ATE466022T1 - Optimierte expression von hpv-52-l1 in hefe - Google Patents

Optimierte expression von hpv-52-l1 in hefe

Info

Publication number: ATE466022T1
Authority: AT; Austria
Prior art keywords: hpv; yeast; optimized expression; optimized; expression
Prior art date: 2004-03-24

Application number

AT05725933T

Other languages

English (en)

Inventor

Janine Bryan

Michelle Brownlow

Loren Schultz

Kathrin Jansen

Original Assignee

Merck Sharp & Dohme

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2004-03-24

Filing date

2005-03-18

Publication date

2010-05-15

2005-03-18 Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme

2010-05-15 Application granted granted Critical

2010-05-15 Publication of ATE466022T1 publication Critical patent/ATE466022T1/de

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
- C07K14/01—DNA viruses
- C07K14/025—Papovaviridae, e.g. papillomavirus, polyomavirus, SV40, BK virus, JC virus
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
- C12N7/04—Inactivation or attenuation; Producing viral sub-units
- C12N7/045—Pseudoviral particles; Non infectious pseudovirions, e.g. genetically engineered
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5258—Virus-like particles
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/20011—Papillomaviridae
- C12N2710/20022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/20011—Papillomaviridae
- C12N2710/20023—Virus like particles [VLP]

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Virology (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Engineering & Computer Science (AREA)
Biochemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Wood Science & Technology (AREA)
Molecular Biology (AREA)
Zoology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Biophysics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Immunology (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Gastroenterology & Hepatology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Biotechnology (AREA)
General Chemical & Material Sciences (AREA)
Microbiology (AREA)
Biomedical Technology (AREA)
General Engineering & Computer Science (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Epidemiology (AREA)
Mycology (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Peptides Or Proteins (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

AT05725933T 2004-03-24 2005-03-18 Optimierte expression von hpv-52-l1 in hefe ATE466022T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US55592604P	2004-03-24	2004-03-24
PCT/US2005/009199 WO2005097821A1 (en)	2004-03-24	2005-03-18	Optimized expression of hpv 52 l1 in yeast

Publications (1)

Publication Number	Publication Date
ATE466022T1 true ATE466022T1 (de)	2010-05-15

Family

ID=34964085

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT05725933T ATE466022T1 (de)	2004-03-24	2005-03-18	Optimierte expression von hpv-52-l1 in hefe

Country Status (30)

Country	Link
US (2)	US7700103B2 (de)
EP (1)	EP1730175B1 (de)
JP (1)	JP4833962B2 (de)
KR (1)	KR101203403B1 (de)
CN (1)	CN1934131B (de)
AR (1)	AR048191A1 (de)
AT (1)	ATE466022T1 (de)
AU (1)	AU2005230907C1 (de)
BR (1)	BRPI0509079B8 (de)
CA (1)	CA2560487C (de)
CY (2)	CY1110349T1 (de)
DE (1)	DE602005020913D1 (de)
DK (1)	DK1730175T3 (de)
ES (1)	ES2343255T3 (de)
FR (1)	FR15C0085I2 (de)
HU (1)	HUS1500062I1 (de)
IL (1)	IL178140A (de)
LT (2)	LTC1730175I2 (de)
LU (1)	LU92903I2 (de)
MY (1)	MY148656A (de)
NL (1)	NL300777I1 (de)
NO (2)	NO338055B1 (de)
NZ (1)	NZ549898A (de)
PL (1)	PL1730175T3 (de)
PT (1)	PT1730175E (de)
RU (1)	RU2373219C2 (de)
SI (1)	SI1730175T1 (de)
TW (1)	TWI349036B (de)
WO (1)	WO2005097821A1 (de)
ZA (1)	ZA200607575B (de)

Families Citing this family (25)

