BR0015610A - Sais estáveis de derivados de 3,3-difenilpropilamina - Google Patents

Sais estáveis de derivados de 3,3-difenilpropilamina

Info

Publication number
BR0015610A
BR0015610A BR0015610-8A BR0015610A BR0015610A BR 0015610 A BR0015610 A BR 0015610A BR 0015610 A BR0015610 A BR 0015610A BR 0015610 A BR0015610 A BR 0015610A
Authority
BR
Brazil
Prior art keywords
stable
diisopropylamino
salts
phenylpropyl
derivatives
Prior art date
Application number
BR0015610-8A
Other languages
English (en)
Other versions
BRPI0015610B1 (pt
BR0015610B8 (pt
BRPI0015610C1 (pt
Inventor
Claus Meese
Original Assignee
Sanol Arznei Schwarz Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=7929277&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR0015610(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Sanol Arznei Schwarz Gmbh filed Critical Sanol Arznei Schwarz Gmbh
Publication of BR0015610A publication Critical patent/BR0015610A/pt
Publication of BRPI0015610B1 publication Critical patent/BRPI0015610B1/pt
Publication of BR0015610B8 publication Critical patent/BR0015610B8/pt
Publication of BRPI0015610C1 publication Critical patent/BRPI0015610C1/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C219/00—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C219/26—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/46—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C215/48—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by hydroxy groups
    • C07C215/54—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by hydroxy groups linked by carbon chains having at least three carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/06—Anti-spasmodics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C219/00—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C219/26—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C219/28—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton having amino groups bound to acyclic carbon atoms of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/38—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to acyclic carbon atoms and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Catalysts (AREA)
  • Luminescent Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Detergent Compositions (AREA)

Abstract

"SAIS ESTáVEIS DE DERIVADOS DE 3,3-DIFENIL-PROPILAMINA". A presente invenção refere-se a compostos estáveis, cristalinos, altamente puros de derivados de 3,3-difenilpropilaminas sob a forma de seus sais, um processo para a fabricação de produtos intermediários estáveis, altamente puros. O processo é particularmente caracterizado por regio e quimiosseletividade e elevado rendimento. São proporcionados sais de monoésteres fenólicos de 3,3-difenilpropilaminas, que são particularmente bem adequados para utilização em formulações farmacêuticas. Compostos preferidos são hidrogênio fumarato do éster R-(+)-diisobutirato de 2-(3-diisopropilamino-1-fenilpropil)-4-hidroximetilfenila e cloridrato do éster R-(+)-isobutirato de 2-(3-diisopropilamino-1-fenilpropil)-4-hidroximetilfenila. Além do mais, são proporcionados produtos intermediários cristalinos, estáveis que são essenciais para a obtenção dos sais acima mencionados. Um produto intermediário preferido é o éster metílico de ácido R-(-)-3-(3-diisopropilamino-fenilapropil)-4-hidróxi benzóico.
BRPI0015610A 1999-11-16 2000-11-15 composto derivado de 3,3-difenilpropilamina, processo para preparação do mesmo, utilização de intermediários na obtenção do referido composto BRPI0015610C1 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19955190A DE19955190A1 (de) 1999-11-16 1999-11-16 Stabile Salze neuartiger Derivate von 3,3-Diphenylpropylaminen
PCT/EP2000/011309 WO2001035957A1 (de) 1999-11-16 2000-11-15 Stabile salze neuartiger derivate von 3,3-diphenylpropylaminen

Publications (4)

Publication Number Publication Date
BR0015610A true BR0015610A (pt) 2002-07-30
BRPI0015610B1 BRPI0015610B1 (pt) 2016-04-19
BR0015610B8 BR0015610B8 (pt) 2017-10-31
BRPI0015610C1 BRPI0015610C1 (pt) 2021-05-25

Family

ID=7929277

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0015610A BRPI0015610C1 (pt) 1999-11-16 2000-11-15 composto derivado de 3,3-difenilpropilamina, processo para preparação do mesmo, utilização de intermediários na obtenção do referido composto

