DE3785198T3 - Liposomes präparat und antibiotikum. - Google Patents
Liposomes präparat und antibiotikum.Info
- Publication number
- DE3785198T3 DE3785198T3 DE3785198T DE3785198T DE3785198T3 DE 3785198 T3 DE3785198 T3 DE 3785198T3 DE 3785198 T DE3785198 T DE 3785198T DE 3785198 T DE3785198 T DE 3785198T DE 3785198 T3 DE3785198 T3 DE 3785198T3
- Authority
- DE
- Germany
- Prior art keywords
- antibiotic
- liposomes preparation
- preparation
- liposomes
- aminoglycoside
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/2242—Atrial natriuretic factor complex: Atriopeptins, atrial natriuretic protein [ANP]; Cardionatrin, Cardiodilatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
- C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
- C07H15/226—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US94639886A | 1986-12-23 | 1986-12-23 | |
US94639186A | 1986-12-23 | 1986-12-23 | |
PCT/US1987/000077 WO1988004573A1 (en) | 1986-12-23 | 1987-01-13 | Liposome preparation and antibiotic |
Publications (3)
Publication Number | Publication Date |
---|---|
DE3785198D1 DE3785198D1 (de) | 1993-05-06 |
DE3785198T2 DE3785198T2 (de) | 1993-07-15 |
DE3785198T3 true DE3785198T3 (de) | 1999-09-02 |
Family
ID=27130236
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE3751871A Expired - Fee Related DE3751871D1 (de) | 1986-12-23 | 1987-01-13 | Guanidinaminoglycosid enthaltende Liposome |
DE3751871T Expired - Lifetime DE3751871T4 (de) | 1986-12-23 | 1987-01-13 | Guanidinaminoglycosid enthaltende Liposome |
DE3785198T Expired - Lifetime DE3785198T3 (de) | 1986-12-23 | 1987-01-13 | Liposomes präparat und antibiotikum. |
Family Applications Before (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE3751871A Expired - Fee Related DE3751871D1 (de) | 1986-12-23 | 1987-01-13 | Guanidinaminoglycosid enthaltende Liposome |
DE3751871T Expired - Lifetime DE3751871T4 (de) | 1986-12-23 | 1987-01-13 | Guanidinaminoglycosid enthaltende Liposome |
Country Status (8)
Country | Link |
---|---|
EP (3) | EP0500143A3 (de) |
JP (1) | JP2528153B2 (de) |
AT (2) | ATE87503T1 (de) |
AU (1) | AU609711B2 (de) |
CA (1) | CA1314481C (de) |
DE (3) | DE3751871D1 (de) |
IL (2) | IL97538A (de) |
WO (1) | WO1988004573A1 (de) |
Families Citing this family (45)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4920016A (en) * | 1986-12-24 | 1990-04-24 | Linear Technology, Inc. | Liposomes with enhanced circulation time |
US5269979A (en) * | 1988-06-08 | 1993-12-14 | Fountain Pharmaceuticals, Inc. | Method for making solvent dilution microcarriers |
CA1340241C (en) * | 1988-06-08 | 1998-12-15 | Fountain Pharmaceuticals, Inc. | Method for marking solvent dilution microcarriers |
BE1001869A3 (fr) * | 1988-10-12 | 1990-04-03 | Franz Legros | Procede d'encapsulation liposomiale d'antibiotiques aminoglucosidiques, en particulier de la gentamycine. |
US5843473A (en) * | 1989-10-20 | 1998-12-01 | Sequus Pharmaceuticals, Inc. | Method of treatment of infected tissues |
CA2046997C (en) * | 1990-07-16 | 2000-12-12 | Hiroshi Kikuchi | Liposomal products |
