UA94913C2 - Применение эритропоэтина для лечения сахарного диабета - Google Patents

Применение эритропоэтина для лечения сахарного диабета

Info

Publication number
UA94913C2
UA94913C2 UAA200801307A UAA200801307A UA94913C2 UA 94913 C2 UA94913 C2 UA 94913C2 UA A200801307 A UAA200801307 A UA A200801307A UA A200801307 A UAA200801307 A UA A200801307A UA 94913 C2 UA94913 C2 UA 94913C2
Authority
UA
Ukraine
Prior art keywords
erythropoietin
diabetes mellitus
treating diabetes
epo
dose
Prior art date
Application number
UAA200801307A
Other languages
English (en)
Ukrainian (uk)
Inventor
Фердинанд Херманн Бальманн
Херманн Халлер
Original Assignee
Эпоплус Гмбх Унд Ко., Кг
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Эпоплус Гмбх Унд Ко., Кг filed Critical Эпоплус Гмбх Унд Ко., Кг
Publication of UA94913C2 publication Critical patent/UA94913C2/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1858—Platelet-derived growth factor [PDGF]
    • A61K38/1866—Vascular endothelial growth factor [VEGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1816—Erythropoietin [EPO]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1891—Angiogenesic factors; Angiogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/193—Colony stimulating factors [CSF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Dermatology (AREA)
  • Urology & Nephrology (AREA)
  • Reproductive Health (AREA)
  • Emergency Medicine (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Pulmonology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

Изобретение касается применения эритропоэтина для получения фармацевтической композиции, содержащей субполицитемическую дозу ЕРО, которая отвечает еженедельной дозе от 1 до 90 международных единиц (Ед)ЕРО/кг массы тела, для лечения сахарного диабета.
UAA200801307A 2002-07-26 2003-07-25 Применение эритропоэтина для лечения сахарного диабета UA94913C2 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE10234192A DE10234192B4 (de) 2002-07-26 2002-07-26 Verwendung von Erythropoetin

Publications (1)

Publication Number Publication Date
UA94913C2 true UA94913C2 (ru) 2011-06-25

Family

ID=30128436

Family Applications (2)

Application Number Title Priority Date Filing Date
UAA200801307A UA94913C2 (ru) 2002-07-26 2003-07-25 Применение эритропоэтина для лечения сахарного диабета
UAA200501760A UA85997C2 (en) 2002-07-26 2003-07-25 Use of erythropoietin

Family Applications After (1)

Application Number Title Priority Date Filing Date
UAA200501760A UA85997C2 (en) 2002-07-26 2003-07-25 Use of erythropoietin

Country Status (27)

