AR094978A1 - Derivados de pirazol agonistas de receptores canabinoides - Google Patents
Derivados de pirazol agonistas de receptores canabinoidesInfo
- Publication number
- AR094978A1 AR094978A1 ARP140100693A ARP140100693A AR094978A1 AR 094978 A1 AR094978 A1 AR 094978A1 AR P140100693 A ARP140100693 A AR P140100693A AR P140100693 A ARP140100693 A AR P140100693A AR 094978 A1 AR094978 A1 AR 094978A1
- Authority
- AR
- Argentina
- Prior art keywords
- substituted
- alkoxy
- halogen
- furazanyl
- cycloalkyl
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Abstract
Reivindicación 1: Un compuesto de la fórmula (1) en la que A¹ es carbono o nitrógeno; A² es carbono o nitrógeno; A³ es -(CH₂)ₙ- o -CH₂C(O)-; R¹ es alquilo, cicloalquilo, alcoxi o halógeno; R² es alcoxi, pirrolidinilo sustituido o dihidropirrolilo sustituido, dichos pirrolidinilo sustituido y dihidropirrolilo sustituido son pirrolidinilo y dihidropirrolilo sustituidos por uno o dos sustituyentes elegidos con independencia entre halógeno, hidroxilo, hidroxialquilo, alcoxialquilo y alquilfurazanilalcoxi; R³ es fenilo, fenilo sustituido, furazanilo sustituido, piridinilo, piridinilo sustituido, dioxotietanilo, tetrahidrofuranilo, tetrazolilo sustituido o triazolilo sustituido, dichos fenilo sustituido, furazanilo sustituido, piridinilo sustituido y triazolilo sustituido son fenilo, piridinilo y triazolilo sustituidos por uno o dos sustituyentes elegidos con independencia entre alquilo, alcoxi, halógeno, haloalquilo, alquilsulfonilo y cicloalquilo, y dichos tetrazolilo sustituido y furazanilo sustituido son tetrazolilo y furazanilo sustituidos por un sustituyente elegido entre alquilo, alcoxi, halógeno, haloalquilo, alquilsulfonilo y cicloalquilo; n es el número 0, 1 ó 2; con la condición de que A¹ y A² no sean ambos carbono al mismo tiempo; o una sal o un éster farmacéuticamente aceptable del mismo.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP13158233 | 2013-03-07 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR094978A1 true AR094978A1 (es) | 2015-09-09 |
Family
ID=47827068
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP140100693A AR094978A1 (es) | 2013-03-07 | 2014-03-05 | Derivados de pirazol agonistas de receptores canabinoides |
Country Status (35)
Country | Link |
---|---|
US (2) | US9512132B2 (es) |
EP (1) | EP2964646B1 (es) |
JP (2) | JP6514119B2 (es) |
KR (2) | KR102217297B1 (es) |
CN (1) | CN105143220B (es) |
AR (1) | AR094978A1 (es) |
AU (1) | AU2014224784B2 (es) |
BR (1) | BR112015020795B1 (es) |
CA (1) | CA2897513C (es) |
CL (1) | CL2015002387A1 (es) |
CR (1) | CR20150447A (es) |
CY (1) | CY1118950T1 (es) |
DK (1) | DK2964646T3 (es) |
EA (1) | EA027935B1 (es) |
ES (1) | ES2629751T3 (es) |
HK (1) | HK1213258A1 (es) |
HR (1) | HRP20170919T1 (es) |
HU (1) | HUE034831T2 (es) |
IL (1) | IL240327B (es) |
LT (1) | LT2964646T (es) |
MA (1) | MA38403A1 (es) |
MX (1) | MX363727B (es) |
MY (1) | MY176797A (es) |
NZ (1) | NZ710052A (es) |
