MX340739B - Quimeras ospa y su uso en vacunas. - Google Patents
Quimeras ospa y su uso en vacunas.Info
- Publication number
- MX340739B MX340739B MX2012013264A MX2012013264A MX340739B MX 340739 B MX340739 B MX 340739B MX 2012013264 A MX2012013264 A MX 2012013264A MX 2012013264 A MX2012013264 A MX 2012013264A MX 340739 B MX340739 B MX 340739B
- Authority
- MX
- Mexico
- Prior art keywords
- ospa
- vaccines
- chimeric
- molecules
- serotype
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/0225—Spirochetes, e.g. Treponema, Leptospira, Borrelia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/14—Ectoparasiticides, e.g. scabicides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/20—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Spirochaetales (O), e.g. Treponema, Leptospira
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
- A61K2039/575—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 humoral response
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6018—Lipids, e.g. in lipopeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/70—Multivalent vaccine
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Virology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
La presente invención se refiere al desarrollo de moléculas quiméricas OspA para su usarse contra la enfermedad de Lyme o vacuna contra borreliosis. Más específicamente, las moléculas quiméricas OspA comprenden la porción próxima de un serotipo de OspA, junto con la porción distal de otro serotipo de OspA, mientras que conserva las propiedades antigénicas de ambos de los polipéptidos parentales. Las moléculas quiméricas OspA se suministran solas o en combinación para proporcionar una protección contra una variedad de genoespecies de Borrelia.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US33490110P | 2010-05-14 | 2010-05-14 | |
PCT/US2011/036533 WO2011143623A1 (en) | 2010-05-14 | 2011-05-13 | Ospa chimeras and use thereof in vaccines |
Publications (2)
Publication Number | Publication Date |
---|---|
MX2012013264A MX2012013264A (es) | 2014-12-05 |
MX340739B true MX340739B (es) | 2016-07-22 |
Family
ID=44121257
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2012013264A MX340739B (es) | 2010-05-14 | 2011-05-13 | Quimeras ospa y su uso en vacunas. |
MX2012013261A MX348113B (es) | 2010-05-14 | 2011-05-13 | Genes ospa quimericos, proteinas, y metodos para usar los mismos. |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2012013261A MX348113B (es) | 2010-05-14 | 2011-05-13 | Genes ospa quimericos, proteinas, y metodos para usar los mismos. |
Country Status (13)
Country | Link |
---|---|
US (6) | US8623375B2 (es) |
EP (4) | EP3650041A1 (es) |
JP (6) | JP6030052B2 (es) |
KR (7) | KR102222869B1 (es) |
CN (3) | CN103118701B (es) |
AU (2) | AU2011252850B2 (es) |
BR (2) | BR112012027315B1 (es) |
CA (2) | CA2799181C (es) |
MX (2) | MX340739B (es) |
PL (2) | PL2569008T3 (es) |
RU (2) | RU2583289C2 (es) |
SI (2) | SI2569008T1 (es) |
WO (2) | WO2011143623A1 (es) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MX340739B (es) | 2010-05-14 | 2016-07-22 | Brookhaven Science Ass Llc | Quimeras ospa y su uso en vacunas. |
US20120124496A1 (en) | 2010-10-20 | 2012-05-17 | Mark Rose | Geographic volume analytics apparatuses, methods and systems |
US10438176B2 (en) | 2011-07-17 | 2019-10-08 | Visa International Service Association | Multiple merchant payment processor platform apparatuses, methods and systems |
US10318941B2 (en) | 2011-12-13 | 2019-06-11 | Visa International Service Association | Payment platform interface widget generation apparatuses, methods and systems |
WO2013090611A2 (en) * | 2011-12-13 | 2013-06-20 | Visa International Service Association | Dynamic widget generator apparatuses, methods and systems |
US8986704B2 (en) | 2012-07-06 | 2015-03-24 | Valneva Austria Gmbh | Mutant fragments of OspA and methods and uses relating thereto |
CN104640563A (zh) * | 2012-07-27 | 2015-05-20 | 巴克斯特国际公司 | 包含嵌合的ospa分子的组合物及其使用方法 |
