GT201300291A - Derivados de piridin-2(1h)-ona útiles como medicamentos para el tratamiento de trastornos mieloproliferativos, rechazo de trasplantes, enfermedades mediadas por el sistema inmune y enfermedades inflamatorias. - Google Patents
Derivados de piridin-2(1h)-ona útiles como medicamentos para el tratamiento de trastornos mieloproliferativos, rechazo de trasplantes, enfermedades mediadas por el sistema inmune y enfermedades inflamatorias.Info
- Publication number
- GT201300291A GT201300291A GT201300291A GT201300291A GT201300291A GT 201300291 A GT201300291 A GT 201300291A GT 201300291 A GT201300291 A GT 201300291A GT 201300291 A GT201300291 A GT 201300291A GT 201300291 A GT201300291 A GT 201300291A
- Authority
- GT
- Guatemala
- Prior art keywords
- piridin
- transplants
- medicines
- rejection
- derivatives
- Prior art date
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/32—Nitrogen atom
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/28—Oxygen atom
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
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- A—HUMAN NECESSITIES
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
- A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Pulmonology (AREA)
- Ophthalmology & Optometry (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Biomedical Technology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Dermatology (AREA)
- Transplantation (AREA)
- Otolaryngology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
EN LA PRESENTE SOLICITUD SE DESCRIBEN COMPUESTOS QUE TIENEN LA ESTRUCTURA QUÍMICA REPRESENTADA POR LA FÓRMULA (I), DESCRITA EN EL EXPEDIENTE; ASÍ COMO UN PROCEDIMIENTO PARA SU PREPARACIÓN, COMPOSICIONES FARMACÉUTICAS QUE LOS COMPRENDEN Y SU USO EN TERAPIA COMO INHIBIDORES DE QUINASAS JANUS (JAK)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP11382170A EP2527344A1 (en) | 2011-05-25 | 2011-05-25 | Pyridin-2(1H)-one derivatives useful as medicaments for the treatment of myeloproliferative disorders, transplant rejection, immune-mediated and inflammatory diseases |
US201161511636P | 2011-07-26 | 2011-07-26 |
Publications (1)
Publication Number | Publication Date |
---|---|
GT201300291A true GT201300291A (es) | 2014-11-13 |
Family
ID=44736146
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GT201300291A GT201300291A (es) | 2011-05-25 | 2013-11-22 | Derivados de piridin-2(1h)-ona útiles como medicamentos para el tratamiento de trastornos mieloproliferativos, rechazo de trasplantes, enfermedades mediadas por el sistema inmune y enfermedades inflamatorias. |
Country Status (20)
Country | Link |
---|---|
US (1) | US20140170110A1 (es) |
EP (2) | EP2527344A1 (es) |
JP (1) | JP2014515362A (es) |
KR (1) | KR20140027318A (es) |
CN (1) | CN103649085A (es) |
AR (1) | AR086546A1 (es) |
AU (1) | AU2012260979A1 (es) |
BR (1) | BR112013029862A2 (es) |
CA (1) | CA2833203A1 (es) |
CL (1) | CL2013003344A1 (es) |
CO (1) | CO6821946A2 (es) |
CR (1) | CR20130617A (es) |
EA (1) | EA201301319A1 (es) |
GT (1) | GT201300291A (es) |
IL (1) | IL229193A0 (es) |
PE (1) | PE20141010A1 (es) |
SG (1) | SG194903A1 (es) |
UY (1) | UY34092A (es) |
WO (1) | WO2012160030A1 (es) |
ZA (1) | ZA201307547B (es) |
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JP5629331B2 (ja) | 2010-01-29 | 2014-11-19 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 置換ナフチリジン及びsykキナーゼ阻害剤としてのその使用 |
UY33213A (es) | 2010-02-18 | 2011-09-30 | Almirall Sa | Derivados de pirazol como inhibidores de jak |
EP2463289A1 (en) | 2010-11-26 | 2012-06-13 | Almirall, S.A. | Imidazo[1,2-b]pyridazine derivatives as JAK inhibitors |
CN103827090B (zh) | 2011-07-26 | 2016-04-20 | 勃林格殷格翰国际有限公司 | 取代的喹啉及其作为药物的用途 |
EP2554544A1 (en) | 2011-08-01 | 2013-02-06 | Almirall, S.A. | Pyridin-2(1h)-one derivatives as jak inhibitors |
CN106008511B (zh) * | 2012-05-14 | 2018-08-14 | 华东理工大学 | 蝶啶酮衍生物及其作为egfr、blk、flt3抑制剂的应用 |
WO2014146246A1 (en) * | 2013-03-19 | 2014-09-25 | Merck Sharp & Dohme Corp. | Cycloalkyl nitrile pyrazolo pyridones as janus kinase inhibitors |
GB201321737D0 (en) * | 2013-12-09 | 2014-01-22 | Ucb Pharma Sa | Therapeutic Agents |