PE (1) | PE20151539A1 (es) |
PH (1) | PH12015501843B1 (es) |
PL (1) | PL2964646T3 (es) |
PT (1) | PT2964646T (es) |
RS (1) | RS56148B1 (es) |
SG (1) | SG11201507168XA (es) |
SI (1) | SI2964646T1 (es) |
TW (1) | TWI609866B (es) |
UA (1) | UA118666C2 (es) |
WO (1) | WO2014135507A1 (es) |
ZA (1) | ZA201505073B (es) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PE20151539A1 (es) * | 2013-03-07 | 2015-10-28 | Hoffmann La Roche | Nuevos derivados de pirazol |
PE20151559A1 (es) | 2013-03-26 | 2015-11-05 | Hoffmann La Roche | Nuevos derivados de piridina |
KR102330794B1 (ko) | 2013-05-02 | 2021-11-26 | 에프. 호프만-라 로슈 아게 | Cb2 수용체 작용제로서의 퓨린 유도체 |
EP2991988B1 (en) | 2013-05-02 | 2017-05-31 | F. Hoffmann-La Roche AG | Pyrrolo[2,3-d]pyrimidine derivatives as cb2 receptor agonists |
EP3483163B1 (en) | 2013-09-06 | 2021-06-23 | F. Hoffmann-La Roche AG | Triazolo[4,5-d]pyrimidine derivatives as cb2 receptor antagonists |
CA2979534A1 (en) * | 2015-03-13 | 2016-09-22 | Abbvie Inc. | (indazol-4-yl)hexahydropyrrolopyrrolones and method of use |
WO2016191935A1 (en) * | 2015-05-29 | 2016-12-08 | Merck Sharp & Dohme Corp. | 6-alkyl dihydropyrazolopyrimidinone compounds as pde2 inhibitors |
WO2016192083A1 (en) | 2015-06-04 | 2016-12-08 | Merck Sharp & Dohme Corp. | Dihydropyrazolopyrimidinone compounds as pde2 inhibitors |
EP3475283B1 (en) | 2016-06-23 | 2021-08-11 | F. Hoffmann-La Roche AG | Novel[1,2,3]triazolo[4,5-d]pyrimidine derivatives |
CN109311886B (zh) | 2016-06-23 | 2021-11-09 | 豪夫迈·罗氏有限公司 | [1,2,3]***并[4,5-d]嘧啶衍生物 |
WO2017220516A1 (en) | 2016-06-23 | 2017-12-28 | F. Hoffmann-La Roche Ag | Novel [1,2,3]triazolo[4,5-d]pyrimidine derivatives |
MY197244A (en) | 2016-06-23 | 2023-06-07 | Hoffmann La Roche | [1,2,3]triazolo[4,5-d]pyrimidine derivatives with affinity for the type-2 cannabinoid receptor |
US20220170826A1 (en) | 2019-03-25 | 2022-06-02 | Nikon Corporation | Cell manipulation device and cell manipulation method |
CN116438200A (zh) | 2020-09-10 | 2023-07-14 | 普雷西里克斯公司 | 针对fap的抗体片段 |
WO2023203135A1 (en) | 2022-04-22 | 2023-10-26 | Precirix N.V. | Improved radiolabelled antibody |
WO2023213801A1 (en) | 2022-05-02 | 2023-11-09 | Precirix N.V. | Pre-targeting |
CN115246832A (zh) * | 2022-06-15 | 2022-10-28 | 深圳湾实验室 | 一类去泛素化酶usp25和usp28靶向抑制剂及制备和应用 |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2980677A (en) * | 1961-04-18 | Certificate of correction | ||
JP2004502642A (ja) * | 2000-02-11 | 2004-01-29 | ブリストル−マイヤーズ スクイブ カンパニー | カンナビノイドレセプターモジュレーター、それらの製造方法、および呼吸系および非呼吸系疾患の処置のためのカンナビノイドレセプターモジュレーターの使用 |
WO2003082191A2 (en) | 2002-03-28 | 2003-10-09 | Merck & Co., Inc. | Substituted 2,3-diphenyl pyridines |
DE10219435A1 (de) * | 2002-05-02 | 2003-11-13 | Bayer Cropscience Ag | Substituierte Pyrazolo-pyrimidin-4-one |
AR051596A1 (es) * | 2004-10-26 | 2007-01-24 | Irm Llc | Compuestos heterociclicos condensados nitrogenados como inhibidores de la actividad del receptor canabinoide 1; composiciones farmaceuticas que los contienen y su empleo en la preparacion de medicamentos para el tratamiento de trastornos alimentarios |
