BE903369A - Water-oplosbare farmaceutische preparaten, welke zouten van (-)cis-1,2-epoxypropylfosfonzuur met aminozuren bevatten - Google Patents

Water-oplosbare farmaceutische preparaten, welke zouten van (-)cis-1,2-epoxypropylfosfonzuur met aminozuren bevatten Download PDF

Info

Publication number: BE903369A
Authority: BE; Belgium
Prior art keywords: water; amino acids; cis; pharmaceutical preparations; soluble pharmaceutical
Prior art date: 1984-10-05

Application number

BE2/60807A

Other languages

English (en)

Dutch (nl)

Original Assignee

Schering Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1984-10-05

Filing date

1985-10-04

Publication date

1986-02-03

1985-10-04 Application filed by Schering Spa filed Critical Schering Spa

1986-02-03 Publication of BE903369A publication Critical patent/BE903369A/nl

Links

150000001413 amino acids Chemical class 0.000 title claims abstract description 18
239000000825 pharmaceutical preparation Substances 0.000 title claims abstract description 5
150000003839 salts Chemical class 0.000 claims abstract description 8
239000004475 Arginine Substances 0.000 claims abstract description 7
ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims abstract description 7
239000000203 mixture Substances 0.000 claims description 5
238000002360 preparation method Methods 0.000 claims description 4
235000001014 amino acid Nutrition 0.000 abstract description 13
AHLPHDHHMVZTML-BYPYZUCNSA-N L-Ornithine Chemical compound NCCC[C@H](N)C(O)=O AHLPHDHHMVZTML-BYPYZUCNSA-N 0.000 abstract description 3
KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 abstract description 3
239000004472 Lysine Substances 0.000 abstract description 3
AHLPHDHHMVZTML-UHFFFAOYSA-N Orn-delta-NH2 Natural products NCCCC(N)C(O)=O AHLPHDHHMVZTML-UHFFFAOYSA-N 0.000 abstract description 3
UTJLXEIPEHZYQJ-UHFFFAOYSA-N Ornithine Natural products OC(=O)C(C)CCCN UTJLXEIPEHZYQJ-UHFFFAOYSA-N 0.000 abstract description 3
239000004480 active ingredient Substances 0.000 abstract description 3
229960003104 ornithine Drugs 0.000 abstract description 3
ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 abstract description 2
KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 abstract description 2
XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 abstract description 2
XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 abstract 1
235000018417 cysteine Nutrition 0.000 abstract 1
150000001875 compounds Chemical class 0.000 description 5
239000000243 solution Substances 0.000 description 5
230000003115 biocidal effect Effects 0.000 description 4
YMDXZJFXQJVXBF-STHAYSLISA-N fosfomycin Chemical compound C[C@@H]1O[C@@H]1P(O)(O)=O YMDXZJFXQJVXBF-STHAYSLISA-N 0.000 description 4
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 2
238000007911 parenteral administration Methods 0.000 description 2
239000008194 pharmaceutical composition Substances 0.000 description 2
-1 phosphomycin arginine salt Chemical class 0.000 description 2
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
239000004471 Glycine Substances 0.000 description 1
QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 description 1
FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 description 1
235000004279 alanine Nutrition 0.000 description 1
125000000129 anionic group Chemical group 0.000 description 1
230000000844 anti-bacterial effect Effects 0.000 description 1
239000007864 aqueous solution Substances 0.000 description 1
125000000637 arginyl group Chemical group N[C@@H](CCCNC(N)=N)C(=O)* 0.000 description 1
230000009286 beneficial effect Effects 0.000 description 1
230000036765 blood level Effects 0.000 description 1
150000001768 cations Chemical class 0.000 description 1
OEYIOHPDSNJKLS-UHFFFAOYSA-N choline Chemical compound C[N+](C)(C)CCO OEYIOHPDSNJKLS-UHFFFAOYSA-N 0.000 description 1
229960001231 choline Drugs 0.000 description 1
230000003750 conditioning effect Effects 0.000 description 1
238000003745 diagnosis Methods 0.000 description 1
201000010099 disease Diseases 0.000 description 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
239000003814 drug Substances 0.000 description 1
239000007911 effervescent powder Substances 0.000 description 1
235000019441 ethanol Nutrition 0.000 description 1
230000002349 favourable effect Effects 0.000 description 1
KWIUHFFTVRNATP-UHFFFAOYSA-N glycine betaine Chemical compound C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 description 1
230000001771 impaired effect Effects 0.000 description 1
230000036512 infertility Effects 0.000 description 1
238000001990 intravenous administration Methods 0.000 description 1
210000003734 kidney Anatomy 0.000 description 1
230000002045 lasting effect Effects 0.000 description 1
239000007788 liquid Substances 0.000 description 1
210000004072 lung Anatomy 0.000 description 1
OKKJLVBELUTLKV-UHFFFAOYSA-N methanol Natural products OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 1
229930182817 methionine Natural products 0.000 description 1
238000000034 method Methods 0.000 description 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
239000008183 oral pharmaceutical preparation Substances 0.000 description 1
210000000056 organ Anatomy 0.000 description 1
150000007530 organic bases Chemical class 0.000 description 1
239000000546 pharmaceutical excipient Substances 0.000 description 1
238000009938 salting Methods 0.000 description 1
238000001228 spectrum Methods 0.000 description 1
235000020357 syrup Nutrition 0.000 description 1
239000006188 syrup Substances 0.000 description 1
230000001225 therapeutic effect Effects 0.000 description 1
238000002560 therapeutic procedure Methods 0.000 description 1
230000002110 toxicologic effect Effects 0.000 description 1
231100000723 toxicological property Toxicity 0.000 description 1
230000010415 tropism Effects 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
- C07F9/65502—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a three-membered ring
- C07F9/65505—Phosphonic acids containing oxirane groups; esters thereof

