UA99540C2 - Замещенные мостиковым хиноксалином пиперидиновые соединения и их применение - Google Patents

Замещенные мостиковым хиноксалином пиперидиновые соединения и их применение

Info

Publication number
UA99540C2
UA99540C2 UAA201102051A UAA201102051A UA99540C2 UA 99540 C2 UA99540 C2 UA 99540C2 UA A201102051 A UAA201102051 A UA A201102051A UA A201102051 A UAA201102051 A UA A201102051A UA 99540 C2 UA99540 C2 UA 99540C2
Authority
UA
Ukraine
Prior art keywords
quinoxaline
substituted
type bridged
piperidine compounds
piperidine
Prior art date
Application number
UAA201102051A
Other languages
English (en)
Ukrainian (uk)
Inventor
Джянгчяо Яо
Джон У.Ф. Уайтхед
Наоки ЦУНО
Коуки ФУЧИНО
Original Assignee
Пердью Фарма Л.П.
Шионоги Энд Ко., Лтд.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Пердью Фарма Л.П., Шионоги Энд Ко., Лтд. filed Critical Пердью Фарма Л.П.
Publication of UA99540C2 publication Critical patent/UA99540C2/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10—Laxatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/04—Drugs for disorders of the respiratory system for throat disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/14—Antitussive agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/14—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing 9-azabicyclo [3.3.1] nonane ring systems, e.g. granatane, 2-aza-adamantane; Cyclic acetals thereof

Abstract

Изобретение касается замещенных мостиковым хиноксалином пиперидиновых соединений, композиций, которые содержат эффективное количество замещенного мостиковым хиноксалином пиперидинового соединения, и способов лечения или предотвращения состояния, такого как боль, которые включают назначение животному, которое в этом нуждается, эффективного количества замещенного мостиковым хиноксалином пиперидинового соединения.
UAA201102051A 2008-07-21 2009-07-20 Замещенные мостиковым хиноксалином пиперидиновые соединения и их применение UA99540C2 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US8248208P 2008-07-21 2008-07-21

Publications (1)

Publication Number Publication Date
UA99540C2 true UA99540C2 (ru) 2012-08-27

Family

ID=41077776

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA201102051A UA99540C2 (ru) 2008-07-21 2009-07-20 Замещенные мостиковым хиноксалином пиперидиновые соединения и их применение

Country Status (32)

