ATE538380T1 - Nukleinsäure-programmierbare protein-arrays - Google Patents
Nukleinsäure-programmierbare protein-arraysInfo
- Publication number
- ATE538380T1 ATE538380T1 AT02707542T AT02707542T ATE538380T1 AT E538380 T1 ATE538380 T1 AT E538380T1 AT 02707542 T AT02707542 T AT 02707542T AT 02707542 T AT02707542 T AT 02707542T AT E538380 T1 ATE538380 T1 AT E538380T1
- Authority
- AT
- Austria
- Prior art keywords
- nucleic acid
- protein arrays
- acid programmable
- programmable protein
- arrays
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B30/00—Methods of screening libraries
- C40B30/04—Methods of screening libraries by measuring the ability to specifically bind a target molecule, e.g. antibody-antigen binding, receptor-ligand binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
- C07K1/047—Simultaneous synthesis of different peptide species; Peptide libraries
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
- G01N33/6845—Methods of identifying protein-protein interactions in protein mixtures
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US26360701P | 2001-01-23 | 2001-01-23 | |
PCT/US2002/001882 WO2002059601A1 (en) | 2001-01-23 | 2002-01-22 | Nucleic-acid programmable protein arrays |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE538380T1 true ATE538380T1 (de) | 2012-01-15 |
Family
ID=23002490
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT02707542T ATE538380T1 (de) | 2001-01-23 | 2002-01-22 | Nukleinsäure-programmierbare protein-arrays |
Country Status (6)
Country | Link |
---|---|
US (2) | US6800453B2 (de) |
EP (1) | EP1360490B1 (de) |
JP (3) | JP4880188B2 (de) |
AT (1) | ATE538380T1 (de) |
CA (1) | CA2434139C (de) |
WO (1) | WO2002059601A1 (de) |
Families Citing this family (109)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE60120713T2 (de) | 2000-08-15 | 2007-06-06 | Discerna Ltd. | Funktionelles protein array |
WO2002059601A1 (en) | 2001-01-23 | 2002-08-01 | President And Fellows Of Harvard College | Nucleic-acid programmable protein arrays |
WO2002092118A1 (en) * | 2001-05-11 | 2002-11-21 | Yale University | Global analysis of protein activities using proteome chips |
WO2003018797A2 (en) * | 2001-08-22 | 2003-03-06 | Helix Biopharma Corporation | Method and device for integrated protein expression, purification and detection |
US20030162179A1 (en) * | 2002-02-27 | 2003-08-28 | General Electric Company | Fabrication, performance testing, and screening of three dimensional arrays of materials |
US20030228709A1 (en) * | 2002-03-25 | 2003-12-11 | Kozlowski Roland Zbignieiw | Arrays |
US20030235814A1 (en) * | 2002-06-19 | 2003-12-25 | Los Alamos National Laboratory | Compositions and methods for selecting open reading frames |
US20040043384A1 (en) * | 2002-08-28 | 2004-03-04 | Oleinikov Andrew V. | In vitro protein translation microarray device |
KR100523212B1 (ko) * | 2003-01-04 | 2005-10-24 | 한국과학기술원 | 반응 단백질과 그의 기질 펩타이드간의 반응분석을 위한단백질 칩 |
CA2512590A1 (en) | 2003-01-07 | 2004-07-29 | Dyax Corporation | Kunitz domain library |
TW200412373A (en) * | 2003-01-15 | 2004-07-16 | Univ Nat Taiwan | RCA combined nanoparticle-based optical detection technique for protein microarray |
CA2514564A1 (en) | 2003-01-31 | 2005-07-26 | Promega Corporation | Covalent tethering of functional groups to proteins |
