BG63394B1 - Производни на кондензирани 2,3-бензодиазепини и използването им като инхибитори на амра-рецептори - Google Patents

Производни на кондензирани 2,3-бензодиазепини и използването им като инхибитори на амра-рецептори Download PDF

Info

Publication number: BG63394B1
Authority: BG; Bulgaria
Prior art keywords: benzodiazepine; imidazo; dioxolo; aminophenyl; methoxy
Prior art date: 1996-02-01

Application number

BG102658A

Other languages

Bulgarian (bg)

English (en)

Other versions

BG102658A (en

Inventor

Ernese Csuzdi

Tamas Hamori

Gizella Abraham

Sandor Solyom

Istvan Tarnava

Pal Berzsenyi

Ferenc Andrasi

Istvan Ling

Antal SIMAI

Melinda Gal

Katalin Horvath

Eszter Szentkuti

Marta Szollosy

Istvan Pallagi

Original Assignee

Schering Aktiengesellschaft

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-02-01

Filing date

1998-07-29

Publication date

2001-12-29

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=7785064&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BG63394(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1998-07-29 Application filed by Schering Aktiengesellschaft filed Critical Schering Aktiengesellschaft

1999-06-30 Publication of BG102658A publication Critical patent/BG102658A/xx

2001-12-29 Publication of BG63394B1 publication Critical patent/BG63394B1/bg

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/14—Ortho-condensed systems

BG102658A 1996-02-01 1998-07-29 Производни на кондензирани 2,3-бензодиазепини и използването им като инхибитори на амра-рецептори BG63394B1 (bg)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE19604919A DE19604919A1 (de)	1996-02-01	1996-02-01	Neue 2,3-Benzodiazepinderivate, deren Herstellung und Verwendung als Arzneimittel
PCT/DE1997/000234 WO1997028163A1 (de)	1996-02-01	1997-01-29	Kondensierte 2,3-benzodiazepin derivate und deren verwendung als ampa-rezeptoren-hemmer

Publications (2)

Publication Number	Publication Date
BG102658A BG102658A (en)	1999-06-30
BG63394B1 true BG63394B1 (bg)	2001-12-29

Family

ID=7785064

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BG102658A BG63394B1 (bg)	1996-02-01	1998-07-29	Производни на кондензирани 2,3-бензодиазепини и използването им като инхибитори на амра-рецептори

Country Status (31)

Country	Link
US (2)	US6323197B1 (da)
EP (1)	EP0888356B1 (da)
JP (1)	JP4141499B2 (da)
KR (1)	KR100465269B1 (da)
CN (1)	CN1096464C (da)
AT (1)	ATE214703T1 (da)
AU (1)	AU724956B2 (da)
BG (1)	BG63394B1 (da)
BR (1)	BR9707335A (da)
CA (1)	CA2245539C (da)
CZ (1)	CZ289658B6 (da)
DE (2)	DE19604919A1 (da)
DK (1)	DK0888356T3 (da)
EE (1)	EE04017B1 (da)
ES (1)	ES2173435T3 (da)
HK (1)	HK1018782A1 (da)
HU (1)	HU224636B1 (da)
IL (1)	IL125480A (da)
IS (1)	IS2103B (da)
MY (1)	MY119140A (da)
NO (1)	NO983510L (da)
NZ (1)	NZ331187A (da)
PL (1)	PL187128B1 (da)
PT (1)	PT888356E (da)
RU (1)	RU2179557C2 (da)
SK (1)	SK283563B6 (da)
TR (1)	TR199801485T2 (da)
TW (1)	TW438801B (da)
UA (1)	UA56157C2 (da)
WO (1)	WO1997028163A1 (da)
ZA (1)	ZA97848B (da)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
HUP9701325A1 (hu)	1997-07-31	2000-08-28	Gyógyszerkutató Intézet Kft.	Új 2,3-benzodiazepin-származékok
UA67749C2 (uk) *	1997-08-12	2004-07-15	Егіш Дьйодьсердьяр Рт.	Похідна 8-заміщеного-9н-1,3-діоксол/4,5-h//2,3/бензодіазепіну з властивостями амра/каїнатного антагоніста, спосіб одержання похідних, фармацевтична композиція (варіанти), спосіб її одержання та спосіб лікування
JP2002519373A (ja) *	1998-07-02	2002-07-02	エーザイ株式会社	製薬組成物及びそれらの使用
US6887867B2 (en) *	2000-06-16	2005-05-03	Transgenomic, Inc.	5H-2,3-benzodiazepine antagonists of excitatory amino acid receptors
DE10041671C1 (de)	2000-08-10	2002-06-13	Schering Ag	Verfahren zur Herstellung von Imidazo[1,2-c][2,3]benzodiazepinen sowie Phenylessigsäureester und Oxazol-Derivate als Zwischenprodukte bei deren Herstellung
US20070280876A1 (en) *	2004-03-25	2007-12-06	William Marsh Rice University	Functionalization of Carbon Nanotubes in Acidic Media
US20060166969A1 (en) *	2005-01-14	2006-07-27	Turski Lechoslaw A	AMPA antagonists for the treatment of dizziness, including vertigo and Meniere's disorder
EP2338492A1 (en)	2009-12-24	2011-06-29	Universidad del Pais Vasco	Methods and compositions for the treatment of alzheimer

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5891871A (en)	1996-03-21	1999-04-06	Cocensys, Inc.	Substituted 2,3-benzodiazepin-4-ones and the use thereof
HU9600871D0 (en) *	1996-04-04	1996-05-28	Gyogyszerkutato Intezet	New 2,3-benzodiazepine derivatives

