AR088768A1 - lNHlBlDORES DEL VlRUS DE LA HEPATlTlS C - Google Patents

lNHlBlDORES DEL VlRUS DE LA HEPATlTlS C

Info

Publication number
AR088768A1
AR088768A1 ARP120104137A ARP120104137A AR088768A1 AR 088768 A1 AR088768 A1 AR 088768A1 AR P120104137 A ARP120104137 A AR P120104137A AR P120104137 A ARP120104137 A AR P120104137A AR 088768 A1 AR088768 A1 AR 088768A1
Authority
AR
Argentina
Prior art keywords
dioxo
carbamoyl
oxy
hexadecahydrocyclopropa
carbamate
Prior art date
Application number
ARP120104137A
Other languages
English (en)
Inventor
Sun L
Qang-Mull Erc
P Glls Erc
S Bowsher Mchael
Zhao Qan
V Renduchntala Kshore
Sarkunam Kandhasamy
Nagalakshm Pulcharla
P V K Babu Suresh
Mchael Scola Paul
Original Assignee
Brlstol Myers Squlbb Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Brlstol Myers Squlbb Company filed Critical Brlstol Myers Squlbb Company
Publication of AR088768A1 publication Critical patent/AR088768A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/002—Heterocyclic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0827—Tripeptides containing heteroatoms different from O, S, or N
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05—Isotopically modified compounds, e.g. labelled

Abstract

También composiciones que comprenden los compuestos y métodos para la utilización de los compuestos para inhibir el VHC. Reivindicación 1: Un compuesto caracterizado porque se selecciona de: ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a-(((1-(fluorometil)ciclopropil)sulfonil)carbamoil)-2-((3-(4-isopropoxifenil)-6-metoxiisoquinolin-1-il)oxi)-7,9-dimetil-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahidrociclopropa[e]pirrolo[1,2-a][1,4]diazaciclopentadecin-6-il)carbamato de (S)-3-(trifluorometil)tetrahidro-2H-piran-3-ilo; ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a-(((1-(fluorometil)ciclopropil)sulfonil)carbamoil)-2-((3-(4-isopropoxifenil)-6-metoxiisoquinolin-1-il)oxi-7,9-dimetil-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahidrociclopropa[e]pirrolo[1,2-a][1,4]diazaciclopentadecin-6-il)carbamato de (R)-3-(trifluorometil)tetrahidro-2H-piran-3-ilo; ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-2-((7-fluoro-6-metoxiisoquinolin-1-il)oxi)14a-(((1-(fluorometil)ciclopropil)sulfonil)carbamoil)-7,9-dimetil-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahidrociclopropa[e]pirrolo[1,2-a][1-4]diazaciclopentadecin-6-il)carbamato de 1,1,1-trifluoro-2-metilpropan-2-ilo; ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-2-((7-fluoro-6-metoxiisoquinolin-1-il)oxi)-14a-(((1-(fluorometil)ciclopropil)sulfonil)carbamoil)-7,9-dimetil-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahidrociclopropa[e]pirrolo[1,2-a][1,4]diazaciclopentadecin-6-il)carbamato de 1,1,1-trifluoro-2-metilpropan-2-ilo; ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-7-etil-2-((7-fluoro-3,6-dimetoxiisoquinolin-1-il)oxi)-9-metil-14a-(((1-metilciclopropil)sulfonil)carbamoil)-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahidrociclopropa[e]pirrolo[1,2-a][1,4]diazaciclopentadecin-6-il)carbamato de 1,1,1-trifluoro-2-metilpropan-2-ilo; ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-7-etil-2-((7-fluoro-3,6-dimetoxiisoquinolin-1-il)oxi)-9-metil-14a-(((1-metilciclopropil)sulfonil)carbamoil)-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahidrociclopropa[e]pirrolo[1,2-a][1,4]diazaciclopentadecin-6-il)carbamato de 3,3-difluoro-2-metilbutan-2-ilo; ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-7-etil-2-((7-fluoro-3,6-dimetoxiisoquinolin-1-il)oxi)-9-metil-14a-(((1-metilciclopropil)sulfonil)carbamoil)-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahidrociclopropa[e]pirrolo[1,2-a][1,4]diazaciclopentadecin-6-il)carbamato de 3-(trifluorometil)tetrahidro-2H-piran-3-ilo; ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-2-((7-fluoro-6-metoxiisoquinolin-1-il)oxi)-14a-(((1-(fluorometil)ciclopropil)sulfonil)carbamoil)-7,9-dimetil-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahidrociclopropa[e]pirrolo[1,2-a][1,4]diazaciclopentadecin-6-il)carbamato de 2-(trifluorometil)tetrahidro-2H-piran-2-ilo; ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-2-((7-fluoro-6-metoxiisoquinolin-1-il)oxi)-14a-(((1-(fluorometil)ciclopropil)sulfonil)carbamoil)-7,9-dimetil-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahidrociclopropa[e]pirrolo[1,2-a][1,4]diazaciclopentadecin-6-il)carbamato de 2-(trifluorometil)tetrahidro-2H-piran-2-ilo; ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-7-etil-2-((7-fluoro-6-metoxiisoquinolin-1-il)oxi)-9-metil-14a-(((1-metilciclopropil)sulfonil)carbamoil)-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahidrociclopropa[e]pirrolo[1,2a][1,4]diazaciclopentadecin-6-il)carbamato de 2-(trifluorometil)tetrahidro-2H-piran-2-ilo; ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-2-((3,6-dimetoxiisoquinolin-1-il)oxi)-7-etil-14a-(((1-(fluorometil)ciclopropil)sulfonil)carbamoil)-9-metil-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahidrociclopropa[e]pirrolo[1,2-a][1,4]diazaciclopentadecin-6-il)carbamato de 1,1,1-trifluoro-2-metilpropan-2-ilo; ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-2-((3,6-dimetoxiisoquinolin-1-il)oxi)-7-etil-14a-(((1-(fluorometil)ciclopropil)sulfonil)carbamoil)-9-metil-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahidrociclopropa[e]pirrolo[1,2-a][1,4]diazaciclopentadecin-6-il)carbamato de 1,1,1-trifluoro-2-metilpropan-2-ilo; ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a-((ciclopropilsulfonil)carbamoil)-7-etil-2-((8-fluoro-9-metoxi-2,3-dihidro-1H-pirano[2,3-c]isoquinolin-6-il)oxi)-9-metil-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahidrociclopropa[e]pirrolo[1,2-a][1,4]diazaciclopentadecin-6-il)carbamato de 1,1,1-trifluoro-2-metilpropan-2-ilo; ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a-((ciclopropilsulfonil)carbamoil)-7-etil-2-((8-fluoro-9-metoxi-2,3-dihidro-1H-pirano[2,3-c]isoquinolin-6-il)oxi)-7,9-dimetil-14a-(((1-metilciclopropil)sulfonil)carbamoil)-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahidrociclopropa[e]pirrolo[1,2-a][1,4]diazaciclopentadecin-6-il)carbamato de 1,1,1-trifluoro-2-metilpropan-2-ilo; ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-7-etil-2-((8-fluoro-9-metoxi-2,3-dihidro-1H-pirano[2,3-c]isoquinolin-6-il)oxi)-9-metil-14a-(((1-metilciclopropil)sulfonil)carbamoil)-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahidrociclopropa[e]pirrolo[1,2-a][1,4]diazaciclopentadecin-6-il)carbamato de 1,1,1-trifluoro-2-metilpropan-2-ilo; ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-7-etil-2-((8-fluoro-9-metoxi-2,3-dihidro-1H-pirano[2,3-c]isoquinolin-6-il)oxi)-9-metil-14a-(((1-metilciclopropil)sulfonil)carbamoil)-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahidrociclopropa[e]pirrolo[1,2-a][1,4]diazaciclopentadecin-6-il)carbamato de 3,3-difluoro-2-metilbutan-2-ilo; ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-7-etil-2-((6-fluoro-2,7-dimetoxiquinolin-4-il)oxi)-9-metil-14a-(((1-metilciclopropil)sulfonil)carbamoil)-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahidrociclopropa[e]pirrolo[1,2-a][1,4]diazaciclopentadecin-6-il)carbamato de 1,1,1-trifluoro-2-metilpropan-2-ilo; ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-7-etil-2-((6-fluoro-2,7-dimetoxiquinolin-4-il)oxi)-9-metil-14a-(((1-metilciclopropil)sulfonil)carbamoil)-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahidrociclopropa[e]pirrolo[1,2-a][1,4]diazaciclopentadecin-6-il)carbamato de 3,3-difluoro-2-metilbutan-2-ilo; ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a-((ciclopropilsulfonil)carbamoil)-7-etil-2-((6-fluoro-2,7-dimetoxiquinolin-4-il)oxi)-9-metil-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahidrociclopropa[e]pirrolo[1,2-a][1,4]diazaciclopentadecin-6-il)carbamato de 1,1,1-trifluoro-2-metilpropan-2-ilo; ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a-((ciclopropilsulfonil)carbamoil)-7-etil-2-((6-fluoro-2,7-dimetoxiquinolin-4-il)oxi)-9-metil-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahidrociclopropa[e]pirrolo[1,2-a][1,4]diazaciclopentadecin-6-il)carbamato de 3,3-difluoro-2-metilbutan-2-ilo; ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-2-((6-fluoro-2,7-dimetoxiquinolin-4-il)oxi)-7,9-dimetil-14a-(((1-metilciclopropil)sulfonil)carbamoil)-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahidrociclopropa[e]pirrolo[1,2-a][1,4]diazaciclopentadecin-6-il)carbamato de 1,1,1-trifluoro-2-metilpropan-2-ilo; ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-2-((6-fluoro-2,7-dimetoxiquinolin-4-il)oxi)-7,9-dimetil-14a-(((1-metilciclopropil)sulfonil)carbamoil)-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahidrociclopropa[e]pirrolo[1,2-a][1,4]diazaciclopentadecin-6-il)carbamato de 3,3-difluoro-2-metilbutan-2-ilo; ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a-((ciclopropilsulfonil)carbamoil)-2-((6-metoxiisoquinolin-1-il)oxi)-7,9-dimetil-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahidrociclopropa[e]pirrolo[1,2-a][1,4]diazaciclopentadecin-6-il)carbamato de terc-butilo; ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a-((ciclopropilsulfonil)carbamoil)-2-((6-metoxiisoquinolin-1-il)oxi)-7,9-dimetil-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahidrociclopropa[e]pirrolo[1,2-a][1,4]diazaciclopentadecin-6-il)carbamato de terc-butilo; ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-2-((7-cloro-4-metoxiisoquinolin-1-il)oxi)14a-((ciclopropilsulfonil)carbamoil)-7,9-dimetil-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahidrociclopropa[e]pirrolo[1,2-a][1,4]diazaciclopentadecin-6-il)carbamato de terc-butilo; ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-2-((7cloro-4-metoxiisoquinolin-1-il)oxi)-14a-((ciclopropilsulfonil)carbamoil)-7,9-dimetil-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahidrociclopropa[e]pirrolo[1,2-a][1,4]diazaciclopentadecin-6-il)carbamato de terc-butilo; ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-2-((2,7dimetoxiquinolin-4-il)oxi)-7-etil-9-metil-14a-(((1-metilciclopropil)sulfonil)carbamoil)-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahidrociclopropa[e]pirrolo[1,2-a][1,4]diazaciclopentadecin-6-il)carbamato de 1,1,1-trifluoro-2-metilpropan-2-ilo; ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-2-((2,7-dimetoxiquinolin-4-il)oxi)-7-etil-9-metil-14a-(((1-metilciclopropil)sulfonil)carbamoil)-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahidrociclopropa[e]pirrolo[1,2-a][1,4]diazaciclopentadecin-6-il)carbamato de 3,3-difluoro-2-metilbutan-2-ilo; ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a-((ciclopropilsulfonil)carbamoil-2-((2,7-dimetoxiquinolin-4-il)oxi)-7-etil-9-metil-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahidrociclopropa[e]pirrolo[1,2-a][1,4]diazaciclopentadecin-6-il)carbamato de 1,1,1-trifluoro-2-metilpropan-2-ilo; ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a-((ciclopropilsulfonil)carbamoil)-2-((2,7-dimetoxiquinolin-4-il)oxi)-7-etil-9-metil-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahidrociclopropa[e]pirrolo[1,2-a][1,4]diazaciclopentadecin-6-il)carbamato de 3,3-difluoro-2-metilbutan-2-ilo; ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-2-((2,7-dimetoxiquinolin-4-il)oxi)-7,9-dimetil-14a-(((1-metilciclopropil)sulfonil)carbamoil)-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahidrociclopropa[e]pirrolo[1,2-a][1,4]diazaciclopentadecin-6-il)carbamato de 1,1,1-trifluoro-2-metilpropan-2-ilo; ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-2-((2,7-dimetoxiquinolin-4-il)oxi)-7,9-dimetil-14a-(((1-metilciclopropil)sulfonil)carbamoil)-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a
ARP120104137A 2012-10-19 2012-11-02 lNHlBlDORES DEL VlRUS DE LA HEPATlTlS C AR088768A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2012/061094 WO2014062196A1 (en) 2012-10-19 2012-10-19 Hepatitis c virus inhibitors

