ATE403429T1 - Spiropyrazol-verbindungen - Google Patents

Spiropyrazol-verbindungen

Info

Publication number
ATE403429T1
ATE403429T1 AT02739163T AT02739163T ATE403429T1 AT E403429 T1 ATE403429 T1 AT E403429T1 AT 02739163 T AT02739163 T AT 02739163T AT 02739163 T AT02739163 T AT 02739163T AT E403429 T1 ATE403429 T1 AT E403429T1
Authority
AT
Austria
Prior art keywords
spiropyrazole
compounds
spiropyrazole compounds
whereinz
compound
Prior art date
Application number
AT02739163T
Other languages
English (en)
Inventor
R Goehring
Donald Kyle
Gary Lee
Parviz Gharagozloo
Sam Victory
Original Assignee
Euro Celtique Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Euro Celtique Sa filed Critical Euro Celtique Sa
Application granted granted Critical
Publication of ATE403429T1 publication Critical patent/ATE403429T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
AT02739163T 2001-04-18 2002-04-18 Spiropyrazol-verbindungen ATE403429T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US28467501P 2001-04-18 2001-04-18

Publications (1)

Publication Number Publication Date
ATE403429T1 true ATE403429T1 (de) 2008-08-15

Family

ID=23091099

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02739163T ATE403429T1 (de) 2001-04-18 2002-04-18 Spiropyrazol-verbindungen

Country Status (28)

Country Link
US (2) US6635653B2 (de)
EP (1) EP1385515B1 (de)
JP (1) JP4342181B2 (de)
KR (1) KR100628292B1 (de)
CN (1) CN1516584A (de)
AT (1) ATE403429T1 (de)
AU (1) AU2002311833B2 (de)
BR (1) BR0209127A (de)
CA (1) CA2444634C (de)
CY (1) CY1108454T1 (de)
CZ (1) CZ20032849A3 (de)
DE (1) DE60228071D1 (de)
DK (1) DK1385515T3 (de)
ES (1) ES2312584T3 (de)
HK (1) HK1062885A1 (de)
HU (1) HUP0401333A3 (de)
IL (2) IL158485A0 (de)
MX (1) MXPA03009604A (de)
NO (1) NO20034660L (de)
NZ (1) NZ528978A (de)
PL (1) PL367263A1 (de)
PT (1) PT1385515E (de)
RU (1) RU2299883C2 (de)
SI (1) SI1385515T1 (de)
UA (1) UA74439C2 (de)
WO (1) WO2002085355A1 (de)
YU (1) YU82403A (de)
ZA (1) ZA200308103B (de)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2444634C (en) * 2001-04-18 2011-06-07 R. Richard Goehring Spiropyrazole compounds
EP1491212B1 (de) 2002-03-29 2012-08-08 Mitsubishi Tanabe Pharma Corporation Mittel zur behandlung von schlafstörungen
KR20050043935A (ko) 2002-09-09 2005-05-11 얀센 파마슈티카 엔.브이. Ｏｒｌ-1 수용체 매개 장애의 치료에 유용한 하이드록시 알킬 치환된 1,3,8-트리아자스피로[4.5]데칸-4-온 유도체
US20110092704A1 (en) * 2002-10-17 2011-04-21 Parvis Gharagozloo Preparation of triazospiro compounds
US20040242583A1 (en) * 2003-01-20 2004-12-02 Aventis Pharma Deutschland Gmbh Pyrimido[5,4-e][1,2,4]triazine-5,7-diones, processes for preparing them and their use
WO2004103305A2 (en) * 2003-05-16 2004-12-02 Euroceltique S.A. Spiropyrazole compound
WO2005011665A1 (en) * 2003-07-22 2005-02-10 Arakis Ltd. The use of proglumide for the treatment of emesis
US20110008327A1 (en) 2004-03-29 2011-01-13 Cheng Jin Q Compositions including triciribine and epidermal growth factor receptor inhibitor compounds or salts thereof and methods of use thereof
US20100009929A1 (en) 2004-03-29 2010-01-14 Cheng Jin Q Compositions including triciribine and bortezomib and derivatives thereof and methods of use thereof
US20100028339A1 (en) 2004-03-29 2010-02-04 Cheng Jin Q Compositions including triciribine and trastuzumab and methods of use thereof
US20100173864A1 (en) 2004-03-29 2010-07-08 Cheng Jin Q Compositions including triciribine and one or more platinum compounds and methods of use thereof
WO2005094322A2 (en) 2004-03-29 2005-10-13 University Of South Florida Effective treatment of tumors and cancer with triciribine and related compounds
US20100009928A1 (en) 2004-03-29 2010-01-14 Cheng Jin Q Compositions including triciribine and taxanes and methods of use thereof
ATE478075T1 (de) 2005-03-08 2010-09-15 Janssen Pharmaceutica Nv Diazaspiro-ä4,4ü-nonanderivate als neurokinin- (nk1)-antagonisten
CN1870631B (zh) * 2005-11-11 2010-04-14 华为技术有限公司 媒体网关的门控方法
US20080051380A1 (en) 2006-08-25 2008-02-28 Auerbach Alan H Methods and compositions for treating cancer
AU2007325355A1 (en) 2006-11-28 2008-06-05 Janssen Pharmaceutica N.V. Salts of 3-(3-amino-2-(R)-hydroxy-propyl)-1-(4-fluoro-phenyl)-8-(8-methyl-naphthalen-1-ylmethyl) -1,3,8-triaza-spiro[4.5]decan-4-one
ES2353448T3 (es) 2007-01-16 2011-03-02 Purdue Pharma L.P. Piperidinas heterocíclico-sustituidas como ligandos de orl-1.
WO2008124209A1 (en) 2007-04-09 2008-10-16 Janssen Pharmaceutica, N.V. 1,3,8-trisubstituted-1,3,8-triaza-spiro[4.5]decan-4-one derivatives as ligands of the orl-i receptor for the treatment of anxiety and depression
TWI448289B (zh) 2007-08-31 2014-08-11 Purdue Pharma Lp 經取代之喹啉型哌啶化合物及其用途
UA99540C2 (ru) 2008-07-21 2012-08-27 Пердью Фарма Л.П. Замещенные мостиковым хиноксалином пиперидиновые соединения и их применение
UA107943C2 (en) * 2009-11-16 2015-03-10 Lilly Co Eli Compounds of spiropiperidines as antagonists of the orl-1 receptors
AU2011346749A1 (en) 2010-12-22 2013-05-02 Purdue Pharma L.P. Phosphorus-substituted quinoxaline-type piperidine compounds and uses thereof
EP2797912B1 (de) 2011-12-01 2016-05-25 Purdue Pharma L.P. Azetidin-substituierte quinoxalin-typ piperidin-verbindungen und ihre verwendungen
US9085561B2 (en) 2012-07-30 2015-07-21 Purdue Pharma L.P. Cyclic urea- or lactam-substituted quinoxaline-type piperidines as ORL-1 modulators
WO2014102588A2 (en) 2012-12-27 2014-07-03 Purdue Pharma L.P. Indole and indoline-type piperidine compounds and uses thereof
WO2014102592A2 (en) 2012-12-27 2014-07-03 Purdue Pharma L.P. Oxime/substituted quinoxaline-type piperidine compounds and uses thereof
WO2014102590A1 (en) 2012-12-27 2014-07-03 Purdue Pharma L.P. Substituted piperidin-4-amino-type compounds and uses thereof
WO2014102589A1 (en) 2012-12-27 2014-07-03 Purdue Pharma L.P. Quinazolin-4(3h)-one-type piperidine compounds and uses thereof
US9090618B2 (en) 2012-12-27 2015-07-28 Purdue Pharma L.P. Substituted benzimidazole-type piperidine compounds and uses thereof
CN111825681A (zh) * 2020-07-07 2020-10-27 扬州大学 一种合成(e)-亚苄基螺吡唑吡咯嗪酮类化合物的方法

