ATE394102T1 - Substituierte chinazolin-derivate und deren verwendung als aurora-2-kinase inhibitoren - Google Patents
Substituierte chinazolin-derivate und deren verwendung als aurora-2-kinase inhibitorenInfo
- Publication number
- ATE394102T1 ATE394102T1 AT01944061T AT01944061T ATE394102T1 AT E394102 T1 ATE394102 T1 AT E394102T1 AT 01944061 T AT01944061 T AT 01944061T AT 01944061 T AT01944061 T AT 01944061T AT E394102 T1 ATE394102 T1 AT E394102T1
- Authority
- AT
- Austria
- Prior art keywords
- aurora
- kinase inhibitors
- quinazoline derivatives
- substituted quinazoline
- substituted
- Prior art date
Links
- 229940043355 kinase inhibitor Drugs 0.000 title 1
- 239000003757 phosphotransferase inhibitor Substances 0.000 title 1
- JWVCLYRUEFBMGU-UHFFFAOYSA-N quinazoline Chemical class N1=CN=CC2=CC=CC=C21 JWVCLYRUEFBMGU-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP00401842 | 2000-06-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE394102T1 true ATE394102T1 (de) | 2008-05-15 |
Family
ID=8173742
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT01944061T ATE394102T1 (de) | 2000-06-28 | 2001-06-21 | Substituierte chinazolin-derivate und deren verwendung als aurora-2-kinase inhibitoren |
Country Status (27)
| Country | Link |
|---|---|
| US (2) | US6919338B2 (de) |
| EP (1) | EP1299381B1 (de) |
| JP (1) | JP2004501914A (de) |
| KR (1) | KR20030014411A (de) |
| CN (1) | CN1267431C (de) |
| AR (1) | AR030432A1 (de) |
| AT (1) | ATE394102T1 (de) |
| AU (1) | AU2001266505A1 (de) |
| BG (1) | BG107376A (de) |
| BR (1) | BR0111754A (de) |
| CA (1) | CA2412592A1 (de) |
| CZ (1) | CZ20024120A3 (de) |
| DE (1) | DE60133897D1 (de) |
| EE (1) | EE200200715A (de) |
| ES (1) | ES2305081T3 (de) |
| HK (1) | HK1053124A1 (de) |
| HU (1) | HUP0301236A2 (de) |
| IL (1) | IL153246A0 (de) |
| IS (1) | IS6656A (de) |
| MX (1) | MXPA02011974A (de) |
| NO (1) | NO20026010L (de) |
| NZ (1) | NZ522696A (de) |
| PL (1) | PL360439A1 (de) |
| RU (1) | RU2283311C2 (de) |
| SK (1) | SK18102002A3 (de) |
| WO (1) | WO2002000649A1 (de) |
| ZA (1) | ZA200209412B (de) |
Families Citing this family (100)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2001292670A1 (en) * | 2000-09-15 | 2002-03-26 | Vertex Pharmaceuticals Incorporated | Pyrazole compounds useful as protein kinase inhibitors |
| US7473691B2 (en) * | 2000-09-15 | 2009-01-06 | Vertex Pharmaceuticals Incorporated | Pyrazole compounds useful as protein kinase inhibitors |
| US6660731B2 (en) * | 2000-09-15 | 2003-12-09 | Vertex Pharmaceuticals Incorporated | Pyrazole compounds useful as protein kinase inhibitors |
| BR0116411A (pt) * | 2000-12-21 | 2003-11-11 | Vertex Pharma | Compostos de pirazol úteis como inibidores de proteìna cinase |
