RU2018135921A - Стабилизированные составы ванкомицина - Google Patents
Стабилизированные составы ванкомицина Download PDFInfo
- Publication number
- RU2018135921A RU2018135921A RU2018135921A RU2018135921A RU2018135921A RU 2018135921 A RU2018135921 A RU 2018135921A RU 2018135921 A RU2018135921 A RU 2018135921A RU 2018135921 A RU2018135921 A RU 2018135921A RU 2018135921 A RU2018135921 A RU 2018135921A
- Authority
- RU
- Russia
- Prior art keywords
- glycopeptide antibiotic
- lipid
- stabilized
- antibiotic composition
- composition according
- Prior art date
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- 239000000203 mixture Substances 0.000 title claims 21
- MYPYJXKWCTUITO-LYRMYLQWSA-N vancomycin Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=C2C=C3C=C1OC1=CC=C(C=C1Cl)[C@@H](O)[C@H](C(N[C@@H](CC(N)=O)C(=O)N[C@H]3C(=O)N[C@H]1C(=O)N[C@H](C(N[C@@H](C3=CC(O)=CC(O)=C3C=3C(O)=CC=C1C=3)C(O)=O)=O)[C@H](O)C1=CC=C(C(=C1)Cl)O2)=O)NC(=O)[C@@H](CC(C)C)NC)[C@H]1C[C@](C)(N)[C@H](O)[C@H](C)O1 MYPYJXKWCTUITO-LYRMYLQWSA-N 0.000 title claims 17
- 108010059993 Vancomycin Proteins 0.000 title 1
- 229960003165 vancomycin Drugs 0.000 title 1
- MYPYJXKWCTUITO-UHFFFAOYSA-N vancomycin Natural products O1C(C(=C2)Cl)=CC=C2C(O)C(C(NC(C2=CC(O)=CC(O)=C2C=2C(O)=CC=C3C=2)C(O)=O)=O)NC(=O)C3NC(=O)C2NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(CC(C)C)NC)C(O)C(C=C3Cl)=CC=C3OC3=CC2=CC1=C3OC1OC(CO)C(O)C(O)C1OC1CC(C)(N)C(O)C(C)O1 MYPYJXKWCTUITO-UHFFFAOYSA-N 0.000 title 1
- 239000003910 polypeptide antibiotic agent Substances 0.000 claims 16
- 150000002632 lipids Chemical class 0.000 claims 15
- 150000001413 amino acids Chemical class 0.000 claims 6
- 230000003115 biocidal effect Effects 0.000 claims 6
- 238000000354 decomposition reaction Methods 0.000 claims 4
- DQJCDTNMLBYVAY-ZXXIYAEKSA-N (2S,5R,10R,13R)-16-{[(2R,3S,4R,5R)-3-{[(2S,3R,4R,5S,6R)-3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-5-(ethylamino)-6-hydroxy-2-(hydroxymethyl)oxan-4-yl]oxy}-5-(4-aminobutyl)-10-carbamoyl-2,13-dimethyl-4,7,12,15-tetraoxo-3,6,11,14-tetraazaheptadecan-1-oic acid Chemical compound NCCCC[C@H](C(=O)N[C@@H](C)C(O)=O)NC(=O)CC[C@H](C(N)=O)NC(=O)[C@@H](C)NC(=O)C(C)O[C@@H]1[C@@H](NCC)C(O)O[C@H](CO)[C@H]1O[C@H]1[C@H](NC(C)=O)[C@@H](O)[C@H](O)[C@@H](CO)O1 DQJCDTNMLBYVAY-ZXXIYAEKSA-N 0.000 claims 1
- 102000002068 Glycopeptides Human genes 0.000 claims 1
- 108010015899 Glycopeptides Proteins 0.000 claims 1
- 150000001412 amines Chemical class 0.000 claims 1
- 230000015556 catabolic process Effects 0.000 claims 1
- 230000007423 decrease Effects 0.000 claims 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
- A61K31/685—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/14—Peptides containing saccharide radicals; Derivatives thereof, e.g. bleomycin, phleomycin, muramylpeptides or vancomycin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/28—Steroids, e.g. cholesterol, bile acids or glycyrrhetinic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Dispersion Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Pulmonology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
Claims (14)
1. Стабилизированная композиция гликопептидного антибиотика на основе липида, содержащая:
липидный компонент;
гликопептидный антибиотик; и
аминокислоту или ее производное,
где аминокислота или ее производное стабилизирует гликопептидный антибиотик.
