ATE141166T1 - Guanidinaminoglycosid enthaltende liposome - Google Patents

Guanidinaminoglycosid enthaltende liposome

Info

Publication number
ATE141166T1
ATE141166T1 AT92106331T AT92106331T ATE141166T1 AT E141166 T1 ATE141166 T1 AT E141166T1 AT 92106331 T AT92106331 T AT 92106331T AT 92106331 T AT92106331 T AT 92106331T AT E141166 T1 ATE141166 T1 AT E141166T1
Authority
AT
Austria
Prior art keywords
minoglycoside
liposomes containing
containing guanidine
aminoglycoside
liposomes
Prior art date
Application number
AT92106331T
Other languages
English (en)
Inventor
Marcel B Bally
Lois E Bolcsak
Pieter R Cullis
Andrew S Janoff
Lawrence D Mayer
Robert P Lenk
Jo Ann Jedrusiak
Original Assignee
Liposome Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27130236&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE141166(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Liposome Co Inc filed Critical Liposome Co Inc
Application granted granted Critical
Publication of ATE141166T1 publication Critical patent/ATE141166T1/de

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22Hormones
    • A61K38/2242Atrial natriuretic factor complex: Atriopeptins, atrial natriuretic protein [ANP]; Cardionatrin, Cardiodilatin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • A61K9/127Liposomes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/02Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20Carbocyclic rings
    • C07H15/22Cyclohexane rings, substituted by nitrogen atoms
    • C07H15/222Cyclohexane rings substituted by at least two nitrogen atoms
    • C07H15/226Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings
AT92106331T 1986-12-23 1987-01-13 Guanidinaminoglycosid enthaltende liposome ATE141166T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US94639186A 1986-12-23 1986-12-23
US94639886A 1986-12-23 1986-12-23

Publications (1)

Publication Number Publication Date
ATE141166T1 true ATE141166T1 (de) 1996-08-15

Family

ID=27130236

Family Applications (2)

Application Number Title Priority Date Filing Date
AT87901176T ATE87503T1 (de) 1986-12-23 1987-01-13 Liposomes praeparat und antibiotikum.
AT92106331T ATE141166T1 (de) 1986-12-23 1987-01-13 Guanidinaminoglycosid enthaltende liposome

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AT87901176T ATE87503T1 (de) 1986-12-23 1987-01-13 Liposomes praeparat und antibiotikum.

Country Status (8)

