BR112014031425A2 - microrganismo recombinante para produção fermentativa de metionina - Google Patents

microrganismo recombinante para produção fermentativa de metionina

Info

Publication number
BR112014031425A2
BR112014031425A2 BR112014031425A BR112014031425A BR112014031425A2 BR 112014031425 A2 BR112014031425 A2 BR 112014031425A2 BR 112014031425 A BR112014031425 A BR 112014031425A BR 112014031425 A BR112014031425 A BR 112014031425A BR 112014031425 A2 BR112014031425 A2 BR 112014031425A2
Authority
BR
Brazil
Prior art keywords
recombinant microorganism
fermentative
methionine
methionine production
microorganism
Prior art date
Application number
BR112014031425A
Other languages
English (en)
Other versions
BR112014031425B1 (pt
Inventor
Figge Rainer
Dischert Wanda
Original Assignee
Metabolic Explorer Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Metabolic Explorer Sa filed Critical Metabolic Explorer Sa
Publication of BR112014031425A2 publication Critical patent/BR112014031425A2/pt
Publication of BR112014031425B1 publication Critical patent/BR112014031425B1/pt

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1003—Transferases (2.) transferring one-carbon groups (2.1)
    • C12N9/1007—Methyltransferases (general) (2.1.1.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/12—Methionine; Cysteine; Cystine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y201/00—Transferases transferring one-carbon groups (2.1)
    • C12Y201/01—Methyltransferases (2.1.1)
    • C12Y201/01014—5-Methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase (2.1.1.14)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2330/00—Production
    • C12N2330/50—Biochemical production, i.e. in a transformed host cell
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells
    • C12N2510/02—Cells for production
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/52—Improvements relating to the production of bulk chemicals using catalysts, e.g. selective catalysts

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

resumo da patente de invenção para: “microrganismo recombinante para produção fermentativa de metionina”. a presente invenção está relacionada com um microrganismo recombinante otimizado para produção fermentativa de metionina, em que a atividade de metionina sintase mete independente de cobalamina é atenuada no referido microrganismo. a invenção também está relacionada a um método para a produção de metionina por fermentação.
BR112014031425-0A 2012-06-18 2012-06-18 Microrganismo recombinante para produção fermentativa de metionina BR112014031425B1 (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/IB2012/001336 WO2013190343A1 (en) 2012-06-18 2012-06-18 Recombinant microorganism for the fermentative production of methionine

Publications (2)

Publication Number Publication Date
BR112014031425A2 true BR112014031425A2 (pt) 2017-08-01
BR112014031425B1 BR112014031425B1 (pt) 2022-01-18

Family

ID=46579255

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112014031425-0A BR112014031425B1 (pt) 2012-06-18 2012-06-18 Microrganismo recombinante para produção fermentativa de metionina

Country Status (14)

Country Link
US (1) US9506093B2 (pt)
EP (1) EP2861726B1 (pt)
JP (1) JP6100370B2 (pt)
KR (1) KR101944150B1 (pt)
CN (1) CN104411821B (pt)
AU (1) AU2012383221A1 (pt)
BR (1) BR112014031425B1 (pt)
CA (1) CA2875139A1 (pt)
ES (1) ES2632170T3 (pt)
MX (1) MX355790B (pt)
MY (1) MY168199A (pt)
PL (1) PL2861726T3 (pt)
RU (1) RU2629760C2 (pt)
WO (1) WO2013190343A1 (pt)

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BR112016004367B1 (pt) 2013-08-30 2022-06-14 Evonik Operations Gmbh Microrganismo recombinante e método para a produção fermentativa de metionina e/ou seus derivados
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CN103981206B (zh) * 2014-06-06 2016-03-02 中国科学院天津工业生物技术研究所 一种筛选高产苏氨酸菌株的方法
CN107109359B (zh) 2014-09-01 2021-06-29 赢创运营有限公司 用于通过具有改进的甲硫氨酸排出的发酵生产甲硫氨酸的方法和微生物
CN108026516A (zh) * 2015-08-07 2018-05-11 赢创德固赛有限公司 通过发酵的蛋白硫代羧化物依赖性l-甲硫氨酸生产
MX2018006434A (es) 2015-11-27 2018-09-28 Evonik Degussa Gmbh Metodo para producir l-metionina.
MX2018008129A (es) 2016-01-08 2018-12-06 Evonik Degussa Gmbh Procedimiento para producir l-metionina por medio de una produccion fermentativa.
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EP3296404A1 (en) 2016-09-15 2018-03-21 Evonik Degussa GmbH Modified microorganism for production of methionine
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JP7444164B2 (ja) 2018-09-28 2024-03-06 味の素株式会社 細菌を用いたｌ－メチオニンの製造方法
EP3861109A1 (en) 2018-10-05 2021-08-11 Ajinomoto Co., Inc. Method for producing target substance by bacterial fermentation
WO2020171227A1 (en) 2019-02-22 2020-08-27 Ajinomoto Co., Inc. METHOD FOR PRODUCING L-AMINO ACIDS USING A BACTERIUM BELONGING TO THE FAMILY Enterobacteriaceae HAVING OVEREXPRESSED ydiJ GENE
JP2022526181A (ja) 2019-04-05 2022-05-23 味の素株式会社 Ｌ－アミノ酸の製造方法
KR102147776B1 (ko) * 2019-09-20 2020-08-26 대상 주식회사 L-라이신 생산능력이 향상된 코리네박테리움속 미생물 및 이를 이용한 라이신의 생산 방법
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CN110819605B (zh) * 2020-01-07 2020-04-07 中国科学院天津工业生物技术研究所 甲硫氨酸合成酶突变体、突变基因及其在制备维生素b12中的应用
CN114381417B (zh) * 2022-03-24 2022-06-24 中国科学院天津工业生物技术研究所 一种提高谷氨酸棒杆菌对抑制物耐受性的方法
WO2024096123A1 (ja) * 2022-11-04 2024-05-10 株式会社バイオパレット 遺伝子が改変された微生物およびその生産方法

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Also Published As

Publication number Publication date
RU2629760C2 (ru) 2017-09-06
MY168199A (en) 2018-10-15
KR101944150B1 (ko) 2019-01-30
WO2013190343A1 (en) 2013-12-27
KR20150033649A (ko) 2015-04-01
US9506093B2 (en) 2016-11-29
RU2014151747A (ru) 2016-08-10
MX355790B (es) 2018-04-27
CN104411821B (zh) 2017-08-08
JP2015519917A (ja) 2015-07-16
US20150247175A1 (en) 2015-09-03
EP2861726A1 (en) 2015-04-22
MX2014015768A (es) 2015-04-10
ES2632170T3 (es) 2017-09-11
CA2875139A1 (en) 2013-12-27
JP6100370B2 (ja) 2017-03-22
AU2012383221A1 (en) 2015-01-15
PL2861726T3 (pl) 2017-11-30
BR112014031425B1 (pt) 2022-01-18
CN104411821A (zh) 2015-03-11
EP2861726B1 (en) 2017-05-31

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Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B25A Requested transfer of rights approved

Owner name: EVONIK DEGUSSA GMBH (DE)

B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B25D Requested change of name of applicant approved

Owner name: EVONIK OPERATIONS GMBH (DE)

B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 18/06/2012, OBSERVADAS AS CONDICOES LEGAIS.