Publications (1)

Publication Number Publication Date
AR088768A1 true AR088768A1 (es) 2014-07-02

Family

ID=47144142

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP120104137A AR088768A1 (es) 2012-10-19 2012-11-02 lNHlBlDORES DEL VlRUS DE LA HEPATlTlS C

Country Status (30)

Country Link
US (1) US9499550B2 (es)
EP (1) EP2909205B1 (es)
JP (1) JP6154474B2 (es)
KR (1) KR20150074051A (es)
CN (1) CN104918941A (es)
AR (1) AR088768A1 (es)
AU (1) AU2012392557B2 (es)
BR (1) BR112015007879A2 (es)
CA (1) CA2888755A1 (es)
CY (1) CY1118729T1 (es)
DK (1) DK2909205T3 (es)
EA (1) EA025560B1 (es)
ES (1) ES2613766T3 (es)
HK (1) HK1212332A1 (es)
HR (1) HRP20161694T1 (es)
HU (1) HUE031625T2 (es)
IL (1) IL238286B (es)
LT (1) LT2909205T (es)
MA (1) MA37992B1 (es)
MX (1) MX360452B (es)
PH (1) PH12015500814A1 (es)
PL (1) PL2909205T3 (es)
PT (1) PT2909205T (es)
RS (1) RS55592B1 (es)
SG (1) SG11201502802PA (es)
SI (1) SI2909205T1 (es)
SM (1) SMT201700117B (es)
TW (1) TWI570125B (es)
WO (1) WO2014062196A1 (es)
ZA (1) ZA201503458B (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9643999B2 (en) * 2012-11-02 2017-05-09 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US9334279B2 (en) 2012-11-02 2016-05-10 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
WO2014070964A1 (en) 2012-11-02 2014-05-08 Bristol-Myers Squibb Company Hepatitis c virus inhibitors
EP2914614B1 (en) 2012-11-05 2017-08-16 Bristol-Myers Squibb Company Hepatitis c virus inhibitors
US9580463B2 (en) 2013-03-07 2017-02-28 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
JP2020193181A (ja) * 2019-05-30 2020-12-03 東ソー株式会社 芳香族ニトリル化合物の製造方法
US20220227806A1 (en) * 2019-06-07 2022-07-21 University Of Massachusetts Hepatitis c virus ns3/4a protease inhibitors
CN112094229B (zh) * 2020-10-12 2022-11-22 苏州康润医药有限公司 6-（三氟甲基）异喹啉-5-醇的合成方法
CN114805204B (zh) * 2022-04-01 2023-09-15 云南师范大学 一种制备4-碘异喹啉-1(2h)-酮类化合物的方法