Country Link
US (4) US7745387B2 (ru)
EP (3) EP2191838A1 (ru)
JP (4) JP4727988B2 (ru)
KR (2) KR20050026513A (ru)
CN (3) CN101099731B (ru)
AT (2) ATE468132T1 (ru)
AU (2) AU2003255290B2 (ru)
BR (1) BR0312981A (ru)
CA (2) CA2493598A1 (ru)
CY (2) CY1108052T1 (ru)
DE (3) DE10234192B4 (ru)
DK (2) DK1526867T3 (ru)
EA (3) EA013966B1 (ru)
ES (2) ES2285195T3 (ru)
HK (2) HK1081841A1 (ru)
HR (3) HRP20050065A2 (ru)
IL (2) IL166401A0 (ru)
IS (3) IS2671B (ru)
MX (1) MXPA05001120A (ru)
NO (1) NO20051002L (ru)
PL (2) PL374874A1 (ru)
PT (2) PT1526867E (ru)
SG (1) SG177004A1 (ru)
SI (2) SI1526867T1 (ru)
UA (2) UA94913C2 (ru)
WO (1) WO2004012759A2 (ru)
ZA (1) ZA200500726B (ru)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7199102B2 (en) * 2000-08-24 2007-04-03 The Regents Of The University Of California Orally administered peptides synergize statin activity
US7723303B2 (en) 2000-08-24 2010-05-25 The Regents Of The University Of California Peptides and peptide mimetics to treat pathologies characterized by an inflammatory response
DE10234192B4 (de) * 2002-07-26 2009-11-26 Epoplus Gmbh Co.Kg Verwendung von Erythropoetin
NZ543612A (en) * 2003-07-29 2008-03-28 Dompe Spa Pharmaceutical combination of G-CSF and PLGF useful for blood stem cell
WO2005063965A1 (de) * 2003-12-30 2005-07-14 Bionethos Holding Gmbh Verfahren zur regeneration von gewebe
DE102004063927A1 (de) * 2004-01-23 2005-12-15 Epoplus Gmbh Co.Kg Einsatz von niedrig dosiertem Erythropoietin zur Stimulation endothelialer Vorläuferzellen sowie zur Organregeneration und Progressionsverlangsamung von Endorganschäden
CA2595067A1 (en) 2004-12-06 2006-06-15 The Regents Of The University Of California Methods for improving the structure and function of arterioles
AR053416A1 (es) 2005-11-10 2007-05-09 Protech Pharma S A Combinacion de glicoisoformas para el tratamiento o prevencion de la septicemia, linea celular transgenica productora de glicoformas de eritropoyetina, composicion farmaceutica que comprende a dicha combinacion, procedimientos para obtener la linea celular, procedimiento para producir dicha combinac
PL1973559T3 (pl) 2005-11-23 2013-06-28 Acceleron Pharma Inc Antagoniści aktywiny-ActRIIa i zastosowanie do pobudzania wzrostu kości
US8128933B2 (en) 2005-11-23 2012-03-06 Acceleron Pharma, Inc. Method of promoting bone growth by an anti-activin B antibody
WO2007142288A1 (ja) * 2006-06-07 2007-12-13 The University Of Tokushima エリスロポエチンを用いた虚血性疾患の治療
KR20090077935A (ko) * 2006-09-29 2009-07-16 센토코 오르토 바이오테크 인코포레이티드 내당능 장애 관련 증상을 예방하거나 치료하기 위한 인간 ｅｐｏ 수용체 작용제, 조성물, 방법 및 용도
US8975374B2 (en) * 2006-10-20 2015-03-10 Chugai Seiyaku Kabushiki Kaisha Pharmaceutical composition comprising anti-HB-EGF antibody as active ingredient
JP5378795B2 (ja) * 2006-10-20 2013-12-25 中外製薬株式会社 抗ｈｂ−ｅｇｆ抗体を有効成分として含む医薬組成物
CA2666809A1 (en) 2006-10-20 2008-04-24 Forerunner Pharma Research Co., Ltd. Anti-cancer agent comprising anti-hb-egf antibody as active ingredient
US8895016B2 (en) 2006-12-18 2014-11-25 Acceleron Pharma, Inc. Antagonists of activin-actriia and uses for increasing red blood cell levels
CA2674368A1 (en) * 2007-01-10 2008-07-17 Edison Pharmaceuticals, Inc. Treatment of respiratory chain disorders using compounds having erythropoietin or thrombopoietin activity
TWI548647B (zh) 2007-02-02 2016-09-11 艾瑟勒朗法瑪公司 衍生自ＡｃｔＲＩＩＢ的變體與其用途
AR065613A1 (es) * 2007-03-09 2009-06-17 Chugai Pharmaceutical Co Ltd Agentes de proteccion para organos transplantados
JP5869219B2 (ja) * 2007-08-16 2016-02-24 レメドー バイオメッド リミテッド 治療および美容適用のためのエリスロポイエチンおよびフィブロネクチン組成物