US10273237B2 (en) * | 2013-12-10 | 2019-04-30 | Bristol-Myers Squibb Company | Imidazopyridazine compounds useful as modulators of IL-12, IL-23 and/or IFN-α responses |
CN106459040A (zh) * | 2014-03-24 | 2017-02-22 | 武田药品工业株式会社 | 杂环化合物 |
CN107567450B (zh) | 2015-03-18 | 2020-03-13 | 百时美施贵宝公司 | 用作tnf抑制剂的杂环化合物 |
MX2017011433A (es) | 2015-03-18 | 2017-11-10 | Bristol Myers Squibb Co | Compuestos heterociclicos triciclicos utiles como inhibidores del factor de necrosis tumoral (tnf). |
KR102654709B1 (ko) | 2015-03-18 | 2024-04-03 | 브리스톨-마이어스 스큅 컴퍼니 | 치환된 트리시클릭 헤테로시클릭 화합물 |
LT3303348T (lt) * | 2015-05-28 | 2019-11-25 | Theravance Biopharma R&D Ip Llc | Naftiridino junginiai, kaip jak kinazės inhibitoriai |
EP3118621A1 (en) * | 2015-07-14 | 2017-01-18 | Fundació Institut d'Investigació Biomèdica de Bellvitge (IDIBELL) | Methods and compositions for the diagnosis and for the treatment of adrenoleukodystrophy |
BR112018001980A2 (pt) | 2015-08-03 | 2018-09-18 | Bristol Myers Squibb Co | compostos cíclicos úteis como moduladores de tnf alfa |
CN107365312B (zh) * | 2016-05-13 | 2021-10-01 | 瑞博(杭州)医药科技有限公司 | 一种制备Oclacitinib的新方法 |
NZ755222A (en) * | 2016-12-20 | 2022-07-01 | Astrazeneca Ab | Amino-triazolopyridine compounds and their use in treating cancer |
RU2019125177A (ru) * | 2017-01-11 | 2021-02-15 | Лео Фарма А/С | Новые производные амино-имидазопиридина в качестве ингибиторов янус-киназы и их фармацевтическое применение |
CN107089929A (zh) * | 2017-06-22 | 2017-08-25 | 广西科技大学 | 反式‑(4‑氰甲基)环己基氨基甲酸叔丁酯的制备方法 |
TWI820146B (zh) | 2018-06-15 | 2023-11-01 | 瑞典商阿斯特捷利康公司 | 嘌呤酮化合物及其在治療癌症中之用途 |
WO2020051568A1 (en) * | 2018-09-08 | 2020-03-12 | Wen Tan | NEW USE OF R-ENANTIOMER OF ADRENERGIC β2 RECEPTOR AGONISTS FOR TREATMENT OF INFLAMMATORY BOWEL DISEASE AND ITS EXTRA INTESTINAL MANIFESTATIONS |
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-
2011
- 2011-05-25 EP EP11382170A patent/EP2527344A1/en not_active Withdrawn
-
2012
- 2012-05-21 PE PE2013002502A patent/PE20141010A1/es not_active Application Discontinuation
- 2012-05-21 SG SG2013083506A patent/SG194903A1/en unknown
- 2012-05-21 EA EA201301319A patent/EA201301319A1/ru unknown
- 2012-05-21 WO PCT/EP2012/059394 patent/WO2012160030A1/en active Application Filing
- 2012-05-21 AU AU2012260979A patent/AU2012260979A1/en not_active Abandoned
- 2012-05-21 CA CA2833203A patent/CA2833203A1/en not_active Abandoned
- 2012-05-21 EP EP12722152.1A patent/EP2714686A1/en not_active Withdrawn
- 2012-05-21 CN CN201280031591.8A patent/CN103649085A/zh active Pending
- 2012-05-21 US US14/119,920 patent/US20140170110A1/en not_active Abandoned
- 2012-05-21 KR KR1020137031136A patent/KR20140027318A/ko not_active Application Discontinuation
- 2012-05-21 JP JP2014511833A patent/JP2014515362A/ja active Pending
- 2012-05-21 BR BR112013029862A patent/BR112013029862A2/pt not_active IP Right Cessation
- 2012-05-23 UY UY0001034092A patent/UY34092A/es unknown
- 2012-05-24 AR ARP120101834A patent/AR086546A1/es unknown
-
2013
- 2013-10-10 ZA ZA2013/07547A patent/ZA201307547B/en unknown
- 2013-10-31 IL IL229193A patent/IL229193A0/en unknown
- 2013-11-15 CO CO13269468A patent/CO6821946A2/es active IP Right Grant
- 2013-11-21 CL CL2013003344A patent/CL2013003344A1/es unknown
- 2013-11-22 CR CR20130617A patent/CR20130617A/es unknown
- 2013-11-22 GT GT201300291A patent/GT201300291A/es unknown
Also Published As
Publication number | Publication date |
---|---|
KR20140027318A (ko) | 2014-03-06 |
EP2527344A1 (en) | 2012-11-28 |
SG194903A1 (en) | 2013-12-30 |
WO2012160030A1 (en) | 2012-11-29 |
CO6821946A2 (es) | 2013-12-31 |
EP2714686A1 (en) | 2014-04-09 |
US20140170110A1 (en) | 2014-06-19 |
CN103649085A (zh) | 2014-03-19 |
AR086546A1 (es) | 2014-01-08 |
ZA201307547B (en) | 2014-07-30 |
PE20141010A1 (es) | 2014-08-17 |
AU2012260979A1 (en) | 2013-12-12 |
CA2833203A1 (en) | 2012-11-29 |
UY34092A (es) | 2013-01-03 |
CR20130617A (es) | 2014-03-04 |
CL2013003344A1 (es) | 2014-05-30 |
BR112013029862A2 (pt) | 2016-12-20 |
EA201301319A1 (ru) | 2014-04-30 |
JP2014515362A (ja) | 2014-06-30 |
IL229193A0 (en) | 2013-12-31 |
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