Family Cites Families (253)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0475255A3 (en) 1990-09-12 1993-04-14 F. Hoffmann-La Roche Ag Process for the preparation of optically pure (s)-alpha-((tert-butylsulfonyl)methyl)hydro cinnamic acid
CZ298749B6 (cs) 1996-10-18 2008-01-16 Vertex Pharmaceuticals Incorporated Inhibitory serinových proteáz a farmaceutické prostředky s jejich obsahem
ZA9710071B (en) 1996-11-21 1998-05-25 Abbott Lab Pharmaceutical composition.
ATE283865T1 (de) 1997-08-11 2004-12-15 Boehringer Ingelheim Ca Ltd Peptidanaloga mit inhibitorischer wirkung auf hepatitis c
ES2241157T3 (es) 1997-08-11 2005-10-16 Boehringer Ingelheim (Canada) Ltd. Peptidos inhibidores de la hepatitis c.
AR022061A1 (es) 1998-08-10 2002-09-04 Boehringer Ingelheim Ca Ltd Peptidos inhibidores de la hepatitis c, una composicion farmaceutica que los contiene, el uso de los mismos para preparar una composicion farmaceutica, el uso de un producto intermedio para la preparacion de estos peptidos y un procedimiento para la preparacion de un peptido analogo de los mismos.
US6323180B1 (en) 1998-08-10 2001-11-27 Boehringer Ingelheim (Canada) Ltd Hepatitis C inhibitor tri-peptides
UA74546C2 (en) * 1999-04-06 2006-01-16 Boehringer Ingelheim Ca Ltd Macrocyclic peptides having activity relative to hepatitis c virus, a pharmaceutical composition and use of the pharmaceutical composition
US7244721B2 (en) 2000-07-21 2007-07-17 Schering Corporation Peptides as NS3-serine protease inhibitors of hepatitis C virus
SI1385870T1 (sl) 2000-07-21 2010-08-31 Schering Corp Peptidi kot NS3-serin proteazni inhibitorji virusa hepatitisa C
CA2429359A1 (en) 2000-11-20 2002-08-08 Bristol-Myers Squibb Company Hepatitis c tripeptide inhibitors
US6867185B2 (en) 2001-12-20 2005-03-15 Bristol-Myers Squibb Company Inhibitors of hepatitis C virus
CA2369711A1 (en) 2002-01-30 2003-07-30 Boehringer Ingelheim (Canada) Ltd. Macrocyclic peptides active against the hepatitis c virus
CA2370396A1 (en) 2002-02-01 2003-08-01 Boehringer Ingelheim (Canada) Ltd. Hepatitis c inhibitor tri-peptides
CA2369970A1 (en) 2002-02-01 2003-08-01 Boehringer Ingelheim (Canada) Ltd. Hepatitis c inhibitor tri-peptides
US6828301B2 (en) 2002-02-07 2004-12-07 Boehringer Ingelheim International Gmbh Pharmaceutical compositions for hepatitis C viral protease inhibitors
MY140680A (en) 2002-05-20 2010-01-15 Bristol Myers Squibb Co Hepatitis c virus inhibitors
ATE503764T1 (de) 2002-05-20 2011-04-15 Bristol Myers Squibb Co Inhibitoren des hepatitis-c-virus
US20060199773A1 (en) 2002-05-20 2006-09-07 Sausker Justin B Crystalline forms of (1R,2S)-N-[(1,1-dimethylethoxy)carbonyl]-3-methyl-L-valyl-(4R)-4-[(6-methoxy-1-isoquinolinyl)oxy]-L-prolyl-1-amino-N-(cyclopropylsulfonyl)-2-ethenyl-cyclopropanecarboxamide, monopotassium salt
ES2350201T3 (es) 2002-05-20 2011-01-20 Bristol-Myers Squibb Company Sulfamidas heterocíclicas como inhibidores del virus de la hepatitis c.
AU2003301959A1 (en) 2002-05-20 2004-06-03 Bristol-Myers Squibb Company Substituted cycloalkyl p1' hepatitis c virus inhibitors
US20040033959A1 (en) 2002-07-19 2004-02-19 Boehringer Ingelheim Pharmaceuticals, Inc. Pharmaceutical compositions for hepatitis C viral protease inhibitors
US20050075279A1 (en) 2002-10-25 2005-04-07 Boehringer Ingelheim International Gmbh Macrocyclic peptides active against the hepatitis C virus
US7601709B2 (en) 2003-02-07 2009-10-13 Enanta Pharmaceuticals, Inc. Macrocyclic hepatitis C serine protease inhibitors
KR100940619B1 (ko) 2003-02-07 2010-02-05 이난타 파마슈티칼스, 인코포레이티드 마크로사이클릭 씨형 간염 세린 단백효소 억제제
WO2004101602A2 (en) 2003-03-05 2004-11-25 Boehringer Ingelheim International Gmbh Hepatitis c inhibitor peptide analogs
CA2516016C (en) 2003-03-05 2012-05-29 Boehringer Ingelheim International Gmbh Hepatitis c inhibiting compounds
NZ543250A (en) 2003-04-02 2008-12-24 Boehringer Ingelheim Int Pharmaceutical compositions for hepatitis C viral protease inhibitors
EP2033654B1 (en) 2003-04-16 2012-05-16 Bristol-Myers Squibb Company Process for resolving a mixture of alkyl ester enantiomers using an enzyme
JP4778893B2 (ja) 2003-04-18 2011-09-21 エナンタ ファーマシューティカルズ インコーポレイテッド キノキサリニル大環状のｃ型肝炎セリンプロテアーゼ阻害剤
PL1654261T3 (pl) 2003-05-21 2008-04-30 Boehringer Ingelheim Int Związki hamujące aktywność wirusa zapalenia wątroby typu C
WO2004113365A2 (en) 2003-06-05 2004-12-29 Enanta Pharmaceuticals, Inc. Hepatitis c serine protease tri-peptide inhibitors
US7125845B2 (en) 2003-07-03 2006-10-24 Enanta Pharmaceuticals, Inc. Aza-peptide macrocyclic hepatitis C serine protease inhibitors
PE20050431A1 (es) 2003-09-22 2005-07-19 Boehringer Ingelheim Int Peptidos macrociclicos activos contra el virus de la hepatitis c
WO2005037860A2 (en) 2003-10-10 2005-04-28 Vertex Pharmaceuticals Incoporated Inhibitors of serine proteases, particularly hcv ns3-ns4a protease
TWI375679B (en) 2003-10-14 2012-11-01 Hoffmann La Roche Macrocyclic carboxylic acids and acylsulfonamides as inhibitors of hcv replication
US7132504B2 (en) 2003-11-12 2006-11-07 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US7309708B2 (en) 2003-11-20 2007-12-18 Birstol-Myers Squibb Company Hepatitis C virus inhibitors
JP2007532479A (ja) 2003-11-20 2007-11-15 シェーリング　コーポレイション Ｃ型肝炎ウイルスｎｓ３プロテアーゼの脱ペプチド化インヒビター
US7135462B2 (en) 2003-11-20 2006-11-14 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
EP1730167B1 (en) 2004-01-21 2011-01-12 Boehringer Ingelheim International GmbH Macrocyclic peptides active against the hepatitis c virus
BRPI0506945A (pt) 2004-01-30 2007-06-12 Medivir Ab inibidores de serina protease ns-3 de hcv
BRPI0508867A (pt) 2004-03-15 2007-09-04 Boehringer Ingelheim Int processo para a preparação de compostos macrocìclicos
AP2006003763A0 (en) 2004-03-30 2006-10-31 Intermune Inc Macrocyclic compounds as inhibitors of viral replication
WO2006016930A2 (en) 2004-05-14 2006-02-16 Intermune, Inc. Methods for treating hcv infection