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Epidemiology (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Oil, Petroleum & Natural Gas (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Dermatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

BE2/60807A 1984-10-05 1985-10-04 Water-oplosbare farmaceutische preparaten, welke zouten van (-)cis-1,2-epoxypropylfosfonzuur met aminozuren bevatten BE903369A (nl)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
CH4792/84A CH660306A5 (de)	1984-10-05	1984-10-05	Wasserloesliche pharmazeutische zusammensetzungen auf der basis von salzen der (-)cis-1,2-epoxypropylphosphonsaeure mit aminosaeuren.

Publications (1)

Publication Number	Publication Date
BE903369A true BE903369A (nl)	1986-02-03

Family

ID=4282621

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BE2/60807A BE903369A (nl)	1984-10-05	1985-10-04	Water-oplosbare farmaceutische preparaten, welke zouten van (-)cis-1,2-epoxypropylfosfonzuur met aminozuren bevatten

Country Status (11)

Country	Link
JP (1)	JPS62223121A (it)
KR (1)	KR860003012A (it)
AT (1)	AT383736B (it)
BE (1)	BE903369A (it)
CH (1)	CH660306A5 (it)
DE (1)	DE3535356A1 (it)
ES (1)	ES8609351A1 (it)
FR (1)	FR2571255B1 (it)
GB (1)	GB2165152B (it)
IT (1)	IT1201479B (it)
NL (1)	NL8502712A (it)

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CH310498A (de) *	1951-11-14	1955-10-31	Waldhof Zellstoff Fab	Verfahren zur Stabilisierung von Alkalisalzen von Adenosinpolyphosphorsäuren.
DE1767212B1 (de) *	1967-04-13	1971-05-06	Sumitomo Chemical Co	Verfahren zur Herstellung injizierbarer Arzneimittel
US3639590A (en) *	1967-07-25	1972-02-01	Merck & Co Inc	Antibacterial composition containing (-) (cis-1 2-epoxypropyl) phosphoric acid
BE756953A (fr) *	1969-10-02	1971-04-01	Merck & Co Inc	Potentialisation d'antibiotiques
IT1161974B (it) *	1978-02-02	1987-03-18	Italchemi Spa	Derivti dell acido cis.i 2 epossipropilfosfonico loro procedimento di preparazione e composizioni farmaceutiche che li contengono
DE2813814A1 (de) *	1978-03-31	1979-10-18	Boehringer Mannheim Gmbh	Hochwirksame, enteral resorbierbare pharmazeutische praeparate
IT1112282B (it) *	1978-07-19	1986-01-13	Zambon Spa	Bis-(2-ammonio-2-idrossimetil-1,3-propandiolo)(2r-cis)-(3-metilossiranil)fosfonato
IT1097578B (it) *	1978-07-31	1985-08-31	Italchemi Spa	Metodo per la preparazione di sali dell'acido (-)
US4235900A (en) *	1978-11-15	1980-11-25	E. R. Squibb & Sons, Inc.	Cephradine compositions