2. Стабилизированная композиция гликопептидного антибиотика на основе липида по п.1, где аминокислота или ее производное уменьшает скорость распада гликопептидного антибиотика.
3. Стабилизированная композиция гликопептидного антибиотика на основе липида по п.1, где стабилизированный комплекс гликопептидный антибиотик-аминокислота захвачен липидным компонентом.
4. Стабилизированная композиция гликопептидного антибиотика на основе липида по п.1, где композиция антибиотика является по меньшей мере на 44% более стабильной, чем композиция антибиотика, содержащая такой же липидный компонент и такой же гликопептидный антибиотик, не содержащая аминокислоту или ее производное.
5. Стабилизированная композиция гликопептидного антибиотика на основе липида по п.1, где композиция антибиотика является по меньшей мере на 77% более стабильной чем композиция антибиотика, содержащая такой же липидный компонент и такой же гликопептидный антибиотик, не содержащая аминокислоту или ее производное.
6. Стабилизированная композиция гликопептидного антибиотика на основе липида по п.1, где композиция антибиотика является по меньшей мере на 88% более стабильной, чем композиция антибиотика, содержащая такой же липидный компонент и такой же гликопептидный антибиотик, не содержащая аминокислоту или ее производное.
7. Стабилизированная композиция гликопептидного антибиотика на основе липида по п.1, где композиция образует продукты распада со скоростью менее 0,05% по массе в неделю при 4°C.
8. Стабилизированная композиция гликопептидного антибиотика на основе липида по п.1, где композиция образует продукты распада со скоростью менее 0,02% по массе в неделю при 4°C.
9. Стабилизированная композиция гликопептидного антибиотика на основе липида по п.1, где композиция образует продукты распада со скоростью менее 0,01% по массе в неделю при 4°C.
10. Стабилизированная композиция гликопептидного антибиотика на основе липида по п.1, где композиция образует продукты распада со скоростью менее приблизительно 0,4% по массе в неделю при комнатной температуре.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261731363P | 2012-11-29 | 2012-11-29 | |
US61/731,363 | 2012-11-29 |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RU2015125293A Division RU2675859C2 (ru) | 2012-11-29 | 2013-11-27 | Стабилизированные составы ванкомицина |
Publications (1)
Publication Number | Publication Date |
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RU2018135921A true RU2018135921A (ru) | 2019-02-05 |
Family
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RU2018135921A RU2018135921A (ru) | 2012-11-29 | 2013-11-27 | Стабилизированные составы ванкомицина |
RU2015125293A RU2675859C2 (ru) | 2012-11-29 | 2013-11-27 | Стабилизированные составы ванкомицина |
Family Applications After (1)
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RU2015125293A RU2675859C2 (ru) | 2012-11-29 | 2013-11-27 | Стабилизированные составы ванкомицина |
Country Status (12)
Country | Link |
---|---|
US (2) | US10124066B2 (ru) |
EP (2) | EP3581186A1 (ru) |
JP (2) | JP6529438B2 (ru) |
CN (1) | CN104884047A (ru) |
AU (1) | AU2013352259B2 (ru) |
BR (1) | BR112015012351A8 (ru) |
CA (1) | CA2891487A1 (ru) |
ES (1) | ES2743039T3 (ru) |
HK (1) | HK1216008A1 (ru) |
MX (1) | MX2015006681A (ru) |
RU (2) | RU2018135921A (ru) |
WO (1) | WO2014085526A1 (ru) |
Families Citing this family (25)
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EP1962805B1 (en) | 2005-12-08 | 2016-07-06 | Insmed Incorporated | Lipid-based compositions of antiinfectives for treating pulmonary infections |
US9119783B2 (en) | 2007-05-07 | 2015-09-01 | Insmed Incorporated | Method of treating pulmonary disorders with liposomal amikacin formulations |