US7514557B2 (en) 2004-05-25 2009-04-07 Boehringer Ingelheim International Gmbh Process for preparing acyclic HCV protease inhibitors
JP4914348B2 (ja) 2004-06-28 2012-04-11 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｃ型肝炎インヒビターペプチド類似体
EP2316839B1 (en) 2004-07-16 2014-03-12 Gilead Sciences, Inc. Antiviral heterocyclic compounds having phosphonate groups
UY29016A1 (es) 2004-07-20 2006-02-24 Boehringer Ingelheim Int Analogos de dipeptidos inhibidores de la hepatitis c
CA2573346C (en) 2004-07-20 2011-09-20 Boehringer Ingelheim International Gmbh Hepatitis c inhibitor peptide analogs
CN101068828A (zh) 2004-08-27 2007-11-07 先灵公司 用作丙型肝炎病毒ns3丝氨酸蛋白酶抑制剂的酰基磺酰胺化合物
EP1794178A1 (en) 2004-09-17 2007-06-13 Boehringer Ingelheim International Gmbh Process for preparing macrocyclic hcv protease inhibitors
WO2007001406A2 (en) 2004-10-05 2007-01-04 Chiron Corporation Aryl-containing macrocyclic compounds
EP1805187A1 (en) 2004-10-21 2007-07-11 Pfizer, Inc. Inhibitors of hepatitis c virus protease, and compositions and treatments using the same
US7323447B2 (en) 2005-02-08 2008-01-29 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
NZ562167A (en) 2005-03-08 2011-01-28 Boehringer Ingelheim Int Process for preparing macrocyclic compounds
AU2006242475B2 (en) 2005-05-02 2011-07-07 Merck Sharp & Dohme Corp. HCV NS3 protease inhibitors
US7592336B2 (en) 2005-05-10 2009-09-22 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US20070021351A1 (en) 2005-06-02 2007-01-25 Schering Corporation Liver/plasma concentration ratio for dosing hepatitis C virus protease inhibitor
WO2006130607A2 (en) 2005-06-02 2006-12-07 Schering Corporation Controlled-release formulation useful for treating disorders associated with hepatitis c virus
US20070004635A1 (en) 2005-06-02 2007-01-04 Schering Corporation Method of treating interferon non-responders using HCV protease inhibitor
WO2006130552A2 (en) 2005-06-02 2006-12-07 Schering Corporation Methods of treating hepatitis c virus
US20060276405A1 (en) 2005-06-02 2006-12-07 Schering Corporation Methods for treating hepatitis C
PL1891089T3 (pl) 2005-06-02 2015-05-29 Merck Sharp & Dohme Inhibitory proteazy HCV w połączeniu z pokarmem
WO2006130688A2 (en) 2005-06-02 2006-12-07 Schering Corporation Compounds for inhibiting cathepsin activity
WO2006130626A2 (en) 2005-06-02 2006-12-07 Schering Corporation Method for modulating activity of hcv protease through use of a novel hcv protease inhibitor to reduce duration of treatment period
WO2006130666A2 (en) 2005-06-02 2006-12-07 Schering Corporation Medicaments and methods combining a hcv protease inhibitor and an akr competitor
US20060276407A1 (en) 2005-06-02 2006-12-07 Schering Corporation Methods of treating hepatitis C virus
JP5160415B2 (ja) 2005-06-02 2013-03-13 メルク・シャープ・アンド・ドーム・コーポレーション 医薬処方物およびそれを用いる治療方法
US7601686B2 (en) 2005-07-11 2009-10-13 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
TWI389908B (zh) 2005-07-14 2013-03-21 Gilead Sciences Inc 抗病毒化合物類
TW200738742A (en) 2005-07-14 2007-10-16 Gilead Sciences Inc Antiviral compounds
WO2007009227A1 (en) 2005-07-20 2007-01-25 Boehringer Ingelheim International Gmbh Hepatitis c inhibitor peptide analogs
US7470664B2 (en) 2005-07-20 2008-12-30 Merck & Co., Inc. HCV NS3 protease inhibitors
NZ565059A (en) 2005-07-25 2011-08-26 Intermune Inc Novel macrocyclic inhibitors of hepatitus C virus replication
TWI383980B (zh) 2005-07-29 2013-02-01 Tibotec Pharm Ltd Ｃ型肝炎病毒之大環抑制劑
US8183277B2 (en) 2005-07-29 2012-05-22 Tibotec Pharmaceuticals Ltd. Macrocylic inhibitors of hepatitis C virus
BRPI0614638A2 (pt) 2005-07-29 2011-04-12 Tibotec Pharm Ltd compostos inibidores macrocìclicos do vìrus da hepatite c, uso dos mesmos, processo para a preparação dos mesmos, combinação e composição farmacêutica
PE20070343A1 (es) 2005-07-29 2007-05-12 Medivir Ab Inhibidores macrociclicos del virus de la hepatitis c
PE20070211A1 (es) 2005-07-29 2007-05-12 Medivir Ab Compuestos macrociclicos como inhibidores del virus de hepatitis c
EP1910347A2 (en) 2005-07-29 2008-04-16 Medivir Ab Macrocylic inhibitors of hepatitis c virus
KR101381387B1 (ko) 2005-07-29 2014-04-11 메디비르 아베 Ｃ형 간염 바이러스의 마크로사이클릭 억제제
JO2768B1 (en) 2005-07-29 2014-03-15 تيبوتيك فارماسيوتيكالز ليمتد Large cyclic inhibitors of hepatitis C virus
JP5230417B2 (ja) 2005-07-29 2013-07-10 テイボテク・フアーマシユーチカルズ Ｃ型肝炎ウイルスの大員環インヒビター
PE20070210A1 (es) 2005-07-29 2007-04-16 Tibotec Pharm Ltd Compuestos macrociclicos como inhibidores del virus de hepatitis c
PL1919899T3 (pl) 2005-07-29 2011-06-30 Tibotec Pharm Ltd Makrocykliczne inhibitory wirusa zapalenia wątroby typu C
EP1915382A2 (en) 2005-08-01 2008-04-30 Phenomix Corporation Hepatitis c serine protease inhibitors and uses therefor
US8278322B2 (en) 2005-08-01 2012-10-02 Merck Sharp & Dohme Corp. HCV NS3 protease inhibitors
AR055395A1 (es) 2005-08-26 2007-08-22 Vertex Pharma Compuestos inhibidores de la actividad de la serina proteasa ns3-ns4a del virus de la hepatitis c
ES2364426T3 (es) 2005-09-09 2011-09-02 Boehringer Ingelheim International Gmbh Proceso de metátesis con cerrado del anillo para la preparación de péptidos macrocíclicos.
JP2009511595A (ja) 2005-10-11 2009-03-19 インターミューン・インコーポレーテッド Ｃ型肝炎ウイルスの複製を阻害する化合物および方法
US7772183B2 (en) 2005-10-12 2010-08-10 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US7741281B2 (en) 2005-11-03 2010-06-22 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US20070161670A1 (en) 2006-01-09 2007-07-12 Bristol-Myers Squibb Company Process for the preparation of substituted heterocycles
EP1998765A2 (en) 2006-03-03 2008-12-10 Schering Corporation Pharmaceutical combinations of hcv-protease and -ires inhibitors
WO2007120595A2 (en) 2006-04-11 2007-10-25 Novartis Ag Amines for the treatment of hcv
GB0609492D0 (en) 2006-05-15 2006-06-21 Angeletti P Ist Richerche Bio Therapeutic agents