1984
- 1984-10-05 CH CH4792/84A patent/CH660306A5/de not_active IP Right Cessation
1985
- 1985-10-02 JP JP60219969A patent/JPS62223121A/ja active Pending
- 1985-10-03 AT AT0287185A patent/AT383736B/de not_active IP Right Cessation
- 1985-10-03 DE DE19853535356 patent/DE3535356A1/de not_active Withdrawn
- 1985-10-04 GB GB08524550A patent/GB2165152B/en not_active Expired
- 1985-10-04 NL NL8502712A patent/NL8502712A/nl not_active Application Discontinuation
- 1985-10-04 ES ES547625A patent/ES8609351A1/es not_active Expired
- 1985-10-04 BE BE2/60807A patent/BE903369A/nl not_active IP Right Cessation
- 1985-10-04 IT IT22367/85A patent/IT1201479B/it active
- 1985-10-05 KR KR1019850007328A patent/KR860003012A/ko not_active IP Right Cessation
- 1985-10-07 FR FR8514800A patent/FR2571255B1/fr not_active Expired

Also Published As

Publication number	Publication date
ATA287185A (de)	1987-01-15
FR2571255B1 (fr)	1988-09-16
KR860003012A (ko)	1986-05-19
GB8524550D0 (en)	1985-11-06
IT1201479B (it)	1989-02-02
DE3535356A1 (de)	1986-04-24
IT8522367A0 (it)	1985-10-04
NL8502712A (nl)	1986-05-01
JPS62223121A (ja)	1987-10-01
ES8609351A1 (es)	1986-09-01
GB2165152B (en)	1988-03-16
FR2571255A1 (fr)	1986-04-11
CH660306A5 (de)	1987-04-15
GB2165152A (en)	1986-04-09
ES547625A0 (es)	1986-09-01
AT383736B (de)	1987-08-10

Legal Events

Date	Code	Title	Description
1985-12-31	CH	Change of patent owner	Owner name: ISTITUTO GENTILI S.P.A. Effective date*: 19851004
1986-12-31	CA	Change of address of the owner of the patent	Owner name: ISTITUTO GENTILI S.P.A.VIA MAZZINI 112, PISA Effective date*: 19860110
1986-12-31	CH	Change of patent owner	Owner name: ISTITUTO GENTILI S.P.A. Effective date*: 19860110
1989-04-30	RE	Patent lapsed	Owner name: ISTITUTO GENTILI S.P.A. Effective date: 19881031

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US4352814A (en)	1982-10-05	Treatment of hepatic and renal disorders with mixed salts of essential or semi-essential amino acids and nitrogen-free analogs
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Drell et al.	1951	Production of pantothenic acid deficiency syndrome in mice with ω-methylpantothenic acid
US5116949A (en)	1992-05-26	Benzoyl urea compound-albumin complex
BE903369A (nl)	1986-02-03	Water-oplosbare farmaceutische preparaten, welke zouten van (-)cis-1,2-epoxypropylfosfonzuur met aminozuren bevatten
BE903368A (nl)	1986-02-03	Water-oplosbare farmaceutische preparaten, welke zouten van (-)cis-1,2-epoxypropylfosfonzuur met aminozuren bevatten
JPS60202822A (ja)	1985-10-14	抗ウイルス薬
JPS6335635B2 (it)	1988-07-15
DE2820794C2 (de)	1980-01-17	Salze der (-Hcis)-l^-Epoxypropylphosphonsäure, Verfahren zu ihrer Herstellung und diese enthaltendes pharmazeutisches Präparat
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JPS5936615A (ja)	1984-02-28	発がん予防剤
DE2609147A1 (de)	1977-02-03	Propionsaeuresalze basischer aminosaeuren
JP2002505257A (ja)	2002-02-19	ベンゾイルフェニル尿素を含む殺菌剤組成物