WO2009143268A2 (en) * 2008-05-22 2009-11-26 Edison Pharmaceuticals, Inc. Treatment of mitochondrial diseases with an erythropoietin mimetic
TWI617316B (zh) 2008-08-14 2018-03-11 艾瑟勒朗法瑪公司 使用ｇｄｆ阱以增加紅血球水平
US8216997B2 (en) 2008-08-14 2012-07-10 Acceleron Pharma, Inc. Methods for increasing red blood cell levels and treating anemia using a combination of GDF traps and erythropoietin receptor activators
WO2010144452A1 (en) 2009-06-08 2010-12-16 Acceleron Pharma Inc. Methods for increasing thermogenic adipocytes
MX351286B (es) 2009-06-12 2017-10-09 Acceleron Pharma Inc Proteinas de fusion actriib-fc truncadas.
BR112012003232B1 (pt) * 2009-08-13 2022-02-22 Acceleron Pharma Inc Uso de um polipeptídeo em conjunto com um ativador do receptor de eritropoetina para aumentar os níveis de célula vermelha no sangue ou tratar anemia
US8710016B2 (en) 2009-11-17 2014-04-29 Acceleron Pharma, Inc. ActRIIB proteins and variants and uses therefore relating to utrophin induction for muscular dystrophy therapy
DK2590666T3 (en) 2010-07-06 2017-07-17 Augustinus Bader TOPICAL APPLICATION OF ERYTHROPOIETIN FOR USE IN THE TREATMENT OF DAMAGE OF THE CORNS
US9956265B2 (en) 2011-04-26 2018-05-01 Ajou University Industry-Academic Cooperation Foundation Composition for aiding surgical procedures for treating ischemic vascular diseases
EP2914277B1 (en) 2012-11-02 2017-09-13 Celgene Corporation Activin-actrii antagonists and uses for treating bone and other disorders
US8992951B2 (en) 2013-01-09 2015-03-31 Sapna Life Sciences Corporation Formulations, procedures, methods and combinations thereof for reducing or preventing the development, or the risk of development, of neuropathology as a result of trauma
JP6220969B2 (ja) * 2013-10-22 2017-10-25 コンシーヴァルブ エルエルシー ステント装着した心臓弁または生体補綴弁の狭窄、閉塞、または石灰化を阻害するための方法
EP3154566B1 (en) 2014-06-13 2022-08-03 Acceleron Pharma Inc. Actrii antagonist for the treatment or prevention of a cutaneous ulcer in a subject that has anemia
JP7199809B2 (ja) 2015-02-13 2023-01-06 ファクター バイオサイエンス インコーポレイテッド 核酸製品及びその投与方法
CN105233256A (zh) * 2015-10-28 2016-01-13 中国人民解放军第三军医大学 ***及其衍生物在制备治疗疾病中促进凋亡细胞清除的药物中的应用
US11534466B2 (en) * 2016-03-09 2022-12-27 Aal Scientifics, Inc. Pancreatic stem cells and uses thereof
GB2550114A (en) * 2016-05-03 2017-11-15 Kymab Ltd Methods, regimens, combinations & antagonists
WO2018035377A1 (en) 2016-08-17 2018-02-22 Factor Bioscience Inc. Nucleic acid products and methods of administration thereof
CN108114282B (zh) * 2016-11-28 2021-03-02 北京大学第三医院 他汀类化合物治疗缺血性疾病的用途
US11851486B2 (en) 2017-05-02 2023-12-26 National Center Of Neurology And Psychiatry Method for predicting and evaluating therapeutic effect in diseases related to IL-6 and neutrophils
KR20200074160A (ko) * 2017-10-20 2020-06-24 가꼬우호우징 효고 이카다이가쿠 항il-6 수용체 항체를 함유하는 수술 후의 유착을 억제하기 위한 의약 조성물
RU2678768C1 (ru) * 2018-09-25 2019-02-01 Федеральное государственное автономное образовательное учреждение высшего образования "Белгородский государственный национальный исследовательский университет" (НИУ "БелГУ") Способ профилактики ишемически-реперфузионных повреждений почек карбамилированным дарбэпоэтином в эксперименте
RU2695334C1 (ru) * 2018-09-25 2019-07-23 Федеральное государственное автономное образовательное учреждение высшего образования "Белгородский государственный национальный исследовательский университет" (НИУ "БелГУ") Способ профилактики нарушений функций почек карбамилированным дарбэпоэтином в эксперименте
US10501404B1 (en) 2019-07-30 2019-12-10 Factor Bioscience Inc. Cationic lipids and transfection methods

