AR082418A1 - CRYSTAL FORMS OF 1- (4-METHYL-5- [2- (2,2,2-TRIFLUORO-1,1-DIMETHYL-Ethyl) -PIRIDIN-4-IL] -TIAZOL-2-IL) -AMIDE OF 2 -AMIDA OF THE ACID (S) -PIRROLIDIN-1,2-DICARBOXILICO - Google Patents
CRYSTAL FORMS OF 1- (4-METHYL-5- [2- (2,2,2-TRIFLUORO-1,1-DIMETHYL-Ethyl) -PIRIDIN-4-IL] -TIAZOL-2-IL) -AMIDE OF 2 -AMIDA OF THE ACID (S) -PIRROLIDIN-1,2-DICARBOXILICOInfo
- Publication number
- AR082418A1 AR082418A1 ARP110102747A ARP110102747A AR082418A1 AR 082418 A1 AR082418 A1 AR 082418A1 AR P110102747 A ARP110102747 A AR P110102747A AR P110102747 A ARP110102747 A AR P110102747A AR 082418 A1 AR082418 A1 AR 082418A1
- Authority
- AR
- Argentina
- Prior art keywords
- trifluoro
- amide
- dimethyl
- ethyl
- methyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Abstract
La presente se refiere a formas sólidas específicas de 1-(4-metil-5-[2-(2,2,2-trifluoro-1,1-dimetil-etil)-piridin-4-il]-tiazol-2-il-amida de 2-amida del ácido (S)-pirrolidin-1,2-dicarboxílico, y sus hidratos y solvatos. La presente se refiere además a procesos para la preparación de estas formas sólidas, a composiciones farmacéuticas que comprenden tales formas sólidas, y a métodos para utilizar las formas sólidas mencionadas y composiciones farmacéuticas para tratar enfermedades.Reivindicación 1: Una forma cristalina del compuesto de la fórmula (1) o un hidrato o solvato de la forma cristalina del compuesto de la fórmula (1).This refers to specific solid forms of 1- (4-methyl-5- [2- (2,2,2-trifluoro-1,1-dimethyl-ethyl) -pyridin-4-yl] -thiazol-2- (S) -Pyrrolidin-1,2-dicarboxylic acid 2-amide, and its hydrates and solvates, also relates to processes for the preparation of these solid forms, to pharmaceutical compositions comprising such solid forms and to methods for using the solid forms mentioned and pharmaceutical compositions for treating diseases. Claim 1: A crystalline form of the compound of the formula (1) or a hydrate or solvate of the crystalline form of the compound of the formula (1).
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US36983710P | 2010-08-02 | 2010-08-02 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR082418A1 true AR082418A1 (en) | 2012-12-05 |
Family
ID=44503814
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP110102747A AR082418A1 (en) | 2010-08-02 | 2011-07-29 | CRYSTAL FORMS OF 1- (4-METHYL-5- [2- (2,2,2-TRIFLUORO-1,1-DIMETHYL-Ethyl) -PIRIDIN-4-IL] -TIAZOL-2-IL) -AMIDE OF 2 -AMIDA OF THE ACID (S) -PIRROLIDIN-1,2-DICARBOXILICO |
Country Status (3)
Country | Link |
---|---|
AR (1) | AR082418A1 (en) |
TW (1) | TW201206922A (en) |
WO (1) | WO2012016970A1 (en) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2839621A1 (en) * | 2011-06-21 | 2012-12-27 | Novartis Ag | Polymorphs of (s)-pyrrolidine-1,2-dicarboxylic acid 2-amide 1-({4-methyl-5-[2-(2,2,2-trifluoro-1,1-dimethyl-ethyl)-pyridin-4-yl]-thiazol-2-yl}-amide |
BR112014023530A2 (en) | 2012-03-29 | 2017-07-18 | Novartis Ag | pharmaceutical diagnosis |
US8980259B2 (en) | 2012-07-20 | 2015-03-17 | Novartis Ag | Combination therapy |
WO2014191938A1 (en) * | 2013-05-31 | 2014-12-04 | Novartis Ag | Combination therapy containing a pi3k-alpha inhibitor and fgfr kinase inhibitor for treating cancer |
PL3200772T3 (en) * | 2014-10-03 | 2022-12-19 | Novartis Ag | Pharmaceutical compositions comprising alpelisib |
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Also Published As
Publication number | Publication date |
---|---|
WO2012016970A1 (en) | 2012-02-09 |
TW201206922A (en) | 2012-02-16 |
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