US7429472B2 (en) | 2003-01-31 | 2008-09-30 | Promega Corporation | Method of immobilizing a protein or molecule via a mutant dehalogenase that is bound to an immobilized dehalogenase substrate and linked directly or indirectly to the protein or molecule |
US7585815B2 (en) * | 2003-07-24 | 2009-09-08 | Lawrence Livermore National Security, Llc | High throughput protein production screening |
US7754497B2 (en) * | 2003-08-29 | 2010-07-13 | Reverse Proteomics Research Institute Co., Ltd. | Method for immobilizing proteins |
US8293503B2 (en) | 2003-10-03 | 2012-10-23 | Promega Corporation | Vectors for directional cloning |
EP1847611B1 (de) * | 2003-10-03 | 2009-09-09 | Promega Corporation | Rhamnose-induzierbares Expressionssystem |
US20050214890A1 (en) * | 2003-11-26 | 2005-09-29 | Zhiqun Tan | Novel "Cleave-N-Read" system for protease activity assay and methods of use thereof |
US20050260653A1 (en) * | 2004-04-14 | 2005-11-24 | Joshua Labaer | Nucleic-acid programmable protein arrays |
CN101133157A (zh) | 2004-06-03 | 2008-02-27 | 阿什洛米克斯控股有限公司 | 诊断应激的药物和方法 |
US20090054255A1 (en) * | 2004-07-01 | 2009-02-26 | The Regents Of The University Of California | Microfluidic devices and methods |
US20070087400A1 (en) * | 2004-07-30 | 2007-04-19 | Aldis Darzins | Covalent tethering of functional groups to proteins and substrates therefor |
US7425436B2 (en) * | 2004-07-30 | 2008-09-16 | Promega Corporation | Covalent tethering of functional groups to proteins and substrates therefor |
US7786261B2 (en) * | 2004-09-02 | 2010-08-31 | National Research Council Of Canada | Coiled-coil fusion proteins comprising cell receptor domains |
JP4868731B2 (ja) * | 2004-11-17 | 2012-02-01 | 独立行政法人理化学研究所 | 哺乳動物培養細胞由来の無細胞タンパク質合成システム |
JP4686682B2 (ja) * | 2004-12-02 | 2011-05-25 | 国立大学法人名古屋大学 | リガンド親和性複合タンパク質の取得方法、抗体スクリーニング方法、抗体スクリーニング用キット、医療方法、抗体医薬、非免疫反応性抗体医薬、投薬方法 |
JPWO2006062200A1 (ja) * | 2004-12-09 | 2008-06-12 | ユニバーサル・バイオ・リサーチ株式会社 | 核酸ライブラリー及びタンパク質ライブラリー |
US20060234265A1 (en) * | 2005-03-21 | 2006-10-19 | Jim Richey | Microarrays having multi-functional, compartmentalized analysis areas and methods of use |
EP1869219A4 (de) * | 2005-03-31 | 2010-06-23 | Perkinelmer Las Inc | Multiplex-testsystem |
US20070003954A1 (en) * | 2005-05-12 | 2007-01-04 | The Board Of Regents Of The University Of Texas System | Protein and antibody profiling using small molecule microarrays |
JP2006337153A (ja) * | 2005-06-01 | 2006-12-14 | Toppan Printing Co Ltd | Dna合成判定装置、核酸タンク装置、dnaチップ装置及びdna判定システム |
GB0511717D0 (en) * | 2005-06-09 | 2005-07-13 | Babraham Inst | Repeatable protein arrays |
WO2007006091A1 (en) | 2005-07-07 | 2007-01-18 | Athlomics Pty Ltd | Polynucleotide marker genes and their expression, for diagnosis of endotoxemia |
WO2007061981A2 (en) | 2005-11-21 | 2007-05-31 | Lumera Corporation | Surface plasmon resonance spectrometer with an actuator-driven angle scanning mechanism |
US7463358B2 (en) * | 2005-12-06 | 2008-12-09 | Lumera Corporation | Highly stable surface plasmon resonance plates, microarrays, and methods |
WO2007092579A2 (en) * | 2006-02-08 | 2007-08-16 | Promega Corporation | Compositions and methods for capturing and analyzing cross-linked biomolecules |
US8178316B2 (en) | 2006-06-29 | 2012-05-15 | President And Fellows Of Harvard College | Evaluating proteins |
