SE8402727L - Forfarande for framstellning av 5-(cyano eller karbamyl)-(3,4-bipyridin)-6(1h)-on - Google Patents
Forfarande for framstellning av 5-(cyano eller karbamyl)-(3,4-bipyridin)-6(1h)-onInfo
- Publication number
- SE8402727L SE8402727L SE8402727A SE8402727A SE8402727L SE 8402727 L SE8402727 L SE 8402727L SE 8402727 A SE8402727 A SE 8402727A SE 8402727 A SE8402727 A SE 8402727A SE 8402727 L SE8402727 L SE 8402727L
- Authority
- SE
- Sweden
- Prior art keywords
- carbamyl
- cyano
- preparing
- bipyridin
- picoline
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
- C07D213/53—Nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/84—Nitriles
- C07D213/85—Nitriles in position 3
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pyridine Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US06/124,808 US4264609A (en) | 1980-02-26 | 1980-02-26 | N-[3-Dimethylamino-2-(4-pyridinyl)-2-propenylidene]-N-methylmethaniminium chloride hydrochloride, its use in preparing 5-(cyano or carbamyl)-[3,4'-bipyridin]-6(1H)-one and its use as a cardiotonic |
Publications (3)
Publication Number | Publication Date |
---|---|
SE8402727L true SE8402727L (sv) | 1984-05-21 |
SE8402727D0 SE8402727D0 (sv) | 1984-05-21 |
SE452764B SE452764B (sv) | 1987-12-14 |
Family
ID=22416880
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SE8101205A SE437514B (sv) | 1980-02-26 | 1981-02-24 | N-/3-dimetylamino-2-(4-pyridinyl)-2-propenyliden/-n-metylmetaniminiumsalt, sett att framstella detta och kardioton komposition for okning av hjertkontraktiliteten |
SE8402727A SE452764B (sv) | 1980-02-26 | 1984-05-21 | Forfarande for framstellning av 5-(cyano eller karbamyl)-(3,4-bipyridin)-6(1h)-on |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SE8101205A SE437514B (sv) | 1980-02-26 | 1981-02-24 | N-/3-dimetylamino-2-(4-pyridinyl)-2-propenyliden/-n-metylmetaniminiumsalt, sett att framstella detta och kardioton komposition for okning av hjertkontraktiliteten |
Country Status (28)
Country | Link |
---|---|
US (1) | US4264609A (sv) |
JP (1) | JPS56128758A (sv) |
KR (2) | KR840002067B1 (sv) |
AR (1) | AR230630A1 (sv) |
AT (2) | AT380237B (sv) |
AU (1) | AU541644B2 (sv) |
BE (1) | BE887663A (sv) |
CA (1) | CA1128523A (sv) |
CH (1) | CH647509A5 (sv) |
DE (1) | DE3107306A1 (sv) |
DK (1) | DK171253B1 (sv) |
ES (1) | ES499776A1 (sv) |
FI (1) | FI76787C (sv) |
FR (1) | FR2476646A1 (sv) |
GB (1) | GB2070600B (sv) |
HK (1) | HK71789A (sv) |
IE (1) | IE51696B1 (sv) |
IL (1) | IL62161A (sv) |
IT (1) | IT1210992B (sv) |
LU (1) | LU83169A1 (sv) |
MX (1) | MX6908E (sv) |
NL (1) | NL192109C (sv) |
NO (1) | NO156689C (sv) |
NZ (1) | NZ196282A (sv) |
PH (2) | PH19904A (sv) |
PT (1) | PT72573B (sv) |
SE (2) | SE437514B (sv) |
ZA (1) | ZA811124B (sv) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE77817T1 (de) | 1985-04-30 | 1992-07-15 | Dresden Arzneimittel | 3-cyan-pyridine, verfahren zu ihrer herstellung und ihre pharmazeutische verwendung. |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4072746A (en) * | 1975-10-14 | 1978-02-07 | Sterling Drug Inc. | 3-Amino-5-(pyridinyl)-2(1H)-pyridinones |
US4004012A (en) * | 1975-10-14 | 1977-01-18 | Sterling Drug Inc. | 3-Cyano-5-(pyridinyl)-2(1H)-pyridinones |
-
1980
- 1980-02-26 US US06/124,808 patent/US4264609A/en not_active Expired - Lifetime
-
1981
- 1981-02-17 NZ NZ196282A patent/NZ196282A/xx unknown
- 1981-02-18 IL IL62161A patent/IL62161A/xx not_active IP Right Cessation
- 1981-02-20 GB GB8105369A patent/GB2070600B/en not_active Expired
- 1981-02-20 ZA ZA00811124A patent/ZA811124B/xx unknown
- 1981-02-20 AU AU67487/81A patent/AU541644B2/en not_active Expired
- 1981-02-24 CH CH1222/81A patent/CH647509A5/fr not_active IP Right Cessation
- 1981-02-24 SE SE8101205A patent/SE437514B/sv not_active IP Right Cessation
- 1981-02-24 FR FR8103609A patent/FR2476646A1/fr active Granted
- 1981-02-24 IT IT8119952A patent/IT1210992B/it active
