236A JP 4600480 A JP4600480 A JP 4600480A JP 4600480 A JP4600480 A JP 4600480A JP S56142236 A JPS56142236 A JP S56142236A
Authority
JP
Japan
Prior art keywords
formula
novel
derivative
methylbutyryl
substitued
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP4600480A
Other languages
Japanese (ja)
Inventor
Aiya Satou
Akira Terahara
Yoshio Tsujita
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sankyo Co Ltd
Original Assignee
Sankyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sankyo Co Ltd filed Critical Sankyo Co Ltd
Priority to JP4600480A priority Critical patent/JPS56142236A/en
Priority to SE8102254A priority patent/SE8102254L/en
Priority to DE3114242A priority patent/DE3114242A1/en
Priority to NL8101749A priority patent/NL8101749A/en
Priority to GB8111061A priority patent/GB2073199A/en
Priority to IT67490/81A priority patent/IT1144327B/en
Priority to FI811080A priority patent/FI811080L/en
Priority to DK158781A priority patent/DK158781A/en
Priority to FR8107028A priority patent/FR2479809A1/en
Priority to BE0/204416A priority patent/BE888332A/en
Publication of JPS56142236A publication Critical patent/JPS56142236A/en
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/42—Unsaturated compounds containing hydroxy or O-metal groups
    • C07C59/46—Unsaturated compounds containing hydroxy or O-metal groups containing rings other than six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/30—Oxygen atoms, e.g. delta-lactones
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14—Fungi; Culture media therefor
    • C12N1/145—Fungal isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/42—Hydroxy-carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/62—Carboxylic acid esters
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/645—Fungi ; Processes using fungi
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/645—Fungi ; Processes using fungi
    • C12R2001/80—Penicillium
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/645—Fungi ; Processes using fungi
    • C12R2001/80—Penicillium
    • C12R2001/82—Penicillium chrysogenum
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/645—Fungi ; Processes using fungi
    • C12R2001/80—Penicillium
    • C12R2001/825—Penicillium notatum

Abstract

NEW MATERIAL:Compounds of formula I (R1 is H, methyl; R2 is metal atom, alkyl, aralkyl and phenacyl, both of which may be substitued on the ring; R3WR5 are H, acyl; where, when R3 is 2-methylbutyryl, neither R4 or R5 are H).
EXAMPLE: Sodium ML-236A carboxylate.
USE: Remedy for hyperlipemia and prophylactic for arteriosclerosis: they prohibits cholesterol synthesis to lower lipids in blood.
PREPARATION: Any of ML-236A of formula II, ML-236B of formula III, novel MB- 530A of formula IV or novel MB-530B of formula V is used as a raw material to be esterified or converted to a metal salt according to the purpose.
COPYRIGHT: (C)1981,JPO&Japio
JP4600480A 1980-04-08 1980-04-08 Ml-236a and mb-530a derivative Pending JPS56142236A (en)

Priority Applications (10)

Application Number Priority Date Filing Date Title
JP4600480A JPS56142236A (en) 1980-04-08 1980-04-08 Ml-236a and mb-530a derivative
SE8102254A SE8102254L (en) 1980-04-08 1981-04-08 ASSOCIATIONS WHICH INHIBIT CHOLESTEROL BIOSYNTHESIS AND PREPARATION THEREOF
DE3114242A DE3114242A1 (en) 1980-04-08 1981-04-08 CARBONIC ACID DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND MEDICINAL PRODUCTS CONTAINING THESE DERIVATIVES
NL8101749A NL8101749A (en) 1980-04-08 1981-04-08 CHOLESTEROL BIOSYNTHESIS INHIBITORY COMPOUNDS AND THEIR PREPARATION.
GB8111061A GB2073199A (en) 1980-04-08 1981-04-08 Compounds Which Inhibit Cholesterol Biosynthesis, and Their Preparation
IT67490/81A IT1144327B (en) 1980-04-08 1981-04-08 CHOLESTEROL BIOSYNTHESIS INHIBITION COMPOUNDS AND PROCEDURE FOR THEIR PREPARATION
FI811080A FI811080L (en) 1980-04-08 1981-04-08 FOERENINGAR SOM INHIBERA KOLESTEROL BIOSYNTHESIS OCH DESS FRAMSTAELLNING
DK158781A DK158781A (en) 1980-04-08 1981-04-08 PROCEDURE FOR PREPARING RELATIONSHIPS WITH INHIBITIVE EFFECTS ON THE NIOSYNTHESIS OF CHOLESTEROL
FR8107028A FR2479809A1 (en) 1980-04-08 1981-04-08 CHOLESTEROL BIOSYNTHESIS INHIBITOR COMPOUNDS, PROCESS FOR PREPARING THEM AND THERAPEUTIC APPLICATION THEREOF
BE0/204416A BE888332A (en) 1980-04-08 1981-04-08 COMPOUNDS INHIBITORS OF THE BIOSYNTHESIS OF CHOLESTEROL, THEIR PREPARATIO AND BIOSYNTHESIS OF CHOLESTEROL PROCESSES. THEIR PREPARATION PROCESS AND THEIR THERAPEUTIC APPLICATION,