WO2008045148A2 (en) | 2006-07-05 | 2008-04-17 | Catalyst Biosciences, Inc. | Protease screening methods and proteases identified thereby |
US8420367B2 (en) | 2006-10-30 | 2013-04-16 | Promega Corporation | Polynucleotides encoding mutant hydrolase proteins with enhanced kinetics and functional expression |
SI2147096T1 (sl) | 2007-04-13 | 2015-07-31 | Catalyst Biosciences, Inc., | Modificirani polipeptidi faktorja VII in njihove uporabe |
CA2704226A1 (en) * | 2007-11-01 | 2009-05-07 | The Arizona Board Of Regents On Behalf Of The University Of Arizona | Cell-free methods for detecting protein-ligand interctions |
WO2009108170A2 (en) * | 2007-11-16 | 2009-09-03 | Invitrogen Corporation | Compositions and methods for determining immune status |
US9328172B2 (en) * | 2008-04-05 | 2016-05-03 | Single Cell Technology, Inc. | Method of obtaining antibodies of interest and nucleotides encoding same |
WO2010033237A2 (en) * | 2008-09-22 | 2010-03-25 | Calmune Corporation | Methods for creating diversity in libraries and libraries, display vectors and methods, and displayed molecules |
EP2352760A2 (de) | 2008-09-22 | 2011-08-10 | Calmune Corporation | Verfahren und vektoren zur präsentation von molekülen und präsentierte moleküle und bibliotheken |
DE102009012169B3 (de) * | 2009-03-06 | 2010-11-04 | Albert-Ludwigs-Universität Freiburg | Vorrichtung und Verfahren zum Herstellen eines Replikats oder eines Derivats aus einem Array von Molekülen und Anwendungen derselben |
US9085798B2 (en) | 2009-04-30 | 2015-07-21 | Prognosys Biosciences, Inc. | Nucleic acid constructs and methods of use |
KR20120034683A (ko) * | 2009-05-29 | 2012-04-12 | 더 보드 오브 리전츠 오브 더 유니버시티 오브 텍사스 시스템 | 자가면역 t-세포의 분리 및 처리를 위한 펩토이드 리간드 |
BRPI1013012A2 (pt) * | 2009-06-02 | 2016-10-18 | Opko Health Inc | identificação de pequenas moléculas reconhecidas por anticorpos em indivíduos com doenças neurodegenerativas |
WO2011035205A2 (en) | 2009-09-18 | 2011-03-24 | Calmune Corporation | Antibodies against candida, collections thereof and methods of use |
TW201124726A (en) * | 2009-10-16 | 2011-07-16 | Univ Texas | Compositions and methods for producing coded peptoid libraries |
KR101866401B1 (ko) | 2010-04-05 | 2018-06-11 | 프로그노시스 바이오사이언스, 인코포레이티드 | 공간적으로 엔코딩된 생물학적 검정 |
US20190300945A1 (en) | 2010-04-05 | 2019-10-03 | Prognosys Biosciences, Inc. | Spatially Encoded Biological Assays |
US10787701B2 (en) | 2010-04-05 | 2020-09-29 | Prognosys Biosciences, Inc. | Spatially encoded biological assays |
US20110287407A1 (en) * | 2010-04-27 | 2011-11-24 | Diomics Corporation | Integrated methods and systems for processing a molecular profile |
DE102011010307A1 (de) | 2011-02-03 | 2012-08-09 | Albert-Ludwigs-Universität Freiburg | Vorrichtung und Verfahren zur Erzeugung von Protein-Mikroarrays |
EP2694709B1 (de) | 2011-04-08 | 2016-09-14 | Prognosys Biosciences, Inc. | Peptidkonstrukte und testsysteme dafür |
GB201106254D0 (en) | 2011-04-13 | 2011-05-25 | Frisen Jonas | Method and product |
WO2013024821A1 (ja) * | 2011-08-12 | 2013-02-21 | 国立大学法人筑波大学 | 並列反応用懸濁液、並列反応方法およびスクリーニング方法 |
DE102011054101A1 (de) | 2011-09-30 | 2013-04-04 | Albert-Ludwigs-Universität Freiburg | Verfahren zur räumlichen Anordnung von Probenfragmenten zur Amplifikation und Immobilisierung für weitere Derivatisierungen |