WO2009051705A1 (en) | 2007-10-18 | 2009-04-23 | Merck & Co., Inc. | Substituted 1,2,4-oxadiazoles and analogs thereof as cb2 receptor modulators, useful in the treatment of pain, respiratory and non-respiratory diseases |
WO2010118367A2 (en) * | 2009-04-10 | 2010-10-14 | Progenics Pharmaceuticals, Inc. | Antiviral pyrimidines |
US9321727B2 (en) | 2011-06-10 | 2016-04-26 | Hoffmann-La Roche Inc. | Pyridine derivatives as agonists of the CB2 receptor |
UA111640C2 (uk) | 2011-11-08 | 2016-05-25 | Ф. Хоффманн-Ля Рош Аг | ПОХІДНІ [1,2,3]ТРИАЗОЛО[4,5-d]ПІРИМІДИНУ ЯК АГОНІСТИ КАНАБІНОЇДНОГО РЕЦЕПТОРА 2 |
WO2014005968A1 (en) | 2012-07-04 | 2014-01-09 | F. Hoffmann-La Roche Ag | Novel adamantyl derivatives as cannabinoid receptor 2 agonists |
MY179412A (en) | 2012-12-07 | 2020-11-05 | Hoffmann La Roche | Pyridine-2-amides useful as cb2 agonists |
JP6426618B2 (ja) | 2012-12-07 | 2018-11-21 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | 新規なピリジン誘導体 |
ES2621958T3 (es) | 2012-12-07 | 2017-07-05 | F. Hoffmann-La Roche Ag | Derivados de pirazina como agonistas receptores de CB2 |
KR20150091080A (ko) | 2012-12-07 | 2015-08-07 | 에프. 호프만-라 로슈 아게 | Cb2 작용제로서 유용한 피리딘-2-아마이드 |
PE20151539A1 (es) * | 2013-03-07 | 2015-10-28 | Hoffmann La Roche | Nuevos derivados de pirazol |
-
2014
- 2014-03-04 PE PE2015001840A patent/PE20151539A1/es active IP Right Grant
- 2014-03-04 SI SI201430259T patent/SI2964646T1/sl unknown
- 2014-03-04 PL PL14709590T patent/PL2964646T3/pl unknown
- 2014-03-04 CA CA2897513A patent/CA2897513C/en active Active
- 2014-03-04 MX MX2015011534A patent/MX363727B/es active IP Right Grant
- 2014-03-04 KR KR1020157024230A patent/KR102217297B1/ko active IP Right Grant
- 2014-03-04 NZ NZ710052A patent/NZ710052A/en unknown
- 2014-03-04 BR BR112015020795-2A patent/BR112015020795B1/pt active IP Right Grant
- 2014-03-04 EA EA201591624A patent/EA027935B1/ru not_active IP Right Cessation
- 2014-03-04 MY MYPI2015702926A patent/MY176797A/en unknown
- 2014-03-04 KR KR1020217003979A patent/KR102369407B1/ko active IP Right Grant
- 2014-03-04 EP EP14709590.5A patent/EP2964646B1/en active Active
- 2014-03-04 ES ES14709590.5T patent/ES2629751T3/es active Active
- 2014-03-04 RS RS20170653A patent/RS56148B1/sr unknown
- 2014-03-04 HU HUE14709590A patent/HUE034831T2/en unknown
- 2014-03-04 AU AU2014224784A patent/AU2014224784B2/en active Active
- 2014-03-04 CN CN201480012444.5A patent/CN105143220B/zh active Active
- 2014-03-04 UA UAA201509653A patent/UA118666C2/uk unknown
- 2014-03-04 JP JP2015560654A patent/JP6514119B2/ja active Active
- 2014-03-04 PT PT147095905T patent/PT2964646T/pt unknown
- 2014-03-04 MA MA38403A patent/MA38403A1/fr unknown
- 2014-03-04 DK DK14709590.5T patent/DK2964646T3/en active
- 2014-03-04 LT LTEP14709590.5T patent/LT2964646T/lt unknown
- 2014-03-04 SG SG11201507168XA patent/SG11201507168XA/en unknown