| HU229477B1 (en) * | 2001-12-24 | 2014-01-28 | Astrazeneca Ab | Substituted quinazoline derivatives as inhibitors of aurora kinases |
| KR20040084896A (ko) * | 2002-02-06 | 2004-10-06 | 버텍스 파마슈티칼스 인코포레이티드 | Ｇｓｋ-3의 억제제로서 유용한 헤테로아릴 화합물 |
| ES2373875T3 (es) * | 2002-03-05 | 2012-02-09 | Transtech Pharma, Inc. | Derivados de azol mono y bicíclicos que inhiben la interacción de ligandos con rage. |
| AU2003218215A1 (en) * | 2002-03-15 | 2003-09-29 | Vertex Pharmaceuticals, Inc. | Azolylaminoazines as inhibitors of protein kinases |
| DE60335099D1 (de) | 2002-05-06 | 2011-01-05 | Vertex Pharma | Thiadiazole oder oxadiazole und ihre verwendung als jak proteinkinaseinhibitoren |
| MY141867A (en) | 2002-06-20 | 2010-07-16 | Vertex Pharma | Substituted pyrimidines useful as protein kinase inhibitors |
| EP1521747B1 (de) | 2002-07-15 | 2018-09-05 | Symphony Evolution, Inc. | Modulatoren von rezeptor-typ-kinase und anwendungsverfahren |
| BR0313176A (pt) * | 2002-08-02 | 2005-06-14 | Vertex Pharma | Composições de pirazol úteis como inibidores de gsk-3 |
| GB0221245D0 (en) * | 2002-09-13 | 2002-10-23 | Astrazeneca Ab | Chemical process |
| KR20050087863A (ko) * | 2002-12-24 | 2005-08-31 | 아스트라제네카 아베 | 퀴나졸린 화합물 |
| CN101074227B (zh) * | 2002-12-24 | 2010-09-29 | 阿斯利康(瑞典)有限公司 | 膦酰氧基喹唑啉衍生物及其药物用途 |
| NZ540698A (en) | 2002-12-24 | 2008-05-30 | Astrazeneca Ab | Phosphonooxy quinazoline derivatives and their pharmaceutical use |
| US7601718B2 (en) * | 2003-02-06 | 2009-10-13 | Vertex Pharmaceuticals Incorporated | Compositions useful as inhibitors of protein kinases |
| EP1613619B1 (de) * | 2003-04-16 | 2008-03-26 | AstraZeneca AB | Quinazolin-derivate für die behandling von krebs |
| EP1635823A1 (de) * | 2003-05-20 | 2006-03-22 | TransTech Pharma Inc. | Rage antagonisten in der behandlung amyloidosis und anderer assoziierten krankheiten |
| JP2006526599A (ja) * | 2003-06-02 | 2006-11-24 | アストラゼネカ アクチボラグ | 癌のような増殖性疾患の治療のためのオーロラキナーゼインヒビターとしての（３−（（キナゾリン−４−イル）アミノ）−１ｈ−ピラゾール−１−イル）アセトアミド誘導体及び関連化合物 |
| TW200505452A (en) * | 2003-06-17 | 2005-02-16 | Astrazeneca Ab | Chemical compounds |
| GB0320793D0 (en) * | 2003-09-05 | 2003-10-08 | Astrazeneca Ab | Chemical process |
| EP2210607B1 (de) | 2003-09-26 | 2011-08-17 | Exelixis Inc. | N-[3-fluoro-4-({6-(methyloxy)-7-[(3-morpholin-4-ylpropyl)oxy]quinolin-4-yl}oxy)phenyl]-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamid zur Behandlung von Krebs |
| PL1678166T3 (pl) * | 2003-10-14 | 2009-12-31 | Univ Arizona | Inhibitory kinaz białkowych |
| US20080051414A1 (en) * | 2003-10-14 | 2008-02-28 | Arizona Board Of Regents On Behalf Of The University Of Arizona | Protein Kinase Inhibitors |
| US20090099165A1 (en) * | 2003-10-14 | 2009-04-16 | Arizona Board Of Regents On Behalf Of The University Of Arizona | Protein Kinase Inhibitors |
