AR108615A2 - Terapia adyuvante con herceptin® - Google Patents
Terapia adyuvante con herceptin®Info
- Publication number
- AR108615A2 AR108615A2 ARP170101322A ARP170101322A AR108615A2 AR 108615 A2 AR108615 A2 AR 108615A2 AR P170101322 A ARP170101322 A AR P170101322A AR P170101322 A ARP170101322 A AR P170101322A AR 108615 A2 AR108615 A2 AR 108615A2
- Authority
- AR
- Argentina
- Prior art keywords
- herceptin
- therapy
- adjutive
- breast cancer
- metastatic breast
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16H20/00—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance
- G16H20/10—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/14—Drugs for genital or sexual disorders; Contraceptives for lactation disorders, e.g. galactorrhoea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A90/00—Technologies having an indirect contribution to adaptation to climate change
- Y02A90/10—Information and communication technologies [ICT] supporting adaptation to climate change, e.g. for weather forecasting or climate simulation
Abstract
Terapia adyuvante del cáncer de mama no metastásico que emplea HERCEPTIN®.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US68112505P | 2005-05-13 | 2005-05-13 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR108615A2 true AR108615A2 (es) | 2018-09-12 |
Family
ID=37450489
Family Applications (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AR20060101586A AR054254A1 (es) | 2005-05-13 | 2006-04-21 | Terapia adyuvante con trastuzumab (herceptin registrado) |
ARP120103682A AR088110A2 (es) | 2005-05-13 | 2012-10-03 | Uso de un inmunoconjugado que comprende un anticuerpo anti-erbb2 para la manufactura de un medicamento |
ARP170101287A AR109246A2 (es) | 2005-05-13 | 2017-05-15 | USO DE UN INMUNOCONJUGADO QUE COMPRENDE UN ANTICUERPO ANTI-ErbB2 PARA LA MANUFACTURA DE UN MEDICAMENTO |
ARP170101322A AR108615A2 (es) | 2005-05-13 | 2017-05-17 | Terapia adyuvante con herceptin® |
Family Applications Before (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AR20060101586A AR054254A1 (es) | 2005-05-13 | 2006-04-21 | Terapia adyuvante con trastuzumab (herceptin registrado) |
ARP120103682A AR088110A2 (es) | 2005-05-13 | 2012-10-03 | Uso de un inmunoconjugado que comprende un anticuerpo anti-erbb2 para la manufactura de un medicamento |
ARP170101287A AR109246A2 (es) | 2005-05-13 | 2017-05-15 | USO DE UN INMUNOCONJUGADO QUE COMPRENDE UN ANTICUERPO ANTI-ErbB2 PARA LA MANUFACTURA DE UN MEDICAMENTO |
Country Status (6)
Country | Link |
---|---|
US (5) | US8591897B2 (es) |
JP (9) | JP2006316040A (es) |
AR (4) | AR054254A1 (es) |
BR (1) | BRPI0601736A (es) |
CA (2) | CA2790058C (es) |
MX (1) | MX344809B (es) |
Families Citing this family (77)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ZA9811162B (en) | 1997-12-12 | 2000-06-07 | Genentech Inc | Treatment with anti-ERBB2 antibodies. |
CN102698265A (zh) * | 2000-05-19 | 2012-10-03 | 杰南技术公司 | 用于提高对ErbB 拮抗剂癌症治疗的有效应答可能性的基因检测试验 |
US8088387B2 (en) | 2003-10-10 | 2012-01-03 | Immunogen Inc. | Method of targeting specific cell populations using cell-binding agent maytansinoid conjugates linked via a non-cleavable linker, said conjugates, and methods of making said conjugates |
SV2006002143A (es) * | 2004-06-16 | 2006-01-26 | Genentech Inc | Uso de un anticuerpo para el tratamiento del cancer resistente al platino |
KR20160096228A (ko) | 2004-07-22 | 2016-08-12 | 제넨테크, 인크. | Her2 항체 조성물 |
JO3000B1 (ar) | 2004-10-20 | 2016-09-05 | Genentech Inc | مركبات أجسام مضادة . |
ZA200704796B (en) * | 2004-12-07 | 2008-11-26 | Genentech Inc | Selecting patients for therapy with a HER inhibitor |
EP3698807A1 (en) | 2005-01-21 | 2020-08-26 | Genentech, Inc. | Fixed dosing of her antibodies |