Country Link
US (6) US8476271B2 (ru)
EP (2) EP2324013B3 (ru)
JP (1) JP5416210B2 (ru)
KR (1) KR101333660B1 (ru)
CN (1) CN102105465B (ru)
AR (1) AR072578A1 (ru)
AU (1) AU2009275218C1 (ru)
BR (1) BRPI0911031B8 (ru)
CA (1) CA2730288C (ru)
CL (1) CL2011000148A1 (ru)
CO (1) CO6341627A2 (ru)
CY (1) CY1113485T1 (ru)
DK (1) DK2324013T6 (ru)
ES (1) ES2393849T7 (ru)
HK (1) HK1157763A1 (ru)
HR (1) HRP20120841T4 (ru)
IL (2) IL210549A (ru)
MX (1) MX2011000872A (ru)
MY (1) MY153948A (ru)
NZ (1) NZ590416A (ru)
PE (2) PE20110416A1 (ru)
PL (1) PL2324013T6 (ru)
PT (1) PT2324013E (ru)
RS (1) RS52590B2 (ru)
RU (1) RU2500678C2 (ru)
SG (1) SG192539A1 (ru)
SI (1) SI2324013T1 (ru)
SM (1) SMT201200053B (ru)
TW (2) TW201016697A (ru)
UA (1) UA99540C2 (ru)
WO (1) WO2010010458A1 (ru)
ZA (1) ZA201100189B (ru)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2833209C (en) 2007-04-27 2016-06-28 Purdue Pharma L.P. Piperidine and piperazine compounds as trpv1 antagonists
EP3564240B1 (en) 2007-08-31 2022-04-06 Purdue Pharma L.P. Piperidine intermediates
AU2009275218C1 (en) 2008-07-21 2015-02-05 Purdue Pharma L.P. Substituted-Quinoxaline-Type Bridged-Piperidine Compounds and the uses thereof
AU2011346749A1 (en) * 2010-12-22 2013-05-02 Purdue Pharma L.P. Phosphorus-substituted quinoxaline-type piperidine compounds and uses thereof
UA113288C2 (xx) 2011-06-22 2017-01-10 Trpv1 антагоністи, що містять дигідроксизамісник, і їх застосування
WO2013021276A1 (en) 2011-08-10 2013-02-14 Purdue Pharma L.P. Trpv1 antagonists including dihydroxy substituent and uses thereof
ES2583146T3 (es) * 2011-12-01 2016-09-19 Purdue Pharma L.P. Compuestos de piperidina de tipo quinoxalina sustituidos con azetidina y usos de éstos
US9085561B2 (en) 2012-07-30 2015-07-21 Purdue Pharma L.P. Cyclic urea- or lactam-substituted quinoxaline-type piperidines as ORL-1 modulators
US10118927B2 (en) 2012-12-27 2018-11-06 Purdue Pharma L.P. Substituted piperidin-4-amino-type compounds and uses thereof
WO2014102588A2 (en) 2012-12-27 2014-07-03 Purdue Pharma L.P. Indole and indoline-type piperidine compounds and uses thereof
US9090618B2 (en) 2012-12-27 2015-07-28 Purdue Pharma L.P. Substituted benzimidazole-type piperidine compounds and uses thereof
WO2014102592A2 (en) 2012-12-27 2014-07-03 Purdue Pharma L.P. Oxime/substituted quinoxaline-type piperidine compounds and uses thereof
JOP20190008A1 (ar) * 2016-07-26 2019-01-24 Purdue Pharma Lp علاج ومنع اضطرابات النوم
MX2020007817A (es) 2018-01-24 2020-09-25 Purdue Pharma Lp Prevención y tratamiento del trastorno del sueño.
EP3917621A1 (en) * 2019-01-31 2021-12-08 Purdue Pharma LP Polymorphic forms of a substituted-quinoxaline-type bridged-piperidine compound
AU2022276010A1 (en) * 2021-05-21 2024-01-18 Purdue Pharma L.P. Methods of treating interstitial cystitis/bladder pain syndrome
WO2023250190A1 (en) * 2022-06-24 2023-12-28 Purdue Pharma L.P. Methods of treating or preventing overactive bladder syndrome