US8987174B2 (en) | 2011-10-28 | 2015-03-24 | Prognosys Biosciences, Inc. | Methods for manufacturing molecular arrays |
US9442111B2 (en) | 2011-12-14 | 2016-09-13 | Arizona Board Of Regents | Method and apparatus for measuring phosphorylation kinetics on large arrays |
CN111233978A (zh) | 2013-03-15 | 2020-06-05 | 普罗格诺西斯生物科学公司 | 用于检测肽/mhc/tcr结合的方法 |
US9938523B2 (en) | 2013-03-15 | 2018-04-10 | Arizona Board Of Regents On Behalf Of Arizona State University | Nucleic acid-tagged compositions and methods for multiplexed protein-protein interaction profiling |
EP3462174B1 (de) | 2013-03-15 | 2021-12-29 | Arizona Board of Regents on behalf of Arizona State University | Biosensor-mikroarrayzusammensetzungen und verfahren |
US9868979B2 (en) | 2013-06-25 | 2018-01-16 | Prognosys Biosciences, Inc. | Spatially encoded biological assays using a microfluidic device |
WO2015070037A2 (en) | 2013-11-08 | 2015-05-14 | Prognosys Biosciences, Inc. | Polynucleotide conjugates and methods for analyte detection |
WO2015175755A1 (en) * | 2014-05-15 | 2015-11-19 | Arizona Board Of Regents On Behalf Of Arizona State University | Nucleic acid-guided ordered protein assemblies and methods |
US20160195546A1 (en) | 2015-01-07 | 2016-07-07 | Arizona Board Of Regents On Behalf Of Arizona State University | Type 1 Diabetes Biomarkers |
ES2955916T3 (es) | 2015-04-10 | 2023-12-11 | Spatial Transcriptomics Ab | Análisis múltiplex de especímenes biológicos de ácidos nucleicos espacialmente distinguidos |
AU2016331663B2 (en) | 2015-09-30 | 2022-04-07 | Immunexpress Pty Ltd | Pathogen biomarkers and uses therefor |
EP3394291B1 (de) | 2015-12-24 | 2021-10-06 | Immunexpress Pty Ltd | Triage-biomarker und verwendungen dafür |
KR102379048B1 (ko) | 2016-05-02 | 2022-03-28 | 엔코디아, 인코포레이티드 | 암호화 핵산을 사용한 거대분자 분석 |
US10055620B2 (en) * | 2017-01-13 | 2018-08-21 | International Business Machines Corporation | Baggage handling |
US10648978B2 (en) | 2017-02-09 | 2020-05-12 | Mayo Foundation For Medical Education And Research | Methods for detecting novel autoantibodies in Crohn's disease |
EP3698136A4 (de) * | 2017-10-16 | 2021-06-23 | Inanobio, Inc. | Krankheitsproteam-protein-arrays und verwendungen davon |
SG11202003924YA (en) | 2017-10-31 | 2020-05-28 | Encodia Inc | Kits for analysis using nucleic acid encoding and/or label |
CN112424608A (zh) | 2018-05-10 | 2021-02-26 | 卫理公会医院 | 用于疾病的预后和管理的方法 |
US11519033B2 (en) | 2018-08-28 | 2022-12-06 | 10X Genomics, Inc. | Method for transposase-mediated spatial tagging and analyzing genomic DNA in a biological sample |
US11926867B2 (en) | 2019-01-06 | 2024-03-12 | 10X Genomics, Inc. | Generating capture probes for spatial analysis |
US11649485B2 (en) | 2019-01-06 | 2023-05-16 | 10X Genomics, Inc. | Generating capture probes for spatial analysis |
WO2020243579A1 (en) | 2019-05-30 | 2020-12-03 | 10X Genomics, Inc. | Methods of detecting spatial heterogeneity of a biological sample |
EP4025711A2 (de) | 2019-11-08 | 2022-07-13 | 10X Genomics, Inc. | Erhöhung der spezifität einer analytbindung |
WO2021091611A1 (en) | 2019-11-08 | 2021-05-14 | 10X Genomics, Inc. | Spatially-tagged analyte capture agents for analyte multiplexing |
SG11202106899SA (en) | 2019-12-23 | 2021-09-29 | 10X Genomics Inc | Methods for spatial analysis using rna-templated ligation |
