CL2011001405A1 - Procedimiento para la preparacion de n-[2-(7-metoxi-1-naftil)etil]acetamida, agometalina. - Google Patents
Procedimiento para la preparacion de n-[2-(7-metoxi-1-naftil)etil]acetamida, agometalina.Info
- Publication number
- CL2011001405A1 CL2011001405A1 CL2011001405A CL2011001405A CL2011001405A1 CL 2011001405 A1 CL2011001405 A1 CL 2011001405A1 CL 2011001405 A CL2011001405 A CL 2011001405A CL 2011001405 A CL2011001405 A CL 2011001405A CL 2011001405 A1 CL2011001405 A1 CL 2011001405A1
- Authority
- CL
- Chile
- Prior art keywords
- preparation
- acetamide
- naphthyl
- methoxy
- ethyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
- C07C233/17—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/18—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C217/74—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with rings other than six-membered aromatic rings being part of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
- C07C255/32—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring
- C07C255/37—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by etherified hydroxy groups
Abstract
Procedimiento para la preparación de n-[2-(7-metoxi-1-naftil)etil]acetamida (compuesto i); forma cristalina X del compuesto; proceso de preparación de X; composición farmacéutica que comprende la forma cristalina X.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US35326610P | 2010-06-10 | 2010-06-10 |
Publications (1)
Publication Number | Publication Date |
---|---|
CL2011001405A1 true CL2011001405A1 (es) | 2012-03-30 |
Family
ID=44509830
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CL2011001405A CL2011001405A1 (es) | 2010-06-10 | 2011-06-09 | Procedimiento para la preparacion de n-[2-(7-metoxi-1-naftil)etil]acetamida, agometalina. |
Country Status (4)
Country | Link |
---|---|
EP (1) | EP2580183B1 (es) |
CL (1) | CL2011001405A1 (es) |
UY (1) | UY33449A (es) |
WO (1) | WO2011154140A2 (es) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101781226B (zh) | 2009-12-23 | 2012-03-28 | 天津泰普药品科技发展有限公司 | 阿戈美拉汀及其药物组合物 |
CN102690209A (zh) * | 2011-03-23 | 2012-09-26 | 上海医药工业研究院 | 阿戈美拉汀的混晶(形式-ⅷ)、其制备方法、应用和包含其的药物组合物 |
ITMI20121444A1 (it) | 2012-08-27 | 2014-02-28 | Procos Spa | Processo per la produzione di agomelatine |
CN102875408B (zh) * | 2012-10-09 | 2014-07-16 | 江西同和药业有限责任公司 | 一种阿戈美拉汀的制备方法 |
CN102942501B (zh) * | 2012-12-10 | 2015-08-19 | 天津泰普药品科技发展有限公司 | 一种氢化制备阿戈美拉汀的生产方法 |
CN103655499B (zh) * | 2013-12-23 | 2015-07-22 | 天津泰普药品科技发展有限公司 | 一种稳定的晶x型阿戈美拉汀片剂及其制备方法 |
CN104016874A (zh) * | 2014-06-16 | 2014-09-03 | 鹤飞扬科技发展(天津)有限公司 | N-[2-(7-甲氧基-1,2,3,4-四氢-1-萘基)乙基]乙酰胺及其制备方法与应用 |
CN105777572A (zh) * | 2014-12-26 | 2016-07-20 | 辽宁药联制药有限公司 | 一种阿戈美拉汀混晶的制备方法及其在片剂中的应用 |
EP3466923A1 (en) | 2017-10-09 | 2019-04-10 | KRKA, d.d., Novo mesto | Process for the preparation of agomelatine in crystalline form |
CN111807968B (zh) * | 2020-07-01 | 2022-05-20 | 复旦大学 | 一种2-(1-环己烯基)乙胺的合成方法 |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2658818B1 (fr) | 1990-02-27 | 1993-12-31 | Adir Cie | Nouveaux derives a structure naphtalenique, leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
EP0781271B1 (en) * | 1994-09-12 | 2000-06-07 | Takeda Chemical Industries, Ltd. | Benzocycloalkene compounds, their production and use |
US7498466B2 (en) | 2004-02-13 | 2009-03-03 | Les Laboratoires Servier | Process for the synthesis and crystalline form of agomelatine |
FR2866335B1 (fr) | 2004-02-13 | 2006-05-26 | Servier Lab | Nouveau procede de synthese de l'agomelatine |
FR2866334B1 (fr) | 2004-02-13 | 2006-05-26 | Servier Lab | Nouveau procede de synthese du (7-methoxy-1-naphtyl) acetonitrile et application a la synthese de l'agomelatine |
US7498465B2 (en) | 2004-02-13 | 2009-03-03 | Les Laboratoires Servier | Process for the synthesis and crystalline form of agomelatine |
FR2866337B1 (fr) | 2004-02-13 | 2006-05-26 | Servier Lab | Nouveau procede de synthese du (7-methoxy-1-naphtyl) acetonitrile et application a la synthese de l'aglomelatine |
FR2866336B1 (fr) | 2004-02-13 | 2006-03-24 | Servier Lab | Nouveau procede de synthese du (7-methoxy-3,4-dihydro-1-naphtalenyl) acetonitrile et application a la synthese de l'agomelatine |
FR2889522B1 (fr) | 2005-08-03 | 2007-12-28 | Servier Lab | Nouvelle forme cristalline iv de l'agomelatine, son procede de preparation et les compositions pharmaceutiques qui la contiennent |
FR2889521B1 (fr) | 2005-08-03 | 2007-12-28 | Servier Lab | Nouvelle forme cristalline iii de l'agomelatine, son procede de preparation et les compositions pharmaceutiques qui la contiennent |
FR2889523B1 (fr) | 2005-08-03 | 2007-12-28 | Servier Lab | Nouvelle forme cristalline v de l'agomelatine, son procede de preparation et les compositions pharmaceutiques qui la contiennent |
US7635721B2 (en) | 2005-08-03 | 2009-12-22 | Les Laboratoires Servier | Crystalline form III of agomelatine, a process for its preparation and pharmaceutical compositions containing it |
FR2919606B1 (fr) | 2007-08-03 | 2010-09-17 | Servier Lab | Nouveau procede de synthese du (7-methoxy-1-naphtyl) acetonitrile et application a la synthese de l'agomelatine. |
FR2934855B1 (fr) | 2008-08-05 | 2010-08-13 | Servier Lab | Nouveau procede de synthese de l'agomelatine |
FR2934857B1 (fr) | 2008-08-05 | 2010-08-27 | Servier Lab | Nouveau procede de synthese de l'agomelatine |
FR2934859B1 (fr) | 2008-08-05 | 2010-08-13 | Servier Lab | Nouveau procede de synthese de l'agomelatine |
WO2011006387A1 (zh) | 2009-07-11 | 2011-01-20 | 浙江华海药业股份有限公司 | 阿戈美拉汀的制备方法、阿戈美拉汀晶形及其制备方法 |
-
2011
- 2011-06-09 EP EP11725636.2A patent/EP2580183B1/en not_active Not-in-force
- 2011-06-09 CL CL2011001405A patent/CL2011001405A1/es unknown
- 2011-06-09 WO PCT/EP2011/002834 patent/WO2011154140A2/en active Application Filing
- 2011-06-10 UY UY0001033449A patent/UY33449A/es not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
EP2580183B1 (en) | 2014-07-23 |
UY33449A (es) | 2012-01-31 |
EP2580183A2 (en) | 2013-04-17 |
WO2011154140A3 (en) | 2012-07-26 |
WO2011154140A2 (en) | 2011-12-15 |
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