EP3581186A1 (en) | 2012-11-29 | 2019-12-18 | Insmed Incorporated | Stabilized vancomycin formulations |
US9895385B2 (en) | 2014-05-15 | 2018-02-20 | Insmed Incorporated | Methods for treating pulmonary non-tuberculous mycobacterial infections |
RS61418B1 (sr) * | 2014-11-06 | 2021-03-31 | Xellia Pharmaceuticals Aps | Kompozicije glikopeptida |
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US20190000789A1 (en) * | 2015-12-24 | 2019-01-03 | Universiteit Leiden | Composition and method for treating infections caused by vancomycin-resistant infectious agents in a subject |
JP6949849B2 (ja) * | 2016-01-15 | 2021-10-13 | サイドース ファーマ エルエルシー | バンコマイシンの製剤 |
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EP3454883A1 (en) | 2016-05-09 | 2019-03-20 | Xellia Pharmaceuticals ApS | Stabilized glycopeptide antibiotic formulations |
WO2018031782A1 (en) * | 2016-08-10 | 2018-02-15 | The Arizona Board Of Regents On Behalf Of The University Of Arizona | Nanoparticle compositions and methods for enhanced stability and delivery of glycopeptide drugs |
RU2019119405A (ru) * | 2016-11-23 | 2020-12-25 | Гуфик Байосайенсиз Лимитед | Лиофилизированные фармацевтические композиции далбаванцина |
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CN109725101B (zh) * | 2017-10-31 | 2021-11-19 | 正大天晴药业集团股份有限公司 | 盐酸特拉万星原料中有关物质的检测方法 |
US11571386B2 (en) | 2018-03-30 | 2023-02-07 | Insmed Incorporated | Methods for continuous manufacture of liposomal drug products |
KR20210024451A (ko) * | 2018-05-02 | 2021-03-05 | 인스메드 인코포레이티드 | 리포솜 약물 제형을 제조하는 방법 |
CN109078001B (zh) * | 2018-09-21 | 2021-05-07 | 深圳浦瑞健康科技有限公司 | 一种万古霉素纳米脂质体组合物及其制备方法 |
CN111103363B (zh) * | 2018-10-26 | 2024-03-22 | 复旦大学附属华山医院 | 测定人血清中万古霉素和降解产物浓度的方法 |
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JPWO2022050369A1 (ru) * | 2020-09-04 | 2022-03-10 | ||
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CN115804832A (zh) * | 2021-09-14 | 2023-03-17 | 海南普利制药股份有限公司 | 一种万古霉素水溶液组合物 |
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- 2013-11-27 EP EP19167132.0A patent/EP3581186A1/en not_active Withdrawn
- 2013-11-27 RU RU2018135921A patent/RU2018135921A/ru not_active Application Discontinuation
- 2013-11-27 RU RU2015125293A patent/RU2675859C2/ru not_active IP Right Cessation
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- 2013-11-27 US US14/648,203 patent/US10124066B2/en not_active Expired - Fee Related
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- 2013-11-27 MX MX2015006681A patent/MX2015006681A/es unknown
- 2013-11-27 CN CN201380068974.7A patent/CN104884047A/zh active Pending
- 2013-11-27 EP EP13858844.7A patent/EP2925298B1/en not_active Not-in-force
- 2013-11-27 CA CA2891487A patent/CA2891487A1/en not_active Abandoned
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ES2743039T3 (es) | 2020-02-18 |
US10471149B2 (en) | 2019-11-12 |
AU2013352259B2 (en) | 2018-06-14 |
EP2925298A4 (en) | 2016-07-13 |
JP2019031554A (ja) | 2019-02-28 |
CA2891487A1 (en) | 2014-06-05 |
EP2925298B1 (en) | 2019-05-29 |
BR112015012351A2 (pt) | 2017-07-11 |
JP2016505545A (ja) | 2016-02-25 |
CN104884047A (zh) | 2015-09-02 |
MX2015006681A (es) | 2016-04-06 |
US10124066B2 (en) | 2018-11-13 |
AU2013352259A1 (en) | 2015-06-04 |
WO2014085526A1 (en) | 2014-06-05 |
RU2015125293A (ru) | 2017-01-10 |
EP3581186A1 (en) | 2019-12-18 |
RU2675859C2 (ru) | 2018-12-25 |
US20190022232A1 (en) | 2019-01-24 |
EP2925298A1 (en) | 2015-10-07 |
US20150314002A1 (en) | 2015-11-05 |
BR112015012351A8 (pt) | 2019-10-01 |
JP6529438B2 (ja) | 2019-06-12 |
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