US11702693B2 (en) | 2020-01-21 | 2023-07-18 | 10X Genomics, Inc. | Methods for printing cells and generating arrays of barcoded cells |
US11732299B2 (en) | 2020-01-21 | 2023-08-22 | 10X Genomics, Inc. | Spatial assays with perturbed cells |
US11821035B1 (en) | 2020-01-29 | 2023-11-21 | 10X Genomics, Inc. | Compositions and methods of making gene expression libraries |
US11898205B2 (en) | 2020-02-03 | 2024-02-13 | 10X Genomics, Inc. | Increasing capture efficiency of spatial assays |
US11732300B2 (en) | 2020-02-05 | 2023-08-22 | 10X Genomics, Inc. | Increasing efficiency of spatial analysis in a biological sample |
US11835462B2 (en) | 2020-02-11 | 2023-12-05 | 10X Genomics, Inc. | Methods and compositions for partitioning a biological sample |
US11891654B2 (en) | 2020-02-24 | 2024-02-06 | 10X Genomics, Inc. | Methods of making gene expression libraries |
US11926863B1 (en) | 2020-02-27 | 2024-03-12 | 10X Genomics, Inc. | Solid state single cell method for analyzing fixed biological cells |
US11768175B1 (en) | 2020-03-04 | 2023-09-26 | 10X Genomics, Inc. | Electrophoretic methods for spatial analysis |
ES2965354T3 (es) | 2020-04-22 | 2024-04-12 | 10X Genomics Inc | Métodos para análisis espacial que usan eliminación de ARN elegido como diana |
EP4153776A1 (de) | 2020-05-22 | 2023-03-29 | 10X Genomics, Inc. | Räumliche analyse zur erkennung von sequenzvarianten |
EP4153775A1 (de) | 2020-05-22 | 2023-03-29 | 10X Genomics, Inc. | Simultane räumlich-zeitliche messung der genexpression und der zellaktivität |
WO2021242834A1 (en) | 2020-05-26 | 2021-12-02 | 10X Genomics, Inc. | Method for resetting an array |
AU2021283174A1 (en) | 2020-06-02 | 2023-01-05 | 10X Genomics, Inc. | Nucleic acid library methods |
EP4158054A1 (de) | 2020-06-02 | 2023-04-05 | 10X Genomics, Inc. | Räumliche transkriptomik für antigenrezeptoren |
WO2021252499A1 (en) | 2020-06-08 | 2021-12-16 | 10X Genomics, Inc. | Methods of determining a surgical margin and methods of use thereof |
WO2021252591A1 (en) | 2020-06-10 | 2021-12-16 | 10X Genomics, Inc. | Methods for determining a location of an analyte in a biological sample |
CN116034166A (zh) | 2020-06-25 | 2023-04-28 | 10X基因组学有限公司 | Dna甲基化的空间分析 |
US11761038B1 (en) | 2020-07-06 | 2023-09-19 | 10X Genomics, Inc. | Methods for identifying a location of an RNA in a biological sample |
US11926822B1 (en) | 2020-09-23 | 2024-03-12 | 10X Genomics, Inc. | Three-dimensional spatial analysis |
US11827935B1 (en) | 2020-11-19 | 2023-11-28 | 10X Genomics, Inc. | Methods for spatial analysis using rolling circle amplification and detection probes |
WO2022140028A1 (en) | 2020-12-21 | 2022-06-30 | 10X Genomics, Inc. | Methods, compositions, and systems for capturing probes and/or barcodes |
EP4301870A1 (de) | 2021-03-18 | 2024-01-10 | 10X Genomics, Inc. | Multiplex-erfassung von gen- und proteinexpression aus einer biologischen probe |
EP4196605A1 (de) | 2021-09-01 | 2023-06-21 | 10X Genomics, Inc. | Verfahren, zusammensetzungen und kits zur blockierung einer erfassungssonde auf einer räumlichen anordnung |
Family Cites Families (64)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2028165A (en) | 1978-08-17 | 1980-03-05 | Pilkington Brothers Ltd | Treatment of flat glass |