US6060080A (en) * | 1990-07-16 | 2000-05-09 | Daiichi Pharmaceutical Co., Ltd. | Liposomal products |
PT100486B (pt) * | 1992-05-14 | 1999-07-30 | Ineti Inst Nac Engenh E Tecnol | Aminoglucosidos lipossomais com altas eficacia de encapsulacao e actividade terapeutica, nomeadamente a netilmicina, e processo para a sua preparcao |
WO1994012155A1 (en) * | 1992-12-02 | 1994-06-09 | Vestar, Inc. | Antibiotic formulation and process |
US5958449A (en) | 1992-12-02 | 1999-09-28 | Nexstar Pharmaceuticals, Inc. | Antibiotic formulation and use for bacterial infections |
CN1040177C (zh) * | 1993-04-23 | 1998-10-14 | 江苏省微生物研究所 | 一种含1-N-乙基庆大霉素C1a或其盐的药用制剂及制备方法 |
US5759571A (en) * | 1993-05-11 | 1998-06-02 | Nexstar Pharmaceuticals, Inc. | Antibiotic formulation and use for drug resistant infections |
ES2149955T3 (es) * | 1993-11-16 | 2000-11-16 | Skyepharma Inc | Vesiculas con liberacion controlada de sustancias activas. |
US6613352B2 (en) | 1999-04-13 | 2003-09-02 | Universite De Montreal | Low-rigidity liposomal formulation |
EP1404297B1 (de) | 2001-06-12 | 2011-04-27 | The Johns Hopkins University School Of Medicine | Reservoirvorrichtung für die intraokulare arzneimittelabgabe |
US20050085432A1 (en) * | 2001-12-26 | 2005-04-21 | Aviva Lapidot | Methods of using conjugates of saccharides and acetamidino or guanidino compounds for treating bacterial infections |
JP5118302B2 (ja) * | 2002-10-29 | 2013-01-16 | トランセイブ, インク. | 抗感染剤の徐放 |
US7718189B2 (en) | 2002-10-29 | 2010-05-18 | Transave, Inc. | Sustained release of antiinfectives |
CA2838111C (en) | 2005-12-08 | 2016-01-19 | Insmed Incorporated | Lipid-based compositions of antiinfectives for treating pulmonary infections and methods of use thereof |
US20100196455A1 (en) | 2007-05-04 | 2010-08-05 | Transave, Inc. | Compositions of Multicationic Drugs for Reducing Interactions with Polyanionic Biomolecules and Methods of Use Thereof |
US9114081B2 (en) | 2007-05-07 | 2015-08-25 | Insmed Incorporated | Methods of treating pulmonary disorders with liposomal amikacin formulations |
US9333214B2 (en) | 2007-05-07 | 2016-05-10 | Insmed Incorporated | Method for treating pulmonary disorders with liposomal amikacin formulations |
US9119783B2 (en) | 2007-05-07 | 2015-09-01 | Insmed Incorporated | Method of treating pulmonary disorders with liposomal amikacin formulations |
SG173167A1 (en) | 2009-01-29 | 2011-08-29 | Forsight Labs Llc | Posterior segment drug delivery |
US8623395B2 (en) | 2010-01-29 | 2014-01-07 | Forsight Vision4, Inc. | Implantable therapeutic device |
WO2013022801A1 (en) | 2011-08-05 | 2013-02-14 | Forsight Vision4, Inc. | Small molecule delivery with implantable therapeutic device |
EP2600930B1 (de) | 2010-08-05 | 2021-02-17 | ForSight Vision4, Inc. | Injektionsapparat zur verabreichung von medikamenten |
CA2807554C (en) | 2010-08-05 | 2021-10-26 | Forsight Vision4 Inc. | Implantable therapeutic device |
EP2600876B1 (de) | 2010-08-05 | 2015-04-29 | Forsight Vision4, Inc. | Verfahren und vorrichtung zur verabreichung kombinierter arzneimittel |