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US7858098B2 (en) *	2002-12-20	2010-12-28	Glaxosmithkline Biologicals, S.A.	Vaccine
CN1869215B (zh) *	2006-05-19	2012-07-04	长春百克生物科技股份公司	一种制备人***瘤病毒的病毒样颗粒的方法
EP2129394B1 (de)	2007-03-09	2012-06-20	Merck Sharp & Dohme Corp.	Impfstoffzusammensetzung gegen papillomavirus
CN101440371B (zh) *	2007-11-23	2012-09-05	上海泽润生物科技有限公司	一种16型人***状瘤病毒主要衣壳蛋白l1基因
EP2223933B1 (de) *	2007-11-23	2016-01-27	Shanghai Zerun Biotechnology Co., Ltd.	Für hauptkapsidprotein l1 humaner papillomaviren kodierende gene
MX340739B (es) *	2010-05-14	2016-07-22	Brookhaven Science Ass Llc	Quimeras ospa y su uso en vacunas.
EP2576840B1 (de)	2010-05-25	2018-10-17	QIAGEN Gaithersburg, Inc.	Hybrid-capture-assay mit schneller ergebnislieferung und zugehörige strategisch gekürzte sonden
IN2013CN00536A (de)	2010-07-02	2015-07-03	Univ Xiamen
US8361720B2 (en)	2010-11-15	2013-01-29	Exact Sciences Corporation	Real time cleavage assay
US9018451B2 (en)	2010-12-03	2015-04-28	M S Technologies, LLC	Optimized expression of glyphosate resistance encoding nucleic acid molecules in plant cells
CN102154325B (zh) *	2011-01-01	2013-08-21	上海生物制品研究所有限责任公司	针对人***瘤状病毒的疫苗及其制法和用途
RU2445357C1 (ru) *	2011-02-15	2012-03-20	Закрытое акционерное общество научно-производственная компания "Комбиотех"	Рекомбинантный штамм дрожжей pichia angusta - продуцент капсидного белка l1 вируса папилломы человека типа 16
RU2445358C1 (ru) *	2011-02-15	2012-03-20	Закрытое акционерное общество научно-производственная компания "Комбиотех"	Рекомбинантный штамм дрожжей pichia angusta - продуцент капсидного белка l1 вируса папилломы человека типа 18
CN110484554B (zh) *	2013-04-26	2024-04-16	北京安百胜生物科技有限公司	用汉逊酵母表达***产生hpv52 l1蛋白的方法
CN104164374B (zh) *	2013-05-17	2019-10-22	北京安百胜生物科技有限公司	用汉逊酵母表达***产生hpv31 l1蛋白的方法
EP3057612B1 (de)	2013-10-16	2020-05-06	Merck Sharp & Dohme Corp.	Verfahren zur herstellung von wärmestabilen getrockneten impfstoffformulierungen
CN104878022A (zh) *	2015-04-27	2015-09-02	段青姣	编码hpv58l1、hpv52l1蛋白的核苷酸序列及其应用
CN106701796B (zh) *	2015-08-12	2021-11-16	北京康乐卫士生物技术股份有限公司	52型重组人***瘤病毒病毒样颗粒及其制备方法
CN109750049B (zh) *	2017-11-07	2023-08-18	上海泽润生物科技有限公司	重组人***瘤病毒52亚型蛋白表达
BR112022015313A2 (pt)	2020-02-14	2022-09-27	Merck Sharp & Dohme Llc	Vacina de hpv
CN114539365B (zh) *	2020-11-26	2023-12-01	中国医学科学院基础医学研究所	一种改造的人***瘤病毒52型l1蛋白及其用途
CN113073105B (zh) *	2021-03-23	2023-06-13	重庆博唯佰泰生物制药有限公司	一种表达hpv 56l1的多核苷酸序列及其表达载体、宿主细胞和应用
CN113549634B (zh) *	2021-06-07	2023-03-31	郑州大学	编码可溶性hpv58 l1蛋白的基因及其重组质粒的构建与应用
TW202313658A (zh)	2021-08-06	2023-04-01	美商默沙東有限責任公司	Hpv疫苗
TW202315602A (zh)	2021-08-19	2023-04-16	美商默沙東有限責任公司	新穎熱穩定脂質奈米粒子及其使用方法

