BE887663A - Sels de n-(3-dimethylamino-2-(4-pyridinyl)-2-propenylidene)-n-methylmethaniminium, leur preparation et leur utilisation comme agents cardiotoniques et comme intermediaires - Google Patents

Sels de n-(3-dimethylamino-2-(4-pyridinyl)-2-propenylidene)-n-methylmethaniminium, leur preparation et leur utilisation comme agents cardiotoniques et comme intermediaires

Info

Publication number: BE887663A
Authority: BE; Belgium
Prior art keywords: methylmethaniminium; propenylidene; pyridinyl; intermediates; dimethylamino
Prior art date: 1980-02-26

Application number

BE1/10150A

Other languages

English (en)

Inventor

K O Gelotte

C J Opalka

Original Assignee

Sterling Drug Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1980-02-26

Filing date

1981-02-25

Publication date

1981-08-25

1981-02-25 Application filed by Sterling Drug Inc filed Critical Sterling Drug Inc

1981-08-25 Publication of BE887663A publication Critical patent/BE887663A/fr

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
- C07D213/53—Nitrogen atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/84—Nitriles
- C07D213/85—Nitriles in position 3

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Cardiology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Heart & Thoracic Surgery (AREA)
Hospice & Palliative Care (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pyridine Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

BE1/10150A 1980-02-26 1981-02-25 Sels de n-(3-dimethylamino-2-(4-pyridinyl)-2-propenylidene)-n-methylmethaniminium, leur preparation et leur utilisation comme agents cardiotoniques et comme intermediaires BE887663A (fr)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US06/124,808 US4264609A (en)	1980-02-26	1980-02-26	N-[3-Dimethylamino-2-(4-pyridinyl)-2-propenylidene]-N-methylmethaniminium chloride hydrochloride, its use in preparing 5-(cyano or carbamyl)-[3,4'-bipyridin]-6(1H)-one and its use as a cardiotonic

Publications (1)

Publication Number	Publication Date
BE887663A true BE887663A (fr)	1981-08-25

Family

ID=22416880

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BE1/10150A BE887663A (fr)	1980-02-26	1981-02-25	Sels de n-(3-dimethylamino-2-(4-pyridinyl)-2-propenylidene)-n-methylmethaniminium, leur preparation et leur utilisation comme agents cardiotoniques et comme intermediaires

Country Status (28)

Country	Link
US (1)	US4264609A (fr)
JP (1)	JPS56128758A (fr)
KR (2)	KR840002067B1 (fr)
AR (1)	AR230630A1 (fr)
AT (2)	AT380237B (fr)
AU (1)	AU541644B2 (fr)
BE (1)	BE887663A (fr)
CA (1)	CA1128523A (fr)
CH (1)	CH647509A5 (fr)
DE (1)	DE3107306A1 (fr)
DK (1)	DK171253B1 (fr)
ES (1)	ES499776A1 (fr)
FI (1)	FI76787C (fr)
FR (1)	FR2476646A1 (fr)
GB (1)	GB2070600B (fr)
HK (1)	HK71789A (fr)
IE (1)	IE51696B1 (fr)
IL (1)	IL62161A (fr)
IT (1)	IT1210992B (fr)
LU (1)	LU83169A1 (fr)
MX (1)	MX6908E (fr)
NL (1)	NL192109C (fr)
NO (1)	NO156689C (fr)
NZ (1)	NZ196282A (fr)
PH (2)	PH19904A (fr)
PT (1)	PT72573B (fr)
SE (2)	SE437514B (fr)
ZA (1)	ZA811124B (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ATE77817T1 (de)	1985-04-30	1992-07-15	Dresden Arzneimittel	3-cyan-pyridine, verfahren zu ihrer herstellung und ihre pharmazeutische verwendung.

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4072746A (en) *	1975-10-14	1978-02-07	Sterling Drug Inc.	3-Amino-5-(pyridinyl)-2(1H)-pyridinones
US4004012A (en) *	1975-10-14	1977-01-18	Sterling Drug Inc.	3-Cyano-5-(pyridinyl)-2(1H)-pyridinones