| US20090143399A1 (en) * | 2003-10-14 | 2009-06-04 | Arizona Board Of Regents On Behalf Of The University Of Arizona | Protein Kinase Inhibitors |
| EP1678149A2 (de) * | 2003-10-31 | 2006-07-12 | Neurogen Corporation | 4-amino(aza)chinolinderivate als capsaicinrezeptoragonisten |
| JP2007513184A (ja) * | 2003-12-04 | 2007-05-24 | バーテックス ファーマシューティカルズ インコーポレイテッド | プロテインキナーゼのインヒビターとして有用なキノキサリン |
| WO2005061519A1 (en) | 2003-12-19 | 2005-07-07 | Takeda San Diego, Inc. | Kinase inhibitors |
| US8119684B2 (en) * | 2003-12-30 | 2012-02-21 | Dana-Farber Cancer Institute, Inc. | Thiophene derivatives for up-regulating HLA-DM activity |
| US7687502B2 (en) * | 2004-03-23 | 2010-03-30 | Banyu Pharmaceutical Co., Ltd. | Substituted quinazoline or pyridopyrimidine derivative |
| US20050250829A1 (en) * | 2004-04-23 | 2005-11-10 | Takeda San Diego, Inc. | Kinase inhibitors |
| JP2008510734A (ja) | 2004-08-18 | 2008-04-10 | タケダ サン ディエゴ インコーポレイテッド | キナーゼ阻害剤 |
| ATE540935T1 (de) * | 2004-10-12 | 2012-01-15 | Astrazeneca Ab | Chinazolinderivate |
| EP1802603A1 (de) * | 2004-10-12 | 2007-07-04 | AstraZeneca AB | Chinolinderivate |
| US7713973B2 (en) | 2004-10-15 | 2010-05-11 | Takeda Pharmaceutical Company Limited | Kinase inhibitors |
| CN1854130B (zh) * | 2005-04-15 | 2011-04-20 | 中国医学科学院药物研究所 | 喹唑啉衍生物、及其制法和药物组合物与用途 |
| GB0509227D0 (en) * | 2005-05-05 | 2005-06-15 | Chroma Therapeutics Ltd | Intracellular enzyme inhibitors |
| GB0510963D0 (en) * | 2005-05-28 | 2005-07-06 | Astrazeneca Ab | Chemical compounds |
| US7737151B2 (en) * | 2005-08-18 | 2010-06-15 | Vertex Pharmaceuticals Incorporated | Pyrazine kinase inhibitors |
| US8119655B2 (en) | 2005-10-07 | 2012-02-21 | Takeda Pharmaceutical Company Limited | Kinase inhibitors |
| CN101316843B (zh) * | 2005-11-03 | 2013-01-02 | 顶点医药品公司 | 用作激酶抑制剂的氨基嘧啶 |
| EP1785420A1 (de) * | 2005-11-14 | 2007-05-16 | 4Sc Ag | Thiazolanalogen und ihre Verwendung |
| GEP20125643B (en) | 2006-01-23 | 2012-09-25 | Amgen Inc | Aurora kinase modulators and method of using same |
| US7560551B2 (en) | 2006-01-23 | 2009-07-14 | Amgen Inc. | Aurora kinase modulators and method of use |
| US7868177B2 (en) * | 2006-02-24 | 2011-01-11 | Amgen Inc. | Multi-cyclic compounds and method of use |
| UY30183A1 (es) | 2006-03-02 | 2007-10-31 | Astrazeneca Ab | Derivados de quinolina |
| JP2009528336A (ja) * | 2006-03-02 | 2009-08-06 | アストラゼネカ アクチボラグ | キノリン誘導体 |
| WO2007113005A2 (en) * | 2006-04-03 | 2007-10-11 | European Molecular Biology Laboratory (Embl) | 2-substituted 3-aminosulfonyl-thiophene derivatives as aurora kinase inhibitors |
| JP2010505962A (ja) | 2006-10-09 | 2010-02-25 | 武田薬品工業株式会社 | キナーゼ阻害剤 |
