AR095421A1 - Moduladores de p2x7 - Google Patents
Moduladores de p2x7Info
- Publication number
- AR095421A1 AR095421A1 ARP140100965A ARP140100965A AR095421A1 AR 095421 A1 AR095421 A1 AR 095421A1 AR P140100965 A ARP140100965 A AR P140100965A AR P140100965 A ARP140100965 A AR P140100965A AR 095421 A1 AR095421 A1 AR 095421A1
- Authority
- AR
- Argentina
- Prior art keywords
- pyridinyl
- phenyl
- pyrazizyl
- thiophenyl
- pyrazinyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/18—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/18—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/18—Bridged systems
Abstract
Reivindicación 1: Un compuesto de la fórmula (1) o un enantiómero o diastereómero de este; o una sal farmacéuticamente aceptable de estos; en donde n es un entero de 0 - 1; X es CH₂ cuando n es 0, o X es CH₂ u oxígeno cuando n es 1; R¹ es fenilo o piridinilo, en donde el fenilo o piridinilo se sustituye, opcionalmente, con 1 a 4 sustituyentes seleccionados independientemente de halógeno y alquilo; y R² es fenilo, piridinilo, pirazinilo, piradizinilo, pirimidinilo, pirrolilo, pirazolilo, tiazolilo o tiofenilo, en donde el fenilo, piridinilo, pirazinilo, piradizinilo, pirimidinilo, pirrolilo, pirazolilo, tiazolilo o tiofenilo se sustituye, opcionalmente, con 1 a 2 sustituyentes seleccionados independientemente del grupo que consiste en halógeno, alquilo, hidroxi y alcoxi.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361785558P | 2013-03-14 | 2013-03-14 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR095421A1 true AR095421A1 (es) | 2015-10-14 |
Family
ID=50631041
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP140100965A AR095421A1 (es) | 2013-03-14 | 2014-03-13 | Moduladores de p2x7 |
Country Status (10)
Country | Link |
---|---|
US (3) | US9540388B2 (es) |
EP (2) | EP3309161B1 (es) |
JP (1) | JP6294954B2 (es) |
AR (1) | AR095421A1 (es) |
ES (2) | ES2776654T3 (es) |
HK (2) | HK1218649A1 (es) |
JO (1) | JO3509B1 (es) |
TW (1) | TWI627174B (es) |
UY (1) | UY35447A (es) |
WO (1) | WO2014152621A1 (es) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9040534B2 (en) | 2013-03-14 | 2015-05-26 | Janssen Pharmaceutica Nv | [1,2,4]triazolo[4,3-a]pyrazines as P2X7 modulators |
JO3509B1 (ar) * | 2013-03-14 | 2020-07-05 | Janssen Pharmaceutica Nv | معدلات p2x7 |
US9096596B2 (en) | 2013-03-14 | 2015-08-04 | Janssen Pharmaceutica Nv | P2X7 modulators |
JO3773B1 (ar) | 2013-03-14 | 2021-01-31 | Janssen Pharmaceutica Nv | معدلات p2x7 |
JP6592510B2 (ja) * | 2014-09-12 | 2019-10-16 | ヤンセン ファーマシューティカ エヌ.ベー. | P2x7調節因子 |
AU2016252686B2 (en) | 2015-04-24 | 2019-03-14 | Shionogi & Co., Ltd. | 6-membered heterocyclic derivative and pharmaceutical composition comprising same |
WO2017040772A1 (en) * | 2015-09-04 | 2017-03-09 | Janssen Pharmaceutica Nv | Therapeutic compounds and synthesis |
CN105596301A (zh) * | 2016-01-29 | 2016-05-25 | 中国药科大学 | 一种以异喹啉为基本骨架的p2x7受体拮抗剂的纳米混悬剂及其制备方法 |
CN105503884B (zh) * | 2016-02-17 | 2017-10-13 | 上海皓元生物医药科技有限公司 | 一种用于合成bet蛋白抑制剂的关键中间体的合成方法 |
MX2019004107A (es) | 2016-10-17 | 2019-08-05 | Shionogi & Co | Derivado heterociclico nitrogenado biciclico y composicion farmaceutica que lo contiene. |
US20200102311A1 (en) | 2018-09-28 | 2020-04-02 | Janssen Pharmaceutica Nv | Monoacylglycerol Lipase Modulators |
EP3856178A1 (en) | 2018-09-28 | 2021-08-04 | Janssen Pharmaceutica NV | Monoacylglycerol lipase modulators |
MA55805A (fr) | 2019-05-03 | 2022-03-09 | Flagship Pioneering Innovations V Inc | Métodes de modulation de l'activité immunitaire |
EP4038070A1 (en) | 2019-09-30 | 2022-08-10 | Janssen Pharmaceutica NV | Radiolabelled mgl pet ligands |
KR20220157999A (ko) | 2020-03-26 | 2022-11-29 | 얀센 파마슈티카 엔.브이. | 모노아실글리세롤 리파아제 조절제 |
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-
2014
- 2014-03-12 JO JOP/2014/0096A patent/JO3509B1/ar active
- 2014-03-12 TW TW103108580A patent/TWI627174B/zh not_active IP Right Cessation
- 2014-03-13 AR ARP140100965A patent/AR095421A1/es unknown
- 2014-03-14 JP JP2016502474A patent/JP6294954B2/ja not_active Expired - Fee Related
- 2014-03-14 UY UY0001035447A patent/UY35447A/es unknown
- 2014-03-14 EP EP17199037.7A patent/EP3309161B1/en active Active
- 2014-03-14 US US14/775,436 patent/US9540388B2/en active Active
- 2014-03-14 US US14/212,808 patent/US9102686B2/en not_active Expired - Fee Related
- 2014-03-14 ES ES17199037T patent/ES2776654T3/es active Active
- 2014-03-14 ES ES14721097.5T patent/ES2652648T3/es active Active
- 2014-03-14 WO PCT/US2014/027540 patent/WO2014152621A1/en active Application Filing
- 2014-03-14 EP EP14721097.5A patent/EP2970287B1/en not_active Not-in-force
-
2016
- 2016-06-08 HK HK16106617.2A patent/HK1218649A1/zh not_active IP Right Cessation
- 2016-12-12 US US15/375,774 patent/US10053462B2/en not_active Expired - Fee Related
-
2018
- 2018-10-15 HK HK18113181.2A patent/HK1254111A1/zh unknown
Also Published As
Publication number | Publication date |
---|---|
HK1218649A1 (zh) | 2017-03-03 |
WO2014152621A1 (en) | 2014-09-25 |
EP3309161A1 (en) | 2018-04-18 |
JO3509B1 (ar) | 2020-07-05 |
UY35447A (es) | 2014-09-30 |
US20140275056A1 (en) | 2014-09-18 |
HK1254111A1 (zh) | 2019-07-12 |
JP6294954B2 (ja) | 2018-03-14 |
ES2776654T3 (es) | 2020-07-31 |
US10053462B2 (en) | 2018-08-21 |
US20170088550A1 (en) | 2017-03-30 |
JP2016513702A (ja) | 2016-05-16 |
ES2652648T3 (es) | 2018-02-05 |
US9102686B2 (en) | 2015-08-11 |
TW201522339A (zh) | 2015-06-16 |
EP2970287A1 (en) | 2016-01-20 |
US20160039836A1 (en) | 2016-02-11 |
EP2970287B1 (en) | 2017-11-01 |
US9540388B2 (en) | 2017-01-10 |
TWI627174B (zh) | 2018-06-21 |
EP3309161B1 (en) | 2019-12-18 |
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