AU2006216732C1 (en) | 2005-02-23 | 2017-07-20 | Genentech, Inc. | Extending time to disease progression or survival in cancer patients using a HER dimerization inhibitor |
PE20070207A1 (es) | 2005-07-22 | 2007-03-09 | Genentech Inc | Tratamiento combinado de los tumores que expresan el her |
KR101617108B1 (ko) | 2006-01-20 | 2016-04-29 | 제넨테크, 인크. | 항-ephrinb2 항체 및 그의 사용 방법 |
EP1913958B1 (en) * | 2006-08-03 | 2009-12-23 | Sanofi-Aventis | Antitumor compositions containing acetylcyclopropyl docetaxel and trastuzumab |
WO2008092796A1 (en) * | 2007-01-29 | 2008-08-07 | Nerviano Medical Sciences S.R.L. | Antitumor combination comprising a morpholinyl anthracycline and an antibody |
WO2008109440A2 (en) | 2007-03-02 | 2008-09-12 | Genentech, Inc. | Predicting response to a her dimerisation inhibitor based on low her3 expression |
KR100972618B1 (ko) | 2007-10-19 | 2010-07-27 | 국립암센터 | 허셉틴을 이용한 유방암 진단 키트, 조성물 및 이들을이용하여 허셉틴 민감성 her2 과발현 세포를 검출하는방법 |
US10416162B2 (en) * | 2007-12-20 | 2019-09-17 | Monogram Biosciences, Inc. | Her2 diagnostic methods |
TWI472339B (zh) | 2008-01-30 | 2015-02-11 | Genentech Inc | 包含結合至her2結構域ii之抗體及其酸性變異體的組合物 |
AU2009223124B2 (en) | 2008-03-14 | 2015-03-26 | Genentech, Inc. | Genetic variations associated with drug resistance |
DK2644194T3 (en) | 2008-03-18 | 2017-07-03 | Genentech Inc | Combinations of an anti-HER2 antibody-drug conjugate and docetaxel |
WO2009131673A1 (en) * | 2008-04-25 | 2009-10-29 | Ludwig Institute For Cancer Research Ltd. | Targeted treatment for subjects with estrogen receptor negative and progesterone receptor negative breast cancers |
ES2342646B1 (es) * | 2008-06-02 | 2011-04-26 | Institut De Recerca Hospital Universitari Vall Hebron | Metodo de diagnostico de canceres que expresan el receptor her-2 o sus variantes truncadas. |
BRPI0812682A2 (pt) | 2008-06-16 | 2010-06-22 | Genentech Inc | tratamento de cáncer de mama metastático |
ES2502940T3 (es) | 2008-08-05 | 2014-10-06 | Toray Industries, Inc. | Composición farmacéutica para el tratamiento y la prevención del cáncer |
ES2570731T3 (es) | 2008-08-05 | 2016-05-20 | Toray Industries | Método de detección de cáncer |
AU2009308707A1 (en) | 2008-10-31 | 2010-05-06 | Biogen Idec Ma Inc. | LIGHT targeting molecules and uses thereof |
WO2010065568A2 (en) | 2008-12-01 | 2010-06-10 | Laboratory Corporation Of America Holdings | METHODS AND ASSAYS FOR MEASURING p95 AND/OR p95 IN A SAMPLE AND ANTIBODIES SPECIFIC FOR p95 |
US20120128732A1 (en) * | 2008-12-11 | 2012-05-24 | Vuong Trieu | Combinations and modes of administration of therapeutic agents and combination therapy |
US20100233732A1 (en) * | 2009-01-15 | 2010-09-16 | Laboratory Corporation Of America Holdings | Methods of Determining Patient Response By Measurement of HER-2 Expression |
ES2535723T3 (es) | 2009-01-15 | 2015-05-14 | Laboratory Corporation Of America Holdings | Métodos de determinación de la respuesta del paciente mediante la medición de Her-3 |
RU2012105641A (ru) * | 2009-07-31 | 2013-09-10 | Индосайт, Инк. | Фолатнацеленные диагностические средства и лечение |
MX340017B (es) | 2010-02-04 | 2016-06-22 | Toray Industries | Composicion farmaceutica para el tratamiento y/o prevencion del cancer. |
EP2532743B1 (en) | 2010-02-04 | 2015-04-15 | Toray Industries, Inc. | Pharmaceutical composition for treatment and/or prevention of cancer |
CN109925511B (zh) | 2010-02-04 | 2024-03-19 | 东丽株式会社 | 用于癌的治疗和/或预防的药物 |
MX342291B (es) | 2010-02-04 | 2016-09-23 | Toray Industries | Composicion farmaceutica para el tratamiento y/o prevencion del cancer. |
CA2788715C (en) | 2010-02-04 | 2021-06-08 | Toray Industries, Inc. | Pharmaceutical composition for treating and/or preventing cancer |