1996
- 1996-02-01 DE DE19604919A patent/DE19604919A1/de not_active Withdrawn
1997
- 1997-01-29 AT AT97916315T patent/ATE214703T1/de not_active IP Right Cessation
- 1997-01-29 EP EP97916315A patent/EP0888356B1/de not_active Expired - Lifetime
- 1997-01-29 ES ES97916315T patent/ES2173435T3/es not_active Expired - Lifetime
- 1997-01-29 JP JP52724897A patent/JP4141499B2/ja not_active Expired - Fee Related
- 1997-01-29 BR BR9707335A patent/BR9707335A/pt not_active IP Right Cessation
- 1997-01-29 SK SK1033-98A patent/SK283563B6/sk unknown
- 1997-01-29 NZ NZ331187A patent/NZ331187A/xx unknown
- 1997-01-29 PL PL97328224A patent/PL187128B1/pl not_active IP Right Cessation
- 1997-01-29 US US09/117,508 patent/US6323197B1/en not_active Expired - Fee Related
- 1997-01-29 AU AU25029/97A patent/AU724956B2/en not_active Ceased
- 1997-01-29 IL IL12548097A patent/IL125480A/en not_active IP Right Cessation
- 1997-01-29 DE DE59706686T patent/DE59706686D1/de not_active Expired - Lifetime
- 1997-01-29 HU HU9901417A patent/HU224636B1/hu not_active IP Right Cessation
- 1997-01-29 CZ CZ19982427A patent/CZ289658B6/cs not_active IP Right Cessation
- 1997-01-29 EE EE9800225A patent/EE04017B1/xx not_active IP Right Cessation
- 1997-01-29 KR KR10-1998-0705917A patent/KR100465269B1/ko not_active IP Right Cessation
- 1997-01-29 TR TR1998/01485T patent/TR199801485T2/xx unknown
- 1997-01-29 RU RU98116292/04A patent/RU2179557C2/ru not_active IP Right Cessation
- 1997-01-29 CA CA002245539A patent/CA2245539C/en not_active Expired - Fee Related
- 1997-01-29 UA UA98084653A patent/UA56157C2/uk unknown
- 1997-01-29 CN CN97192012A patent/CN1096464C/zh not_active Expired - Fee Related
- 1997-01-29 WO PCT/DE1997/000234 patent/WO1997028163A1/de active IP Right Grant
- 1997-01-29 PT PT97916315T patent/PT888356E/pt unknown
- 1997-01-29 DK DK97916315T patent/DK0888356T3/da active
- 1997-01-31 ZA ZA9700848A patent/ZA97848B/xx unknown
- 1997-01-31 MY MYPI97000379A patent/MY119140A/en unknown
- 1997-02-01 TW TW086101218A patent/TW438801B/zh not_active IP Right Cessation
1998
- 1998-07-06 IS IS4794A patent/IS2103B/is unknown
- 1998-07-29 BG BG102658A patent/BG63394B1/bg unknown
- 1998-07-30 NO NO983510A patent/NO983510L/no unknown
1999
- 1999-09-02 HK HK99103802A patent/HK1018782A1/xx not_active IP Right Cessation
2001
- 2001-11-27 US US09/993,646 patent/US6600036B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
IL125480A (en)	2002-07-25
HUP9901417A2 (hu)	1999-08-30
PT888356E (pt)	2002-09-30
TW438801B (en)	2001-06-07
JP4141499B2 (ja)	2008-08-27
ATE214703T1 (de)	2002-04-15
DK0888356T3 (da)	2002-06-03
US20020052364A1 (en)	2002-05-02
CZ289658B6 (cs)	2002-03-13
PL187128B1 (pl)	2004-05-31
TR199801485T2 (xx)	1998-10-21
CZ242798A3 (cs)	1999-01-13
KR100465269B1 (ko)	2005-04-14
AU724956B2 (en)	2000-10-05
NZ331187A (en)	2000-01-28
PL328224A1 (en)	1999-01-18
DE19604919A1 (de)	1997-08-07
EE9800225A (et)	1998-12-15
WO1997028163A1 (de)	1997-08-07
JP2000503997A (ja)	2000-04-04
EE04017B1 (et)	2003-04-15
DE59706686D1 (de)	2002-04-25
BG102658A (en)	1999-06-30
IL125480A0 (en)	1999-03-12
NO983510L (no)	1998-09-30
UA56157C2 (uk)	2003-05-15
CN1096464C (zh)	2002-12-18
ZA97848B (en)	1997-08-04
IS2103B (is)	2006-05-15
MY119140A (en)	2005-04-30
KR19990082192A (ko)	1999-11-25
HU224636B1 (hu)	2005-12-28
ES2173435T3 (es)	2002-10-16
US6323197B1 (en)	2001-11-27
CA2245539C (en)	2005-10-04
CA2245539A1 (en)	1997-08-07
SK283563B6 (sk)	2003-09-11
RU2179557C2 (ru)	2002-02-20
EP0888356B1 (de)	2002-03-20
HUP9901417A3 (en)	2001-11-28
US6600036B2 (en)	2003-07-29
NO983510D0 (no)	1998-07-30
IS4794A (is)	1998-07-06
SK103398A3 (en)	1999-01-11
HK1018782A1 (en)	2000-01-07
EP0888356A1 (de)	1999-01-07
BR9707335A (pt)	1999-07-20
CN1210538A (zh)	1999-03-10
AU2502997A (en)	1997-08-22

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JPH01250383A (ja)	1989-10-05	ベンゾチエピノ〔５，４−ｃ〕ピリダジン化合物