Country Link
EP (3) EP0498471B1 (de)
JP (1) JP2528153B2 (de)
AT (2) ATE87503T1 (de)
AU (1) AU609711B2 (de)
CA (1) CA1314481C (de)
DE (3) DE3785198T3 (de)
IL (2) IL97538A (de)
WO (1) WO1988004573A1 (de)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4920016A (en) * 1986-12-24 1990-04-24 Linear Technology, Inc. Liposomes with enhanced circulation time
IL90561A (en) * 1988-06-08 1993-08-18 Fountain Pharm Inc Method for making solvent dilution microcarriers
US5269979A (en) * 1988-06-08 1993-12-14 Fountain Pharmaceuticals, Inc. Method for making solvent dilution microcarriers
BE1001869A3 (fr) * 1988-10-12 1990-04-03 Franz Legros Procede d'encapsulation liposomiale d'antibiotiques aminoglucosidiques, en particulier de la gentamycine.
US5843473A (en) * 1989-10-20 1998-12-01 Sequus Pharmaceuticals, Inc. Method of treatment of infected tissues
US6060080A (en) * 1990-07-16 2000-05-09 Daiichi Pharmaceutical Co., Ltd. Liposomal products
CA2046997C (en) * 1990-07-16 2000-12-12 Hiroshi Kikuchi Liposomal products
PT100486B (pt) * 1992-05-14 1999-07-30 Ineti Inst Nac Engenh E Tecnol Aminoglucosidos lipossomais com altas eficacia de encapsulacao e actividade terapeutica, nomeadamente a netilmicina, e processo para a sua preparcao
WO1994012155A1 (en) * 1992-12-02 1994-06-09 Vestar, Inc. Antibiotic formulation and process
US5958449A (en) 1992-12-02 1999-09-28 Nexstar Pharmaceuticals, Inc. Antibiotic formulation and use for bacterial infections
CN1040177C (zh) * 1993-04-23 1998-10-14 江苏省微生物研究所 一种含1-N-乙基庆大霉素C1a或其盐的药用制剂及制备方法
US5759571A (en) * 1993-05-11 1998-06-02 Nexstar Pharmaceuticals, Inc. Antibiotic formulation and use for drug resistant infections
PT729351E (pt) * 1993-11-16 2000-12-29 Skyepharma Inc Vesiculas com libertacao controlada de activos
US6613352B2 (en) 1999-04-13 2003-09-02 Universite De Montreal Low-rigidity liposomal formulation
EP1404297B1 (de) 2001-06-12 2011-04-27 The Johns Hopkins University School Of Medicine Reservoirvorrichtung für die intraokulare arzneimittelabgabe
US20050085432A1 (en) * 2001-12-26 2005-04-21 Aviva Lapidot Methods of using conjugates of saccharides and acetamidino or guanidino compounds for treating bacterial infections
US7544369B2 (en) * 2002-10-29 2009-06-09 Transave, Inc. Sustained release of antiinfectives
US7718189B2 (en) 2002-10-29 2010-05-18 Transave, Inc. Sustained release of antiinfectives
CA2896083A1 (en) 2005-12-08 2007-06-14 Insmed Incorporated Lipid-based compositions of antiinfectives for treating pulmonary infections and methods of use thereof
WO2008137717A1 (en) 2007-05-04 2008-11-13 Transave, Inc. Compositions of multicationic drugs for reducing interactions with polyanionic biomolecules and methods and uses thereof
US9114081B2 (en) 2007-05-07 2015-08-25 Insmed Incorporated Methods of treating pulmonary disorders with liposomal amikacin formulations
US9119783B2 (en) 2007-05-07 2015-09-01 Insmed Incorporated Method of treating pulmonary disorders with liposomal amikacin formulations
US9333214B2 (en) 2007-05-07 2016-05-10 Insmed Incorporated Method for treating pulmonary disorders with liposomal amikacin formulations
WO2010088548A1 (en) 2009-01-29 2010-08-05 Forsight Labs, Llc Posterior segment drug delivery
US8623395B2 (en) 2010-01-29 2014-01-07 Forsight Vision4, Inc. Implantable therapeutic device
WO2012019139A1 (en) 2010-08-05 2012-02-09 Forsight Vision4, Inc. Combined drug delivery methods and apparatus
EP3861969A1 (de) 2010-08-05 2021-08-11 ForSight Vision4, Inc. Injektorvorrichtung zur arzneimittelabgabe
SI2600812T1 (sl) 2010-08-05 2021-12-31 ForSight Vision4, Inc., Naprava za zdravljenje očesa
US20140031769A1 (en) 2010-11-19 2014-01-30 Forsight Vision4, Inc. Therapeutic agent formulations for implanted devices
EP4249059A3 (de) 2011-06-28 2023-11-29 ForSight Vision4, Inc. Vorrichtung zum sammeln einer flüssigkeitsprobe aus einer reservoirkammer einer therapeutischen vorrichtung für das auge
EP2739252A4 (de) 2011-08-05 2015-08-12 Forsight Vision4 Inc Abgabe kleiner moleküle über eine implantierbare therapeutische vorrichtung
LT2755600T (lt) 2011-09-16 2021-04-26 Forsight Vision4, Inc. Skysčio pakeitimo aparatas
WO2013116061A1 (en) 2012-02-03 2013-08-08 Forsight Vision4, Inc. Insertion and removal methods and apparatus for therapeutic devices
JP6402097B2 (ja) 2012-05-21 2018-10-10 インスメッド インコーポレイテッド 肺感染症を処置するためのシステム
RU2018135921A (ru) 2012-11-29 2019-02-05 Инсмед Инкорпорейтед Стабилизированные составы ванкомицина
EP2968113B8 (de) 2013-03-14 2020-10-28 Forsight Vision4, Inc. Systeme zur verzögerten intraokularen abgabe schwerlöslicher verbindungen aus einem implantat mit einem portabgabesystem
CA2907681C (en) 2013-03-28 2022-11-22 Forsight Vision4, Inc. Ophthalmic implant for delivering therapeutic substances
BR112016026699B1 (pt) 2014-05-15 2022-09-13 Insmed Incorporated Uso de uma composição farmaceutica de amicacina ou de um sal farmaceuticamente aceitável desta
KR102416726B1 (ko) 2014-07-15 2022-07-05 포사이트 비젼4, 인크. 안구 이식물 전달 디바이스 및 방법
EP3177289A4 (de) 2014-08-08 2018-03-21 Forsight Vision4, Inc. Stabile und lösliche formulierungen von rezeptortyrosinkinaseinhibitoren und verfahren zur herstellung davon
AU2015346450B2 (en) 2014-11-10 2020-01-30 Forsight Vision4, Inc. Expandable drug delivery devices and method of use
EP3377009B1 (de) 2015-11-20 2020-10-28 ForSight Vision4, Inc. Poröse strukturen für arzneimittelabgabevorrichtungen mit verlängerter freisetzung
EP3439591B1 (de) 2016-04-05 2020-09-23 ForSight Vision4, Inc. Implantierbare okulare arzneimittelabgabevorrichtungen
KR20200093581A (ko) 2017-11-21 2020-08-05 포사이트 비젼4, 인크. 확장 가능한 포트 전달 시스템을 위한 유체 교환 기기 및 사용 방법
JP7460534B2 (ja) 2018-03-30 2024-04-02 インスメッド インコーポレイテッド リポソーム医薬品の連続製造方法