HUE030102T2 (en) | 2010-02-04 | 2017-04-28 | Toray Industries | A pharmaceutical composition comprising anti-caprin-1 antibodies for the treatment and / or prevention of cancer |
EP2648719A1 (en) * | 2010-12-09 | 2013-10-16 | F.Hoffmann-La Roche Ag | Treatment of her2-positive cancer with paclitaxel and trastuzumab-mcc-dm1 |
BR112014002619A2 (pt) | 2011-08-04 | 2018-10-09 | Toray Industries, Inc | composição farmacêutica e método de tratamento e/ou prevenção de câncer pancreático e combinação farmacêutica |
MX348579B (es) | 2011-08-04 | 2017-06-20 | Toray Industries | Composicion farmaceutica para el tratamiento y/o prevencion del cancer. |
JP6065591B2 (ja) | 2011-08-04 | 2017-01-25 | 東レ株式会社 | 癌の治療及び/又は予防用医薬組成物 |
DK2740798T3 (en) | 2011-08-04 | 2017-03-06 | Toray Industries | Drug composition for cancer treatment and / or prevention |
AU2012290957B2 (en) | 2011-08-04 | 2017-04-20 | Toray Industries, Inc. | Pharmaceutical composition for treatment and/or prophylaxis of cancer |
DK2740794T3 (en) | 2011-08-04 | 2018-06-14 | Toray Industries | PHARMACEUTICAL COMPOSITION FOR TREATMENT AND / OR CANCER PREVENTION |
RU2624040C2 (ru) | 2011-08-04 | 2017-06-30 | Торэй Индастриз, Инк. | Способ обнаружения рака поджелудочной железы |
DK2766040T3 (da) | 2011-10-14 | 2019-07-22 | Hoffmann La Roche | Pertuzumab, trastuzumab, docetaxel og carboplatin til behandling af brystkræft i et tidligt stadie |
BR112014021099A2 (pt) | 2012-02-21 | 2020-12-01 | Toray Industries, Inc | anticorpo, composição farmacêutica, dna e método de tratamento e/ou prevenção de câncer e uso de um anticorpo |
IN2014KN01715A (es) | 2012-02-21 | 2015-10-23 | Toray Industries | |
AU2013223147B2 (en) | 2012-02-21 | 2017-10-05 | Toray Industries, Inc. | Pharmaceutical composition for treatment and/or prevention of cancer |
CA2864864C (en) | 2012-02-21 | 2020-05-12 | Toray Industries, Inc. | Pharmaceutical composition for treatment and/or prevention of cancer |
PT2832365T (pt) | 2012-03-30 | 2018-01-24 | Toray Industries | Composição farmacêutica para o tratamento e/ou prevenção do cancro hepático |
JP6107655B2 (ja) | 2012-03-30 | 2017-04-05 | 東レ株式会社 | 胆嚢癌の治療及び/又は予防用医薬組成物 |
ES2718348T3 (es) | 2012-07-19 | 2019-07-01 | Toray Industries | Método para detectar cáncer |
PT2876447T (pt) | 2012-07-19 | 2020-02-03 | Toray Industries | Método para deteção de cancro |
US20160067182A1 (en) * | 2013-04-09 | 2016-03-10 | Merrimack Pharmaceuticals, Inc. | Methods and compositions for improving outcomes of liposomal chemotherapy |
AR095863A1 (es) | 2013-04-16 | 2015-11-18 | Genentech Inc | Variantes de pertuzumab, su evaluación, método de tratamiento, método de preparación y artículo de fabricación |
AU2014303375B2 (en) | 2013-08-09 | 2019-07-04 | Toray Industries, Inc. | Pharmaceutical composition for treatment and/or prevention of cancer |
EP3134440A1 (en) | 2014-04-25 | 2017-03-01 | F. Hoffmann-La Roche AG | Methods of treating early breast cancer with trastuzumab-mcc-dm1 and pertuzumab |
WO2015195925A1 (en) | 2014-06-18 | 2015-12-23 | Mersana Therapeutics, Inc. | Protein-polymer-drug conjugates and methods of using same |
TWI695011B (zh) | 2014-06-18 | 2020-06-01 | 美商梅爾莎納醫療公司 | 抗her2表位之單株抗體及其使用之方法 |
EP3302551A2 (en) | 2015-05-30 | 2018-04-11 | H. Hoffnabb-La Roche Ag | Methods of treating her2-positive locally advanced or previously untreated metastatic breast cancer |
ES2731377T3 (es) | 2015-07-07 | 2019-11-15 | Hoffmann La Roche | Politerapia con un conjugado anticuerpo anti-HER2-fármaco y un inhibidor de bcl-2 |
US11554138B2 (en) | 2015-07-16 | 2023-01-17 | The University Of Hong Kong | Bismuth(III) complexes as adjuvants in the treatment of cancer using platinum-based chemotherapy |