Family Cites Families (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ210501A (en) 1983-12-13 1991-08-27 Kirin Amgen Inc Erythropoietin produced by procaryotic or eucaryotic expression of an exogenous dna sequence
IL77081A (en) 1984-12-04 1999-10-28 Genetics Inst AND sequence encoding human erythropoietin, a process for its preparation and a pharmacological preparation of human erythropoietin
US4732889A (en) 1985-02-06 1988-03-22 Chugai Seiyaku Kabushiki Kaisha Pharmaceutical composition for the treatment of the anemia of rheumatoid arthritis
US4921837A (en) 1985-11-27 1990-05-01 Genetics Institute Inc. Treatment of AIDS-type disease
US5198417A (en) * 1985-11-27 1993-03-30 Genetics Institute, Inc. Methods of treating pancytopenia and AIDS by co-administering EPO and colony stimulating factors
DK173067B1 (da) 1986-06-27 1999-12-13 Univ Washington Humant erythropoietin-gen, fremgangsmåde til ekspression deraf i transficerede cellelinier, de transficerede cellelinier sa
US5013718A (en) 1986-11-21 1991-05-07 Amgen, Inc. Method for treating iron overload using EPO
DE3729863A1 (de) 1987-09-05 1989-03-16 Boehringer Mannheim Gmbh Stabilisierte erythropoietin-lyophilisate
WO1989007944A1 (en) 1988-02-24 1989-09-08 American National Red Cross Device for site directed neovascularization and method for same
US5024841A (en) * 1988-06-30 1991-06-18 Collagen Corporation Collagen wound healing matrices and process for their production
DE4014654A1 (de) 1990-05-08 1991-11-14 Behringwerke Ag Galenische waessrige formulierungen von erythropoietin und ihre verwendung
EP0575555B1 (en) * 1991-03-11 2001-07-18 Curis, Inc. Protein-induced morphogenesis
US5354934A (en) * 1993-02-04 1994-10-11 Amgen Inc. Pulmonary administration of erythropoietin
EP0744953A4 (en) 1993-04-29 1998-05-06 Abbott Lab METHODS AND COMPOSITIONS OF ERYTHROPO ETINE ANALOGS
ZA946122B (en) 1993-08-17 1995-03-20 Amgen Inc Erythropoietin analogs
JPH08205860A (ja) * 1994-01-21 1996-08-13 Usa Government 造血細胞の膨大化および移植方法
ITFI940106A1 (it) * 1994-05-27 1995-11-27 Menarini Ricerche Sud Spa Molecola ibrida di formula gm-csf-l-epo o epo-l-gm-csf per la stimolaz ione eritropoietica
ES2206521T3 (es) 1994-11-03 2004-05-16 Roche Diagnostics Gmbh Utilizacion de la eritropoyetina en el tratamiento de artritis reumatoide.
US5837675A (en) * 1995-02-03 1998-11-17 Brox; Alan G. Synergistic effect of insulin-like growth factor-I and erythropoietin
US20020052309A1 (en) * 1996-09-11 2002-05-02 Athanasius A. Anagnostou Method of treating endothelial injury
US5980887A (en) * 1996-11-08 1999-11-09 St. Elizabeth's Medical Center Of Boston Methods for enhancing angiogenesis with endothelial progenitor cells
US6284260B1 (en) 1998-02-04 2001-09-04 Veronica L. Zaharia Czeizler Treatment with erythropoietin of bleeding from benign and malignant lesions with normal and abnormal coagulation parameters
US6274158B1 (en) * 1998-02-04 2001-08-14 Veronica L. Zaharia Czeizler Treatment with recombinant human erythropoietin of bleeding in patients with normal and abnormal hemostasis
DE19857609A1 (de) 1998-12-14 2000-06-15 Hannelore Ehrenreich Verwendung von Erythropoietin zur Behandlung von cerebralen Ischämien des Menschen
CN1607957B (zh) * 1999-04-13 2012-10-10 肯尼思S.沃伦协会有限公司 外周给药的红细胞生成素对应激组织功能的调制
DE60131393D1 (de) 2000-05-02 2007-12-27 Action Pharma As Verfahren zur behandlung von erkrankungen assoziiert mit akuten entzündung unter nichtischämischen zustände
US7259146B2 (en) * 2000-05-26 2007-08-21 Ortho-Mcneil Pharmaceutical, Inc. Neuroprotective peptides
US7078376B1 (en) 2000-08-11 2006-07-18 Baxter Healthcare S.A. Therapeutic methods for treating subjects with a recombinant erythropoietin having high activity and reduced side effects
US20020065214A1 (en) * 2000-11-29 2002-05-30 Adrian Iaina Method of treating congestive heart failure
PA8536201A1 (es) 2000-12-29 2002-08-29 Kenneth S Warren Inst Inc Protección y mejoramiento de células, tejidos y órganos que responden a la eritropoyetina
AU2002319142B2 (en) * 2001-04-04 2008-02-21 Genodyssee New polynucleotides and polypeptides of the erythropoietin gene
US6784154B2 (en) * 2001-11-01 2004-08-31 University Of Utah Research Foundation Method of use of erythropoietin to treat ischemic acute renal failure
WO2003045423A1 (en) * 2001-11-28 2003-06-05 Ortho-Mcneil Pharmaceutical, Inc. Erythropoietin dosing regimen for treating anemia
CN1612747A (zh) 2002-01-09 2005-05-04 克鲁塞尔荷兰公司 ***在预防或治疗心力衰竭中的用途
US6748154B2 (en) * 2002-03-28 2004-06-08 Nortel Networks Limited Optical module access tray
DE10234192B4 (de) * 2002-07-26 2009-11-26 Epoplus Gmbh Co.Kg Verwendung von Erythropoetin
DE102004063927A1 (de) * 2004-01-23 2005-12-15 Epoplus Gmbh Co.Kg Einsatz von niedrig dosiertem Erythropoietin zur Stimulation endothelialer Vorläuferzellen sowie zur Organregeneration und Progressionsverlangsamung von Endorganschäden