- 2014-03-04 WO PCT/EP2014/054107 patent/WO2014135507A1/en active Application Filing
- 2014-03-05 AR ARP140100693A patent/AR094978A1/es active IP Right Grant
- 2014-03-06 TW TW103107745A patent/TWI609866B/zh active
-
2015
- 2015-07-15 ZA ZA2015/05073A patent/ZA201505073B/en unknown
- 2015-08-03 IL IL240327A patent/IL240327B/en active IP Right Grant
- 2015-08-20 PH PH12015501843A patent/PH12015501843B1/en unknown
- 2015-08-26 CL CL2015002387A patent/CL2015002387A1/es unknown
- 2015-08-27 CR CR20150447A patent/CR20150447A/es unknown
- 2015-09-03 US US14/844,991 patent/US9512132B2/en active Active
-
2016
- 2016-02-04 HK HK16101304.1A patent/HK1213258A1/zh unknown
- 2016-10-24 US US15/332,398 patent/US9694012B2/en active Active
-
2017
- 2017-06-14 HR HRP20170919TT patent/HRP20170919T1/hr unknown
- 2017-06-16 CY CY20171100638T patent/CY1118950T1/el unknown
-
2018
- 2018-12-06 JP JP2018229203A patent/JP2019055986A/ja active Pending
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
AR094978A1 (es) | Derivados de pirazol agonistas de receptores canabinoides | |
EA201790715A1 (ru) | Новые соединения | |
EA201591503A1 (ru) | Производные нафтиридина, полезные в качестве антагонистов альфа-v-бета-6 интегрина | |
RS54492B1 (en) | KINASE INHIBITOR REGULATING THE SIGNAL PATH OF APOPTOSIS | |
AR094712A1 (es) | Modificador de sabor dulce | |
PH12015502031B1 (en) | Tetrahydropyrrolothiazine compounds | |
AR097082A1 (es) | Compuestos terapéuticamente activos y sus métodos de uso | |
AR101558A1 (es) | Difluoropirrolidinas como moduladores del receptor de orexina | |
AR101815A1 (es) | Compuestos y composiciones como inhibidores de quinasa | |
AR096153A1 (es) | Derivados de pirrolo[2,3-d]pirimidina | |
AR097866A1 (es) | Derivados de 4-azaindol | |
RS54730B1 (sr) | Inhibitori beta sekretaze | |
AR103170A1 (es) | Compuestos y composiciones farmacéuticas de los mismos para el tratamiento de desordenes inflamatorios y osteoartritis | |
AR095421A1 (es) | Moduladores de p2x7 | |
MX2015015786A (es) | Compuestos de n-(tetrazol-5-il)- y n-(triazol-5-il) arilcarboxamida sustituidos y su uso como herbicidas. | |
AR102539A1 (es) | Triazolo[4,5-d]pirimidinas | |
AR099932A1 (es) | Derivados de piridina | |
AR095523A1 (es) | Derivados piridin-4-ilo | |
AR096152A1 (es) | Derivados de purina | |
CL2012000640A1 (es) | Uso del compuesto n-(4-((3-(2-amino-4-pirimidinil)-2-piridinil)oxi)fenil)-4-(4-metil-2-tienil)-1-ftalazinamina o su sal para el tratamiento de cancer refractario a tratamiento con un agente anti-cancer. | |
AR089753A1 (es) | Derivados de amida heterociclicos como antagonistas del receptor p2x7 | |
EA201591915A1 (ru) | Соединения феноксиэтил дигидро-1h-изохинолина | |
AR101359A1 (es) | Derivados de 2-oxa-5-azabiciclo[2.2.1]heptan-3-ilo | |
AR100439A1 (es) | Derivados de carboxamida | |
EA201591645A1 (ru) | Hантагонисты, имеющие феноксипиперидиновое ядро в структуре |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG | Grant, registration |