| EP2073807A1 (de) | 2006-10-12 | 2009-07-01 | Astex Therapeutics Limited | Pharmazeutische kombinationen |
| US8916552B2 (en) | 2006-10-12 | 2014-12-23 | Astex Therapeutics Limited | Pharmaceutical combinations |
| WO2008057280A1 (en) | 2006-10-27 | 2008-05-15 | Amgen Inc. | Multi-cyclic compounds and methods of use |
| WO2008055233A1 (en) * | 2006-10-31 | 2008-05-08 | Supergen, Inc. | Protein kinase inhibitors |
| EP2086965B1 (de) * | 2006-11-02 | 2010-02-10 | Vertex Pharmaceuticals, Inc. | Als inhibitoren von proteinkinasen geeignete aminopyridine und aminopyrimidine |
| EP2099787B1 (de) * | 2006-12-19 | 2010-07-21 | Vertex Pharmaceuticals, Inc. | Als inhibitoren von proteinkinasen geeignete aminopyrimidine |
| CA2679884A1 (en) * | 2007-03-09 | 2008-09-18 | Vertex Pharmaceuticals Incorporated | Aminopyrimidines useful as inhibitors of protein kinases |
| AU2008226461A1 (en) | 2007-03-09 | 2008-09-18 | Vertex Pharmaceuticals Incorporated | Aminopyridines useful as inhibitors of protein kinases |
| NZ579485A (en) * | 2007-03-09 | 2012-02-24 | Vertex Pharma | Aminopyrimidines useful as inhibitors of protein kinases |
| CA2682504C (en) | 2007-04-05 | 2012-10-30 | Amgen Inc. | Aurora kinase modulators and method of use |
| CA2683785A1 (en) | 2007-04-13 | 2008-10-23 | Vertex Pharmaceuticals Incorporated | Aminopyrimidines useful as kinase inhibitors |
| MX2009011812A (es) * | 2007-05-02 | 2010-01-14 | Vertex Pharma | Aminopirimidinas utiles como inhibidores de cinasa. |
| AU2008247595A1 (en) * | 2007-05-02 | 2008-11-13 | Vertex Pharmaceuticals Incorporated | Aminopyrimidines useful as kinase inhibitors |
| AU2008247592A1 (en) | 2007-05-02 | 2008-11-13 | Vertex Pharmaceuticals Incorporated | Thiazoles and pyrazoles useful as kinase inhibitors |
| GB0709031D0 (en) * | 2007-05-10 | 2007-06-20 | Sareum Ltd | Pharmaceutical compounds |
| MX2009012719A (es) * | 2007-05-24 | 2010-02-04 | Vertex Pharma | Tiazoles y pirazoles utiles como inhibidores de cinasa. |
| CA2690141A1 (en) * | 2007-06-20 | 2008-12-24 | Merck Sharp & Dohme Corp. | Inhibitors of janus kinases |
| CN101687821A (zh) * | 2007-06-21 | 2010-03-31 | Irm责任有限公司 | 蛋白激酶抑制剂及其使用方法 |
| AU2008282156B2 (en) | 2007-07-31 | 2014-07-17 | Vertex Pharmaceuticals Incorporated | Process for preparing 5-fluoro-1H-pyrazolo [3, 4-b] pyridin-3-amine and derivatives thereof |
| DE102008015033A1 (de) | 2008-03-17 | 2009-09-24 | Aicuris Gmbh & Co. Kg | Substituierte (Pyrazolyl-carbonyl)imidazolidinone und ihre Verwendung |
| DE102008015032A1 (de) | 2008-03-17 | 2009-09-24 | Aicuris Gmbh & Co. Kg | Substituierte Pyrazolamide und ihre Verwendung |
| JP2011515401A (ja) * | 2008-03-20 | 2011-05-19 | アムジエン・インコーポレーテツド | オーロラキナーゼモジュレーターおよび使用方法 |
