MX2009010224A - Microorganismos y metodos para la produccion de 1,2-propanodiol y acetol. - Google Patents

Microorganismos y metodos para la produccion de 1,2-propanodiol y acetol.

Info

Publication number
MX2009010224A
MX2009010224A MX2009010224A MX2009010224A MX2009010224A MX 2009010224 A MX2009010224 A MX 2009010224A MX 2009010224 A MX2009010224 A MX 2009010224A MX 2009010224 A MX2009010224 A MX 2009010224A MX 2009010224 A MX2009010224 A MX 2009010224A
Authority
MX
Mexico
Prior art keywords
acetol
propanediol
microorganisms
production
methods
Prior art date
Application number
MX2009010224A
Other languages
English (en)
Inventor
Isabelle Meynial-Salles
Philippe Soucaille
Rainer Figge
Francois Voelker
Original Assignee
Metabolic Explorer Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Metabolic Explorer Sa filed Critical Metabolic Explorer Sa
Publication of MX2009010224A publication Critical patent/MX2009010224A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
    • C12P7/18—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic polyhydric
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/24—Preparation of oxygen-containing organic compounds containing a carbonyl group
    • C12P7/26—Ketones
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
    • C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
    • C12Y101/01283—Methylglyoxal reductase (NADPH-dependent) (1.1.1.283)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y402/00—Carbon-oxygen lyases (4.2)
    • C12Y402/03—Carbon-oxygen lyases (4.2) acting on phosphates (4.2.3)
    • C12Y402/03003—Methylglyoxal synthase (4.2.3.3)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

La presente invención se refiere a un microorganismo modificado que presenta un aumento de la actividad de reductasas de metilglioxal; asimismo, se refiere a su uso para la preparación de 1,2-propanodiol y/o acetol; en particular, este aumento de la actividad de reductasas de metilglioxal se obtiene mediante el aumento de la expresión de genes específicos a partir de microorganismos; esta invención también se refiere a un método para la producción de 1,2-propanodiol y/o acetol mediante la fermentación de un microorganismo con un aumento de a actividad de reductasas de metilglioxal.
MX2009010224A 2007-03-23 2008-03-21 Microorganismos y metodos para la produccion de 1,2-propanodiol y acetol. MX2009010224A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IB2007001677 2007-03-23
PCT/EP2008/053448 WO2008116853A1 (en) 2007-03-23 2008-03-21 Microorganisms and methods for production of 1,2-propanediol and acetol

Publications (1)

Publication Number Publication Date
MX2009010224A true MX2009010224A (es) 2009-10-26

Family

ID=38578517

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009010224A MX2009010224A (es) 2007-03-23 2008-03-21 Microorganismos y metodos para la produccion de 1,2-propanodiol y acetol.

Country Status (15)

