BR0311195A - Processo de preparação de rosuvastatina - Google Patents
Processo de preparação de rosuvastatinaInfo
- Publication number
- BR0311195A BR0311195A BR0311195-4A BR0311195A BR0311195A BR 0311195 A BR0311195 A BR 0311195A BR 0311195 A BR0311195 A BR 0311195A BR 0311195 A BR0311195 A BR 0311195A
- Authority
- BR
- Brazil
- Prior art keywords
- rosuvastatin
- preparation process
- preparation
- rosuvastatin preparation
- pyrimidinoc
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
"PROCESSO DE PREPARAçãO DE ROSUVASTATINA". A presente invenção se refere a um processo, industrialmente vantajoso e eficaz sob o ponto de vista de custos, para a preparação de 4-4(fluorfenil)-6-isopropil-2-(N-metil-N-metilsulfonilamino)-5-pirimidinoc arboxaldeído, aqui referido como pirimidino-aldeído de Fórmula estrutural I, e ao uso deste composto como intermediário para a preparação de rosuvastatina.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IN575DE2002 | 2002-05-21 | ||
PCT/IB2003/001946 WO2003097614A2 (en) | 2002-05-21 | 2003-05-21 | Process for the preparation of rosuvastatin |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0311195A true BR0311195A (pt) | 2005-02-22 |
Family
ID=29434392
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0311195-4A BR0311195A (pt) | 2002-05-21 | 2003-05-21 | Processo de preparação de rosuvastatina |
Country Status (7)
Country | Link |
---|---|
US (1) | US20050222415A1 (pt) |
EP (1) | EP1585736A2 (pt) |
AR (1) | AR039836A1 (pt) |
AU (1) | AU2003228010A1 (pt) |
BR (1) | BR0311195A (pt) |
EA (1) | EA200401533A1 (pt) |
WO (1) | WO2003097614A2 (pt) |
Families Citing this family (56)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2453505C (en) | 2001-07-13 | 2011-04-19 | Astrazeneca Uk Limited | Preparation of aminopyrimidine compounds |
GB0218781D0 (en) | 2002-08-13 | 2002-09-18 | Astrazeneca Ab | Chemical process |
GB0312896D0 (en) | 2003-06-05 | 2003-07-09 | Astrazeneca Ab | Chemical process |
WO2005021511A1 (en) * | 2003-08-27 | 2005-03-10 | Hetero Drugs Limited | A novel process for amorphous rosuvastatin calcium |
EP1816126A1 (en) * | 2003-08-28 | 2007-08-08 | Teva Pharmaceutical Industries Limited | Process for preparation of rosuvastatin calcium |
CA2657076A1 (en) * | 2003-08-28 | 2005-03-17 | Teva Pharmaceutical Industries Ltd. | Process for the preparation of rosuvastatin calcium |
UY28501A1 (es) | 2003-09-10 | 2005-04-29 | Astrazeneca Uk Ltd | Compuestos químicos |
GB0324791D0 (en) | 2003-10-24 | 2003-11-26 | Astrazeneca Ab | Chemical process |
CA2546701C (en) * | 2003-11-24 | 2010-07-27 | Teva Pharmaceutical Industries Ltd. | Crystalline ammonium salts of rosuvastatin |
WO2005056534A1 (en) * | 2003-12-02 | 2005-06-23 | Teva Pharmaceutical Industries Ltd. | Reference standard for characterization of rosuvastatin |
US7851624B2 (en) | 2003-12-24 | 2010-12-14 | Teva Pharamaceutical Industries Ltd. | Triol form of rosuvastatin and synthesis of rosuvastatin |
WO2006017357A1 (en) * | 2004-07-13 | 2006-02-16 | Teva Pharmaceutical Industries Ltd. | A process for the preparation of rosuvastatin involving a tempo-mediated oxidation step |
CZ298330B6 (cs) * | 2004-07-19 | 2007-08-29 | Zentiva, A. S. | Zpusob výroby 4-(4-fluorfenyl)-6-isopropyl-2-(N-methyl-N-methylsulfonylamino)-5-pyrimidinkarbaldehydu a jeho použití |
KR100622494B1 (ko) * | 2004-09-06 | 2006-09-19 | 현대자동차주식회사 | 조향 휠의 조립 구조 |
CN1763015B (zh) * | 2004-10-22 | 2011-06-22 | 四川抗菌素工业研究所有限公司 | 一种罗舒伐他汀及其药用盐的制备方法及中间体 |
CN100351240C (zh) * | 2005-01-19 | 2007-11-28 | 安徽省庆云医药化工有限公司 | 瑞舒伐他汀钙的合成方法 |