| US9126935B2 (en) | 2008-08-14 | 2015-09-08 | Amgen Inc. | Aurora kinase modulators and methods of use |
| AU2009288200A1 (en) * | 2008-09-03 | 2010-03-11 | Vertex Pharmaceuticals Incorporated | Co-crystals and pharmaceutical formulations comprising the same |
| GB0820819D0 (en) | 2008-11-13 | 2008-12-24 | Sareum Ltd | Pharmaceutical compounds |
| SG196784A1 (en) | 2008-12-03 | 2014-02-13 | Scripps Research Inst | Stem cell cultures |
| DE102008062863A1 (de) | 2008-12-17 | 2010-06-24 | Aicuris Gmbh & Co. Kg | Substituierte (Thiophenyl-carbonyl)imidazolidinone und ihre Verwendung |
| DE102008062878A1 (de) | 2008-12-17 | 2010-06-24 | Aicuris Gmbh & Co. Kg | Substituierte Furancarboxamide und ihre Verwendung |
| KR20200137052A (ko) | 2009-01-16 | 2020-12-08 | 엑셀리시스, 인코포레이티드 | 암의 치료를 위한 ｎ-（４-｛〔６，７-비스（메틸옥시）퀴놀린-4-일〕옥시｝페닐）-ｎ＇-（４-플루오로페닐）사이클로프로판-1,1-디카르복사미드의 말산염 및 그 결정형 |
| EA020731B1 (ru) * | 2009-02-11 | 2015-01-30 | Мерк Патент Гмбх | Аминоазагетероциклические карбоксамиды |
| UA108618C2 (uk) | 2009-08-07 | 2015-05-25 | Застосування c-met-модуляторів в комбінації з темозоломідом та/або променевою терапією для лікування раку | |
| JP5805646B2 (ja) | 2009-09-30 | 2015-11-04 | ブイティーブイ・セラピューティクス・エルエルシー | アルツハイマー病の治療のための置換イミダゾール誘導体 |
| WO2011130459A1 (en) | 2010-04-14 | 2011-10-20 | Bristol-Myers Squibb Company | Novel glucokinase activators and methods of using same |
| CN103221048A (zh) * | 2010-11-18 | 2013-07-24 | 卡斯纳莱拉创新药物私人有限公司 | 取代的4-(硒吩-2(或3)-基氨基)嘧啶化合物及其使用方法 |
| US9090633B2 (en) | 2010-11-18 | 2015-07-28 | Kasina Laila Innova Pharmaceuticals Private Limited | Substituted 4-(arylamino) selenophenopyrimidine compounds and methods of use thereof |
| US8785459B2 (en) * | 2011-12-27 | 2014-07-22 | Development Center For Biotechnology | Quinazoline compounds as kinase inhibitors |
| GB201202027D0 (en) | 2012-02-06 | 2012-03-21 | Sareum Ltd | Pharmaceutical compounds |
| EP3040336B1 (de) | 2012-03-02 | 2020-04-08 | Sareum Limited | Verbindungen zur verwendung in der behandlung von tyk2 kinase vermittelten erkrankungen |
| CN103788085B (zh) * | 2012-10-31 | 2016-09-07 | 复旦大学 | 2-（喹唑啉-4-氨基）-5-噻唑甲酰胺类衍生物及其生物药物用途 |
| CN104098551B (zh) * | 2013-04-03 | 2019-03-22 | 广东东阳光药业有限公司 | 作为欧若拉激酶抑制剂的取代喹唑啉类衍生物 |
| AU2014320088B2 (en) | 2013-09-16 | 2017-06-01 | Astrazeneca Ab | Therapeutic polymeric nanoparticles and methods of making and using same |
| EP3359526A4 (de) | 2015-10-05 | 2019-04-03 | The Trustees of Columbia University in the City of New York | Aktivatoren von autophagischem fluss und phospholipase d und reinigung von proteinaggregaten einschliesslich tau und behandlung von proteinopathien |
| GB201617871D0 (en) | 2016-10-21 | 2016-12-07 | Sareum Limited | Pharmaceutical compounds |