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB157497A (de) *
US3161645A (en) 1962-12-18 1964-12-15 Res Lab Dr C Janssen N V 1-(1-aroylpropyl-4-piperidyl)-2-benzimidazolinones and related compounds
US3318900A (en) 1964-05-06 1967-05-09 Janssen Pharmaceutica Nv Derivatives of benzimidazolinyl piperidine
US3325499A (en) 1964-11-02 1967-06-13 Mcneilab Inc 1-(1-hydrocarbyl-4-piperdyl)-2-indolinone
US3923993A (en) * 1973-06-28 1975-12-02 American Home Prod Process for treating neuroendocrinopathic diseases employing fluspirilene
DE2609645A1 (de) 1976-03-09 1977-09-15 Boehringer Sohn Ingelheim Aminoalkylheterocyclen
US4329353A (en) 1980-10-22 1982-05-11 Janssen Pharmaceutica, N.V. 1-(4-Aryl-cyclohexyl)piperidine derivatives, method of use thereof and pharmaceutical compositions thereof
US4410528A (en) 1980-05-16 1983-10-18 Kyowa Hakko Kogyo Co., Ltd. Hypotensive piperidine derivatives
JPS58180481A (ja) 1982-04-15 1983-10-21 Kyowa Hakko Kogyo Co Ltd 新規なピペリジン誘導体
JPS60120872A (ja) 1983-12-01 1985-06-28 Kyowa Hakko Kogyo Co Ltd 新規なヘテロ環状化合物及び強心剤
CA2187767A1 (en) 1994-04-14 1995-10-26 Joel R. Huff Alpha1c adrenergic receptor antagonists
FR2722190B1 (fr) 1994-07-05 1996-10-04 Sanofi Sa Derives de 1-benzyl-1,3-dihydro-2h-benzimidazol-2-one, leur preparation, les compositions pharmaceutique en contenant
US5767118A (en) 1994-10-26 1998-06-16 Merck & Co., Inc. 4-Heterocyclic peperidines promote release of growth hormone
US5574044A (en) 1994-10-27 1996-11-12 Merck & Co., Inc. Muscarine antagonists
US6150355A (en) 1995-09-13 2000-11-21 Kyowa Hakko Kogyo Co., Ltd. Phenylpiperidine derivative
US6180649B1 (en) 1996-04-19 2001-01-30 Nerosearch A/S 1-(4-piperidyl)-benzimidazoles having neurotrophic activity
US6063796A (en) 1997-04-04 2000-05-16 Merck & Co., Inc. Somatostatin agonists
WO1998054168A1 (fr) 1997-05-30 1998-12-03 Banyu Pharmaceutical Co., Ltd. Derives de 2-0xoimidazole
JPH10330377A (ja) 1997-06-02 1998-12-15 Kyowa Hakko Kogyo Co Ltd ピペリジン誘導体
US6166037A (en) 1997-08-28 2000-12-26 Merck & Co., Inc. Pyrrolidine and piperidine modulators of chemokine receptor activity
SI0921125T1 (en) 1997-12-05 2002-04-30 F. Hoffmann-La Roche Ag 1,3,8-Triazaspiro(4,5)decan-4-on derivatives
US6166209A (en) 1997-12-11 2000-12-26 Hoffmann-La Roche Inc. Piperidine derivatives
AU1679099A (en) 1998-01-19 1999-08-02 Pfizer Inc. 4-(2-keto-1-benzimidazolinyl)piperidine compounds as orl1-receptor agonists
HUP0101275A3 (en) 1998-03-26 2002-12-28 Japan Tobacco Inc Amide derivatives and pharmaceutical compositions containing them as nociceptin antagonists
AU3809999A (en) 1998-05-18 1999-12-06 Novo Nordisk A/S Novel 1,3,8-triazaspiro[4.5]decanones with high affinity for opioid receptor subtypes
ID29137A (id) 1998-07-27 2001-08-02 Schering Corp Ligan-ligan afinitas tinggi untuk reseptor nosiseptin orl-1
US6262066B1 (en) 1998-07-27 2001-07-17 Schering Corporation High affinity ligands for nociceptin receptor ORL-1
MA26659A1 (fr) 1998-08-06 2004-12-20 Pfizer Dérivés de benzimidazole nouveaux, compositions pharmaceutiques les contenant et procédé pour leur préparation.
SE9904652D0 (sv) 1999-12-17 1999-12-17 Astra Pharma Prod Novel Compounds
DE60136546D1 (de) 2000-09-06 2008-12-24 Ortho Mcneil Pharm Inc Methode zum bekämpfen der allergien durch verwendung von substituierten pyrazolen
CA2444634C (en) * 2001-04-18 2011-06-07 R. Richard Goehring Spiropyrazole compounds

