BR112015020795A2 - derivados de pirazol novos - Google Patents

derivados de pirazol novos

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Publication number
BR112015020795A2
BR112015020795A2 BR112015020795A BR112015020795A BR112015020795A2 BR 112015020795 A2 BR112015020795 A2 BR 112015020795A2 BR 112015020795 A BR112015020795 A BR 112015020795A BR 112015020795 A BR112015020795 A BR 112015020795A BR 112015020795 A2 BR112015020795 A2 BR 112015020795A2
Authority
BR
Brazil
Prior art keywords
pyrazole derivatives
new pyrazole
new
compound
formula
Prior art date
Application number
BR112015020795A
Other languages
English (en)
Other versions
BR112015020795B1 (pt
Inventor
Kimbara Atsushi
Ricklin Fabienne
Rogers-Evans Mark
Nettekoven Matthias
Roever Stephan
Schulz-Gasch Tanja
Grether Uwe
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of BR112015020795A2 publication Critical patent/BR112015020795A2/pt
Publication of BR112015020795B1 publication Critical patent/BR112015020795B1/pt

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
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    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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    • A61P19/00—Drugs for skeletal disorders
    • A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P25/00—Drugs for disorders of the nervous system
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    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
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    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Abstract

1/1 resumo “derivados de pirazol novos” a invenção relaciona-se a um composto de fórmula (i) em que a1 a a3 e r1 a r3 são definidos como na descrição e nas reivindicações. o composto de fórmula (i) pode ser usado como medicamento.
BR112015020795-2A 2013-03-07 2014-03-04 Derivados de pirazol BR112015020795B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP13158233.0 2013-03-07
EP13158233 2013-03-07
PCT/EP2014/054107 WO2014135507A1 (en) 2013-03-07 2014-03-04 Novel pyrazol derivatives

Publications (2)

Publication Number Publication Date
BR112015020795A2 true BR112015020795A2 (pt) 2017-07-18
BR112015020795B1 BR112015020795B1 (pt) 2022-08-16

Family

ID=47827068

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BR112015020795-2A BR112015020795B1 (pt) 2013-03-07 2014-03-04 Derivados de pirazol

Country Status (35)

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US (2) US9512132B2 (pt)
EP (1) EP2964646B1 (pt)
JP (2) JP6514119B2 (pt)
KR (2) KR102217297B1 (pt)
CN (1) CN105143220B (pt)
AR (1) AR094978A1 (pt)
AU (1) AU2014224784B2 (pt)
BR (1) BR112015020795B1 (pt)
CA (1) CA2897513C (pt)
CL (1) CL2015002387A1 (pt)
CR (1) CR20150447A (pt)
CY (1) CY1118950T1 (pt)
DK (1) DK2964646T3 (pt)
EA (1) EA027935B1 (pt)
ES (1) ES2629751T3 (pt)
HK (1) HK1213258A1 (pt)
HR (1) HRP20170919T1 (pt)
HU (1) HUE034831T2 (pt)
IL (1) IL240327B (pt)
LT (1) LT2964646T (pt)
MA (1) MA38403A1 (pt)
MX (1) MX363727B (pt)
MY (1) MY176797A (pt)
NZ (1) NZ710052A (pt)
PE (1) PE20151539A1 (pt)
PH (1) PH12015501843A1 (pt)
PL (1) PL2964646T3 (pt)
PT (1) PT2964646T (pt)
RS (1) RS56148B1 (pt)
SG (1) SG11201507168XA (pt)
SI (1) SI2964646T1 (pt)
TW (1) TWI609866B (pt)
UA (1) UA118666C2 (pt)
WO (1) WO2014135507A1 (pt)
ZA (1) ZA201505073B (pt)

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IL240327B (en) 2019-01-31
TWI609866B (zh) 2018-01-01
IL240327A0 (en) 2015-09-24
EP2964646B1 (en) 2017-04-19
PH12015501843B1 (en) 2015-12-07
ES2629751T3 (es) 2017-08-14
US20170035769A1 (en) 2017-02-09
UA118666C2 (uk) 2019-02-25
BR112015020795B1 (pt) 2022-08-16
SI2964646T1 (sl) 2017-08-31
AR094978A1 (es) 2015-09-09
KR102217297B1 (ko) 2021-02-22
KR102369407B1 (ko) 2022-03-02
MY176797A (en) 2020-08-21
CR20150447A (es) 2015-10-08
CN105143220A (zh) 2015-12-09
TW201506023A (zh) 2015-02-16
SG11201507168XA (en) 2015-10-29
ZA201505073B (en) 2016-07-27
MA38403A1 (fr) 2017-11-30
RS56148B1 (sr) 2017-11-30
LT2964646T (lt) 2017-07-10
KR20210019578A (ko) 2021-02-22
PE20151539A1 (es) 2015-10-28
CA2897513A1 (en) 2014-09-12
MX2015011534A (es) 2016-02-05
US9694012B2 (en) 2017-07-04
CN105143220B (zh) 2018-06-22
CA2897513C (en) 2021-03-16
EA201591624A1 (ru) 2016-01-29
JP6514119B2 (ja) 2019-05-15
AU2014224784A1 (en) 2015-07-23
US9512132B2 (en) 2016-12-06
KR20150126355A (ko) 2015-11-11
WO2014135507A1 (en) 2014-09-12
EA027935B1 (ru) 2017-09-29
HUE034831T2 (en) 2018-03-28
AU2014224784B2 (en) 2018-03-08
JP2016510054A (ja) 2016-04-04
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US20150376192A1 (en) 2015-12-31
JP2019055986A (ja) 2019-04-11
CL2015002387A1 (es) 2016-03-04
PT2964646T (pt) 2017-06-29
EP2964646A1 (en) 2016-01-13
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PL2964646T3 (pl) 2017-09-29

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