PL223175B1 (pl) | 2012-10-22 | 2016-10-31 | Inst Chemii Bioorganicznej Polskiej Akademii Nauk | Szczepionka przeciw boreliozie, konstrukt genetyczny, rekombinowane białko, sposób otrzymywania konstruktu genetycznego, sposób otrzymywania szczepionki, sposób otrzymywania rekombinowanych białek, zastosowanie rekombinowanych białek do wytwarzania szczepionki przeciwko boreliozie |
US20160213766A1 (en) * | 2013-09-23 | 2016-07-28 | Ventria Bioscience, Inc. | OspA Fusion Protein for Vaccination against Lyme Disease |
AU2015205520B2 (en) | 2014-01-09 | 2017-06-29 | Valneva Austria Gmbh | Mutant fragments of OspA and methods and uses relating thereto |
CZ2014320A3 (cs) * | 2014-05-09 | 2015-11-18 | VÝZKUMNÝ ÚSTAV VETERINÁRNÍHO LÉKAŘSTVÍ, v.v.i. | Polyepitopový antigen, vakcinační konstrukt a vakcína pro prevenci lymeské boreliózy |
CA2958018A1 (en) | 2014-08-11 | 2016-02-18 | University Of Massachusetts | Anti-ospa antibodies and methods of use |
US11216468B2 (en) | 2015-02-08 | 2022-01-04 | Visa International Service Association | Converged merchant processing apparatuses, methods and systems |
KR102106547B1 (ko) * | 2015-08-14 | 2020-05-06 | 텔레호낙티에볼라게트 엘엠 에릭슨(피유비엘) | 패킷 데이터 네트워크 연결을 관리하기 위한 노드 및 방법 |
CN110167584B (zh) * | 2016-11-07 | 2024-06-07 | 威斯塔解剖学和生物学研究所 | 用于针对莱姆病的dna抗体构建体 |
EP3609911B1 (en) * | 2017-04-13 | 2023-07-05 | Valneva Austria GmbH | Multivalent ospa polypeptides and methods and uses relating thereto |
JP2021519598A (ja) | 2018-04-03 | 2021-08-12 | サノフイSanofi | 抗原性エプスタインバーウイルスポリペプチド |
EP3773698A1 (en) | 2018-04-03 | 2021-02-17 | Sanofi | Ferritin proteins |
JP2021519599A (ja) * | 2018-04-03 | 2021-08-12 | サノフイSanofi | 抗原性ospaポリペプチド |
CN110483624B (zh) * | 2019-08-22 | 2021-02-09 | 中国疾病预防控制中心传染病预防控制所 | 伽氏疏螺旋体OspA蛋白C端肽段及其应用 |
CN111196842A (zh) * | 2020-01-09 | 2020-05-26 | 济南大学 | 一种外膜转运通道蛋白的非跨膜结构域的表达纯化方法 |
CA3174599A1 (en) | 2020-04-09 | 2021-10-14 | Robert Schlegl | Improvements in vaccine formulations for medical use |
WO2022261050A1 (en) * | 2021-06-07 | 2022-12-15 | The University Of Massachusetts | Apparatus and method for continuous production of rna |
WO2023170680A1 (en) | 2022-03-08 | 2023-09-14 | Equashield Medical Ltd | Fluid transfer station in a robotic pharmaceutical preparation system |
Family Cites Families (51)
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DK590288D0 (da) | 1988-10-24 | 1988-10-24 | Symbicom Ab | Kemiske forbindelser |
US4179337A (en) | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
US4376110A (en) | 1980-08-04 | 1983-03-08 | Hybritech, Incorporated | Immunometric assays using monoclonal antibodies |
SE8205892D0 (sv) | 1982-10-18 | 1982-10-18 | Bror Morein | Immunogent membranproteinkomplex, sett for framstellning och anvendning derav som immunstimulerande medel och sasom vaccin |
US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
DE3572982D1 (en) | 1984-03-06 | 1989-10-19 | Takeda Chemical Industries Ltd | Chemically modified lymphokine and production thereof |
SE8405493D0 (sv) | 1984-11-01 | 1984-11-01 | Bror Morein | Immunogent komplex samt sett for framstellning derav och anvendning derav som immunstimulerande medel |
US4877612A (en) | 1985-05-20 | 1989-10-31 | Frank M. Berger | Immunological adjuvant and process for preparing the same, pharmaceutical compositions, and process |
DE3521994A1 (de) | 1985-06-20 | 1987-01-02 | Bayer Ag | N-(2-aminoacylamido-2-desoxy-hexosyl)-amide-, -carbamate und -harnstoffe, verfahren zu ihrer herstellung sowie ihre verwendung in arzneimitteln |
EP0231039B1 (en) | 1986-01-14 | 1992-01-08 | De Staat Der Nederlanden Vertegenwoordigd Door De Minister Van Welzijn, Volksgezondheid En Cultuur | Process for preparing immunological complexes and pharmaceutical composition containing these complexes |
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US6143872A (en) * | 1988-10-24 | 2000-11-07 | Symbicom Aktiebolag | Borrelia burdorferi Osp A and B proteins and immunogenic peptides |