1980
- 1980-02-26 US US06/124,808 patent/US4264609A/en not_active Expired - Lifetime
1981
- 1981-02-17 NZ NZ196282A patent/NZ196282A/xx unknown
- 1981-02-18 IL IL62161A patent/IL62161A/xx not_active IP Right Cessation
- 1981-02-20 GB GB8105369A patent/GB2070600B/en not_active Expired
- 1981-02-20 ZA ZA00811124A patent/ZA811124B/xx unknown
- 1981-02-20 AU AU67487/81A patent/AU541644B2/en not_active Expired
- 1981-02-24 CH CH1222/81A patent/CH647509A5/fr not_active IP Right Cessation
- 1981-02-24 SE SE8101205A patent/SE437514B/sv not_active IP Right Cessation
- 1981-02-24 FR FR8103609A patent/FR2476646A1/fr active Granted
- 1981-02-24 IT IT8119952A patent/IT1210992B/it active
- 1981-02-24 PH PH25258A patent/PH19904A/en unknown
- 1981-02-25 AT AT0088581A patent/AT380237B/de not_active IP Right Cessation
- 1981-02-25 PT PT72573A patent/PT72573B/pt unknown
- 1981-02-25 BE BE1/10150A patent/BE887663A/fr not_active IP Right Cessation
- 1981-02-25 KR KR1019810000616A patent/KR840002067B1/ko active
- 1981-02-25 NO NO810639A patent/NO156689C/no unknown
- 1981-02-25 CA CA371,690A patent/CA1128523A/fr not_active Expired
- 1981-02-25 IE IE397/81A patent/IE51696B1/en not_active IP Right Cessation
- 1981-02-25 ES ES499776A patent/ES499776A1/es not_active Expired
- 1981-02-25 FI FI810582A patent/FI76787C/fi not_active IP Right Cessation
- 1981-02-25 DK DK083981A patent/DK171253B1/da not_active IP Right Cessation
- 1981-02-25 NL NL8100922A patent/NL192109C/nl not_active IP Right Cessation
- 1981-02-25 MX MX819321U patent/MX6908E/es unknown
- 1981-02-26 LU LU83169A patent/LU83169A1/fr unknown
- 1981-02-26 DE DE19813107306 patent/DE3107306A1/de active Granted
- 1981-02-26 JP JP2759981A patent/JPS56128758A/ja active Granted
- 1981-02-26 AR AR284447A patent/AR230630A1/es active
1982
- 1982-03-01 PH PH26927A patent/PH17145A/en unknown
1983
- 1983-08-26 AT AT0305683A patent/AT380236B/de not_active IP Right Cessation
1984
- 1984-05-21 SE SE8402727A patent/SE452764B/sv not_active IP Right Cessation
- 1984-08-22 KR KR1019840005058A patent/KR840002066B1/ko not_active IP Right Cessation
1989
- 1989-09-07 HK HK717/89A patent/HK71789A/xx not_active IP Right Cessation

Also Published As

Publication number	Publication date
NO810639L (no)	1981-08-27
ATA88581A (de)	1985-09-15
SE8402727L (sv)	1984-05-21
FI76787C (fi)	1988-12-12
MX6908E (es)	1986-11-07
IT1210992B (it)	1989-09-29
IT8119952A0 (it)	1981-02-24
AT380236B (de)	1986-04-25
CA1128523A (fr)	1982-07-27
FI76787B (fi)	1988-08-31
PT72573B (en)	1982-02-12
DK83981A (da)	1981-08-27
SE8101205L (sv)	1981-08-27
PT72573A (pt)	1981-03-01
NL8100922A (nl)	1981-09-16
CH647509A5 (fr)	1985-01-31
FI810582L (fi)	1981-08-27
DK171253B1 (da)	1996-08-12
NL192109B (nl)	1996-10-01
US4264609A (en)	1981-04-28
IL62161A (en)	1984-06-29
FR2476646B1 (fr)	1984-08-17
SE452764B (sv)	1987-12-14
DE3107306A1 (de)	1981-12-17
FR2476646A1 (fr)	1981-08-28
IL62161A0 (en)	1981-03-31
PH17145A (en)	1984-06-04
IE810397L (en)	1981-08-26
JPH0141626B2 (fr)	1989-09-06
DE3107306C2 (fr)	1990-11-29
IE51696B1 (en)	1987-02-18
ZA811124B (en)	1982-03-31
NL192109C (nl)	1997-02-04
AU541644B2 (en)	1985-01-17
NO156689C (no)	1987-11-04
SE8402727D0 (sv)	1984-05-21
HK71789A (en)	1989-09-14
LU83169A1 (fr)	1981-09-11
JPS56128758A (en)	1981-10-08
AR230630A1 (es)	1984-05-31
NZ196282A (en)	1983-12-16
ATA305683A (de)	1985-09-15
PH19904A (en)	1986-08-13
GB2070600A (en)	1981-09-09
AU6748781A (en)	1981-09-03
GB2070600B (en)	1984-07-11
NO156689B (no)	1987-07-27
AT380237B (de)	1986-04-25
KR840002066B1 (ko)	1984-11-09
KR830005143A (ko)	1983-08-03
SE437514B (sv)	1985-03-04
ES499776A1 (es)	1984-06-16
KR840002067B1 (ko)	1984-11-09

Legal Events

Date

Code

Title

Description

1997-12-31

CH

Change of patent owner

1997-12-31

CN

Change of patent owner's name

2001-01-01

RE20

Patent expired

Owner name: SANOFI-SYNTHELABO INC.