WO2017087280A1 (en) | 2015-11-16 | 2017-05-26 | Genentech, Inc. | Methods of treating her2-positive cancer |
CN109562067A (zh) * | 2016-08-02 | 2019-04-02 | 库里尔克思股份有限公司 | 制备脂质体的方法 |
TW201815418A (zh) * | 2016-09-27 | 2018-05-01 | Vertex Pharma | 使用dna破壞劑及dna-pk抑制劑之組合治療癌症的方法 |
CN110099926A (zh) | 2016-12-28 | 2019-08-06 | 豪夫迈·罗氏有限公司 | 晚期her2表达性癌症的治疗 |
RU2750821C2 (ru) | 2017-01-17 | 2021-07-05 | Дженентек, Инк. | Препараты антител против her2 для подкожного введения |
AU2018220736A1 (en) | 2017-02-20 | 2019-09-05 | Dragonfly Therapeutics, Inc. | Proteins binding HER2, NKG2D and CD16 |
FI3589661T3 (fi) | 2017-03-02 | 2024-01-31 | Genentech Inc | Her2-positiivisen rintasyövän adjuvanttihoito |
CN110536969A (zh) | 2017-04-24 | 2019-12-03 | 豪夫迈·罗氏有限公司 | 跨膜或近膜域中的erbb2/her2突变 |
WO2019009436A1 (ja) | 2017-07-06 | 2019-01-10 | 学校法人京都薬科大学 | 腎ターゲティング型薬物送達用担体 |
CN112368012A (zh) | 2018-02-08 | 2021-02-12 | 蜻蜓疗法股份有限公司 | 靶向nkg2d受体的抗体可变结构域 |
CN109739435B (zh) * | 2018-12-03 | 2023-10-13 | 中科恒运股份有限公司 | 文件存储和更新方法及装置 |
IL303350A (en) | 2020-12-04 | 2023-08-01 | Macrogenics Inc | Preparations containing an antibody against HER2/NEU and their use |
CA3173758A1 (en) | 2021-04-29 | 2022-11-03 | Hui Zhang | Preparation method and application of antibody drug conjugate |
CA3223304A1 (en) | 2021-06-17 | 2022-12-22 | Minghui Pharmaceutical (Hangzhou) Limited | Antitumor compound and its application |
US20230295348A1 (en) | 2022-01-24 | 2023-09-21 | Novimmune Sa | Composition and methods for the selective activation of cytokine signaling pathways |
Family Cites Families (92)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4935341A (en) | 1986-06-04 | 1990-06-19 | Whitehead Institute For Biomedical Research | Detection of point mutations in neu genes |
US7838216B1 (en) | 1986-03-05 | 2010-11-23 | The United States Of America, As Represented By The Department Of Health And Human Services | Human gene related to but distinct from EGF receptor gene |
US5401638A (en) | 1986-06-04 | 1995-03-28 | Oncogene Science, Inc. | Detection and quantification of neu related proteins in the biological fluids of humans |
US4968603A (en) | 1986-12-31 | 1990-11-06 | The Regents Of The University Of California | Determination of status in neoplastic disease |
US5824311A (en) | 1987-11-30 | 1998-10-20 | Trustees Of The University Of Pennsylvania | Treatment of tumors with monoclonal antibodies against oncogene antigens |
US5720937A (en) | 1988-01-12 | 1998-02-24 | Genentech, Inc. | In vivo tumor detection assay |
WO1989006692A1 (en) | 1988-01-12 | 1989-07-27 | Genentech, Inc. | Method of treating tumor cells by inhibiting growth factor receptor function |
DK0474727T3 (da) | 1989-05-19 | 1998-01-12 | Genentech Inc | HER2 ekstracellulært domæne |
US5705157A (en) | 1989-07-27 | 1998-01-06 | The Trustees Of The University Of Pennsylvania | Methods of treating cancerous cells with anti-receptor antibodies |
EP0444181B2 (en) | 1989-08-04 | 2010-11-24 | Bayer Schering Pharma Aktiengesellschaft | C-erbb-2 external domain: gp75 |
US6884418B1 (en) | 1989-08-04 | 2005-04-26 | Berlex Laboratories, Inc. | Use of ligand-mimicking agents and anti-neoplastic drugs in cancer therapy |
US5183884A (en) | 1989-12-01 | 1993-02-02 | United States Of America | Dna segment encoding a gene for a receptor related to the epidermal growth factor receptor |
US5571894A (en) | 1991-02-05 | 1996-11-05 | Ciba-Geigy Corporation | Recombinant antibodies specific for a growth factor receptor |
IL101943A0 (en) | 1991-05-24 | 1992-12-30 | Genentech Inc | Structure,production and use of heregulin |
ES2206447T3 (es) | 1991-06-14 | 2004-05-16 | Genentech, Inc. | Anticuerpo humanizado para heregulina. |
US6800738B1 (en) | 1991-06-14 | 2004-10-05 | Genentech, Inc. | Method for making humanized antibodies |