US7094391B1 (en) | 1988-10-24 | 2006-08-22 | The University Of Texas System | Compositions and methods for administering Borrelia burgdorferi antigens |
CA2006596C (en) | 1988-12-22 | 2000-09-05 | Rika Ishikawa | Chemically-modified g-csf |
US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
CA2084413A1 (en) * | 1990-06-15 | 1991-12-16 | Richard A. Flavell | Compositions and methods for the prevention and diagnosis of lyme disease |
US5252714A (en) | 1990-11-28 | 1993-10-12 | The University Of Alabama In Huntsville | Preparation and use of polyethylene glycol propionaldehyde |
WO1992014488A1 (en) | 1991-02-15 | 1992-09-03 | Uab Research Foundation | Structural gene of pneumococcal protein |
US6676942B1 (en) | 1991-08-15 | 2004-01-13 | Smithkline Beecham Biologicals (S.A.) | Osp a proteins of Borrelia burgdorferi subgroups, encoding genes and vaccines |
EP0874051A3 (en) * | 1991-08-15 | 1998-11-04 | SMITHKLINE BEECHAM BIOLOGICALS s.a. | OSP a protein of borrelia burgdorferi subgroups, encoding genes and vaccines. |
US5234784A (en) | 1992-04-01 | 1993-08-10 | Eastman Kodak Company | Method of making a projection viewable transparency comprising an electrostatographic toner image |
WO1995012676A1 (en) * | 1993-11-01 | 1995-05-11 | Associated Universities, Inc. | Chimeric proteins comprising borrelia polypeptides: uses therefor |
US7008625B2 (en) | 1993-11-01 | 2006-03-07 | Research Foundation Of The State University Of New York | Recombinant constructs of Borrelia burgdorferi |
US6248562B1 (en) | 1993-11-01 | 2001-06-19 | Research Foundation State University Of New York | Chimeric proteins comprising borrelia polypeptides and uses therefor |
DE69716240T2 (de) | 1996-02-12 | 2003-06-26 | Ml Lab Plc London | Neue methode zur impfung sowie impfstoffe dafür, die eine epitopkodierende nukleinsäure und ein epitopenthaltende peptid beinhalten |
US6368603B1 (en) * | 1997-03-05 | 2002-04-09 | Merial Limited | Lyme combination compositions and uses |
AU8177298A (en) | 1997-06-30 | 1999-01-19 | The Administrators Of The Tulane Eductional Fund | Surface antigens and proteins useful in compositions for the diagnosis and prevention of lyme disease |
US6342220B1 (en) | 1997-08-25 | 2002-01-29 | Genentech, Inc. | Agonist antibodies |
GB9726555D0 (en) | 1997-12-16 | 1998-02-11 | Smithkline Beecham Plc | Vaccine |
US6541011B2 (en) * | 1998-02-11 | 2003-04-01 | Maxygen, Inc. | Antigen library immunization |
GB9811219D0 (en) | 1998-05-26 | 1998-07-22 | Smithkline Beecham Biolog | Novel process |
EP1939294A1 (en) | 2000-08-18 | 2008-07-02 | Research Foundation Of State University Of New York | Recombinant constructs of borrelia burgdorferi |
WO2002016421A2 (en) * | 2000-08-18 | 2002-02-28 | Research Foundation Of The State University Of New York | Altered ospa of borrelia burgdorferi |
PT1311682E (pt) * | 2000-08-18 | 2008-03-11 | Brookhaven Sciences Ass Llc | Construcões recombinantes de borrelia burgdorferi |
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CA2522751A1 (en) * | 2003-04-16 | 2004-11-04 | Wyeth Holdings Corporation | Novel immunogenic compositions for the prevention and treatment of meningococcal disease |
ATE466022T1 (de) * | 2004-03-24 | 2010-05-15 | Merck Sharp & Dohme | Optimierte expression von hpv-52-l1 in hefe |
EP1768688A4 (en) * | 2004-07-02 | 2009-09-30 | Raymond J Dattwyler | ORAL BORRELIOSE VACCINE |
GB0417494D0 (en) | 2004-08-05 | 2004-09-08 | Glaxosmithkline Biolog Sa | Vaccine |
WO2007065098A2 (en) | 2005-11-29 | 2007-06-07 | Virginia Commonwealth University | Polyvalent chimeric ospc vaccinogen and diagnostic antigen |
RU2008126239A (ru) * | 2005-11-29 | 2010-01-10 | Вирджиния Коммонвелт Юниверсити (Us) | Поливалентный химерный вакциноген и диагностический антиген ospc |
EP2287176A1 (en) | 2006-09-15 | 2011-02-23 | Intercell AG | Borrelia antigens |
ATE496935T1 (de) | 2007-02-22 | 2011-02-15 | Baxter Int | Verfahren zur aufreinigung hydrophober proteine |
AU2008267208B2 (en) * | 2007-06-26 | 2012-01-19 | Glaxosmithkline Biologicals S.A. | Vaccine comprising streptococcus pneumoniae capsular polysaccharide conjugates |