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CA1339729C (en) *	1988-10-26	1998-03-17	Wayne D. Lancaster	Human papillomavirus type 52 dna sequences and methods for employing thesame
US5821087A (en) *	1995-03-30	1998-10-13	Merck & Co., Inc.	Production of recombinant human papillomavirus type II protein utilizing papillomavirus 6/11 hybrid DNA
IL117591A0 (en) *	1995-03-30	1996-07-23	Merck & Co Inc	Synthetic DNA encoding human papillomavirus type 11 L1 protein
DE69836206T2 (de)	1997-02-07	2007-08-23	Merck & Co., Inc.	Synthetische hiv gag gene
EP1002091B1 (de)	1997-07-09	2012-02-29	Coridon Pty Limited	Nukleinsäuresequenz und verfahren zur selektiven expression eines proteins in einer zielzelle oder -gewebe
ES2262333T3 (es) *	1998-08-14	2006-11-16	MERCK & CO., INC.	Procedimiento para purificar particulas similares a virus de papilomavirus humano.
EP1105157B1 (de)	1998-08-14	2006-11-02	Merck & Co., Inc.	Protein-verabreichungssystem, das dem menschlichen papillomavirus ähnliche partikel benützt.
SE514982C2 (sv) *	1999-09-30	2001-05-28	Active Biotech Ab	Bärare innehållande ett huvudkapsidprotein L1 från humant papillomavirus samt dess användning
DE60016765T2 (de) *	1999-08-25	2005-11-24	Merck & Co., Inc.	Synthetische papillomavirus gene, welche für expression in menschlichen zellen optimiert sind
US6436402B1 (en)	1999-10-15	2002-08-20	Merck & Co., Inc.	Process for making human papillomavirus virus-like particles with improved properties
BR0112637A (pt)	2000-07-21	2003-06-10	Glaxo Group Ltd	Sequências do vìrus do papiloma códon-otimizadas
US20030226155A1 (en) *	2001-08-30	2003-12-04	Biorexis Pharmaceutical Corporation	Modified transferrin-antibody fusion proteins
EP1608767B1 (de)	2003-03-24	2012-02-22	Merck Sharp & Dohme Corp.	Optimierte expression von hpv 31 l1 in hefe
MY140664A (en) *	2003-09-29	2010-01-15	Merck Sharp & Dohme	Optimized expression of hpv 45 l1 in yeast
MY139500A (en) *	2003-11-12	2009-10-30	Merck Sharp & Dohme	Optimized expression of hpv 58 l1 in yeast

2005
- 2005-03-18 AT AT05725933T patent/ATE466022T1/de active
- 2005-03-18 SI SI200531052T patent/SI1730175T1/sl unknown
- 2005-03-18 DK DK05725933.5T patent/DK1730175T3/da active
- 2005-03-18 PT PT05725933T patent/PT1730175E/pt unknown
- 2005-03-18 NZ NZ549898A patent/NZ549898A/en unknown
- 2005-03-18 EP EP05725933A patent/EP1730175B1/de active Active
- 2005-03-18 TW TW094108431A patent/TWI349036B/zh active
- 2005-03-18 JP JP2007505032A patent/JP4833962B2/ja active Active
- 2005-03-18 MY MYPI20051180A patent/MY148656A/en unknown
- 2005-03-18 DE DE602005020913T patent/DE602005020913D1/de active Active
- 2005-03-18 AU AU2005230907A patent/AU2005230907C1/en active Active
- 2005-03-18 CN CN2005800095956A patent/CN1934131B/zh active Active
- 2005-03-18 ES ES05725933T patent/ES2343255T3/es active Active
- 2005-03-18 KR KR1020067019673A patent/KR101203403B1/ko active IP Right Grant
- 2005-03-18 WO PCT/US2005/009199 patent/WO2005097821A1/en active Application Filing
- 2005-03-18 PL PL05725933T patent/PL1730175T3/pl unknown
- 2005-03-18 BR BRPI0509079A patent/BRPI0509079B8/pt active IP Right Grant
- 2005-03-18 CA CA2560487A patent/CA2560487C/en active Active
- 2005-03-18 US US10/594,064 patent/US7700103B2/en active Active
- 2005-03-18 RU RU2006137363/13A patent/RU2373219C2/ru active
- 2005-03-23 AR ARP050101174A patent/AR048191A1/es active IP Right Grant
2006
- 2006-09-11 ZA ZA200607575A patent/ZA200607575B/xx unknown
- 2006-09-17 IL IL178140A patent/IL178140A/en active IP Right Grant
- 2006-10-23 NO NO20064815A patent/NO338055B1/no active Protection Beyond IP Right Term
2009
- 2009-10-14 US US12/578,995 patent/US7744892B2/en active Active
2010
- 2010-07-26 CY CY20101100698T patent/CY1110349T1/el unknown
2015
- 2015-11-30 NL NL300777C patent/NL300777I1/nl unknown
- 2015-12-02 HU HUS1500062C patent/HUS1500062I1/hu unknown
- 2015-12-04 FR FR15C0085C patent/FR15C0085I2/fr active Active
- 2015-12-07 CY CY2015052C patent/CY2015052I2/el unknown
- 2015-12-08 LT LTPA2015050C patent/LTC1730175I2/lt unknown
- 2015-12-08 LT LTPA2015050D patent/LTPA2015050I1/lt unknown
- 2015-12-08 LU LU92903C patent/LU92903I2/xx unknown
2017
- 2017-01-20 NO NO2017005C patent/NO2017005I1/no unknown