Family Cites Families (60)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3536809A (en) 1969-02-17 1970-10-27 Alza Corp Medication method
US3598123A (en) 1969-04-01 1971-08-10 Alza Corp Bandage for administering drugs
US3845770A (en) 1972-06-05 1974-11-05 Alza Corp Osmatic dispensing device for releasing beneficial agent
US3916899A (en) 1973-04-25 1975-11-04 Alza Corp Osmotic dispensing device with maximum and minimum sizes for the passageway
US4008719A (en) 1976-02-02 1977-02-22 Alza Corporation Osmotic system having laminar arrangement for programming delivery of active agent
IE58110B1 (en) 1984-10-30 1993-07-14 Elan Corp Plc Controlled release powder and process for its preparation
US5073543A (en) 1988-07-21 1991-12-17 G. D. Searle & Co. Controlled release formulations of trophic factors in ganglioside-lipsome vehicle
US5225402A (en) * 1989-02-10 1993-07-06 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivatives
IT1229203B (it) 1989-03-22 1991-07-25 Bioresearch Spa Impiego di acido 5 metiltetraidrofolico, di acido 5 formiltetraidrofolico e dei loro sali farmaceuticamente accettabili per la preparazione di composizioni farmaceutiche in forma a rilascio controllato attive nella terapia dei disturbi mentali organici e composizioni farmaceutiche relative.
US5120548A (en) 1989-11-07 1992-06-09 Merck & Co., Inc. Swelling modulated polymeric drug delivery device
US5733566A (en) 1990-05-15 1998-03-31 Alkermes Controlled Therapeutics Inc. Ii Controlled release of antiparasitic agents in animals
US5698155A (en) 1991-05-31 1997-12-16 Gs Technologies, Inc. Method for the manufacture of pharmaceutical cellulose capsules
US5580578A (en) 1992-01-27 1996-12-03 Euro-Celtique, S.A. Controlled release formulations coated with aqueous dispersions of acrylic polymers
US20020061554A1 (en) * 1992-08-13 2002-05-23 Evans Christopher J. Orphan opioid receptor and recombinant materials for its production
US5591767A (en) 1993-01-25 1997-01-07 Pharmetrix Corporation Liquid reservoir transdermal patch for the administration of ketorolac
ATE216580T1 (de) 1993-07-16 2002-05-15 Merck & Co Inc Benzoxazinon- und benzopyrimidinon- piperidinyl- verbindungen als tokolytische oxytocin-rezeptor- antagonisten
IT1270594B (it) 1994-07-07 1997-05-07 Recordati Chem Pharm Composizione farmaceutica a rilascio controllato di moguisteina in sospensione liquida
DE69635048T2 (de) 1995-06-12 2006-02-16 G.D. Searle & Co. Mittel, enthaltend einen cyclooxygenase-2 inhibitor und einen 5-lipoxygenase inhibitor
JP3776201B2 (ja) 1997-04-17 2006-05-17 株式会社リコー 光記録媒体
DE69826278T2 (de) 1997-05-30 2005-11-10 Banyu Pharmaceutical Co., Ltd. 2-oxoimidazol-derivate
HUP0002853A3 (en) 1997-09-01 2001-12-28 Kyorin Seiyaku Kk 6,7-asymmetrically disubstituted quinoxalinecarboxylic acid derivatives, and pharmaceutical compositions containing them
SE9800836D0 (sv) 1998-03-13 1998-03-13 Astra Ab New Compounds
JP2002509923A (ja) 1998-03-31 2002-04-02 ワーナー−ランバート・カンパニー Ｘａ因子およびトロンビンのようなセリンプロテアーゼ阻害剤としてのキノキサリノン
EP1067123B1 (en) * 1998-03-31 2011-01-19 Kyowa Hakko Kirin Co., Ltd. Nitrogenous heterocyclic compounds
ID29137A (id) * 1998-07-27 2001-08-02 Schering Corp Ligan-ligan afinitas tinggi untuk reseptor nosiseptin orl-1
US6262066B1 (en) 1998-07-27 2001-07-17 Schering Corporation High affinity ligands for nociceptin receptor ORL-1
MA26659A1 (fr) 1998-08-06 2004-12-20 Pfizer Dérivés de benzimidazole nouveaux, compositions pharmaceutiques les contenant et procédé pour leur préparation.
DE60033071T2 (de) 1999-12-06 2007-08-23 Euro-Celtique S.A. Triazospiroverbindungen mit nociceptin-rezeptoraffinität
WO2001039775A1 (en) 1999-12-06 2001-06-07 Euro-Celtique, S.A. Benzimidazole compounds having nociceptin receptor affinity
