ATE242775T1 - Purinderivate und antagonisten des adenosin-a2- rezeptors, welche zur vorsorge oder heilung von diabetes dienen - Google Patents

Purinderivate und antagonisten des adenosin-a2- rezeptors, welche zur vorsorge oder heilung von diabetes dienen

Info

Publication number
ATE242775T1
ATE242775T1 AT98961528T AT98961528T ATE242775T1 AT E242775 T1 ATE242775 T1 AT E242775T1 AT 98961528 T AT98961528 T AT 98961528T AT 98961528 T AT98961528 T AT 98961528T AT E242775 T1 ATE242775 T1 AT E242775T1
Authority
AT
Austria
Prior art keywords
antagonists
receptor
adenosine
prevent
purine derivatives
Prior art date
Application number
AT98961528T
Other languages
English (en)
Inventor
Osamu Asano
Hitoshi Harada
Yorihisa Hoshino
Seiji Yoshikawa
Takashi Inoue
Tatsuo Horizoe
Nobuyuki Yasuda
Kaya Nagata
Junsaku Nagaoka
Manabu Murakami
Seiichi Kobayashi
Original Assignee
Eisai Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai Co Ltd filed Critical Eisai Co Ltd
Application granted granted Critical
Publication of ATE242775T1 publication Critical patent/ATE242775T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/28—Oxygen atom
    • C07D473/30—Oxygen atom attached in position 6, e.g. hypoxanthine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
AT98961528T 1998-01-05 1998-12-24 Purinderivate und antagonisten des adenosin-a2- rezeptors, welche zur vorsorge oder heilung von diabetes dienen ATE242775T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP52698 1998-01-05
PCT/JP1998/005870 WO1999035147A1 (fr) 1998-01-05 1998-12-24 Derives de purine et antagonistes du recepteur a2 d'adenosine utiles comme moyens de prevention/traitement du diabete

Publications (1)

Publication Number Publication Date
ATE242775T1 true ATE242775T1 (de) 2003-06-15

Family

ID=11476226

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98961528T ATE242775T1 (de) 1998-01-05 1998-12-24 Purinderivate und antagonisten des adenosin-a2- rezeptors, welche zur vorsorge oder heilung von diabetes dienen

Country Status (7)

Country Link
US (2) US6579868B1 (de)
EP (2) EP1054012B1 (de)
AT (1) ATE242775T1 (de)
AU (1) AU1688599A (de)
CA (1) CA2315736A1 (de)
DE (1) DE69815554T2 (de)
WO (1) WO1999035147A1 (de)

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Also Published As

Publication number Publication date
DE69815554T2 (de) 2004-05-06
EP1054012A4 (de) 2001-12-12
DE69815554D1 (de) 2003-07-17
EP1054012A1 (de) 2000-11-22
US6579868B1 (en) 2003-06-17
USRE39112E1 (en) 2006-05-30
AU1688599A (en) 1999-07-26
EP1300147A1 (de) 2003-04-09
EP1054012B1 (de) 2003-06-11
WO1999035147A1 (fr) 1999-07-15
CA2315736A1 (en) 1999-07-15

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