US20070281884A1 (en) 2006-06-06 2007-12-06 Ying Sun Macrocyclic oximyl hepatitis C protease inhibitors
US8268776B2 (en) 2006-06-06 2012-09-18 Enanta Pharmaceuticals, Inc. Macrocylic oximyl hepatitis C protease inhibitors
GB0612423D0 (en) 2006-06-23 2006-08-02 Angeletti P Ist Richerche Bio Therapeutic agents
AR061629A1 (es) 2006-06-26 2008-09-10 Enanta Pharm Inc Quinoxalinil macrociclicos inhibidores de serina proteasa del virus de la hepatitis c. proceso de obtencion y composiciones farmaceuticas
KR20090024834A (ko) 2006-07-05 2009-03-09 인터뮨, 인크. Ｃ형 간염 바이러스 복제의 신규 억제제
ATE554776T1 (de) 2006-07-07 2012-05-15 Gilead Sciences Inc Antivirale phosphinatverbindungen
EP2049474B1 (en) 2006-07-11 2015-11-04 Bristol-Myers Squibb Company Hepatitis c virus inhibitors
EA017448B1 (ru) 2006-07-13 2012-12-28 Ачиллион Фармасьютикалз, Инк. 4-амино-4-оксобутаноиловые пептиды как ингибиторы вирусной репликации
CA2656816A1 (en) 2006-08-04 2008-02-14 Enanta Pharmaceuticals, Inc. Tetrazolyl macrocyclic hepatitis c serine protease inhibitors
WO2008019303A2 (en) 2006-08-04 2008-02-14 Enanta Pharmaceuticals, Inc. Pyridazinonyl macrocyclic hepatitis c serine protease inhibitors
US20090035267A1 (en) 2007-07-31 2009-02-05 Moore Joel D Acyclic, pyridazinone-derived hepatitis c serine protease inhibitors
US7635683B2 (en) 2006-08-04 2009-12-22 Enanta Pharmaceuticals, Inc. Quinoxalinyl tripeptide hepatitis C virus inhibitors
US20090035268A1 (en) 2007-08-01 2009-02-05 Ying Sun Tetrazolyl acyclic hepatitis c serine protease inhibitors
US7605126B2 (en) 2006-08-11 2009-10-20 Enanta Pharmaceuticals, Inc. Acylaminoheteroaryl hepatitis C virus protease inhibitors
WO2008022006A2 (en) 2006-08-11 2008-02-21 Enanta Pharmaceuticals, Inc. Arylalkoxyl hepatitis c virus protease inhibitors
WO2008021960A2 (en) 2006-08-11 2008-02-21 Enanta Pharmaceuticals, Inc. Triazolyl macrocyclic hepatitis c serine protease inhibitors
US20080038225A1 (en) 2006-08-11 2008-02-14 Ying Sun Triazolyl acyclic hepatitis c serine protease inhibitors
US7582605B2 (en) 2006-08-11 2009-09-01 Enanta Pharmaceuticals, Inc. Phosphorus-containing hepatitis C serine protease inhibitors
JP2010507656A (ja) 2006-10-24 2010-03-11 メルク エンド カムパニー インコーポレーテッド Ｈｃｖｎｓ３プロテアーゼ阻害剤
CA2667266C (en) 2006-10-24 2015-11-24 Merck & Co., Inc. Hcv ns3 protease inhibitors
EP2079479B1 (en) 2006-10-24 2014-11-26 Merck Sharp & Dohme Corp. Hcv ns3 protease inhibitors
ES2444575T3 (es) 2006-10-27 2014-02-25 Merck Sharp & Dohme Corp. Inhibidores de la proteasa NS3 del VHC
MX2009004556A (es) 2006-10-27 2009-07-10 Merck & Co Inc Inhibidores de la proteasa ns3 del hcv.
US20080107623A1 (en) 2006-11-01 2008-05-08 Bristol-Myers Squibb Company Inhibitors of Hepatitis C Virus
US20080107625A1 (en) 2006-11-01 2008-05-08 Bristol-Myers Squibb Company Inhibitors of Hepatitis C Virus
US8343477B2 (en) 2006-11-01 2013-01-01 Bristol-Myers Squibb Company Inhibitors of hepatitis C virus
TW200827364A (en) 2006-11-02 2008-07-01 Taigen Biotechnology Co Ltd HCV protease inhibitors
US7772180B2 (en) 2006-11-09 2010-08-10 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US7763584B2 (en) 2006-11-16 2010-07-27 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
WO2008070358A2 (en) 2006-11-16 2008-06-12 Phenomix Corporation N-cyclopropyl-hydroxyproline-based tripeptidic hepatitis c serine protease inhibitors containing an isoindole, pyrrolopyridine, pyrrolopyrimidine or pyrrolopyrazine heterocycle in the side chain
US7888464B2 (en) 2006-11-16 2011-02-15 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US8003604B2 (en) 2006-11-16 2011-08-23 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
ES2470568T3 (es) 2006-11-17 2014-06-24 Janssen R&D Ireland Inhibidores macroc�clicos del virus de la hepatitis C
CA2679563A1 (en) 2007-01-08 2008-07-17 Phenomix Corporation Macrocyclic hepatitis c protease inhibitors
BRPI0806853B1 (pt) 2007-02-01 2018-03-20 Janssen Sciences Ireland Uc Processos e intermediários para preparar um inibidor de protease macrocíclico de hcv
WO2008095058A1 (en) 2007-02-01 2008-08-07 Taigen Biotechnology Co. Ltd. Hcv protease inhibitors
JP5523110B2 (ja) 2007-02-01 2014-06-18 ヤンセン・アールアンドデイ・アイルランド Ｈｃｖの大員環状阻害剤の多形形態
WO2008095999A1 (en) 2007-02-08 2008-08-14 Tibotec Pharmaceuticals Ltd. Pyrimidine substituted macrocyclic hcv inhibitors
CN101627020B (zh) 2007-02-08 2015-06-17 泰博特克药品有限公司 抑制hcv的大环苯基氨基甲酸酯
WO2008096002A1 (en) 2007-02-08 2008-08-14 Tibotec Pharmaceuticals Ltd. Hcv inhibiting macrocyclic phosphonates and amidophosphates
JP2010518128A (ja) 2007-02-16 2010-05-27 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｃ型肝炎ｎｓ３プロテアーゼのインヒビター
WO2008101665A1 (en) 2007-02-20 2008-08-28 Novartis Ag Macrocyclic compounds as hcv ns3 protease inhibitors
EP2495249A1 (en) 2007-02-26 2012-09-05 Achillion Pharmaceuticals, Inc. Tertiary amine substituted peptides useful as inhibitors of HCV replication
ATE490961T1 (de) 2007-04-24 2010-12-15 Hoffmann La Roche Verfahren für hcv-proteasehemmerzwischenprodukt
US20080279821A1 (en) 2007-04-26 2008-11-13 Deqiang Niu Arylpiperidinyl and arylpyrrolidinyl macrocyclic hepatitis c serine protease inhibitors
WO2008134398A1 (en) 2007-04-26 2008-11-06 Enanta Pharmaceuticals, Inc. Oximyl dipeptide hepatitis c protease inhibitors
WO2008134395A1 (en) 2007-04-26 2008-11-06 Enanta Pharmaceuticals, Inc. Aza-peptide macrocyclic hepatitis c serine protease inhibitors
WO2008134397A1 (en) 2007-04-26 2008-11-06 Enanta Pharmaceuticals, Inc. Aza-tripeptide hepatitis c serine protease inhibitors
EP2177523A1 (en) 2007-05-03 2010-04-21 Intermune, Inc. Novel macrocyclic inhibitors of hepatitis c virus replication
CL2008001381A1 (es) 2007-05-10 2008-11-03 Intermune Inc Y Array Biopharma Inc Compuestos derivados de tripeptidos que contienen heterociclos nitrogenados; composicion farmaceutica que comprende a dichos compuestos; y uso para tratar una infeccion de hepatitis c o vih.