Country Status (30)

Country Link
US (1) US6858650B1 (pt)
EP (3) EP1481964B1 (pt)
JP (6) JP4083431B2 (pt)
KR (2) KR100563149B1 (pt)
CN (1) CN1215045C (pt)
AT (3) ATE337293T1 (pt)
AU (1) AU778132B2 (pt)
BR (1) BRPI0015610C1 (pt)
CA (1) CA2389749C (pt)
CY (2) CY1106204T1 (pt)
CZ (2) CZ302497B6 (pt)
DE (5) DE29923134U1 (pt)
DK (3) DK1690536T3 (pt)
EA (1) EA005588B1 (pt)
ES (3) ES2236032T7 (pt)
GE (1) GEP20084430B (pt)
HK (3) HK1067114A1 (pt)
HU (2) HU228197B1 (pt)
IL (2) IL149567A0 (pt)
IS (2) IS2124B (pt)
MX (1) MXPA02004603A (pt)
NO (2) NO323920B1 (pt)
NZ (1) NZ519230A (pt)
PL (1) PL201422B1 (pt)
PT (3) PT1230209E (pt)
SI (3) SI1690536T1 (pt)
SK (3) SK288185B6 (pt)
UA (2) UA73324C2 (pt)
WO (1) WO2001035957A1 (pt)
ZA (1) ZA200203315B (pt)

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EP0957073A1 (en) 1998-05-12 1999-11-17 Schwarz Pharma Ag Novel derivatives of 3,3-diphenylpropylamines
DE29923134U1 (de) * 1999-11-16 2000-06-29 Sanol Arznei Schwarz Gmbh Stabile Salze neuartiger Derviate von 3,3-Diphenylpropylaminen
DE10028443C1 (de) * 2000-06-14 2002-05-29 Sanol Arznei Schwarz Gmbh Verfahren zur Herstellung von 3,3-Diarylpropylaminen, (R,S)- und (R)-4-Phenyl-2-chromanon-6-carbonsäure sowie (R)-4-Phenyl-2-chromanon-carbonsäure-cinchonidinsalz und deren Verwendung zur Herstellung eines rechtsdrehenden Hydroxybenzylalkohols und von pharmazeutischen Zusammensetzungen
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EP2294047A2 (en) * 2008-04-04 2011-03-16 Actavis Group PTC EHF Novel mandelate salt of fesoterodine
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IT1392082B1 (it) * 2008-12-10 2012-02-09 Chemi Spa Nuove forme solide della fesoterodina fumarato
CA2761602C (en) 2009-05-11 2015-07-07 Ratiopharm Gmbh Desfesoterodine in the form of a tartaric acid salt
IT1394219B1 (it) 2009-05-15 2012-06-01 Chemi Spa Metodo di preparazione di fesoterodina fumarato di elevata purezza.
IT1394217B1 (it) * 2009-05-15 2012-06-01 Chemi Spa Metodo di preparazione di fesoterodina e/o fesoterodina fumarato.
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TWI520732B (zh) 2011-01-18 2016-02-11 輝瑞有限公司 固體分子分散液
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Also Published As