WO1994004679A1 (en) | 1991-06-14 | 1994-03-03 | Genentech, Inc. | Method for making humanized antibodies |
US5939531A (en) | 1991-07-15 | 1999-08-17 | Novartis Corp. | Recombinant antibodies specific for a growth factor receptor |
EP0656367A1 (en) | 1991-08-22 | 1995-06-07 | Becton, Dickinson and Company | Method and composition for cancer therapy and for prognosticating responses to cancer theraphy |
US7018809B1 (en) | 1991-09-19 | 2006-03-28 | Genentech, Inc. | Expression of functional antibody fragments |
US5288477A (en) | 1991-09-27 | 1994-02-22 | Becton, Dickinson And Company | Method for prognosticating response to cancer therapy |
US5587458A (en) | 1991-10-07 | 1996-12-24 | Aronex Pharmaceuticals, Inc. | Anti-erbB-2 antibodies, combinations thereof, and therapeutic and diagnostic uses thereof |
AU675929B2 (en) | 1992-02-06 | 1997-02-27 | Curis, Inc. | Biosynthetic binding protein for cancer marker |
WO1994009022A1 (en) | 1992-10-09 | 1994-04-28 | Oncor, Inc. | Methods for the detection of chromosome structural abnormalities by in situ hybridization to fixed tissue |
US6733752B1 (en) | 1994-03-30 | 2004-05-11 | The Trustees Of The University Of Pennsylvania | Prevention of tumors with monoclonal antibodies against neu |
US6811779B2 (en) | 1994-02-10 | 2004-11-02 | Imclone Systems Incorporated | Methods for reducing tumor growth with VEGF receptor antibody combined with radiation and chemotherapy |
US20030108545A1 (en) | 1994-02-10 | 2003-06-12 | Patricia Rockwell | Combination methods of inhibiting tumor growth with a vascular endothelial growth factor receptor antagonist |
US5910486A (en) | 1994-09-06 | 1999-06-08 | Uab Research Foundation | Methods for modulating protein function in cells using, intracellular antibody homologues |
US5846749A (en) | 1994-10-12 | 1998-12-08 | The Regents Of The University Of California | Quantitative measurement of tissue protein identified by immunohistochemistry and standardized protein determination |
US5804396A (en) | 1994-10-12 | 1998-09-08 | Sugen, Inc. | Assay for agents active in proliferative disorders |
US6214388B1 (en) | 1994-11-09 | 2001-04-10 | The Regents Of The University Of California | Immunoliposomes that optimize internalization into target cells |
US5783404A (en) | 1995-04-13 | 1998-07-21 | Amgen Inc. | Methods and compositions for determining HER-2/neu expression using monoclonal antibodies |
US6410690B1 (en) | 1995-06-07 | 2002-06-25 | Medarex, Inc. | Therapeutic compounds comprised of anti-Fc receptor antibodies |
US5977322A (en) | 1995-06-14 | 1999-11-02 | The Regents Of The University Of California | High affinity human antibodies to tumor antigens |
US6267958B1 (en) | 1995-07-27 | 2001-07-31 | Genentech, Inc. | Protein formulation |
US6685940B2 (en) | 1995-07-27 | 2004-02-03 | Genentech, Inc. | Protein formulation |
US5783186A (en) | 1995-12-05 | 1998-07-21 | Amgen Inc. | Antibody-induced apoptosis |
US5925519A (en) | 1996-06-03 | 1999-07-20 | The Regents Of The University Of California | Genetic alterations associated with prostate cancer |
US5922845A (en) | 1996-07-11 | 1999-07-13 | Medarex, Inc. | Therapeutic multispecific compounds comprised of anti-Fcα receptor antibodies |
EP1864999B1 (en) | 1996-11-27 | 2009-03-18 | Genentech, Inc. | Affinity purification of polypeptide on protein a matrix |
US5994071A (en) | 1997-04-04 | 1999-11-30 | Albany Medical College | Assessment of prostate cancer |
US20020076695A1 (en) | 1997-04-04 | 2002-06-20 | Jeffrey S. Ross | Methods for treating prostate cancer |
ZA9811162B (en) | 1997-12-12 | 2000-06-07 | Genentech Inc | Treatment with anti-ERBB2 antibodies. |
US6358682B1 (en) | 1998-01-26 | 2002-03-19 | Ventana Medical Systems, Inc. | Method and kit for the prognostication of breast cancer |