CN101128437A (zh) * | 2005-02-22 | 2008-02-20 | 特瓦制药工业有限公司 | 不含罗苏伐他汀烷基醚的罗苏伐他汀及其盐以及制备它们的方法 |
US20070167625A1 (en) * | 2005-02-22 | 2007-07-19 | Anna Balanov | Preparation of rosuvastatin |
JP4713574B2 (ja) * | 2005-02-22 | 2011-06-29 | テバ ファーマシューティカル インダストリーズ リミティド | ロスバスタチンアルキルエーテルを含まないロスバスタチンおよびその塩およびそれらを製造する方法 |
US20070037979A1 (en) * | 2005-02-22 | 2007-02-15 | Valerie Niddam-Hildesheim | Preparation of rosuvastatin |
EP1863773A1 (en) * | 2005-03-22 | 2007-12-12 | Unichem Laboratories Limited | Process for preparation of rosuvastatin |
US20080161560A1 (en) * | 2005-04-04 | 2008-07-03 | Pandurang Balwant Deshpande | Process for Preparation of Calcium Salt of Rosuvastatin |
EP1893585A1 (en) * | 2005-06-01 | 2008-03-05 | Fermion Oy | Process for the preparation of n-[4-(4-fluorophenyl)-5-formyl-6-isopropyl-pyrimidin-2-yl]-n-methylmethanesulfonamide |
WO2006136407A1 (en) * | 2005-06-24 | 2006-12-28 | Lek Pharmaceuticals D.D. | Process for preparing amorphous rosuvastatin calcium free of impurities |
MX2007004423A (es) * | 2005-08-16 | 2007-06-14 | Teva Pharma | Calcio de rosuvastatina con bajo contenido de sal. |
EP1805148A2 (en) * | 2005-08-16 | 2007-07-11 | Teva Pharmaceutical Industries Ltd. | Crystalline rosuvastatin intermediate |
CN100436428C (zh) * | 2005-08-22 | 2008-11-26 | 鲁南制药集团股份有限公司 | 瑞舒伐他汀及其盐的制备方法 |
TW200804305A (en) * | 2005-10-03 | 2008-01-16 | Teva Pharma | Diastereomeric purification of rosuvastatin |
WO2007074391A2 (en) * | 2005-12-28 | 2007-07-05 | Bakulesh Mafatlal Khamar | Preparation of a key intermediate in the synthesis of rosuvastatin |
WO2007125547A2 (en) | 2006-05-03 | 2007-11-08 | Manne Satyanarayana Reddy | Novel process for statins and its pharmaceutically acceptable salts thereof |
JP2008539278A (ja) * | 2006-09-18 | 2008-11-13 | テバ ファーマシューティカル インダストリーズ リミティド | 結晶性ロスバスタチンカルシウム |
US8404841B2 (en) | 2006-10-09 | 2013-03-26 | Msn Laboratories Limited | Process for the preparation of statins and their pharmaceutically acceptable salts thereof |
WO2008053334A2 (en) | 2006-10-31 | 2008-05-08 | Aurobindo Pharma Limited | An improved process for preparing rosuvastatin calcium |
WO2008072078A1 (en) * | 2006-12-13 | 2008-06-19 | Aurobindo Pharma Limited | An improved process for preparing rosuvastatin caclium |
WO2008093205A2 (en) * | 2007-01-31 | 2008-08-07 | Orchid Chemicals & Pharmaceuticals Limited | A method for the purification of rosuvastatin intermediate |
WO2008096257A1 (en) | 2007-02-08 | 2008-08-14 | Aurobindo Pharma Limited | An improved process for preparation of rosuvastatin calcium |
PL2172471T3 (pl) | 2007-04-18 | 2013-08-30 | Teva Pharma | Sposób otrzymywania produktów pośrednich inhibitorów reduktazy HMG-CoA |
CN101323597B (zh) * | 2007-06-11 | 2012-09-05 | 安徽省庆云医药化工有限公司 | 4-(4-氟苯基)-6-异丙基-2-(n-甲基-n-甲磺酰氨基)嘧啶-5-甲醛的制备方法 |
EP2178890A1 (en) | 2007-07-12 | 2010-04-28 | Teva Pharmaceutical Industries Ltd. | Purification of rosuvastatin intermediate by thin film evaporation and chemical method |
EP2022784A1 (en) * | 2007-08-08 | 2009-02-11 | LEK Pharmaceuticals D.D. | Process for the preparation of methyl ester of rosuvastatin |
EP2223909A1 (en) | 2007-08-28 | 2010-09-01 | Ratiopharm GmbH | Process for preparing pentanoic diacid derivatives |
WO2009143776A1 (zh) | 2008-05-27 | 2009-12-03 | 常州制药厂有限公司 | 瑞舒伐他汀钙盐的制备方法及其中间体 |
EP2350025A1 (en) * | 2008-09-30 | 2011-08-03 | Aurobindo Pharma Limited | An improved process for preparing pyrimidine propenaldehyde |