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP4600480A JPS56142236A (en) 1980-04-08 1980-04-08 Ml-236a and mb-530a derivative

Publications (1)

Publication Number Publication Date
JPS56142236A true JPS56142236A (en) 1981-11-06

Family

ID=12734918

Family Applications (1)

Application Number Title Priority Date Filing Date
JP4600480A Pending JPS56142236A (en) 1980-04-08 1980-04-08 Ml-236a and mb-530a derivative

Country Status (10)

Country Link
JP (1) JPS56142236A (en)
BE (1) BE888332A (en)
DE (1) DE3114242A1 (en)
DK (1) DK158781A (en)
FI (1) FI811080L (en)
FR (1) FR2479809A1 (en)
GB (1) GB2073199A (en)
IT (1) IT1144327B (en)
NL (1) NL8101749A (en)
SE (1) SE8102254L (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002020453A1 (en) * 2000-09-07 2002-03-14 Kaneka Corporation Methods for crystallization of hydroxycarboxylic acids

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4450171A (en) * 1980-08-05 1984-05-22 Merck & Co., Inc. Antihypercholesterolemic compounds
JPS5855443A (en) * 1981-09-25 1983-04-01 Sankyo Co Ltd Octahydronaphthalene derivative and its preparation
CA1327360C (en) * 1983-11-14 1994-03-01 William F. Hoffman Oxo-analogs of mevinolin-like antihypercholesterolemic agents
EP0164049B1 (en) * 1984-06-04 1990-12-12 Merck & Co. Inc. Process for preparing hmg-coa reductase inhibtors with a 3,5-dihydroxypentanoate subunit
EP0204287A3 (en) * 1985-06-04 1987-07-01 Merck & Co. Inc. Process for the preparation of hmg-coa reductase inhibitors with a 3,5-dihydroxypentanoate subunit
US4997848A (en) * 1987-10-27 1991-03-05 Sankyo Company, Limited Octahydronaphthalene oxime derivatives for cholesterol synthesis inhibition
US5250435A (en) * 1991-06-04 1993-10-05 Merck & Co., Inc. Mutant strains of Aspergillus terreus for producing 7-[1,2,6,7,8,8a(R)-hexa-hydro-2(S),6(R)-dimethyl-8(S)-hydroxy-1(S)-naphthyl]-3(R),5(R)-dihydroxyheptanoic acid (triol acid),I)
GB0003305D0 (en) 2000-02-15 2000-04-05 Zeneca Ltd Pyrimidine derivatives
SK242004A3 (en) 2001-06-13 2004-06-08 Ranbaxy Lab Ltd Methyl analogs of simvastatin as novel HMG-CoA reductase inhibitors
US8158362B2 (en) 2005-03-30 2012-04-17 Decode Genetics Ehf. Methods of diagnosing susceptibility to myocardial infarction and screening for an LTA4H haplotype

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS51136885A (en) * 1975-05-12 1976-11-26 Sankyo Co Ltd New biologically active substance, ml-236a, and its pr eparation
JPS5356314A (en) * 1976-11-02 1978-05-22 Sankyo Co Ltd Remedies for hyperlipemia containing ml-236b metal salt as main component

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5612114B2 (en) 1974-06-07 1981-03-18
JPS5925599B2 (en) 1979-02-20 1984-06-19 三共株式会社 New physiologically active substance monacolin K and its production method
JPS55150898A (en) 1979-05-11 1980-11-25 Sankyo Co Ltd Preparation of a new physiologically active substance mb-530b

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS51136885A (en) * 1975-05-12 1976-11-26 Sankyo Co Ltd New biologically active substance, ml-236a, and its pr eparation
JPS5356314A (en) * 1976-11-02 1978-05-22 Sankyo Co Ltd Remedies for hyperlipemia containing ml-236b metal salt as main component

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002020453A1 (en) * 2000-09-07 2002-03-14 Kaneka Corporation Methods for crystallization of hydroxycarboxylic acids
US7034180B2 (en) 2000-09-07 2006-04-25 Kaneka Corporation Method for crystallization of hydroxycarboxylic acids
US7323592B2 (en) 2000-09-07 2008-01-29 Kaneka Corporation Methods for crystallization of hydroxycarboxylic acids
JP4870320B2 (en) * 2000-09-07 2012-02-08 株式会社カネカ Method for crystallizing hydroxycarboxylic acid
JP2012025757A (en) * 2000-09-07 2012-02-09 Kaneka Corp Method of crystallizing hydroxycarboxylic acid

Also Published As

Publication number Publication date
SE8102254L (en) 1981-10-09
BE888332A (en) 1981-10-08
NL8101749A (en) 1981-11-02
GB2073199A (en) 1981-10-14
FR2479809A1 (en) 1981-10-09
DK158781A (en) 1981-10-09
IT1144327B (en) 1986-10-29
IT8167490A0 (en) 1981-04-08
FI811080L (en) 1981-10-09
DE3114242A1 (en) 1982-06-16

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