Effective date: 20010225

Publication	Publication Date	Title
BE888122A (fr)	1981-09-28	Diamino-pyridines, leur preparation et leur utilisation comme intermediaires et agents cardiotoniques
FR2470124B1 (fr)	1986-12-19	5-(pyridinyl)-2(1h)pyridinones, leur preparation et leur utilisation comme agents cardiotoniques
NO162465C (no)	1990-01-10	Substituerte imidazolinyl-pyridiner og -kinoliner og anvendelse derav som herbicide midler.
BE888088A (fr)	1981-09-24	Imidazopyridines, leur preparation et leur utilisation comme agents cardiotoniques
BE864029A (fr)	1978-08-16	N'-(4-(phenethyloxy substitue-phenyl)-n-methyk-n-methoxyurees et leur utilisation comme herbicides
IT1209345B (it)	1989-07-16	Urea n-benzoil n'-piridilossi fenilica.
BE888834A (fr)	1981-11-18	4-(arylaliphatique)-isoxazoles, leur preparation et leur utilisation comme agents antiviraux
RO81054A (fr)	1983-06-01	Composition herbicide sinergique
BE887890A (fr)	1981-09-11	Derives de pyrazpolopyridine, leur preparation et leur utilisation comme agents cardiotoniques.
BE886766A (fr)	1981-06-19	3-acylamino-5(pyridinyl)-2(1h)-pyridinones, leur preparation et leur utilisation comme agents cardiotoniques
BE887663A (fr)	1981-08-25	Sels de n-(3-dimethylamino-2-(4-pyridinyl)-2-propenylidene)-n-methylmethaniminium, leur preparation et leur utilisation comme agents cardiotoniques et comme intermediaires
IT7983339A0 (it)	1979-02-21	Giuntatrice di nastri non tessuti.
LU81575A1 (fr)	1979-12-07	1-(2,6-dihalobenzoyl)-3-(2-pyridinyl-5-substitue)urees,leur preparation et leur utilisation comme insecticides
BE869481A (fr)	1979-02-05	Procede de preparation de pyridazinones-3, nouvelles pyridazinones-3 et leur utilisation comme herbicides
BE891493A (fr)	1982-06-16	Derives de 1,2-dihydro-5(pyridinyl) nicotinamide, leur preparation et leur utilisation comme agents cardiotoniques et intermediaires
BE884329A (fr)	1981-01-16	3-(hydroxy ou hydroxymethyl)-5-(4-pyridinyl)-2(1h)-pyridinones< leur preparation et leur utilisation comme agents carciotoniques
BE864673A (fr)	1978-09-08	N-hydroxy-n-phosphonomethylglycine, ses sels et leur utilisation comme herbicides
NO823977L (no)	1980-12-02	Mellomprodukt for anvendelse ved fremstilling av n-(2-amino-3,5-dibrombenzyl)-n-metylcykloheksylamin
BE843480A (fr)	1976-12-28	3,5-diphenyl-4 (1h)-pyridazinones (thiones), leur synthese et leur utilisation comme herbicides
NL7808596A (nl)	1979-02-21	N-(4-pyrazolidinyl) benzamiden.
DK248181A (da)	1981-12-05	Derivat af 4-(n-(substitueret-benzy-liden) aminomethyl) cyklohexan-1-carboxylsyre
BE889599A (fr)	1982-01-13	Pyridinyl-amino-phenols, leur preparation et leur utilisation comme agents cardiotoniques
BE886675A (fr)	1981-06-16	(phenyl substitue) pyridines, leur preparation et leur utilisation comme agents cardiotoniques
BE872991A (fr)	1979-06-22	Carbothioamides heterocycliques et leur utilisation comme insecticides
FR2543549B1 (fr)	1986-09-05	Nouvelles anilines substituees, leur preparation et leur utilisation comme herbicides