Country Link
US (1) US9051588B2 (es)
EP (1) EP2126101B1 (es)
JP (1) JP5546870B2 (es)
KR (2) KR20100015815A (es)
CN (1) CN101641444B (es)
AR (1) AR066197A1 (es)
BR (1) BRPI0808970B1 (es)
CA (1) CA2688450C (es)
DK (1) DK2126101T3 (es)
ES (1) ES2550361T3 (es)
IL (1) IL200660A (es)
MX (1) MX2009010224A (es)
PL (1) PL2126101T3 (es)
TW (1) TWI521062B (es)
WO (1) WO2008116853A1 (es)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8647642B2 (en) 2008-09-18 2014-02-11 Aviex Technologies, Llc Live bacterial vaccines resistant to carbon dioxide (CO2), acidic PH and/or osmolarity for viral infection prophylaxis or treatment
MX2011004842A (es) * 2008-11-07 2011-05-30 Metabolic Explorer Sa Uso de sacarosa como sustrato para la produccion fermentativa de 1,2-propanodiol.
US8969053B2 (en) 2009-07-30 2015-03-03 Metabolic Explorer Mutant YqhD enzyme for the production of a biochemical by fermentation
US20110136190A1 (en) * 2009-12-04 2011-06-09 E. I. Du Pont De Nemours And Company Recombinant bacteria for producing glycerol and glycerol-derived products from sucrose
US9157102B2 (en) 2011-04-01 2015-10-13 University Of Florida Research Foundation, Incorporated Over-expression of NADH-dependent oxidoreductase (fucO) for increasing furfural or 5-hydroxymethylfurfural tolerance
AU2012268965A1 (en) 2011-06-15 2013-12-19 B.R.A.I.N. Biotechnology Research And Information Network Ag New means and methods for producing propanediol
CN102994577B (zh) * 2012-10-26 2015-01-21 上海交通大学 微生物细胞转化法生产丙酮醇的方法
CN104178442B (zh) * 2013-05-24 2017-10-31 中国科学院天津工业生物技术研究所 含有突变的lpdA基因的大肠杆菌及其应用
CN104560842A (zh) * 2013-10-18 2015-04-29 常州邱鸿生物技术有限公司 一种重组大肠杆菌利用甘油生产1,2-丙二醇的方法
KR101835173B1 (ko) * 2014-06-23 2018-03-07 씨제이제일제당 (주) L-트립토판 생산능을 갖는 에스케리키아속 미생물 및 이를 이용한 l-트립토판의 제조 방법
EP3303375A1 (en) 2015-06-04 2018-04-11 BioAmber Inc. Biobased production of functionalized alpha-substituted acrylates and c4-dicarboxylates
US10731137B2 (en) 2015-09-10 2020-08-04 Metabolic Explorer Lactaldehyde reductases for the production of 1,2-propanediol
CN105154476B (zh) * 2015-09-25 2018-10-19 华东理工大学 一种通过降低副产物乙酸高效生产1，3－丙二醇的方法
EP3365427B1 (en) 2015-10-23 2020-08-19 Metabolic Explorer Microorganism modified for the assimilation of levulinic acid
EP3196312B1 (en) 2016-01-25 2020-01-15 Metabolic Explorer Efficient conversion of methylglyoxal into hydroxyacetone using novel enzymes and appli cations thereof
US20190276859A1 (en) * 2016-07-08 2019-09-12 Evonik Degussa Gmbh Method for the fermentative production of methionine or its hydroxy analog form by microorganisms comprising genes coding sugar phosphotransferase system (pts)
US11180535B1 (en) 2016-12-07 2021-11-23 David Gordon Bermudes Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria
US11129906B1 (en) 2016-12-07 2021-09-28 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria
EP3342873A1 (en) 2016-12-29 2018-07-04 Metabolic Explorer Conversion of methylglyoxal into hydroxyacetone using enzymes and applications thereof
CN110527692B (zh) * 2018-05-25 2021-11-16 中国科学院微生物研究所 产l-鼠李糖的工程菌及其构建方法与应用
KR102346757B1 (ko) * 2019-09-30 2021-12-31 서강대학교산학협력단 1,2-프로필렌글라이콜 생산성이 증강된 메틸영양세균 및 이를 이용한 1,2-프로필렌글라이콜 생산방법

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4128692A1 (de) 1991-08-29 1993-03-04 Henkel Kgaa Verfahren zum herstellen von acetol
US6087140A (en) * 1997-02-19 2000-07-11 Wisconsin Alumni Research Foundation Microbial production of 1,2-propanediol from sugar
US7371558B2 (en) 2002-10-04 2008-05-13 E.I. Du Pont De Nemours And Company Process for the biological production of 1,3-propanediol with high yield
MXPA05008857A (es) * 2003-02-18 2006-03-09 Metabolic Explorer Sa Procedimiento de preparacion de microorganismos evolucionados que permite la creacion o la modificacion de vias metabolicas.
FR2864967B1 (fr) * 2004-01-12 2006-05-19 Metabolic Explorer Sa Microorganisme evolue pour la production de 1,2-propanediol
BRPI0507874B1 (pt) 2004-03-25 2019-03-12 Galen J. Suppes Processos para converter glicerol em propileno glicol e também em acetol com seletividade elevada
US8129157B2 (en) * 2006-03-31 2012-03-06 William Marsh Rice University Anaerobic fermentation of glycerol