CA2818612C (en) | 2010-11-19 | 2020-12-29 | Forsight Vision4, Inc. | Therapeutic agent formulations for implanted devices |
EP2726016B1 (de) | 2011-06-28 | 2023-07-19 | ForSight Vision4, Inc. | Vorrichtung zum sammeln einer flüssigkeitsprobe aus einer reservoirkammer einer therapeutischen vorrichtung für das auge |
PT2755600T (pt) | 2011-09-16 | 2021-04-19 | Forsight Vision4 Inc | Aparelhos de troca de fluidos |
US10010448B2 (en) | 2012-02-03 | 2018-07-03 | Forsight Vision4, Inc. | Insertion and removal methods and apparatus for therapeutic devices |
CN108743537B (zh) | 2012-05-21 | 2021-06-11 | 英斯麦德公司 | 治疗肺部感染的*** |
US10124066B2 (en) | 2012-11-29 | 2018-11-13 | Insmed Incorporated | Stabilized vancomycin formulations |
WO2014152959A1 (en) | 2013-03-14 | 2014-09-25 | Forsight Vision4, Inc. | Systems for sustained intraocular delivery of low solubility compounds from a port delivery system implant |
US9526654B2 (en) | 2013-03-28 | 2016-12-27 | Forsight Vision4, Inc. | Ophthalmic implant for delivering therapeutic substances |
ES2820226T3 (es) | 2014-05-15 | 2021-04-20 | Insmed Inc | Métodos para tratar infecciones pulmonares micobacterianas no tuberculosas |
CN106687079B (zh) | 2014-07-15 | 2019-10-11 | 弗赛特影像4股份有限公司 | 眼睛植入输送装置和方法 |
EP3177289A4 (de) | 2014-08-08 | 2018-03-21 | Forsight Vision4, Inc. | Stabile und lösliche formulierungen von rezeptortyrosinkinaseinhibitoren und verfahren zur herstellung davon |
WO2016077371A1 (en) | 2014-11-10 | 2016-05-19 | Forsight Vision4, Inc. | Expandable drug delivery devices and method of use |
US11432959B2 (en) | 2015-11-20 | 2022-09-06 | Forsight Vision4, Inc. | Porous structures for extended release drug delivery devices |
EP3439591B1 (de) | 2016-04-05 | 2020-09-23 | ForSight Vision4, Inc. | Implantierbare okulare arzneimittelabgabevorrichtungen |
WO2019103906A1 (en) | 2017-11-21 | 2019-05-31 | Forsight Vision4, Inc. | Fluid exchange apparatus for expandable port delivery system and methods of use |
EP3773505A4 (de) | 2018-03-30 | 2021-12-22 | Insmed Incorporated | Verfahren zur kontinuierlichen herstellung von liposomalen arzneimittelprodukten |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3993754A (en) * | 1974-10-09 | 1976-11-23 | The United States Of America As Represented By The United States Energy Research And Development Administration | Liposome-encapsulated actinomycin for cancer chemotherapy |
JPS5186117A (en) * | 1975-01-27 | 1976-07-28 | Tanabe Seiyaku Co | Johoseibiryushiseizainoseiho |
US4086257A (en) * | 1976-10-12 | 1978-04-25 | Sears Barry D | Phosphatidyl quaternary ammonium compounds |
CH624011A5 (de) * | 1977-08-05 | 1981-07-15 | Battelle Memorial Institute | |
US4235871A (en) * | 1978-02-24 | 1980-11-25 | Papahadjopoulos Demetrios P | Method of encapsulating biologically active materials in lipid vesicles |
US4397846A (en) * | 1981-05-15 | 1983-08-09 | Murray Weiner | Storage-stable lipid vesicles and method of preparation |
JPS59500952A (ja) * | 1982-03-29 | 1984-05-31 | ザ リポソ−ム カンパニ−、インコ−ポレ−テッド | 安定なプルリラメラベシクル類 |
US4522803A (en) * | 1983-02-04 | 1985-06-11 | The Liposome Company, Inc. | Stable plurilamellar vesicles, their preparation and use |