- 1981-02-24 PH PH25258A patent/PH19904A/en unknown
- 1981-02-25 AT AT0088581A patent/AT380237B/de not_active IP Right Cessation
- 1981-02-25 PT PT72573A patent/PT72573B/pt unknown
- 1981-02-25 BE BE1/10150A patent/BE887663A/fr not_active IP Right Cessation
- 1981-02-25 KR KR1019810000616A patent/KR840002067B1/ko active
- 1981-02-25 NO NO810639A patent/NO156689C/no unknown
- 1981-02-25 CA CA371,690A patent/CA1128523A/en not_active Expired
- 1981-02-25 IE IE397/81A patent/IE51696B1/en not_active IP Right Cessation
- 1981-02-25 ES ES499776A patent/ES499776A1/es not_active Expired
- 1981-02-25 FI FI810582A patent/FI76787C/sv not_active IP Right Cessation
- 1981-02-25 DK DK083981A patent/DK171253B1/da not_active IP Right Cessation
- 1981-02-25 NL NL8100922A patent/NL192109C/nl not_active IP Right Cessation
- 1981-02-25 MX MX819321U patent/MX6908E/es unknown
- 1981-02-26 LU LU83169A patent/LU83169A1/fr unknown
- 1981-02-26 DE DE19813107306 patent/DE3107306A1/de active Granted
- 1981-02-26 JP JP2759981A patent/JPS56128758A/ja active Granted
- 1981-02-26 AR AR284447A patent/AR230630A1/es active
-
1982
- 1982-03-01 PH PH26927A patent/PH17145A/en unknown
-
1983
- 1983-08-26 AT AT0305683A patent/AT380236B/de not_active IP Right Cessation
-
1984
- 1984-05-21 SE SE8402727A patent/SE452764B/sv not_active IP Right Cessation
- 1984-08-22 KR KR1019840005058A patent/KR840002066B1/ko not_active IP Right Cessation
-
1989
- 1989-09-07 HK HK717/89A patent/HK71789A/xx not_active IP Right Cessation
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
AU748352B2 (en) | Pyrazolopyrimidinone cGMP PDE5 inhibitors for the treatment of sexual dysfunction | |
CN101166732B (zh) | 氰基吡啶衍生物及其作为药物的应用 | |
SE8102022L (sv) | Intermediat i form av 2(ih)-pyridinoner samt forfarande for framstellning derav | |
JP7219902B2 (ja) | ブルトン型チロシンキナーゼ阻害剤 | |
ES471526A1 (es) | Procedimiento para la preparacion de derivados de acido fe- noxi-feniltio-alcan-carboxilico | |
JP2021504317A (ja) | ハロアリルアミン類のssao/vap−1阻害剤とその用途 | |
ES8202816A1 (es) | Un procedimiento para preparar diaminopiridinas | |
PE20030761A1 (es) | Derivados del 7-amino-benzotiazol | |
EP3908579A1 (en) | Dihydroorotate dehydrogenase inhibitors | |
JP5042833B2 (ja) | マクロファージエラスターゼの阻害剤としての5−[3−(4−ベンジルオキシフェニルチオ)−フラ−2−イル]−イミダゾリジン−2,4−ジオン及び類似体 | |
JP2022516555A (ja) | 線維芽細胞活性化タンパク質の阻害剤 | |
EP3381916A1 (en) | Condensed pyrimidine compound or salt thereof | |
SE8402727L (sv) | Forfarande for framstellning av 5-(cyano eller karbamyl)-(3,4-bipyridin)-6(1h)-on | |
Miki et al. | Novel synthesis and 1, 3-dipolar cycloaddition reaction of pyridinium N-methylide | |
Dolzhenko et al. | Synthesis and biological activity of fluorinated 7-benzylamino-2-phenyl-1, 2, 4-triazolo [1, 5-a][1, 3, 5] triazin-5-amines | |
FI74001B (fi) | Foerfarande foer framstaellning av ett terapeutiskt aktivt 5-alkyl-1,6-naftyridin-2(1h)-onderivat. | |
US4144343A (en) | Heterocycle substituted (3-loweralkylamino-2-R1 O-propoxy)pyridines | |
US4857527A (en) | Morpholine containing pyridine compounds, compositions and use | |
KR850004756A (ko) | 4,5,6,7-테트라하이드로 티아졸로[5,4-c]피리딘 유도체의 제조방법 | |
US4156004A (en) | Substituted (3-loweralkylamino-2-R1 O-propoxy)pyridines, and use | |
MX2007014224A (es) | Estirilsulfonamidas, su obtencion y uso como agentes farmaceuticos. | |
DE60103129D1 (de) | Benzofurancarboxamide und deren therapeutische verwendung | |
US20150166521A1 (en) | Substituted dialkyl(oxido)-lambda4-sulfanylidene nicotinamide derivatives as kinase inhibitors | |
ES391492A1 (es) | Procedimiento para la obtencion de ureidofenilisotioureas. | |
JPS60169467A (ja) | 新規なフエニルピペラジン誘導体 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
NAL | Patent in force |
Ref document number: 8402727-5 Format of ref document f/p: F |
|
NUG | Patent has lapsed |
Ref document number: 8402727-5 Format of ref document f/p: F |