US20020192211A1 (en) | 1998-03-17 | 2002-12-19 | Hudziak Robert M. | Method of treating tumor cells by inhibiting growth factor receptor function |
WO1999048527A1 (en) | 1998-03-27 | 1999-09-30 | Genentech, Inc. | Apo-2 ligand-anti-her-2 antibody synergism |
ATE321066T1 (de) | 1998-05-06 | 2006-04-15 | Genentech Inc | Anti-her2 antikörperzusammensetzung |
SE512710C2 (sv) | 1998-07-08 | 2000-05-02 | Ericsson Telefon Ab L M | Kapsel för högeffekttransistorchip för höga frekvenser innefattande en elektriskt och termiskt ledande fläns |
US6573043B1 (en) | 1998-10-07 | 2003-06-03 | Genentech, Inc. | Tissue analysis and kits therefor |
DE60041808D1 (de) | 1999-01-27 | 2009-04-30 | Cornell Res Foundation Inc | Behandlung von mit her-2/neu-überexprimierung einhergehendem krebs |
US6333348B1 (en) | 1999-04-09 | 2001-12-25 | Aventis Pharma S.A. | Use of docetaxel for treating cancers |
ES2320311T3 (es) * | 1999-05-14 | 2009-05-21 | Genentech, Inc. | Tratamiento con anticuerpos anti-erbb2. |
JP3485252B2 (ja) | 1999-06-16 | 2004-01-13 | インターナショナル・ビジネス・マシーンズ・コーポレーション | 情報処理方法、情報端末支援サーバ、コラボレーション・システム、情報処理プログラムを格納する記憶媒体 |
DK2283866T3 (en) * | 1999-06-25 | 2015-05-18 | Genentech Inc | METHODS OF TREATMENT USING ANTI-ERBB ANTIBODY-MAYTANSINOID CONJUGATES |
US20030086924A1 (en) | 1999-06-25 | 2003-05-08 | Genentech, Inc. | Treatment with anti-ErbB2 antibodies |
US20040013667A1 (en) | 1999-06-25 | 2004-01-22 | Genentech, Inc. | Treatment with anti-ErbB2 antibodies |
US6949245B1 (en) * | 1999-06-25 | 2005-09-27 | Genentech, Inc. | Humanized anti-ErbB2 antibodies and treatment with anti-ErbB2 antibodies |
ES2330301T3 (es) * | 1999-08-27 | 2009-12-09 | Genentech, Inc. | Dosificaciones para tratamiento con anticuerpos anti-erbb2. |
CA2385528C (en) | 1999-10-01 | 2013-12-10 | Immunogen, Inc. | Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents |
US7303749B1 (en) | 1999-10-01 | 2007-12-04 | Immunogen Inc. | Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents |
US20030022918A1 (en) | 2000-02-29 | 2003-01-30 | Horak Ivan David | Farnesyl protein transferase inhibitor combinations with an her2 antibody |
US6632979B2 (en) | 2000-03-16 | 2003-10-14 | Genentech, Inc. | Rodent HER2 tumor model |
US7097840B2 (en) * | 2000-03-16 | 2006-08-29 | Genentech, Inc. | Methods of treatment using anti-ErbB antibody-maytansinoid conjugates |
US6767541B2 (en) | 2000-03-20 | 2004-07-27 | The Regents Of The University Of California | HER-2/neu overexpression abrogates growth inhibitory pathways |
WO2001076630A1 (fr) | 2000-04-06 | 2001-10-18 | Kyowa Hakko Kogyo Co., Ltd. | Diagnostics et remedes contre la polyarthrite rhumatoide |
GB0008368D0 (en) | 2000-04-06 | 2000-05-24 | Astrazeneca Ab | Combination product |
US7306801B2 (en) | 2000-05-15 | 2007-12-11 | Health Research, Inc. | Methods of therapy for cancers characterized by overexpression of the HER2 receptor protein |
CN102698265A (zh) | 2000-05-19 | 2012-10-03 | 杰南技术公司 | 用于提高对ErbB 拮抗剂癌症治疗的有效应答可能性的基因检测试验 |
TWI317285B (en) | 2000-07-28 | 2009-11-21 | Dainippon Sumitomo Pharma Co | New use and kit for remedies for cancer |
US6984494B2 (en) | 2000-08-15 | 2006-01-10 | Genentech, Inc. | Analytical method |
US6582919B2 (en) | 2001-06-11 | 2003-06-24 | Response Genetics, Inc. | Method of determining epidermal growth factor receptor and HER2-neu gene expression and correlation of levels thereof with survival rates |
US20020142328A1 (en) | 2000-12-01 | 2002-10-03 | Danenberg Kathleen D. | Method of determining a chemotherapeutic regimen by assaying gene expression in primary tumors |
US6602670B2 (en) | 2000-12-01 | 2003-08-05 | Response Genetics, Inc. | Method of determining a chemotherapeutic regimen based on ERCC1 expression |