SU1123697A1 (ru) * | 1982-08-18 | 1984-11-15 | Всесоюзный научно-исследовательский институт фармации | Способ получени липосомальной формы антибиотиков стрептомицинового р да |
US4588578A (en) * | 1983-08-08 | 1986-05-13 | The Liposome Company, Inc. | Lipid vesicles prepared in a monophase |
JPS59210013A (ja) * | 1983-05-04 | 1984-11-28 | Ajinomoto Co Inc | 活性物質含有リポソ−ム |
US4515736A (en) * | 1983-05-12 | 1985-05-07 | The Regents Of The University Of California | Method for encapsulating materials into liposomes |
WO1985001103A1 (en) * | 1983-08-31 | 1985-03-14 | Diagraph Corporation | Ink jet printing apparatus |
US4532089A (en) * | 1984-01-14 | 1985-07-30 | Northwestern University | Method of preparing giant size liposomes |
US4610868A (en) * | 1984-03-20 | 1986-09-09 | The Liposome Company, Inc. | Lipid matrix carriers for use in drug delivery systems |
JPH0655676B2 (ja) * | 1984-07-26 | 1994-07-27 | ザ リポソ−ム カンパニ−、インコ−ポレ−テツド | 脂質小胞体中に含有された抗菌物質の混合物による抗菌活性の増高 |
JPH0680767A (ja) * | 1992-09-03 | 1994-03-22 | Matsushita Electric Ind Co Ltd | 電子・電気機器用エポキシ樹脂組成物 |
-
1987
- 1987-01-13 EP EP19920106330 patent/EP0500143A3/en not_active Withdrawn
- 1987-01-13 AU AU69345/87A patent/AU609711B2/en not_active Ceased
- 1987-01-13 DE DE3751871A patent/DE3751871D1/de not_active Expired - Fee Related
- 1987-01-13 IL IL9753887A patent/IL97538A/en not_active IP Right Cessation
- 1987-01-13 CA CA000527232A patent/CA1314481C/en not_active Expired - Fee Related
- 1987-01-13 DE DE3751871T patent/DE3751871T4/de not_active Expired - Lifetime
- 1987-01-13 DE DE3785198T patent/DE3785198T3/de not_active Expired - Lifetime
- 1987-01-13 AT AT87901176T patent/ATE87503T1/de not_active IP Right Cessation
- 1987-01-13 JP JP62501069A patent/JP2528153B2/ja not_active Expired - Fee Related
- 1987-01-13 EP EP92106331A patent/EP0498471B1/de not_active Expired - Lifetime
- 1987-01-13 WO PCT/US1987/000077 patent/WO1988004573A1/en active IP Right Grant
- 1987-01-13 EP EP87901176A patent/EP0295248B2/de not_active Expired - Lifetime
- 1987-01-13 AT AT92106331T patent/ATE141166T1/de not_active IP Right Cessation
-
1991
- 1991-03-13 IL IL97538A patent/IL97538A0/xx unknown
Also Published As
Publication number | Publication date |
---|---|
AU6934587A (en) | 1988-07-15 |
EP0498471B1 (de) | 1996-08-14 |
DE3751871T4 (de) | 1998-03-26 |
EP0295248B1 (de) | 1993-03-31 |
JPH01501619A (ja) | 1989-06-08 |
EP0295248A4 (de) | 1988-12-19 |
EP0498471A2 (de) | 1992-08-12 |
ATE87503T1 (de) | 1993-04-15 |
WO1988004573A1 (en) | 1988-06-30 |
IL97538A0 (en) | 1992-06-21 |
AU609711B2 (en) | 1991-05-09 |
EP0500143A2 (de) | 1992-08-26 |
DE3751871D1 (de) | 1996-09-19 |
DE3785198D1 (de) | 1993-05-06 |
CA1314481C (en) | 1993-03-16 |
EP0498471A3 (en) | 1993-03-03 |
DE3785198T2 (de) | 1993-07-15 |
JP2528153B2 (ja) | 1996-08-28 |
ATE141166T1 (de) | 1996-08-15 |
EP0295248B2 (de) | 1999-04-28 |
IL97538A (en) | 1995-03-15 |
EP0500143A3 (en) | 1993-03-03 |
EP0295248A1 (de) | 1988-12-21 |
DE3751871T2 (de) | 1997-03-13 |
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