NL8102178A (nl) * | 1981-05-02 | 1982-12-01 | Stichting Centraal Lab | Werkwijze voor het aantonen van tegen bepaalde antigenen gerichte antistoffen, alsmede inrichting en reagentia voor het uitvoeren van deze werkwijze. |
SE8801070D0 (sv) | 1988-03-23 | 1988-03-23 | Pharmacia Ab | Method for immobilizing a dna sequence on a solid support |
US4868311A (en) | 1988-04-02 | 1989-09-19 | The Trustees Of Columbia University In The City Of New York | Biotinylated psoralens |
EP0446299A4 (en) * | 1988-11-18 | 1992-05-13 | The Regents Of The University Of California | Method for site-specifically incorporating unnatural amino acids into proteins |
US5744101A (en) | 1989-06-07 | 1998-04-28 | Affymax Technologies N.V. | Photolabile nucleoside protecting groups |
US6346413B1 (en) | 1989-06-07 | 2002-02-12 | Affymetrix, Inc. | Polymer arrays |
US6919211B1 (en) | 1989-06-07 | 2005-07-19 | Affymetrix, Inc. | Polypeptide arrays |
US5143854A (en) * | 1989-06-07 | 1992-09-01 | Affymax Technologies N.V. | Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof |
US5800992A (en) | 1989-06-07 | 1998-09-01 | Fodor; Stephen P.A. | Method of detecting nucleic acids |
US5874564A (en) * | 1990-03-21 | 1999-02-23 | Isis Pharmaceuticals, Inc. | Reagents and methods for modulating gene expression through RNA mimicry |
US5283179A (en) * | 1990-09-10 | 1994-02-01 | Promega Corporation | Luciferase assay method |
US6399296B1 (en) * | 1994-07-20 | 2002-06-04 | The General Hospital Corporation | Interaction trap systems for detecting protein interactions |
US6143557A (en) * | 1995-06-07 | 2000-11-07 | Life Technologies, Inc. | Recombination cloning using engineered recombination sites |
WO1996040724A1 (en) * | 1995-06-07 | 1996-12-19 | Life Technologies, Inc. | Recombinational cloning using engineered recombination sites |
US5691152A (en) | 1995-11-09 | 1997-11-25 | E. R. Squibb & Sons, Inc. | Stable avidin composition |
US5854033A (en) | 1995-11-21 | 1998-12-29 | Yale University | Rolling circle replication reporter systems |
JPH1025299A (ja) | 1996-07-12 | 1998-01-27 | Nec Corp | 整列ペプチド、及びそれを用いたタンパク質の結合・相互作用部位検出方法 |
SE9604108D0 (sv) * | 1996-11-08 | 1996-11-08 | Maans Ehrenberg | A method for the labelling of polypeptides and novel labelled polypeptides |
DE69835143T2 (de) | 1997-01-21 | 2007-06-06 | The General Hospital Corp., Boston | Selektion von proteinen mittels rns-protein fusionen |
CA2338865A1 (en) | 1997-07-29 | 1999-02-11 | James S. Huston | Methods for detecting binding events using multiple binding partners and muliple targets |
US6207370B1 (en) * | 1997-09-02 | 2001-03-27 | Sequenom, Inc. | Diagnostics based on mass spectrometric detection of translated target polypeptides |
CA2302147C (en) | 1997-09-03 | 2008-05-13 | Biovation Limited | Methods for protein screening |
US6511803B1 (en) * | 1997-10-10 | 2003-01-28 | President And Fellows Of Harvard College | Replica amplification of nucleic acid arrays |
US6303323B1 (en) | 1997-10-21 | 2001-10-16 | Cancer Research Campaign Technology Limited | Detection of dysplastic or neoplastic cells using anti-MCM5 antibodies |
US5922617A (en) * | 1997-11-12 | 1999-07-13 | Functional Genetics, Inc. | Rapid screening assay methods and devices |
US6914137B2 (en) | 1997-12-06 | 2005-07-05 | Dna Research Innovations Limited | Isolation of nucleic acids |