EA200971074A1 (ru) 2007-06-29 2010-08-30 Джилид Сайэнс, Инк. Антивирусные соединения
US20090047252A1 (en) 2007-06-29 2009-02-19 Gilead Sciences, Inc. Antiviral compounds
EA025794B1 (ru) 2007-06-29 2017-01-30 Джилид Сайэнс, Инк. Противовирусные соединения
US8927569B2 (en) 2007-07-19 2015-01-06 Merck Sharp & Dohme Corp. Macrocyclic compounds as antiviral agents
WO2009014730A1 (en) 2007-07-26 2009-01-29 Idenix Pharmaceuticals, Inc. Macrocyclic serine protease inhibitors
AR068756A1 (es) 2007-10-10 2009-12-02 Novartis Ag Compuestos peptidicos, formulacion farmaceutica y sus usos como moduladores del virus de la hepatitis c
WO2009053828A2 (en) 2007-10-22 2009-04-30 Enanta Pharmaceuticals, Inc. P3 hydroxyamino macrocyclic hepatitis c serine protease inhibitors
US20090111757A1 (en) 2007-10-25 2009-04-30 Taigen Biotechnology Co., Ltd. Hcv protease inhibitors
US8304385B2 (en) 2007-11-14 2012-11-06 Enanta Pharmaceuticals, Inc. Macrocyclic tetrazolyl hepatitis C serine protease inhibitors
CL2008003384A1 (es) 2007-11-14 2009-12-11 Enanta Pharm Inc Compuestos derivados de quinoxalina macrocíclica, inhibidores de serina proteasa; composicion farmaceutica que los comprende; y su uso en el tratamiento de la hepatitis c.
US8030307B2 (en) 2007-11-29 2011-10-04 Enanta Pharmaceuticals, Inc. Bicyclic, C5-substituted proline derivatives as inhibitors of the hepatitis C virus NS3 protease
US8263549B2 (en) 2007-11-29 2012-09-11 Enanta Pharmaceuticals, Inc. C5-substituted, proline-derived, macrocyclic hepatitis C serine protease inhibitors
WO2009076173A2 (en) 2007-12-05 2009-06-18 Enanta Pharmaceuticals, Inc. Fluorinated tripeptide hcv serine protease inhibitors
CN101932242A (zh) 2007-12-05 2010-12-29 益安药业 喹喔啉基衍生物
US8361958B2 (en) 2007-12-05 2013-01-29 Enanta Pharmaceuticals, Inc. Oximyl HCV serine protease inhibitors
US8268777B2 (en) 2007-12-05 2012-09-18 Enanta Pharmaceuticals, Inc. Oximyl macrocyclic derivatives
CA2708047A1 (en) 2007-12-06 2009-06-11 Enanta Pharmaceuticals, Inc. Process for making macrocyclic oximyl hepatitis c protease inhibitors
US8273709B2 (en) 2007-12-14 2012-09-25 Enanta Pharmaceuticals, Inc. Triazole-containing macrocyclic HCV serine protease inhibitors
MX2010006518A (es) 2007-12-14 2010-08-10 Enanta Pharm Inc Inhibidores de serina proteasa de hepatitis c de oximil macrociclica.
CN104557861A (zh) 2007-12-21 2015-04-29 阿维拉制药公司 Hcv蛋白酶抑制剂和其用途
US8309685B2 (en) 2007-12-21 2012-11-13 Celgene Avilomics Research, Inc. HCV protease inhibitors and uses thereof
US8202996B2 (en) 2007-12-21 2012-06-19 Bristol-Myers Squibb Company Crystalline forms of N-(tert-butoxycarbonyl)-3-methyl-L-valyl-(4R)-4-((7-chloro-4-methoxy-1-isoquinolinyl)oxy)-N- ((1R,2S)-1-((cyclopropylsulfonyl)carbamoyl)-2-vinylcyclopropyl)-L-prolinamide
US8293705B2 (en) 2007-12-21 2012-10-23 Avila Therapeutics, Inc. HCV protease inhibitors and uses thereof
JP5439384B2 (ja) 2007-12-21 2014-03-12 エフ．ホフマン−ラ ロシュ アーゲー 大員環の製造方法
CA2710144A1 (en) 2007-12-21 2009-07-02 Avila Therapeutics, Inc. Hcv protease inhibitors and uses thereof
US8101567B2 (en) 2008-01-24 2012-01-24 Enanta Pharmaceuticals, Inc. Heteroaryl-containing tripeptide HCV serine protease inhibitors
EP2245015A4 (en) 2008-01-24 2012-05-30 Enanta Pharm Inc DIFLUORATED TRIPEPTIDES AS INHIBITORS OF HCV SERINE PROTEASE
WO2009108507A1 (en) 2008-02-25 2009-09-03 Merck & Co., Inc. Therapeutic compounds
US8372802B2 (en) 2008-03-20 2013-02-12 Enanta Pharmaceuticals, Inc. Fluorinated macrocyclic compounds as hepatitis C virus inhibitors
AP2010005416A0 (en) 2008-04-15 2010-10-31 Intermune Inc Novel macrocyclic inhibitors of hepatitis c virus replication.
US8163921B2 (en) 2008-04-16 2012-04-24 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
CA2720850A1 (en) 2008-04-28 2009-11-05 Merck Sharp & Dohme Corp. Hcv ns3 protease inhibitors
WO2009134987A1 (en) 2008-04-30 2009-11-05 Enanta Pharmaceuticals, Inc. Difluoromethyl-containing macrocyclic compounds as hepatitis c virus inhibitors
US20090285773A1 (en) * 2008-05-15 2009-11-19 Bristol-Myers Squibb Company Hepatitis C Virus Inhibitors
US20090285774A1 (en) 2008-05-15 2009-11-19 Bristol-Myers Squibb Company Hepatitis C Virus Inhibitors
CN101580535B (zh) 2008-05-16 2012-10-03 太景生物科技股份有限公司 丙型肝炎病毒蛋白酶抑制剂
US7964560B2 (en) 2008-05-29 2011-06-21 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US8044023B2 (en) 2008-05-29 2011-10-25 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
PT2540350E (pt) 2008-07-22 2014-08-27 Merck Sharp & Dohme Combinações de um composto de quinoxalina macrocílico o qual é um inibidor da protease ns3 do hcv com outros agentes do hcv
CN102112442B (zh) 2008-08-07 2014-12-10 弗·哈夫曼-拉罗切有限公司 制备大环的方法
UY32099A (es) 2008-09-11 2010-04-30 Enanta Pharm Inc Inhibidores macrocíclicos de serina proteasas de hepatitis c
WO2010033466A1 (en) 2008-09-16 2010-03-25 Phenomix Corporation Macrocyclic inhibitors of hepatitis c protease
WO2010031832A2 (en) 2008-09-18 2010-03-25 Ortho-Mcneil-Janssen Pharmaceuticals, Inc Synergistic combinations of a macrocyclic inhibitor of hcv and a thiophene-2-carboxylic acid derivative
TW201023858A (en) 2008-09-18 2010-07-01 Ortho Mcneil Janssen Pharm Synergistic combinations of a macrocyclic inhibitor of HCV and a nucleoside
CA2737958A1 (en) 2008-09-23 2010-04-01 Boehringer Ingelheim International Gmbh Hepatitis c inhibitor compounds
US20100080770A1 (en) 2008-09-29 2010-04-01 Bristol-Myers Squibb Company Hepatitis C Virus Inhibitors
US8044087B2 (en) 2008-09-29 2011-10-25 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US8563505B2 (en) 2008-09-29 2013-10-22 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
EP2350114A1 (en) 2008-11-20 2011-08-03 Achillion Pharmaceuticals, Inc. Cyclic carboxamide compounds and analogues thereof as of hepatitis c virus
US20100272674A1 (en) 2008-12-04 2010-10-28 Bristol-Myers Squibb Company Hepatitis C Virus Inhibitors