Also Published As

Publication number Publication date
CN1681526A (zh) 2005-10-12
DE10234192B4 (de) 2009-11-26
CY1110713T1 (el) 2015-06-10
ATE468132T1 (de) 2010-06-15
DK1526867T3 (da) 2007-09-17
HRP20050065A2 (en) 2005-10-31
SI1779862T1 (sl) 2010-09-30
CN101099860B (zh) 2011-06-01
EP1779862B1 (de) 2010-05-19
DE50312729D1 (de) 2010-07-01
CN101099731A (zh) 2008-01-09
DE50307140D1 (en) 2007-06-06
SI1526867T1 (sl) 2007-10-31
MXPA05001120A (es) 2005-08-03
EA009463B1 (ru) 2007-12-28
CN101099860A (zh) 2008-01-09
EA200500281A1 (ru) 2005-06-30
IL166401A0 (en) 2006-01-15
EA013966B1 (ru) 2010-08-30
JP2010280670A (ja) 2010-12-16
NO20051002L (no) 2005-04-18
EP2191838A1 (de) 2010-06-02
US20100247452A1 (en) 2010-09-30
HK1108625A1 (en) 2008-05-16
KR20100077033A (ko) 2010-07-06
EA200801236A1 (ru) 2009-02-27
US20100247451A1 (en) 2010-09-30
JP2010280671A (ja) 2010-12-16
EP1526867B1 (de) 2007-04-25
ES2345673T3 (es) 2010-09-29
EP1779862A1 (de) 2007-05-02
IS8817A (is) 2009-05-06
IS8909A (is) 2010-07-02
HK1081841A1 (en) 2006-05-26
PT1779862E (pt) 2010-08-18
HRP20070189A2 (en) 2007-07-31
PL395151A1 (pl) 2011-08-16
PL374874A1 (en) 2005-11-14
DK1779862T3 (da) 2010-08-16
CA2710100A1 (en) 2004-02-12
IS7633A (is) 2005-01-06
WO2004012759B1 (de) 2004-07-08
KR20050026513A (ko) 2005-03-15
IL204577A (en) 2012-08-30
US7745387B2 (en) 2010-06-29
EP1526867A2 (de) 2005-05-04
JP4727988B2 (ja) 2011-07-20
US20100247450A1 (en) 2010-09-30
CN101099731B (zh) 2011-02-16
WO2004012759A3 (de) 2004-06-03
AU2003255290A1 (en) 2004-02-23
ZA200500726B (en) 2006-06-28
BR0312981A (pt) 2005-06-14
EA200700196A1 (ru) 2007-04-27
JP2006503001A (ja) 2006-01-26
AU2003255290B2 (en) 2009-04-09
JP2010280672A (ja) 2010-12-16
CY1108052T1 (el) 2013-09-04
SG177004A1 (en) 2012-01-30
CA2493598A1 (en) 2004-02-12
WO2004012759A2 (de) 2004-02-12
PT1526867E (pt) 2007-07-09
ATE360436T1 (de) 2007-05-15
ES2285195T3 (es) 2007-11-16
IS2671B (is) 2010-09-15
HRP20100187A2 (en) 2010-08-31
US20050272634A1 (en) 2005-12-08
AU2009200748A1 (en) 2009-03-19
DE10234192A1 (de) 2004-02-12
UA85997C2 (en) 2009-03-25