Also Published As

Publication number Publication date
CA2688450C (en) 2016-10-25
IL200660A (en) 2015-09-24
EP2126101A1 (en) 2009-12-02
CA2688450A1 (en) 2008-10-02
WO2008116853A1 (en) 2008-10-02
TW200904983A (en) 2009-02-01
EP2126101B1 (en) 2015-09-02
JP2010521959A (ja) 2010-07-01
CN101641444B (zh) 2013-08-07
IL200660A0 (en) 2010-05-17
KR101734793B1 (ko) 2017-05-11
KR20100015815A (ko) 2010-02-12
TWI521062B (zh) 2016-02-11
KR20160067228A (ko) 2016-06-13
AR066197A1 (es) 2009-08-05
CN101641444A (zh) 2010-02-03
BRPI0808970B1 (pt) 2017-02-14
BRPI0808970A2 (pt) 2014-08-26
PL2126101T3 (pl) 2016-01-29
JP5546870B2 (ja) 2014-07-09
DK2126101T3 (en) 2015-09-28
US9051588B2 (en) 2015-06-09
US20110201070A1 (en) 2011-08-18
ES2550361T3 (es) 2015-11-06

Similar Documents

Publication Publication Date Title
MX2009010224A (es) Microorganismos y metodos para la produccion de 1,2-propanodiol y acetol.
WO2012177619A3 (en) Microorganisms for producing 1,3-butanediol and methods related thereto
WO2008102861A1 (ja) Ｌ－アミノ酸の製造法
EA201071379A1 (ru) Получение бутандиола с помощью анаэробной микробной ферментации
MX2013008988A (es) Microorganismo y metodos para la biosintesis de butadieno.
UA103364C2 (ru) Способ ферментативного производства четырехатомных спиртов
PE20100095A1 (es) Microorganismo productor del acido l-glutamico y metodo para producir acido l-glutamico
MX348612B (es) Microorganismos y metodos para producir 2,4 - pentadienoato, butadieno, propileno, 1,3 - butanodiol y alcoholes relacionados.
MY175283A (en) Mutant microorganisms having high ability to produce putrescine and method for producing putrescine using the same
MY165103A (en) Recombinant microorganisms and methods of use thereof
EP2749652A3 (en) A method for producing a target substance by fermentation
BRPI0506369A (pt) microorganismos, e, métodos para produzir um l-aminoácido
WO2007130518A3 (en) Fermentive production of four carbon alcohols
MY163228A (en) Process for Producing 3-Hydroxybutyric Acid or Salt Thereof
MY156222A (en) Enzyme associated with equol synthesis
WO2012177599A3 (en) Microorganisms for producing n-propanol 1, 3-propanediol, 1,2-propanediol or glycerol and methods related thereto
MX2019010195A (es) Nuevo medio de fermentacion para crecimiento de bacterias metanotrofas y metodo para producir dicho medio.
WO2012018699A3 (en) Improved fermentation process for the production of organic acids
WO2009028338A1 (ja) 新規オキシダーゼ遺伝子、および該遺伝子を利用する３－インドールピルビン酸の製造方法
EA201101626A1 (ru) Бактерии с высокоэффективным метаболизмом
MY163223A (en) Method for producing hydrocarbons
WO2011036213A3 (en) Fermentation process for producing glycolic acid
MX2014007623A (es) Produccion mejorada de isopreno con el uso de celulas hospederas que tienen actividad de ispa reducida.
WO2011115439A3 (ko) 5'-크산틸산 및 5'-구아닐산 생산능이 향상된 미생물 및 이를 이용한 5'-크산틸산 또는 5'-구아닐산의 생산방법
MX2013007053A (es) Uso de compuestos que libera peroxigeno libre de nitrogeno para reducir el crecimiento de microorganismos contaminates en la fermentacion de etanol.

Legal Events

Date Code Title Description
FG Grant or registration