CA2746264C (en) 2008-12-10 2017-11-14 Achillion Pharmaceuticals, Inc. New 4-amino-4-oxobutanoyl peptides as inhibitors of viral replication
EA021794B1 (ru) 2008-12-10 2015-09-30 Ачиллион Фармасьютикалз, Инк. Циклические аналоги 4-амино-4-оксобутаноил пептидов, ингибиторы репликации вирусов
US8283310B2 (en) 2008-12-15 2012-10-09 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
BRPI0923184A2 (pt) 2008-12-19 2019-09-24 Gilead Sciences Inc inibidores de hcv ns3 protease
US20100173939A1 (en) 2008-12-22 2010-07-08 Gilead Sciences, Inc. Antiviral compounds
JP2012516351A (ja) 2009-01-30 2012-07-19 アナコール ファーマシューティカルズ，インコーポレーテッド 化合物
US8512690B2 (en) 2009-04-10 2013-08-20 Novartis Ag Derivatised proline containing peptide compounds as protease inhibitors
US20110182850A1 (en) 2009-04-10 2011-07-28 Trixi Brandl Organic compounds and their uses
JP5639155B2 (ja) 2009-05-13 2014-12-10 エナンタ ファーマシューティカルズ インコーポレイテッド Ｃ型肝炎ウイルスインヒビターとしての大環状化合物
CN101921308A (zh) 2009-06-16 2010-12-22 上海唐润医药科技有限公司 具有抗hcv活性的化合物及其用途
US8232246B2 (en) 2009-06-30 2012-07-31 Abbott Laboratories Anti-viral compounds
PT2451438E (pt) 2009-07-07 2014-03-26 Boehringer Ingelheim Int Composição farmacêutica para um inibidor de protease viral da hepatite c
EP2459582B1 (en) 2009-07-30 2015-05-27 Merck Sharp & Dohme Corp. Hepatitis c virus ns3 protease inhibitors
US8637449B2 (en) 2009-08-27 2014-01-28 Merck Sharp & Dohme Corp. Processes for preparing protease inhibitors of hepatitis C virus
EP2477980B1 (en) 2009-09-15 2016-06-08 Taigen Biotechnology Co., Ltd. Hcv protease inhibitors
EP2483290A4 (en) 2009-09-28 2013-05-01 Intermune Inc CYCLIC PEPTIC INHIBITORS FOR REPLICATION OF HEPATITIS C VIRUS
EP2483273A4 (en) 2009-09-28 2013-05-01 Hoffmann La Roche NOVEL MACROCYCLIC INHIBITORS FOR HEPATITIS C VIRUS REPLICATION
WO2011041551A1 (en) 2009-10-01 2011-04-07 Intermune, Inc. Therapeutic antiviral peptides
US8415374B2 (en) 2009-10-12 2013-04-09 Bristol-Myers Squibb Company Combinations of hepatitis C virus inhibitors
WO2011049908A2 (en) 2009-10-19 2011-04-28 Enanta Pharmaceuticals, Inc. Bismacrokyclic compounds as hepatitis c virus inhibitors
WO2011063501A1 (en) 2009-11-24 2011-06-03 Boehringer Ingelheim International Gmbh Hepatitis c inhibitor compounds
EP2504344A4 (en) 2009-11-24 2013-06-05 Boehringer Ingelheim Int HEPATITIS C INHIBITOR COMPOUNDS
CN102753173A (zh) 2009-12-18 2012-10-24 贝林格尔.英格海姆国际有限公司 Hcv组合疗法
RU2535664C2 (ru) 2010-01-27 2014-12-20 Аб Фарма Лтд Полигетероциклические соединения, используемые в качестве высокоэффективных ингибиторов вируса гепатита с
WO2011112558A2 (en) 2010-03-10 2011-09-15 Abbott Laboratories Solid compositions
WO2011150190A2 (en) 2010-05-26 2011-12-01 Anacor Pharmaceuticals, Inc. Hcv inhibitor compounds and methods of use thereof
MX2012014301A (es) 2010-06-07 2013-04-29 Enanta Pharm Inc Inhibidores macrociclicos de serina proteasa de hepatitis c.
US20120196794A1 (en) 2010-08-06 2012-08-02 Bristol-Myers Squibb Company Combinations of Hepatitis C Virus Inhibitors
WO2012019299A1 (en) 2010-08-11 2012-02-16 Boehringer Ingelheim International Gmbh Hepatitis c inhibitor compounds
WO2012037259A1 (en) 2010-09-15 2012-03-22 Intermune, Inc. Novel inhibitors of hepatitis c virus replication
RS54638B1 (en) 2010-09-21 2016-08-31 Enanta Pharmaceuticals, Inc. HCV SERIN PROTEASE INHIBITORS DERIVED FROM MACROCYCLIC PROLINE
EP2618665A4 (en) 2010-09-21 2014-08-20 Merck Sharp & Dohme HCV NS3 PROTEASE INHIBITORS
WO2012040242A1 (en) 2010-09-22 2012-03-29 Intermune, Inc. Substituted proline inhibitors of hepatitis c virus replication
WO2012047764A1 (en) 2010-10-04 2012-04-12 Intermune, Inc. Therapeutic antiviral peptides
WO2012054874A1 (en) 2010-10-22 2012-04-26 Intermune, Inc. Novel macrocyclic inhibitors of hepatitis c virus replication
BR112013010372A2 (pt) 2010-12-14 2016-07-05 Merck Sharp & Dohme composto, e, método para preparar um composto
SG191759A1 (en) 2010-12-30 2013-08-30 Enanta Pharm Inc Phenanthridine macrocyclic hepatitis c serine protease inhibitors
US8937041B2 (en) 2010-12-30 2015-01-20 Abbvie, Inc. Macrocyclic hepatitis C serine protease inhibitors
US8957203B2 (en) * 2011-05-05 2015-02-17 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
ES2650223T3 (es) 2011-05-27 2018-01-17 Bristol-Myers Squibb Company Tripéptidos que incorporan deuterio como inhibidores del virus de la hepatitis C
US8691757B2 (en) 2011-06-15 2014-04-08 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
RU2014110399A (ru) 2011-08-19 2015-09-27 Мерк Шарп И Доум Корп. Кристаллические формы вгс протеазного ингибитора
MX2014003180A (es) 2011-09-16 2014-04-25 Abbvie Inc Metodos para tratar vhc.
RU2014122154A (ru) 2011-10-31 2015-12-10 Мерк Шарп И Доум Корп. Композиции, пригодные для лечения вирусных заболеваний
EP2780026B1 (en) 2011-11-15 2019-10-23 Merck Sharp & Dohme Corp. Hcv ns3 protease inhibitors
WO2013106689A1 (en) 2012-01-12 2013-07-18 Ref Pharma, Llc. Hcv ns3 protease inhibitors
CN102617705B (zh) 2012-02-16 2014-12-31 上海纬诺医药科技有限公司 抑制丙肝病毒复制的大环类化合物
US20130302414A1 (en) 2012-05-07 2013-11-14 Bristol-Myers Squibb Company Solubilized capsule formulation of 1,1-dimethylethyl [(1s)-1-carbamoyl)pyrrolidin-1-yl]carbonyl}-2,2-dimethylpropyl]carbamate
UA119315C2 (uk) 2012-07-03 2019-06-10 Гіліад Фармассет Елелсі Інгібітори вірусу гепатиту с
TWI610916B (zh) 2012-08-03 2018-01-11 廣東東陽光藥業有限公司 作爲丙型肝炎抑制劑的橋環化合物及其在藥物中的應用
TW201408669A (zh) 2012-08-08 2014-03-01 Merck Sharp & Dohme Ｈｃｖ ｎｓ３蛋白酶抑制劑
US9334279B2 (en) 2012-11-02 2016-05-10 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US9643999B2 (en) 2012-11-02 2017-05-09 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
WO2014070964A1 (en) 2012-11-02 2014-05-08 Bristol-Myers Squibb Company Hepatitis c virus inhibitors
EP2914614B1 (en) 2012-11-05 2017-08-16 Bristol-Myers Squibb Company Hepatitis c virus inhibitors
US9580463B2 (en) 2013-03-07 2017-02-28 Bristol-Myers Squibb Company Hepatitis C virus inhibitors