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3993754A (en) * 1974-10-09 1976-11-23 The United States Of America As Represented By The United States Energy Research And Development Administration Liposome-encapsulated actinomycin for cancer chemotherapy
JPS5186117A (en) * 1975-01-27 1976-07-28 Tanabe Seiyaku Co Johoseibiryushiseizainoseiho
US4086257A (en) * 1976-10-12 1978-04-25 Sears Barry D Phosphatidyl quaternary ammonium compounds
CH624011A5 (de) * 1977-08-05 1981-07-15 Battelle Memorial Institute
US4235871A (en) * 1978-02-24 1980-11-25 Papahadjopoulos Demetrios P Method of encapsulating biologically active materials in lipid vesicles
US4397846A (en) * 1981-05-15 1983-08-09 Murray Weiner Storage-stable lipid vesicles and method of preparation
JPS59500952A (ja) * 1982-03-29 1984-05-31 ザ リポソ−ム カンパニ−、インコ−ポレ−テッド 安定なプルリラメラベシクル類
US4522803A (en) * 1983-02-04 1985-06-11 The Liposome Company, Inc. Stable plurilamellar vesicles, their preparation and use
SU1123697A1 (ru) * 1982-08-18 1984-11-15 Всесоюзный научно-исследовательский институт фармации Способ получени липосомальной формы антибиотиков стрептомицинового р да
US4588578A (en) * 1983-08-08 1986-05-13 The Liposome Company, Inc. Lipid vesicles prepared in a monophase
JPS59210013A (ja) * 1983-05-04 1984-11-28 Ajinomoto Co Inc 活性物質含有リポソ−ム
US4515736A (en) * 1983-05-12 1985-05-07 The Regents Of The University Of California Method for encapsulating materials into liposomes
MX160365A (es) * 1983-08-31 1990-02-12 Rockwell International Corp Mejoras a metodo para formar un piston de frenado para freno de disco
US4532089A (en) * 1984-01-14 1985-07-30 Northwestern University Method of preparing giant size liposomes
US4610868A (en) * 1984-03-20 1986-09-09 The Liposome Company, Inc. Lipid matrix carriers for use in drug delivery systems
JPH0655676B2 (ja) * 1984-07-26 1994-07-27 ザ リポソ−ム カンパニ−、インコ−ポレ−テツド 脂質小胞体中に含有された抗菌物質の混合物による抗菌活性の増高
JPH0680767A (ja) * 1992-09-03 1994-03-22 Matsushita Electric Ind Co Ltd 電子・電気機器用エポキシ樹脂組成物

Also Published As

Publication number Publication date
DE3785198T3 (de) 1999-09-02
IL97538A0 (en) 1992-06-21
WO1988004573A1 (en) 1988-06-30
EP0295248B1 (de) 1993-03-31
EP0295248B2 (de) 1999-04-28
AU609711B2 (en) 1991-05-09
DE3751871T4 (de) 1998-03-26
CA1314481C (en) 1993-03-16
EP0500143A3 (en) 1993-03-03
EP0500143A2 (de) 1992-08-26
DE3785198D1 (de) 1993-05-06
DE3751871T2 (de) 1997-03-13
IL97538A (en) 1995-03-15
AU6934587A (en) 1988-07-15
JPH01501619A (ja) 1989-06-08
DE3751871D1 (de) 1996-09-19
EP0498471A2 (de) 1992-08-12
ATE87503T1 (de) 1993-04-15
EP0498471B1 (de) 1996-08-14
DE3785198T2 (de) 1993-07-15
EP0295248A1 (de) 1988-12-21
JP2528153B2 (ja) 1996-08-28
EP0295248A4 (de) 1988-12-19
EP0498471A3 (en) 1993-03-03

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Legal Events

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REN Ceased due to non-payment of the annual fee