JP2002510505A (ja) | 1998-04-03 | 2002-04-09 | フィロス インク. | 位置特定可能な蛋白質アレイ |
US6406921B1 (en) * | 1998-07-14 | 2002-06-18 | Zyomyx, Incorporated | Protein arrays for high-throughput screening |
US6780582B1 (en) | 1998-07-14 | 2004-08-24 | Zyomyx, Inc. | Arrays of protein-capture agents and methods of use thereof |
EP1018408B1 (de) * | 1998-12-28 | 2002-10-02 | Adolf Mohr Maschinenfabrik GmbH & Co. KG | Planschneidmaschine zum Schneiden von gestapeltem, blattförmigem Gut |
US6251601B1 (en) | 1999-02-02 | 2001-06-26 | Vysis, Inc. | Simultaneous measurement of gene expression and genomic abnormalities using nucleic acid microarrays |
US6225061B1 (en) | 1999-03-10 | 2001-05-01 | Sequenom, Inc. | Systems and methods for performing reactions in an unsealed environment |
EP1159615A2 (de) | 1999-03-10 | 2001-12-05 | National Institutes of Health, as represented by the Secretary, Department of Health and Human Services of the Government | Universales eiweiseinreihungssystem |
GB9917027D0 (en) | 1999-07-20 | 1999-09-22 | Affibody Technology Sweeden Ab | In vitro selection and optional identification of polypeptides using solid support carriers |
GB9928787D0 (en) | 1999-12-03 | 2000-02-02 | Medical Res Council | Direct screening method |
SG121902A1 (en) | 2000-01-11 | 2006-05-26 | Maxygen Inc | Integrated systems for diversity generation and screening |
EP1203238B1 (de) | 2000-01-31 | 2010-08-11 | Sense Proteomic Limited | Verfahren zur herstellung von protein expression arrays und anwendung derselben in schnellem screening |
US7816098B2 (en) | 2000-01-31 | 2010-10-19 | Sense Proteomic Limited | Methods of making and using a protein array |
EP1354037A2 (de) | 2000-04-17 | 2003-10-22 | TransTech Pharma, Inc. | Arrays von systemen zur proteinexpression und deren verwendung bei biologischem nachweis |
EP1283909A4 (de) | 2000-05-04 | 2006-06-07 | Univ Yale | Proteinarrays mit hoher dichte zum screenen von proteinaktivität |
US20020049152A1 (en) | 2000-06-19 | 2002-04-25 | Zyomyx, Inc. | Methods for immobilizing polypeptides |
DE60130211T2 (de) | 2000-06-23 | 2008-05-29 | Domantis Ltd., Brentford | Matrix-screening-verfahren |
US6706474B1 (en) * | 2000-06-27 | 2004-03-16 | Board Of Trustees Of The University Of Illinois | Nucleic acid enzyme biosensors for ions |
WO2002012893A2 (en) | 2000-08-03 | 2002-02-14 | Massachusetts Institute Of Technology | Microarrays of functional biomolecules, and uses therefor |
DE60120713T2 (de) * | 2000-08-15 | 2007-06-06 | Discerna Ltd. | Funktionelles protein array |
AU2001285252A1 (en) | 2000-08-25 | 2002-03-13 | Gendaq, Ltd. | Analysis of binding interactions |
US6420150B1 (en) * | 2000-11-27 | 2002-07-16 | Pe Corporation (Ny) | Isolated human drug-metabolizing proteins, nucleic acid molecules encoding human drug-metabolizing proteins, and uses thereof |
US6911311B2 (en) * | 2001-01-04 | 2005-06-28 | Myriad Genetics, Inc. | Method of detecting protein-protein interactions |
WO2002059601A1 (en) | 2001-01-23 | 2002-08-01 | President And Fellows Of Harvard College | Nucleic-acid programmable protein arrays |
US20020168640A1 (en) | 2001-02-22 | 2002-11-14 | Min Li | Biochips comprising nucleic acid/protein conjugates |