| AR112027A1 (es) * | 2017-06-15 | 2019-09-11 | Biocryst Pharm Inc | Inhibidores de alk 2 quinasa que contienen imidazol |
| WO2021043966A1 (en) * | 2019-09-06 | 2021-03-11 | Inflazome Limited | Nlrp3 inhibitors |
| CN110746398A (zh) * | 2019-10-18 | 2020-02-04 | 刘沛友 | 4-杂环取代喹唑啉类衍生物及其制备方法和用途 |
| CN111574473A (zh) * | 2020-06-04 | 2020-08-25 | 宁夏农林科学院农业资源与环境研究所（宁夏土壤与植物营养重点实验室） | 一种氨基噻唑类化合物的合成方法 |
| CN113311166B (zh) * | 2021-04-28 | 2022-10-28 | 新疆农垦科学院 | 一种用于绵羊早期妊娠诊断的蛋白生物标志物及其用于绵羊早期妊娠检测的方法 |
| CN115557601A (zh) * | 2022-11-08 | 2023-01-03 | 成都理工大学 | 生物质微球及其制备方法与应用、生物反应器、地下井 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3870725A (en) * | 1971-03-30 | 1975-03-11 | Lilly Industries Ltd | Nitrothiazole derivatives |
| SG64322A1 (en) | 1991-05-10 | 1999-04-27 | Rhone Poulenc Rorer Int | Bis mono and bicyclic aryl and heteroaryl compounds which inhibit egf and/or pdgf receptor tyrosine kinase |
| US5710158A (en) | 1991-05-10 | 1998-01-20 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Aryl and heteroaryl quinazoline compounds which inhibit EGF and/or PDGF receptor tyrosine kinase |
| NZ243082A (en) * | 1991-06-28 | 1995-02-24 | Ici Plc | 4-anilino-quinazoline derivatives; pharmaceutical compositions, preparatory processes, and use thereof |
| IL117620A0 (en) * | 1995-03-27 | 1996-07-23 | Fujisawa Pharmaceutical Co | Heterocyclic compounds processes for the preparation thereof and pharmaceutical compositions containing the same |
| GB9514265D0 (en) | 1995-07-13 | 1995-09-13 | Wellcome Found | Hetrocyclic compounds |
| US6716575B2 (en) * | 1995-12-18 | 2004-04-06 | Sugen, Inc. | Diagnosis and treatment of AUR1 and/or AUR2 related disorders |
| TW436485B (en) | 1997-08-01 | 2001-05-28 | American Cyanamid Co | Substituted quinazoline derivatives |
| GB9800569D0 (en) | 1998-01-12 | 1998-03-11 | Glaxo Group Ltd | Heterocyclic compounds |
| GB9800575D0 (en) | 1998-01-12 | 1998-03-11 | Glaxo Group Ltd | Heterocyclic compounds |
| US7262201B1 (en) * | 1998-10-08 | 2007-08-28 | Astrazeneca Ab | Quinazoline derivatives |
| GB9922171D0 (en) | 1999-09-21 | 1999-11-17 | Zeneca Ltd | Chemical compounds |
-
2001
- 2001-06-21 SK SK1810-2002A patent/SK18102002A3/sk unknown
- 2001-06-21 KR KR1020027017913A patent/KR20030014411A/ko not_active Application Discontinuation
- 2001-06-21 JP JP2002505773A patent/JP2004501914A/ja active Pending
- 2001-06-21 DE DE60133897T patent/DE60133897D1/de not_active Expired - Fee Related
- 2001-06-21 WO PCT/SE2001/001450 patent/WO2002000649A1/en active IP Right Grant
- 2001-06-21 CN CNB018146201A patent/CN1267431C/zh not_active Expired - Fee Related
- 2001-06-21 EE EEP200200715A patent/EE200200715A/xx unknown
- 2001-06-21 US US10/311,916 patent/US6919338B2/en not_active Expired - Fee Related