Also Published As

Publication number Publication date
NZ528978A (en) 2004-06-25
RU2003133455A (ru) 2005-05-10
HUP0401333A3 (en) 2004-11-29
UA74439C2 (uk) 2005-12-15
HUP0401333A2 (hu) 2004-10-28
MXPA03009604A (es) 2004-04-02
AU2002311833B2 (en) 2005-04-28
ES2312584T3 (es) 2009-03-01
CZ20032849A3 (en) 2004-03-17
US20040087641A1 (en) 2004-05-06
CA2444634C (en) 2011-06-07
PL367263A1 (en) 2005-02-21
KR100628292B1 (ko) 2006-09-27
NO20034660L (no) 2003-12-17
BR0209127A (pt) 2006-03-21
IL158485A (en) 2009-09-01
CY1108454T1 (el) 2014-04-09
DE60228071D1 (de) 2008-09-18
HK1062885A1 (en) 2004-12-03
WO2002085355A1 (en) 2002-10-31
EP1385515B1 (de) 2008-08-06
US6635653B2 (en) 2003-10-21
KR20040008159A (ko) 2004-01-28
EP1385515A4 (de) 2004-06-30
SI1385515T1 (sl) 2008-12-31
CA2444634A1 (en) 2002-10-31
RU2299883C2 (ru) 2007-05-27
YU82403A (sh) 2006-08-17
CN1516584A (zh) 2004-07-28
NO20034660D0 (no) 2003-10-17
EP1385515A1 (de) 2004-02-04
US20030027834A1 (en) 2003-02-06
ZA200308103B (en) 2004-10-18
PT1385515E (pt) 2008-09-15
IL158485A0 (en) 2004-05-12
JP2004531531A (ja) 2004-10-14
JP4342181B2 (ja) 2009-10-14
DK1385515T3 (da) 2008-10-27

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