CA2764307C (en) | 2001-06-29 | 2015-03-03 | Meso Scale Technologies, Llc. | Assay plates, reader systems and methods for luminescence test measurements |
US6929944B2 (en) | 2001-08-31 | 2005-08-16 | Beckman Coulter, Inc. | Analysis using a distributed sample |
WO2003031591A2 (en) | 2001-10-10 | 2003-04-17 | Superarray Bioscience Corporation | Detecting targets by unique identifier nucleotide tags |
US20060234229A1 (en) | 2002-06-03 | 2006-10-19 | Van Beuningen Marinus G J | Novel method for monitoring biomolecular interactions |
WO2004011031A1 (en) | 2002-07-29 | 2004-02-05 | Potomac, Pharma, Llc. | Antipsychotic combination therapies and compositions of an alpha-2 adrenergic receptor antagonist and an atypical antipsychotic neuroleptic |
EP1578428A4 (de) | 2002-10-18 | 2008-11-26 | Massachusetts Mental Health In | Behandlung von alkohol- oderdrogenmissbrauch durch antagonisierung von alpha-a2 drenergen rezeptoren mitschwacher dopamin-blockierung |
US20040076961A1 (en) | 2002-10-21 | 2004-04-22 | Lewis Mark A. | Biomolecule retaining material and methods for attaching biomolecules to a surface |
US7276283B2 (en) | 2004-03-24 | 2007-10-02 | Wisconsin Alumni Research Foundation | Plasma-enhanced functionalization of carbon-containing substrates |
US20050260653A1 (en) | 2004-04-14 | 2005-11-24 | Joshua Labaer | Nucleic-acid programmable protein arrays |
US20060099704A1 (en) | 2004-07-14 | 2006-05-11 | Predki Paul F | Method for providing protein microarrays |
US20060207467A1 (en) * | 2005-03-19 | 2006-09-21 | Bailey Samuel W | Low voltage pyrotechnic igniter assembly |
GB0511717D0 (en) | 2005-06-09 | 2005-07-13 | Babraham Inst | Repeatable protein arrays |
US8178316B2 (en) | 2006-06-29 | 2012-05-15 | President And Fellows Of Harvard College | Evaluating proteins |
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2002
- 2002-01-22 WO PCT/US2002/001882 patent/WO2002059601A1/en active Search and Examination
- 2002-01-22 AT AT02707542T patent/ATE538380T1/de active
- 2002-01-22 US US10/055,432 patent/US6800453B2/en not_active Expired - Lifetime
- 2002-01-22 CA CA2434139A patent/CA2434139C/en not_active Expired - Fee Related
- 2002-01-22 JP JP2002559667A patent/JP4880188B2/ja not_active Expired - Lifetime
- 2002-01-22 EP EP02707542A patent/EP1360490B1/de not_active Expired - Lifetime
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2004
- 2004-08-03 US US10/910,718 patent/US8609344B2/en not_active Expired - Lifetime
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2009
- 2009-01-05 JP JP2009000176A patent/JP2009150897A/ja active Pending
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2010
- 2010-01-15 JP JP2010006896A patent/JP2010119392A/ja not_active Withdrawn
Also Published As
Publication number | Publication date |
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JP2010119392A (ja) | 2010-06-03 |
CA2434139A1 (en) | 2002-08-01 |
WO2002059601A1 (en) | 2002-08-01 |
JP4880188B2 (ja) | 2012-02-22 |
JP2009150897A (ja) | 2009-07-09 |
EP1360490A1 (de) | 2003-11-12 |
US8609344B2 (en) | 2013-12-17 |
CA2434139C (en) | 2014-05-27 |
EP1360490B1 (de) | 2011-12-21 |
US20050048580A1 (en) | 2005-03-03 |
EP1360490A4 (de) | 2007-11-28 |
US20020192673A1 (en) | 2002-12-19 |
US6800453B2 (en) | 2004-10-05 |
JP2004536565A (ja) | 2004-12-09 |
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