Publication number Publication date
IL149567A0 (en) 2002-11-10
HU227608B1 (en) 2011-09-28
EP1690536A2 (de) 2006-08-16
DE50009239D1 (de) 2005-02-17
CN1215045C (zh) 2005-08-17
JP4083431B2 (ja) 2008-04-30
HK1045148A1 (en) 2002-11-15
EP1481964A1 (de) 2004-12-01
EP1230209B3 (de) 2011-10-05
HUP0204034A2 (hu) 2003-03-28
EP1481964B1 (de) 2006-08-23
IS2124B (is) 2006-07-14
DE50015163D1 (de) 2008-06-26
JP2011148824A (ja) 2011-08-04
DE29923134U1 (de) 2000-06-29
WO2001035957A8 (de) 2001-06-21
GEP20084430B (pt) 2008-07-25
PT1481964E (pt) 2006-12-29
SK6572002A3 (en) 2002-12-03
DK1481964T3 (da) 2006-11-27
PT1230209E (pt) 2005-05-31
HU228197B1 (en) 2013-01-28
CN1390194A (zh) 2003-01-08
ZA200203315B (en) 2003-09-23
HUP0204034A3 (en) 2004-12-28
AU778132B2 (en) 2004-11-18
NO332637B1 (no) 2012-11-26
SK287430B6 (sk) 2010-09-07
BRPI0015610B1 (pt) 2016-04-19
NO323920B1 (no) 2007-07-23
KR20050100711A (ko) 2005-10-19
ES2236032T7 (es) 2012-06-14
IS2673B (is) 2010-09-15
DK1230209T3 (da) 2005-05-30
ATE286872T1 (de) 2005-01-15
JP5290351B2 (ja) 2013-09-18
US6858650B1 (en) 2005-02-22
JP2014111589A (ja) 2014-06-19
SI1690536T1 (sl) 2008-08-31
IL149567A (en) 2007-08-19
BR0015610B8 (pt) 2017-10-31
SK288185B6 (sk) 2014-04-02
UA73324C2 (uk) 2005-07-15
EA200200511A1 (ru) 2002-10-31
PT1690536E (pt) 2008-07-14
NZ519230A (en) 2004-11-26
ES2236032T3 (es) 2005-07-16
CY1106204T1 (el) 2011-06-08
IS6351A (is) 2002-04-19
JP5717824B2 (ja) 2015-05-13
PL356766A1 (en) 2004-07-12
ES2303708T3 (es) 2008-08-16
ATE395056T1 (de) 2008-05-15
CZ302497B6 (cs) 2011-06-15
BRPI0015610C1 (pt) 2021-05-25
JP2010180242A (ja) 2010-08-19
EP1690536B1 (de) 2008-05-14
SI1481964T1 (sl) 2006-12-31
JP2007137895A (ja) 2007-06-07
CZ302967B6 (cs) 2012-01-25
JP2003514018A (ja) 2003-04-15
DE19955190A1 (de) 2001-06-21
CA2389749C (en) 2009-03-31
UA77322C2 (en) 2006-11-15
JP5503393B2 (ja) 2014-05-28
HU0900587D0 (en) 2009-11-30
AU2666701A (en) 2001-05-30
NO20065380L (no) 2002-05-15
ATE337293T1 (de) 2006-09-15
PL201422B1 (pl) 2009-04-30
CZ20021343A3 (cs) 2002-09-11
EP1230209B1 (de) 2005-01-12
NO20022314D0 (no) 2002-05-15
KR20020059744A (ko) 2002-07-13
EP1690536A3 (de) 2006-08-23
NO20022314L (no) 2002-05-15
IS8382A (is) 2006-03-29
HK1045148B (zh) 2005-05-06
CA2389749A1 (en) 2001-05-25
SK288384B6 (sk) 2016-08-01
KR100536095B1 (ko) 2005-12-12
CY1110389T1 (el) 2015-04-29
ES2270240T3 (es) 2007-04-01
HUP0900587A3 (en) 2010-04-28
MXPA02004603A (es) 2004-09-10
EP1230209A2 (de) 2002-08-14
WO2001035957A1 (de) 2001-05-25
DE50013365D1 (de) 2006-10-05
EA005588B1 (ru) 2005-04-28
KR100563149B1 (ko) 2006-03-21
JP5650924B2 (ja) 2015-01-07
WO2001035957A3 (de) 2001-12-27
HK1095736A1 (en) 2007-05-18
HK1067114A1 (en) 2005-04-01
DK1690536T3 (da) 2008-09-01
JP2010180243A (ja) 2010-08-19
SI1230209T1 (en) 2005-06-30

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