Also Published As

Publication number	Publication date
NL300777I2 (de)	2015-12-29
BRPI0509079B1 (pt)	2020-05-19
NO338055B1 (no)	2016-07-25
AU2005230907C1 (en)	2016-07-28
RU2006137363A (ru)	2008-04-27
AU2005230907A1 (en)	2005-10-20
MY148656A (en)	2013-05-15
ZA200607575B (en)	2008-08-27
DE602005020913D1 (de)	2010-06-10
US7744892B2 (en)	2010-06-29
AR048191A1 (es)	2006-04-05
BRPI0509079A (pt)	2007-08-21
ES2343255T3 (es)	2010-07-27
JP2007530040A (ja)	2007-11-01
NO20064815L (no)	2006-10-23
NL300777I1 (de)	2015-12-29
FR15C0085I2 (fr)	2016-11-25
CN1934131B (zh)	2010-12-29
TWI349036B (en)	2011-09-21
IL178140A (en)	2010-11-30
WO2005097821A1 (en)	2005-10-20
NO2017005I1 (no)	2017-01-20
LU92903I2 (fr)	2016-03-08
CA2560487C (en)	2013-01-29
CY2015052I1 (el)	2016-06-22
LTPA2015050I1 (lt)	2016-01-11
KR20060134120A (ko)	2006-12-27
HUS1500062I1 (hu)	2017-07-28
LTC1730175I2 (lt)	2017-05-10
PL1730175T3 (pl)	2010-09-30
NZ549898A (en)	2009-06-26
EP1730175A1 (de)	2006-12-13
IL178140A0 (en)	2006-12-31
DK1730175T3 (da)	2010-08-23
CA2560487A1 (en)	2005-10-20
CY1110349T1 (el)	2015-04-29
PT1730175E (pt)	2010-06-25
SI1730175T1 (sl)	2010-08-31
FR15C0085I1 (de)	2016-08-01
JP4833962B2 (ja)	2011-12-07
TW200602490A (en)	2006-01-16
CN1934131A (zh)	2007-03-21
KR101203403B1 (ko)	2012-11-21
BRPI0509079B8 (pt)	2021-07-06
US7700103B2 (en)	2010-04-20
EP1730175B1 (de)	2010-04-28
AU2005230907B2 (en)	2011-05-19
RU2373219C2 (ru)	2009-11-20
US20100035818A1 (en)	2010-02-11
US20080226660A1 (en)	2008-09-18
CY2015052I2 (el)	2016-06-22

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2010-11-15

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Publication	Publication Date	Title
ATE466022T1 (de)	2010-05-15	Optimierte expression von hpv-52-l1 in hefe
ATE452977T1 (de)	2010-01-15	Optimierte expression von hpv-58-l1 in hefe
LTPA2015049I1 (lt)	2016-01-11	Žpv 45 l1 optimizuota ekspresija mielėse
ATE423121T1 (de)	2009-03-15	Diphenylimidazopyrimidin- und -imidazolamine als b-sekretase-inhibitoren
DK2341147T3 (da)	2019-11-11	Præprimitive stribe- og mesendodermceller
DK1738044T3 (da)	2009-03-23	Nöglekombinationseelement i nögleråemne og nögle
DE602004032418D1 (de)	2011-06-09	Oberflächenmodifikation von Kieselsäure in wässriger Umgebung
NO20051704D0 (no)	2005-04-06	Virvler
DE602006005389D1 (de)	2009-04-09	Enzymatische produktion von persäuren unter verwen
ITPI20040084A1 (it)	2005-02-18	Interfaccia aptica portabile
FI20041220A0 (fi)	2004-09-21	Uusi lakkaasientsyymi ja sen käyttö
FR2865955B1 (fr)	2006-12-22	Etabli-treteau-polyvalent et pliable
DE602005016808D1 (de)	2009-11-05	Enzymatische brennstoffzelle
FI20045005A0 (fi)	2004-01-15	Palamisen tehostaminen tulisijoissa
DK1615776T3 (da)	2012-11-19	Forbedringer med hensyn til foldbare publikationer
SE0402053D0 (sv)	2004-08-20	Sol- och insynsarrangemang
FI6319U1 (fi)	2004-06-30	Sovitelma rakennuksen nurkkarakenteessa
FI20041097A (fi)	2006-02-20	Uusi geeni ja sen käyttö
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