CA2436910C (en) | 2000-12-01 | 2014-06-17 | Response Genetics, Inc. | Method of determining epidermal growth factor receptor and her2-neu gene expression and correlation of levels thereof with survival rates |
US7005278B2 (en) | 2001-03-02 | 2006-02-28 | Danenberg Kathleen D | Method of determining dihydropyrimidine dehydrogenase gene expression |
WO2002045653A2 (en) | 2000-12-08 | 2002-06-13 | Uab Research Foundation | Combination radiation therapy and chemotherapy in conjuction with administration of growth factor receptor antibody |
WO2002087619A1 (fr) | 2001-04-27 | 2002-11-07 | Takeda Chemical Industries, Ltd. | Methode de prevention et de traitement du cancer |
US20030068318A1 (en) | 2001-09-28 | 2003-04-10 | O'brien Timothy | Treatment of uterine serous papillary cancer |
US20030175845A1 (en) | 2002-03-13 | 2003-09-18 | Kalbag Suresh M. | Use of sulfitolysis in high performance peptide mapping |
US20030190689A1 (en) | 2002-04-05 | 2003-10-09 | Cell Signaling Technology,Inc. | Molecular profiling of disease and therapeutic response using phospho-specific antibodies |
CA2481515C (en) | 2002-04-10 | 2013-10-01 | Genentech, Inc. | Anti-her2 antibody variants |
ITTO20020340A1 (it) | 2002-04-19 | 2003-10-20 | Biother Di Contardi Gabriella | Localizzazione del recettore her2 mediante anticorpo umanizzato biotinilato. |
US20030202973A1 (en) | 2002-04-29 | 2003-10-30 | Dr. George Pieczenik | Treatment of refractory human tumors with epidermal growth factor receptor and HER1 mitogenic ligand (EGFRML) antagonists |
CA2486124A1 (en) | 2002-05-17 | 2003-11-27 | Aventis Pharma S.A. | Use of docetaxel/doxorubicin/cyclophosphamide in adjuvant therapy of breast and ovarian cancer |
PT1585966E (pt) | 2002-07-15 | 2012-02-20 | Hoffmann La Roche | Tratamento de cancro com o anticorpo anti-erbb2 rhumab 2c4 |
US20040013297A1 (en) | 2002-07-18 | 2004-01-22 | Roger Lo | Method for performing color gamut compression |
ES2629602T5 (es) | 2002-09-11 | 2021-06-08 | Genentech Inc | Purificación de proteínas |
WO2004048525A2 (en) | 2002-11-21 | 2004-06-10 | Genentech, Inc. | Therapy of non-malignant diseases or disorders with anti-erbb2 antibodies |
US20040231909A1 (en) | 2003-01-15 | 2004-11-25 | Tai-Yang Luh | Motorized vehicle having forward and backward differential structure |
US8088387B2 (en) | 2003-10-10 | 2012-01-03 | Immunogen Inc. | Method of targeting specific cell populations using cell-binding agent maytansinoid conjugates linked via a non-cleavable linker, said conjugates, and methods of making said conjugates |
KR101424624B1 (ko) * | 2003-05-14 | 2014-07-31 | 이뮤노젠 아이엔씨 | 약물 콘쥬게이트 조성물 |
NZ551180A (en) | 2004-06-01 | 2009-10-30 | Genentech Inc | Antibody drug conjugates and methods |
-
2005
- 2005-10-25 JP JP2005310518A patent/JP2006316040A/ja active Pending
-
2006
- 2006-03-21 CA CA2790058A patent/CA2790058C/en active Active
- 2006-03-21 CA CA2540547A patent/CA2540547C/en active Active
- 2006-04-06 US US11/400,638 patent/US8591897B2/en active Active
- 2006-04-21 MX MX2013009514A patent/MX344809B/es unknown
- 2006-04-21 AR AR20060101586A patent/AR054254A1/es unknown
- 2006-04-25 BR BRPI0601736-3A patent/BRPI0601736A/pt not_active Application Discontinuation
-
2011
- 2011-08-08 US US13/205,523 patent/US8597654B2/en active Active
-
2012
- 2012-10-03 AR ARP120103682A patent/AR088110A2/es unknown
-
2013
- 2013-04-25 JP JP2013092728A patent/JP6133668B2/ja active Active
- 2013-05-24 JP JP2013109685A patent/JP2013163694A/ja active Pending
- 2013-10-25 US US14/063,885 patent/US20140086940A1/en not_active Abandoned
-
2015
- 2015-07-14 JP JP2015140158A patent/JP2015187168A/ja not_active Withdrawn
-
2017