Similar Documents

Publication Publication Date Title
UA94913C2 (ru) Применение эритропоэтина для лечения сахарного диабета
MY129512A (en) Novel medicament compositions, based on tiotropium bromide and salmeterol
ZA200604114B (en) Use of substituted 2-aminotetralines for the preventative treatment of parkinson's disease
AP2088A (en) Phenethanolamine derivatives for treatment of respiratory diseases
DE60318193D1 (en) Phenethanolaminderivate
MXPA04002405A (es) Derivados de fenetanolamina para tratamiento de enfermedades respiratorias.
EG24124A (en) Pharmaceutical compositions for the treatment of type-II diabetes mellitus
WO2004037768A3 (en) Phenethanolamine derivatives
DE69719798D1 (de) Periphäre verabreichung von glp-1 analogen und derivate zur reguleirung der fettleibigkeit
HK1087337A1 (en) Use of a hif-alpha stabilizing agent for the preparation of medicament for treatment of diabetes
EP1138673A3 (en) Novel carbamates and ureas as modifiers of multi-drug resistance
MY145590A (en) Phenylacetamides and their use as glucokinase modulators
WO2004037807A3 (en) Medicinal arylethanolamine compounds
EP0703785A4 (en) METHODS FOR TREATING MUSCLE DISEASES AND MUSCLE DISORDER
CA2284732A1 (en) Analogs of ***e
TNSN04203A1 (en) Benzoxazinone-derived compounds, their preparation and use as medicaments
HK1054299A1 (en) Phaseolamin compositions and methods for using thesame
WO2002065979A3 (en) (diazolo-pyridinyl)-pyrimidines for use in treatment of cns disorders and diabetes
AP2001002377A0 (en) Substituted phenoxyacetic acids.
UA29466C2 (ru) Фармацевтическая композиция с антиопухолевой активностью
JO2409B1 (en) Second-phenyl carboxy amides are useful as lipid-lowering agents
NZ508585A (en) Metabolites of ecteinascidin 743
JO2390B1 (en) Diphenylcarboxamides act as lipid-lowering agents
IL157653A0 (en) Novel amides, preparation and therapeutic use as modulators of ccr-receptor activity
ATE528279T1 (de) 3-butenyl-1-aminederivate und ihre verwendung als ih modulatoren von therapie für psychiatrische erkrankungen