MX2010007461A (es) * | 2008-01-11 | 2010-10-20 | VGX Pharmaceuticals LLC | Nuevas vacunas contra multiples subtipos del virus del dengue. |
WO2009131665A1 (en) | 2008-04-22 | 2009-10-29 | Research Foundation Of State University Of New York | Borrelia burgdorferi cell envelope protein array |
WO2009135118A2 (en) | 2008-05-02 | 2009-11-05 | Virginia Commonwealth University | Lyme disease vaccine |
MX340739B (es) * | 2010-05-14 | 2016-07-22 | Brookhaven Science Ass Llc | Quimeras ospa y su uso en vacunas. |
CN104640563A (zh) * | 2012-07-27 | 2015-05-20 | 巴克斯特国际公司 | 包含嵌合的ospa分子的组合物及其使用方法 |
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2011
- 2011-05-13 MX MX2012013264A patent/MX340739B/es active IP Right Grant
- 2011-05-13 KR KR1020207005820A patent/KR102222869B1/ko active IP Right Grant
- 2011-05-13 RU RU2012153752/10A patent/RU2583289C2/ru active
- 2011-05-13 EP EP19201651.7A patent/EP3650041A1/en not_active Withdrawn
- 2011-05-13 SI SI201131835T patent/SI2569008T1/sl unknown
- 2011-05-13 US US13/107,787 patent/US8623375B2/en active Active
- 2011-05-13 KR KR1020187007814A patent/KR102085465B1/ko active IP Right Grant
- 2011-05-13 CN CN201180033682.0A patent/CN103118701B/zh active Active
- 2011-05-13 EP EP19217974.5A patent/EP3705133B1/en active Active
- 2011-05-13 KR KR1020187019612A patent/KR20180082633A/ko not_active Application Discontinuation
- 2011-05-13 BR BR112012027315-9A patent/BR112012027315B1/pt active IP Right Grant
- 2011-05-13 AU AU2011252850A patent/AU2011252850B2/en active Active
- 2011-05-13 KR KR1020207018904A patent/KR102230562B1/ko active IP Right Grant
- 2011-05-13 CA CA2799181A patent/CA2799181C/en active Active
- 2011-05-13 CN CN201710853809.2A patent/CN107641151B/zh active Active
- 2011-05-13 PL PL11720967T patent/PL2569008T3/pl unknown
- 2011-05-13 KR KR1020197006820A patent/KR102130584B1/ko active IP Right Grant
- 2011-05-13 EP EP11720967.6A patent/EP2569008B1/en active Active
- 2011-05-13 CN CN201180033687.3A patent/CN103108652B/zh active Active
- 2011-05-13 KR KR1020127032560A patent/KR20130133120A/ko active Application Filing
- 2011-05-13 AU AU2011252844A patent/AU2011252844B2/en active Active
- 2011-05-13 JP JP2013510352A patent/JP6030052B2/ja active Active
- 2011-05-13 CA CA2798331A patent/CA2798331C/en active Active
- 2011-05-13 MX MX2012013261A patent/MX348113B/es active IP Right Grant
- 2011-05-13 WO PCT/US2011/036533 patent/WO2011143623A1/en active Application Filing
- 2011-05-13 RU RU2012153972A patent/RU2636455C2/ru active
- 2011-05-13 JP JP2013510354A patent/JP6227407B2/ja active Active
- 2011-05-13 US US13/107,796 patent/US8623376B2/en active Active
- 2011-05-13 SI SI201131829T patent/SI2569009T1/sl unknown
- 2011-05-13 KR KR1020127032561A patent/KR20130062954A/ko not_active Application Discontinuation
- 2011-05-13 PL PL11722243T patent/PL2569009T3/pl unknown
- 2011-05-13 BR BR112012029058-4A patent/BR112012029058B1/pt active IP Right Grant
- 2011-05-13 EP EP11722243.0A patent/EP2569009B1/en active Active
- 2011-05-13 WO PCT/US2011/036525 patent/WO2011143617A1/en active Application Filing
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2013
- 2013-11-12 US US14/078,390 patent/US9303073B2/en active Active
- 2013-11-12 US US14/078,367 patent/US9334311B2/en active Active
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2016
- 2016-02-22 US US15/049,438 patent/US9895434B2/en active Active
- 2016-06-27 JP JP2016126631A patent/JP2016171816A/ja active Pending
- 2016-06-27 JP JP2016126608A patent/JP2016168057A/ja not_active Withdrawn
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2018
- 2018-01-19 US US15/875,479 patent/US11305000B2/en active Active
- 2018-07-09 JP JP2018129896A patent/JP2018150386A/ja not_active Withdrawn
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2020
- 2020-08-11 JP JP2020135857A patent/JP6965417B2/ja active Active
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