WO2010081861A1 (en) | 2009-01-14 | 2010-07-22 | Krka, Tovarna Zdravil, D.D., Novo Mesto | Process for the preparation of rosuvastatin |
BRPI1005147A2 (pt) | 2009-01-15 | 2019-09-24 | Egis Gyogyszergyar Nyilvanosan Muekoedoe Reszvenytarsasag | processo de preparação de sais de rosuvastatina |
WO2010089770A2 (en) | 2009-01-19 | 2010-08-12 | Msn Laboratories Limited | Improved process for the preparation of highly pure (3r,5s)-7-[2-cyclopropyl-4-(4-fluorophenyl) quinolin-3-yl]-3,5-dihydroxy-6(e)-heptenoic acid and pharmaceutically acceptable salts thereof |
KR101160152B1 (ko) * | 2009-02-24 | 2012-06-27 | 한미사이언스 주식회사 | 스타틴 화합물 또는 그 염의 신규 제조방법, 및 이에 사용되는 중간체 화합물 |
WO2011086584A2 (en) | 2010-01-18 | 2011-07-21 | Msn Laboratories Limited | Improved process for the preparation of amide intermediates and their use thereof |
WO2011141934A1 (en) | 2010-05-13 | 2011-11-17 | Matrix Laboratories Ltd. | An improved process for the preparation of an intermediate of hmg-coa reductase inhibitors |
WO2012011129A2 (en) * | 2010-07-22 | 2012-01-26 | Msn Laboratories Limited | Novel polymorph of bis[(e)-7-[4-(4-fluorophenyl)-6-iso-propyl-2-[methyl (methylsulfonyl)amino]pyrimidin-5-yl](3r,5s)-3,5-dihydroxyhept-6-enoic acid] calcium salt |
CN101955463B (zh) * | 2010-08-04 | 2012-01-04 | 重庆博腾制药科技股份有限公司 | 瑞舒伐他汀钙中间体的制备方法 |
HU230987B1 (hu) | 2010-11-29 | 2019-08-28 | Egis Gyógyszergyár Nyrt. | Eljárás nagy tisztaságú gyógyszeripari intermedierek előállítására |
CA2857078A1 (en) | 2011-11-28 | 2013-06-06 | Mylan Laboratories Ltd | Process for producing chiral statin side chain intermediates employing candida/antarctica lipase b |
CN103134893B (zh) * | 2013-01-25 | 2014-12-03 | 峨眉山天梁星制药有限公司 | 一种3-叔丁基二甲硅氧基戊二酸酐的高效液相色谱分析法 |
CN111548312A (zh) * | 2020-06-01 | 2020-08-18 | 雅本化学股份有限公司 | 一种瑞舒伐他汀钙片及其制备工艺 |
CN113754590B (zh) * | 2021-09-06 | 2023-06-13 | 浙江乐普药业股份有限公司 | 一种瑞舒伐他汀钙中间体的制备方法 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2698326A (en) * | 1954-12-28 | S-aminomethylpyrimtoines | ||
JP2648897B2 (ja) * | 1991-07-01 | 1997-09-03 | 塩野義製薬株式会社 | ピリミジン誘導体 |
JP3400038B2 (ja) * | 1993-10-19 | 2003-04-28 | 塩野義製薬株式会社 | ピリミジン誘導体の製造方法 |
DE4338866C1 (de) * | 1993-11-13 | 1995-06-14 | Wolf Gmbh Richard | Medizinisches Instrument zur Applikation von Heißgas |
SK284027B6 (sk) * | 1999-03-10 | 2004-08-03 | Lonza Ag | Spôsob výroby N-[5-(difenylfosfinoylmetyl)-4-(4-fluórfenyl)-6- izopropylpyrimidin-2-yl]-N-metylmetánsulfónamidu |
GB0003305D0 (en) * | 2000-02-15 | 2000-04-05 | Zeneca Ltd | Pyrimidine derivatives |
CZ2004337A3 (cs) * | 2001-08-16 | 2005-01-12 | Teva Pharmaceutical Industries Ltd. | Způsob přípravy vápenatých solí statinů |
-
2003
- 2003-05-21 AU AU2003228010A patent/AU2003228010A1/en not_active Abandoned
- 2003-05-21 BR BR0311195-4A patent/BR0311195A/pt not_active IP Right Cessation
- 2003-05-21 EA EA200401533A patent/EA200401533A1/ru unknown
- 2003-05-21 AR ARP030101769A patent/AR039836A1/es unknown
- 2003-05-21 WO PCT/IB2003/001946 patent/WO2003097614A2/en not_active Application Discontinuation
- 2003-05-21 EP EP03725478A patent/EP1585736A2/en not_active Withdrawn
- 2003-05-21 US US10/515,361 patent/US20050222415A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
EA200401533A1 (ru) | 2005-06-30 |
AR039836A1 (es) | 2005-03-02 |
WO2003097614A3 (en) | 2004-05-21 |
EP1585736A2 (en) | 2005-10-19 |
US20050222415A1 (en) | 2005-10-06 |
WO2003097614A2 (en) | 2003-11-27 |
AU2003228010A1 (en) | 2003-12-02 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 5A,6A E 7A ANUIDADES. |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2051 DE 27/04/2010. |