AU6594401A (en) 2000-05-24 2001-12-03 Bayer Aktiengesellschaft 6-heterocyclyl-3-oxo-3,4-dihydro-quinoxalines
ES2316559T3 (es) 2001-04-18 2009-04-16 Euro-Celtique S.A. Compuestos espiroindeno y espiroindano.
MXPA03009602A (es) 2001-04-18 2004-04-02 Euro Celtique Sa Analogos de nociceptina.
DK1975164T3 (da) 2001-04-18 2010-05-25 Euro Celtique Sa Octahydrobenzimidazolon-forbindelser som analgetika
EP1918279A3 (en) 2001-04-18 2008-07-16 Euro-Celtique S.A. 1-(4-piperidinyl)-1,3-dihydro-2h-benzoxazole-2-one derivatives and related compounds as nociceptin analogs and opioid receptor like receptor (orl1) ligands for the treatment of pain
HUP0401333A3 (en) 2001-04-18 2004-11-29 Euro Celtique Sa Spiropyrazole compounds and pharmaceutical compositions containing them
EP1382598A4 (en) * 2001-04-26 2005-03-23 Takeda Pharmaceutical NEW HETEROCYCLIC DERIVATIVES
DE10123163A1 (de) * 2001-05-09 2003-01-16 Gruenenthal Gmbh Substituierte Cyclohexan-1,4-diaminderivate
JPWO2002094790A1 (ja) * 2001-05-23 2004-09-09 三菱ウェルファーマ株式会社 縮合ヘテロ環化合物およびその医薬用途
AR037211A1 (es) * 2001-11-07 2004-10-27 Schering Corp Derivados de heteroarilo como ligandos superiores para el receptor de nociceptina orl-1
JPWO2003062234A1 (ja) 2002-01-23 2005-05-19 山之内製薬株式会社 キノキサリン化合物
US7026312B2 (en) * 2002-03-14 2006-04-11 Boehringer Ingelheim Pharma Gmbh & Co. Kg Substituted piperidines, pharmaceutical compositions containing these compounds, their use and processes for the preparation thereof
DK1491212T3 (da) 2002-03-29 2012-10-29 Mitsubishi Tanabe Pharma Corp Middel til behandling af søvnforstyrrelser
WO2004034983A2 (en) 2002-10-17 2004-04-29 Euro-Celtique, S.A. Preparation of triazospiro compounds
DE10343098A1 (de) 2003-09-18 2005-04-14 Bayer Healthcare Ag Tetrahydrochinoxaline und ihre Verwendung
US8067603B2 (en) * 2003-09-25 2011-11-29 Solvay Pharmaceuticals B.V. Benzimidazolone and quinazolinone derivatives as agonists on human ORL1 receptors
WO2005060947A2 (en) * 2003-12-19 2005-07-07 Sri International Agonist and antagonist ligands of the nociceptin receptor
DE10360793A1 (de) * 2003-12-23 2005-07-28 Grünenthal GmbH Spirocyclische Cyclohexan-Derivate
WO2005075459A1 (en) 2004-02-03 2005-08-18 Euro-Celtique S.A. Synthesis of cyanoimino-benzoimidazoles
DE102004023332A1 (de) 2004-05-12 2006-01-19 Bayer Cropscience Gmbh Chinoxalin-2-on-derivate, diese enthaltende nutzpflanzenschützende Mittel und Verfahren zu ihrer Herstellung und deren Verwendung
EP1676843A1 (en) * 2004-12-31 2006-07-05 Nikem Research S.R.L. Substituted indole ligands for the ORL-1 receptor
CA2612299A1 (en) * 2005-06-17 2006-12-21 Pfizer Inc. Alpha-(aryl-or heteroaryl-methyl)-beta piperidino propanamide compounds as orl1-receptor antagonists
US7300947B2 (en) * 2005-07-13 2007-11-27 Banyu Pharmaceutical Co., Ltd. N-dihydroxyalkyl-substituted 2-oxo-imidazole derivatives
PE20071159A1 (es) * 2005-10-31 2007-11-30 Schering Corp Derivados de tropano 3-monosustituido como ligandos de receptores de nociceptina
TW200815405A (en) 2006-06-09 2008-04-01 Astrazeneca Ab Novel compounds
EP1873150A1 (en) 2006-06-30 2008-01-02 Nikem Research S.R.L. Fluorinated indoleamides useful as ligands of the ORL-1 receptor
CN101595100B (zh) * 2007-01-16 2014-06-11 普渡制药公司 作为orl-1配体的杂环取代的哌啶
MX2009009355A (es) * 2007-03-01 2009-09-11 Mitsubishi Tanabe Pharma Corp Compuesto de bencimidazol y uso farmaceutico del mismo.
EP3564240B1 (en) * 2007-08-31 2022-04-06 Purdue Pharma L.P. Piperidine intermediates
AU2009270984A1 (en) * 2008-07-16 2010-01-21 Schering Corporation Bicyclic Heterocycle Derivatives and methods of use thereof
AU2009275218C1 (en) 2008-07-21 2015-02-05 Purdue Pharma L.P. Substituted-Quinoxaline-Type Bridged-Piperidine Compounds and the uses thereof