- 2017-02-09 US US15/428,807 patent/US20180236093A1/en not_active Abandoned
- 2017-04-27 JP JP2017088352A patent/JP2017132806A/ja active Pending
- 2017-04-27 JP JP2017088351A patent/JP2017132805A/ja not_active Withdrawn
- 2017-05-15 AR ARP170101287A patent/AR109246A2/es unknown
- 2017-05-17 AR ARP170101322A patent/AR108615A2/es unknown
-
2018
- 2018-10-25 JP JP2018200936A patent/JP2019011374A/ja active Pending
-
2020
- 2020-01-30 US US16/777,345 patent/US20200155701A1/en not_active Abandoned
- 2020-03-11 JP JP2020041610A patent/JP2020094061A/ja not_active Withdrawn
-
2022
- 2022-05-02 JP JP2022075920A patent/JP2022093642A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
CA2540547A1 (en) | 2006-11-13 |
AR109246A2 (es) | 2018-11-14 |
BRPI0601736A (pt) | 2007-05-15 |
CA2790058A1 (en) | 2006-11-13 |
AR054254A1 (es) | 2007-06-13 |
US20060275305A1 (en) | 2006-12-07 |
JP2022093642A (ja) | 2022-06-23 |
US20120003217A1 (en) | 2012-01-05 |
US20200155701A1 (en) | 2020-05-21 |
CA2540547C (en) | 2016-08-16 |
JP2017132805A (ja) | 2017-08-03 |
US8597654B2 (en) | 2013-12-03 |
JP2006316040A (ja) | 2006-11-24 |
JP2019011374A (ja) | 2019-01-24 |
JP2020094061A (ja) | 2020-06-18 |
JP2013163694A (ja) | 2013-08-22 |
JP2013144718A (ja) | 2013-07-25 |
CA2790058C (en) | 2019-01-15 |
US8591897B2 (en) | 2013-11-26 |
JP2015187168A (ja) | 2015-10-29 |
US20180236093A1 (en) | 2018-08-23 |
AR088110A2 (es) | 2014-05-07 |
MX344809B (es) | 2017-01-09 |
US20140086940A1 (en) | 2014-03-27 |
JP6133668B2 (ja) | 2017-05-24 |
JP2017132806A (ja) | 2017-08-03 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
AR108615A2 (es) | Terapia adyuvante con herceptin® | |
AR077866A1 (es) | Terapia de combinacion de un anticuerpo cd20 afucosilado y bendamustina | |
EA201171367A1 (ru) | Винилиндазолильные соединения | |
EA200901074A1 (ru) | Лечение метастатической стадии рака предстательной железы дегареликсом | |
JO2788B1 (en) | Amido phenoxyendazole compounds beneficial as C-MET inhibitors | |
EA201400178A1 (ru) | Лечение рака молочной железы | |
MX2013002084A (es) | Biomarcadores y metodos de tratamiento. | |
MY184101A (en) | Indoles | |
EA200971068A1 (ru) | Триазолиламинопиримидиновые соединения | |
MX2009012625A (es) | Metodos para el tratamiento, diagnostico y deteccion de trastornos asociados con el fgf21. | |
DK1893196T3 (da) | Diarylhydantoin-forbindelse | |
WO2010146059A3 (en) | Biomarkers for igf-1r inhibitor therapy | |
UY31432A1 (es) | Compuestos de diarilhidantoina | |
PA8851101A1 (es) | Compuesto amino pirazol | |
MX2011011431A (es) | Composicion para el tratamiento de cancer de prostata. | |
MX2012001783A (es) | Terapia combinatoria de un anticuerpo anti-cd20 afucosilado con fludarabina y/o mitoxantrona. | |
EA201890598A2 (ru) | Антиандрогены для лечения неметастатического кастрационно-резистентного рака простаты | |
MX2009005058A (es) | Metodos para tratar, diagnosticar o detectar cancer. | |
MX2009011822A (es) | Hidroxi sulfonatos de compuestos de quinonicos y sus usos. | |
CL2012000387A1 (es) | Método para tratar a un paciente diagnosticado con cáncer de mama previamente tratado metastásico que comprende la combinación de una quimioterapia con la administración de un anticuerpo anti-vegf; y kit utilizado. | |
EA200971067A1 (ru) | Триазолиламинопиримидиновые соединения | |
EP2099458A4 (en) | COMPOUNDS AND METHODS FOR IMAGING AND THERAPY OF ENZYME-MEDIATED TUMORS | |
UA29848U (uk) | Застосування системної реконструктивної терапії як способу лікування мігрені | |
UA101379C2 (en) | Amidophenoxyindazoles useful in the treatment of cancer | |
TN2011000013A1 (en) | Amidophenoxyindazoles useful as inhibitors of c-met |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FB | Suspension of granting procedure |