Also Published As

Publication number Publication date
HUE031625T2 (en) 2017-07-28
TWI570125B (zh) 2017-02-11
CA2888755A1 (en) 2014-04-24
ZA201503458B (en) 2017-11-29
JP2015533836A (ja) 2015-11-26
RS55592B1 (sr) 2017-06-30
PL2909205T3 (pl) 2017-06-30
EP2909205A1 (en) 2015-08-26
NZ708239A (en) 2018-03-23
IL238286B (en) 2018-05-31
BR112015007879A2 (pt) 2017-07-04
CN104918941A (zh) 2015-09-16
ES2613766T3 (es) 2017-05-25
SI2909205T1 (sl) 2017-02-28
WO2014062196A1 (en) 2014-04-24
EA025560B1 (ru) 2017-01-30
AU2012392557A1 (en) 2015-06-04
US9499550B2 (en) 2016-11-22
EA201590770A1 (ru) 2015-09-30
HK1212332A1 (en) 2016-06-10
US20150284391A1 (en) 2015-10-08
LT2909205T (lt) 2016-12-27
AU2012392557B2 (en) 2017-06-01
EP2909205B1 (en) 2016-11-23
MX2015004424A (es) 2015-07-06
HRP20161694T1 (hr) 2017-03-10
IL238286A0 (en) 2015-06-30
SMT201700117B (it) 2017-03-08
CY1118729T1 (el) 2017-07-12
SG11201502802PA (en) 2015-05-28
PH12015500814A1 (en) 2015-06-08
PT2909205T (pt) 2017-02-06
MA37992B1 (fr) 2018-09-28
MX360452B (es) 2018-11-01
JP6154474B2 (ja) 2017-06-28
MA37992A1 (fr) 2018-02-28
DK2909205T3 (en) 2017-03-06
KR20150074051A (ko) 2015-07-01
TW201416366A (zh) 2014-05-01

Similar Documents

Publication Publication Date Title
AR088768A1 (es) lNHlBlDORES DEL VlRUS DE LA HEPATlTlS C
KR102335970B1 (ko) 톨 유사 수용체 조정제 화합물
PE20150637A1 (es) Derivados de pirrolotriazinona como inhibidores de pi3k
CL2019002150A1 (es) Derivados de 3-fenil-4-amino-imidazo[4,5-c]piridin-2-ona y 7-fenil-6-amino-purin-8-ona sustituidos, inhibidores de tirosinacinasas, en particular tirosinacinasa de bruton (btk); composiciones que contiene los compuestos; y uso para enfermedades tales como cáncer, autoinmunitarias, inflamatorias y tromboembólicas. (divisional solicitud 201703073)
AR107127A1 (es) Indazoles sustituidos, procedimientos para su preparación, preparaciones farmacéuticas que los contienen, así como su uso para la preparación de medicamentos
MA44610A (fr) Formulations liquides de (s)-n-(5-((r)-2-(2,5-difluorophényl)-pyrrolidin-1-yl)-pyrazolo[1,5-a]pyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamide
UA98473C2 (ru) СОЛИ И КРИСТАЛЛИЧЕСКИЕ ФОРМЫ 2-МЕТИЛ-2-[4-(3-МЕТИЛ-2-ОКСО-8-ХИНОЛИН-3-ИЛ-2,3-ДИГИДРОИМИДАЗО[4,5-с]ХИНОЛИН-1-ИЛ)ФЕНИЛ]ПРОПИОНИТРИЛА
UY35369A (es) Inhibidores quinazolínicos de formas mutadas activantes del receptor del factor de crecimiento epidérmico
PE20141205A1 (es) Spiro-[1,3]-oxacinas y spiro-[1,4]-oxacepinas como inhibidores de bace1 y/o bace2
GT201300180A (es) "compuesto de imidazo (4,5-c) quinolin-2-ona y su uso como inhibidor dual de cinasa pi3/mtor"
CL2011002956A1 (es) Compuestos derivados de pirrolo[2,3-d]pirimidina, inhibidores de la quinasa janus (jak1); composicion farmaceutica; y uso para el tratamiento de una enfermedad autoinmune, cancer, trastorno mieloproliferativo, una enfermedad inflamatoria o rechazo de trasplante de organos.
CL2015002635A1 (es) Compuestos y composiciones para el tratamiento de enfermedades parasitarias
PE20151413A1 (es) Inhibidores de bmi-1 de pirimidina inversa sustituida
AR079134A1 (es) Procedimiento para la preparacion de (4,6-diamino -2-(1-(2- fluorobencil )-1h- pirazolo (3,4-b) piridin-3-il) pirimidin -5-il) metil carbamato de metilo y su purificacion para su uso como principio activo farmaceutico
CL2012002270A1 (es) Compuestos derivados de pirrolo[2,3-d]-pirimidina composición farmacéutica que los comprende; utiles en el tratamiento del cancer.
CL2014001752A1 (es) Compuestos biciclicos sustituidos; composicion farmaceutica que los comprende; y uso en el tratamiento de enfermedades tales como cancer, alzheimer, sida, entre otras.
DK3489238T3 (da) Farmaceutiske sammensætninger af 6h-pyrido[3,2-e][1,2,4]triazolo[1,5-c]pyrimidin-5-on- og [1,2,4]triazolo[1,5-c]pteridin-5(6h)-on-derivater som pde1-inhibitorer til behandling af for eksempel neurologiske lidelser
PE20121276A1 (es) Compuestos espirociclicos que contienen nitrogeno y su uso medicinal
EP4233869A3 (en) Use of pyrazolopyrimidine derivatives for the treatment of pi3k related disorders
GT201300291A (es) Derivados de piridin-2(1h)-ona útiles como medicamentos para el tratamiento de trastornos mieloproliferativos, rechazo de trasplantes, enfermedades mediadas por el sistema inmune y enfermedades inflamatorias.
CL2014000492A1 (es) Compuestos derivados de n-[3-(1,2,4-oxadiazol-(5-il/amino/carbamoil)fenil]imidazo[1,2-a]pirdina-3-carboxamida, inhibidores de la quinasa c-kit; composicion farmaceutica; y su uso para el tratamiento de la enfermedad de alzheimer, artritis, aterosclerosis, entre otras
EA201290147A1 (ru) Пирроло[2,3-d]пиримидиновые соединения
UY31730A (es) Derivados polisustituidos de 6-heteroaril-imidazo[1,2-a]piridinas, su preparación y su aplicación en terapéutica.
PE20142366A1 (es) Compuestos triazolo como inhibidores de pde 10
MX2012009074A (es) Compuestos de urea pirrolo [2, 3-d] pirimidina como inhibidores de janus quinasa.

Legal Events

Date Code Title Description
FB Suspension of granting procedure