Also Published As

Publication number Publication date
PL2324013T6 (pl) 2015-11-30
CA2730288A1 (en) 2010-01-28
PE20110416A1 (es) 2011-06-22
US8476271B2 (en) 2013-07-02
EP2537844A1 (en) 2012-12-26
EP2324013A1 (en) 2011-05-25
HRP20120841T4 (hr) 2015-07-03
MY153948A (en) 2015-04-15
US10519156B2 (en) 2019-12-31
JP5416210B2 (ja) 2014-02-12
PE20140102A1 (es) 2014-02-06
SI2324013T1 (sl) 2012-12-31
BRPI0911031B8 (pt) 2021-05-25
US20130274265A1 (en) 2013-10-17
US20110178090A1 (en) 2011-07-21
HRP20120841T1 (hr) 2012-11-30
AU2009275218C1 (en) 2015-02-05
IL210549A0 (en) 2011-03-31
CN102105465A (zh) 2011-06-22
US11111246B2 (en) 2021-09-07
PL2324013T3 (pl) 2013-05-31
DK2324013T6 (en) 2014-12-15
ZA201100189B (en) 2011-09-28
IL210549A (en) 2017-09-28
US9890164B2 (en) 2018-02-13
EP2324013B3 (en) 2014-10-22
CO6341627A2 (es) 2011-11-21
CA2730288C (en) 2016-09-13
AU2009275218B2 (en) 2012-11-08
US20160009717A1 (en) 2016-01-14
TWI432434B (zh) 2014-04-01
CY1113485T1 (el) 2016-06-22
JP2011528707A (ja) 2011-11-24
RS52590B (en) 2013-04-30
SG192539A1 (en) 2013-08-30
US20180370971A1 (en) 2018-12-27
HK1157763A1 (en) 2012-07-06
MX2011000872A (es) 2011-07-29
IL254218A0 (en) 2017-10-31
AU2009275218A1 (en) 2010-01-28
US20180148449A1 (en) 2018-05-31
DK2324013T3 (da) 2012-11-19
EP2324013B1 (en) 2012-09-19
RU2011106375A (ru) 2012-08-27
CN102105465B (zh) 2015-03-11
SMT201200053B (it) 2013-01-14
PT2324013E (pt) 2012-12-24
AR072578A1 (es) 2010-09-08
RU2500678C2 (ru) 2013-12-10
WO2010010458A1 (en) 2010-01-28
ES2393849T3 (es) 2012-12-28
KR20110031993A (ko) 2011-03-29
US20200223847A1 (en) 2020-07-16
BRPI0911031B1 (pt) 2021-05-11
US9145408B2 (en) 2015-09-29
ES2393849T7 (es) 2015-01-28
NZ590416A (en) 2012-10-26
TW201016697A (en) 2010-05-01
TW201329077A (zh) 2013-07-16
CL2011000148A1 (es) 2011-09-02
BRPI0911031A2 (pt) 2017-01-17
RS52590B2 (sr) 2018-05-31
KR101333660B1 (ko) 2013-11-27

Similar Documents

Publication Publication Date Title
MY153948A (en) Substituted-quinoxaline-type bridged-piperidine compounds and the uses thereof
MY150602A (en) Subtituted-quinoxaline-type piperidine compounds and the uses thereof
MX2009007644A (es) Compuestos de piperidina heterociclicos sustituidos y usos de los mismos.
MX2010001565A (es) Compuestos triazolicos que modulan la actividad de proteina de choque termico (hsp) 90.
MX2009008547A (es) Compuestos de triazol que son utiles en el tratamiento de trastornos proliferativos tales como cancer.
WO2009129246A3 (en) Compositions and methods for preparing and using same
PH12016500511A1 (en) Selective grp94 inhibitors and uses thereof
HK1133787A1 (en) Bicycloheteroaryl compounds as p2x7 modulators and uses thereof
EA201290919A1 (ru) Индазольные соединения и их применение
UA111464C2 (ru) Композиции, содержащие моноглицериды органическх кислот c1-c7 и глицерин, и ее применение как антибактериальное и протиплиснявого средства
MY148657A (en) Trpv1 antagonists and uses thereof
MX2009000657A (es) Composiciones y metodos para el tratamiento de mucositis.
IN2012DN03883A (ru)
MX2009003911A (es) Formulaciones de liberacion inmediata, mejoradas de topiramato.
WO2012024620A3 (en) Autotaxin inhibitors and uses thereof
MX2010004219A (es) Agentes de enlace de cd19 y usos de los mismos.
MA33803B1 (fr) Inhibiteur de bromodomaine de benzodiazépine
WO2009089494A3 (en) Pharmaceutical compositions
IN2012DN00624A (ru)
MX2011011950A (es) Composiciones de dexmedetomidina sublinguales y metodos de uso de las mismas.
AU2016216741A1 (en) Compositions and methods of use of an inappetance-controlling compound
WO2009011910A3 (en) Imidazolidinone compounds, methods to inhibit deubiquitination and methods of treatment
ZA201008160B (en) Compositions for the treatment of hair loss
WO2011011706A3 (en) Methods and compositions for treating or preventing autoimmune diseases using immunomodulatory agents
WO2010042212A3 (en) Methods for treating or preventing pain using spicamycin derivatives