- 2001-06-21 PL PL01360439A patent/PL360439A1/xx not_active Application Discontinuation
- 2001-06-21 CA CA002412592A patent/CA2412592A1/en not_active Abandoned
- 2001-06-21 BR BR0111754-8A patent/BR0111754A/pt not_active IP Right Cessation
- 2001-06-21 AU AU2001266505A patent/AU2001266505A1/en not_active Abandoned
- 2001-06-21 EP EP01944061A patent/EP1299381B1/de not_active Expired - Lifetime
- 2001-06-21 IL IL15324601A patent/IL153246A0/xx unknown
- 2001-06-21 MX MXPA02011974A patent/MXPA02011974A/es unknown
- 2001-06-21 HU HU0301236A patent/HUP0301236A2/hu unknown
- 2001-06-21 CZ CZ20024120A patent/CZ20024120A3/cs unknown
- 2001-06-21 AT AT01944061T patent/ATE394102T1/de not_active IP Right Cessation
- 2001-06-21 RU RU2003102389/04A patent/RU2283311C2/ru not_active IP Right Cessation
- 2001-06-21 ES ES01944061T patent/ES2305081T3/es not_active Expired - Lifetime
- 2001-06-21 NZ NZ522696A patent/NZ522696A/en unknown
- 2001-06-28 AR ARP010103092A patent/AR030432A1/es not_active Application Discontinuation
-
2002
- 2002-11-19 ZA ZA200209412A patent/ZA200209412B/en unknown
- 2002-12-11 BG BG107376A patent/BG107376A/bg unknown
- 2002-12-13 NO NO20026010A patent/NO20026010L/no unknown
- 2002-12-17 IS IS6656A patent/IS6656A/is unknown
-
2003
- 2003-07-31 HK HK03105517A patent/HK1053124A1/xx not_active IP Right Cessation
-
2005
- 2005-03-02 US US11/070,057 patent/US20060046987A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| IL153246A0 (en) | 2003-07-06 |
| US20030187002A1 (en) | 2003-10-02 |
| PL360439A1 (en) | 2004-09-06 |
| AU2001266505A1 (en) | 2002-01-08 |
| BG107376A (bg) | 2003-09-30 |
| EE200200715A (et) | 2004-08-16 |
| SK18102002A3 (sk) | 2003-07-01 |
| CN1267431C (zh) | 2006-08-02 |
| NO20026010D0 (no) | 2002-12-13 |
| JP2004501914A (ja) | 2004-01-22 |
| ZA200209412B (en) | 2004-02-19 |
| BR0111754A (pt) | 2003-04-29 |
| WO2002000649A1 (en) | 2002-01-03 |
| HUP0301236A2 (hu) | 2003-10-28 |
| EP1299381B1 (de) | 2008-05-07 |
| CZ20024120A3 (cs) | 2003-03-12 |
| WO2002000649A9 (en) | 2007-09-20 |
| NZ522696A (en) | 2004-08-27 |
| MXPA02011974A (es) | 2004-09-06 |
| HK1053124A1 (en) | 2003-10-10 |
| CA2412592A1 (en) | 2002-01-03 |
| CN1496364A (zh) | 2004-05-12 |
| EP1299381A1 (de) | 2003-04-09 |
| US20060046987A1 (en) | 2006-03-02 |
| KR20030014411A (ko) | 2003-02-17 |
| RU2283311C2 (ru) | 2006-09-10 |
| US6919338B2 (en) | 2005-07-19 |
| DE60133897D1 (de) | 2008-06-19 |
| IS6656A (is) | 2002-12-17 |
| ES2305081T3 (es) | 2008-11-01 |
| AR030432A1 (es) | 2003-08-20 |
| NO20026010L (no) | 2002-12-13 |
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| Date | Code | Title | Description |
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| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |