CL2013003078A1 - Uso de una combinación farmacéutica que comprende el compuesto 1-({4-metil-5-[2-(2,2,2-trifluoro-1,1-dimetiletil)piridin-4-il]-tiazol-2-il}-amida) de 2-amida del ácido (s) pirrolidin-1,2-dicarboxílico y el inhibidor de mtor everolimus para tratar cáncer de mama; y uso de la composición farmacéutica - Google Patents

Uso de una combinación farmacéutica que comprende el compuesto 1-({4-metil-5-[2-(2,2,2-trifluoro-1,1-dimetiletil)piridin-4-il]-tiazol-2-il}-amida) de 2-amida del ácido (s) pirrolidin-1,2-dicarboxílico y el inhibidor de mtor everolimus para tratar cáncer de mama; y uso de la composición farmacéutica

Info

Publication number: CL2013003078A1
Authority: CL; Chile
Prior art keywords: amide; dimethylethyl; thiazol; pyrrolidin; trifluoro
Prior art date: 2011-04-25

Application number

CL2013003078A

Other languages

English (en)

Inventor

Xizhong Huang

Carlos Garcia-Echeverria

Christine Fritsch

Sauveur-Michel Maira

Original Assignee

Novartis Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2011-04-25

Filing date

2013-10-24

Publication date

2014-05-30

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=46018130&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CL2013003078(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2013-10-24 Application filed by Novartis Ag filed Critical Novartis Ag

2014-05-30 Publication of CL2013003078A1 publication Critical patent/CL2013003078A1/es

Links

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
- A—HUMAN NECESSITIES
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
- A—HUMAN NECESSITIES
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
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- A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
- A—HUMAN NECESSITIES
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CL2013003078A 2011-04-25 2013-10-24 Uso de una combinación farmacéutica que comprende el compuesto 1-({4-metil-5-[2-(2,2,2-trifluoro-1,1-dimetiletil)piridin-4-il]-tiazol-2-il}-amida) de 2-amida del ácido (s) pirrolidin-1,2-dicarboxílico y el inhibidor de mtor everolimus para tratar cáncer de mama; y uso de la composición farmacéutica CL2013003078A1 (es)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US201161478572P	2011-04-25	2011-04-25

Publications (1)

Publication Number	Publication Date
CL2013003078A1 true CL2013003078A1 (es)	2014-05-30

Family

ID=46018130

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CL2013003078A CL2013003078A1 (es)	2011-04-25	2013-10-24	Uso de una combinación farmacéutica que comprende el compuesto 1-({4-metil-5-[2-(2,2,2-trifluoro-1,1-dimetiletil)piridin-4-il]-tiazol-2-il}-amida) de 2-amida del ácido (s) pirrolidin-1,2-dicarboxílico y el inhibidor de mtor everolimus para tratar cáncer de mama; y uso de la composición farmacéutica

Country Status (25)

Country	Link
US (3)	US20140066474A1 (es)
EP (1)	EP2701703A1 (es)
JP (2)	JP6086902B2 (es)
KR (1)	KR101925656B1 (es)
CN (1)	CN103491955B (es)
AR (1)	AR086481A1 (es)
AU (2)	AU2012250010A1 (es)
BR (1)	BR112013027486A2 (es)
CA (1)	CA2833962A1 (es)
CL (1)	CL2013003078A1 (es)
CO (1)	CO6801759A2 (es)
EA (1)	EA025948B1 (es)
EC (1)	ECSP13012994A (es)
GT (1)	GT201300263A (es)
IL (1)	IL229008A (es)
MA (1)	MA35038B1 (es)
MX (1)	MX2013012385A (es)
NZ (1)	NZ615593A (es)
PE (1)	PE20140601A1 (es)
SG (1)	SG193919A1 (es)
TN (1)	TN2013000392A1 (es)
TW (1)	TWI602567B (es)
UA (1)	UA110961C2 (es)
WO (1)	WO2012148846A1 (es)
ZA (1)	ZA201306973B (es)

Families Citing this family (8)

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EP2776026A1 (en) *	2011-11-02	2014-09-17	Novartis AG	2-carboxamide cycloamino urea derivatives for use in treating vegf - dependent diseases
JP2016512835A (ja) *	2013-03-15	2016-05-09	インテリカイン，エルエルシー	キナーゼ阻害剤の組み合わせ及びそれらの使用
WO2015073644A1 (en) *	2013-11-13	2015-05-21	Novartis Ag	Mtor inhibitors for enhancing the immune response
CA2937504A1 (en) *	2014-02-11	2015-08-20	Novartis Ag	Pharmaceutical combinations comprising a pi3k inhibitor for the treatment of cancer
WO2015148626A1 (en) *	2014-03-26	2015-10-01	Millennium Pharmaceuticals, Inc.	Treatment of fibrotic disorders
ES2929554T3 (es) *	2014-10-03	2022-11-30	Novartis Ag	Composiciones farmacéuticas que comprenden alpelisib
US20160339030A1 (en) *	2015-05-19	2016-11-24	University Of Maryland, Baltimore	Treatment agents for inhibiting hiv and cancer in hiv infected patients
GB202010627D0 (en) *	2020-07-10	2020-08-26	Qbd (Qs-Ip) Ltd	Blocking method

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PT98990A (pt)	1990-09-19	1992-08-31	American Home Prod	Processo para a preparacao de esteres de acidos carboxilicos de rapamicina
US5120842A (en)	1991-04-01	1992-06-09	American Home Products Corporation	Silyl ethers of rapamycin
US5100883A (en)	1991-04-08	1992-03-31	American Home Products Corporation	Fluorinated esters of rapamycin
US5118678A (en)	1991-04-17	1992-06-02	American Home Products Corporation	Carbamates of rapamycin
US5118677A (en)	1991-05-20	1992-06-02	American Home Products Corporation	Amide esters of rapamycin
US5151413A (en)	1991-11-06	1992-09-29	American Home Products Corporation	Rapamycin acetals as immunosuppressant and antifungal agents
GB9125660D0 (en)	1991-12-03	1992-01-29	Smithkline Beecham Plc	Novel compound
ZA935112B (en)	1992-07-17	1994-02-08	Smithkline Beecham Corp	Rapamycin derivatives
ZA935111B (en)	1992-07-17	1994-02-04	Smithkline Beecham Corp	Rapamycin derivatives
US5256790A (en)	1992-08-13	1993-10-26	American Home Products Corporation	27-hydroxyrapamycin and derivatives thereof
GB9221220D0 (en)	1992-10-09	1992-11-25	Sandoz Ag	Organic componds
US5258389A (en)	1992-11-09	1993-11-02	Merck & Co., Inc.	O-aryl, O-alkyl, O-alkenyl and O-alkynylrapamycin derivatives
CA2175215C (en)	1993-11-19	2008-06-03	Yat Sun Or	Semisynthetic analogs of rapamycin (macrolides) being immunomodulators
EP0734389B1 (en)	1993-12-17	2000-03-29	Novartis AG	Rapamycin derivatives useful as immunosuppressants
DE69624921T2 (de)	1995-06-09	2003-09-11	Novartis Ag	Rapamycinderivate
EP0937082A2 (en)	1996-07-12	1999-08-25	Ariad Pharmaceuticals, Inc.	Materials and method for treating or preventing pathogenic fungal infection
AU783158B2 (en)	1999-08-24	2005-09-29	Ariad Pharmaceuticals, Inc.	28-epirapalogs
AR044519A1 (es) *	2003-05-02	2005-09-14	Novartis Ag	Derivados de piridin-tiazol amina y de pirimidin-tiazol amina
EP1962839A4 (en) *	2005-11-14	2010-08-25	Ariad Pharma Inc	ADMINISTRATION OF A MNTOR INHIBITOR FOR THE TREATMENT OF PATIENTS WITH CANCER
UA104147C2 (uk)	2008-09-10	2014-01-10	Новартис Аг	Похідна піролідиндикарбонової кислоти та її застосування у лікуванні проліферативних захворювань
MX2011004585A (es) *	2008-10-31	2011-06-01	Novartis Ag	Combinacion de un inhibidor de fosfatidilinositol-3-cinasa (p13k) y un inhibidor de mtor.

2012
- 2012-04-23 US US14/113,316 patent/US20140066474A1/en not_active Abandoned
- 2012-04-23 MX MX2013012385A patent/MX2013012385A/es unknown
- 2012-04-23 PE PE2013002391A patent/PE20140601A1/es not_active Application Discontinuation
- 2012-04-23 KR KR1020137027718A patent/KR101925656B1/ko active IP Right Grant
- 2012-04-23 WO PCT/US2012/034647 patent/WO2012148846A1/en active Application Filing
- 2012-04-23 NZ NZ615593A patent/NZ615593A/en not_active IP Right Cessation
- 2012-04-23 EA EA201391565A patent/EA025948B1/ru not_active IP Right Cessation
- 2012-04-23 BR BR112013027486A patent/BR112013027486A2/pt not_active Application Discontinuation
- 2012-04-23 JP JP2014508463A patent/JP6086902B2/ja not_active Expired - Fee Related
- 2012-04-23 SG SG2013070461A patent/SG193919A1/en unknown
- 2012-04-23 CN CN201280020528.4A patent/CN103491955B/zh not_active Expired - Fee Related
- 2012-04-23 AR ARP120101389A patent/AR086481A1/es unknown
- 2012-04-23 AU AU2012250010A patent/AU2012250010A1/en not_active Abandoned
- 2012-04-23 MA MA36325A patent/MA35038B1/fr unknown
- 2012-04-23 EP EP12717568.5A patent/EP2701703A1/en not_active Withdrawn
- 2012-04-23 CA CA2833962A patent/CA2833962A1/en not_active Abandoned
- 2012-04-23 UA UAA201311138A patent/UA110961C2/uk unknown
- 2012-04-24 TW TW101114591A patent/TWI602567B/zh not_active IP Right Cessation
2013
- 2013-09-17 ZA ZA2013/06973A patent/ZA201306973B/en unknown
- 2013-09-27 TN TNP2013000392A patent/TN2013000392A1/fr unknown
- 2013-10-21 IL IL229008A patent/IL229008A/en active IP Right Grant
- 2013-10-24 CL CL2013003078A patent/CL2013003078A1/es unknown
- 2013-10-24 CO CO13252726A patent/CO6801759A2/es not_active Application Discontinuation
- 2013-10-25 EC ECSP13012994 patent/ECSP13012994A/es unknown
- 2013-10-25 GT GT201300263A patent/GT201300263A/es unknown
2016
- 2016-04-14 AU AU2016202372A patent/AU2016202372B2/en not_active Ceased
- 2016-10-27 US US15/335,957 patent/US20170095463A1/en not_active Abandoned
- 2016-11-18 JP JP2016224893A patent/JP2017061527A/ja active Pending
2017
- 2017-09-26 US US15/715,865 patent/US20180085362A1/en not_active Abandoned

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Publication number	Publication date
JP2014513097A (ja)	2014-05-29
AU2016202372A1 (en)	2016-05-05
JP6086902B2 (ja)	2017-03-01
CO6801759A2 (es)	2013-11-29
IL229008A (en)	2017-11-30
BR112013027486A2 (pt)	2017-02-14
GT201300263A (es)	2015-11-24
TWI602567B (zh)	2017-10-21
KR101925656B1 (ko)	2018-12-05
AU2016202372B2 (en)	2017-07-20
KR20140012147A (ko)	2014-01-29
ZA201306973B (en)	2014-06-25
TW201244716A (en)	2012-11-16
PE20140601A1 (es)	2014-05-24
US20140066474A1 (en)	2014-03-06
UA110961C2 (uk)	2016-03-10
ECSP13012994A (es)	2013-12-31
IL229008A0 (en)	2013-12-31
JP2017061527A (ja)	2017-03-30
CA2833962A1 (en)	2012-11-01
CN103491955A (zh)	2014-01-01
US20170095463A1 (en)	2017-04-06
SG193919A1 (en)	2013-11-29
WO2012148846A1 (en)	2012-11-01
US20180085362A1 (en)	2018-03-29
NZ615593A (en)	2015-05-29
EP2701703A1 (en)	2014-03-05
MX2013012385A (es)	2013-11-04
CN103491955B (zh)	2015-12-23
EA025948B1 (ru)	2017-02-28
EA201391565A1 (ru)	2014-02-28
AR086481A1 (es)	2013-12-18
TN2013000392A1 (en)	2015-01-20
AU2012250010A1 (en)	2013-10-10
MA35038B1 (fr)	2014-04-03

Publication	Publication Date	Title
CL2013003078A1 (es)	2014-05-30	Uso de una combinación farmacéutica que comprende el compuesto 1-({4-metil-5-[2-(2,2,2-trifluoro-1,1-dimetiletil)piridin-4-il]-tiazol-2-il}-amida) de 2-amida del ácido (s) pirrolidin-1,2-dicarboxílico y el inhibidor de mtor everolimus para tratar cáncer de mama; y uso de la composición farmacéutica
IL268984B (en)	2021-04-29	Derivatives of oxyntomodulin and a pharmaceutical preparation containing them for the treatment of obesity
BR112014016287A2 (pt)	2017-07-04	composto, composição farmacêutica, método para aumentar a inclusão de exon 7 de smn2, método para aumentar a quantidade de proteína, método para o tratamento de sma
RS54476B1 (en)	2016-06-30	DERIVATIVES 1 - ((5-HETEROARYLTHIAZOL-2-IL) AMINOCARBONYL) PYROLIDINE-2-CARBOXAMIDE AS PHOSPHATIDYLINOSITOL 3-KINASE (PI3K) INHIBITORS USEFUL IN THE TREATMENT OF PROLIFERATIVE DISEASES
ECSP12011799A (es)	2012-07-31	Compuestos de espiropiperidina y uso farmacéutico de los mismos
BR112013023175A2 (pt)	2016-12-13	composto, inibidor, medicamento, agente anticâncer, composição farmacêutica, método para o tratamento de câncer, e, uso de um composto
BR112014010206A2 (pt)	2017-05-16	composto, composição farmacêutica, uso de composto, e, método para a profilaxia ou tratamento de um estado ou condição de doença
ECSP12011930A (es)	2012-07-31	Nuevos compuestos de espiropiperidina
BR112013029999A2 (pt)	2017-01-31	derivados de tiazol
BR112014005235A2 (pt)	2017-04-11	composto heterocíclico, composição farmacêutica, agente profilático e/ou terapêutico, e, método para prevenir e/ou tratar uma doença neurológica central
CL2011001299A1 (es)	2012-01-13	Compuestos derivados de benzotiazoles; composicion farmaceutica; y su uso como inhibidores de raf para el tratamiento o profilaxis del cancer.
BR112014010179A2 (pt)	2017-04-25	composto, composição farmacêutica, uso de um composto, e, método para a profilaxia ou tratamento de um estado ou condição
ES2654908T8 (es)	2018-04-11	Análogos de tiazolidindiona para el tratamiento de enfermedades mediadas por una inflamación metabólica
IL259824B (en)	2020-04-30	History of 2-[3-(azolyl)phenyl]-3,1-thiazole-5-carboxylic acid for use as drugs
EA201391028A1 (ru)	2013-12-30	Гиполипидемическое противодиабетическое средство
CL2014000149A1 (es)	2014-09-05	Metodo para sintetizar n-[5-(aminosulfonil)-4-metil-1,3-tiazol-2-il]-n-metil-2-[4-(2-piridinil) fenil)]acetamida y mesilato monohidrato cristalino del mismo; composicion farmaceutica que lo contiene; combinacion farmaceutica; uso en el tratamiento y/o profilaxis de una infeccion por virus herpes simplex.
BR112012021476A2 (pt)	2019-09-24	composto, processo para preparação do composto, composição farmacêutica compreendendo uma quantidade terapeuticamente eficaz do composto e emprego de tal composto
EP3069720A4 (en)	2017-06-21	Pharmaceutical composition containing glutarimide derivatives, and application thereof for treating eosinophilic diseases
MX2015000746A (es)	2015-09-10	Terapia de combinacion de inhibidores para el receptor del factor de crecimiento insulinico tipo 1 (igf1r) y fosfatidilinositol 3-cinasa (pi3k).
CL2013000513A1 (es)	2014-08-29	Uso de una composicion farmaceutica que comprende: a) un compuesto monohidratado formado por dos aniones y un cation o b) valsartan y un etil-ester de acido, para el tratamiento de hipertension y/o la prevencion o el tratamiento de insuficiencia cardiaca en un mamifero que recibe terapia anti-coagulante.
CL2014002845A1 (es)	2015-01-30	Compuestos derivados de pirazol inhibidores de sglt1; metodo para tratar la diabetes; composicion farmaceutica; uso del compuesto para el tratamiento de la diabetes tipo 1 y tipo 2.
CL2013002193A1 (es)	2014-05-09	Uso de un producto que comprende macitentano o una sal del mismo en combinacion con un agente alquilante o un inhibidor mitotico para preparar un medicamento util en el tratamiento de glioma maligno.
CL2014002576A1 (es)	2015-01-23	Un metodo para tratar a un sujeto que tenga cancer que comprende administrar 1-(1(4-metil-5-(2-(2,2,2-trifluoro-1,1-dimetil-etil)-piridin-4-il)-tiazol-2-il)-amida) de 2-amida del acido (s)-pirrolidin-1,2-dicarboxilico en un sujeto que tenga una glutamina en la posicion 859 de la subunidad catalitica p110alfa de pi3k.
BR112012020629A2 (pt)	2018-06-19	forma cristalina, e, método para a terapia de um distúrbio
AR082418A1 (es)	2012-12-05	Formas cristalinas de 1-(4-metil-5-[2-(2,2,2-trifluoro-1,1-dimetil-etil)-piridin-4-il]-tiazol-2-il)-amida de 2-amida del acido (s)-pirrolidin-1,2-dicarboxilico