AR053065A1 - Compuestos azolicos neuroterapeuticos y composiciones farmaceuticas que los contienen - Google Patents
Compuestos azolicos neuroterapeuticos y composiciones farmaceuticas que los contienenInfo
- Publication number
- AR053065A1 AR053065A1 ARP060101598A ARP060101598A AR053065A1 AR 053065 A1 AR053065 A1 AR 053065A1 AR P060101598 A ARP060101598 A AR P060101598A AR P060101598 A ARP060101598 A AR P060101598A AR 053065 A1 AR053065 A1 AR 053065A1
- Authority
- AR
- Argentina
- Prior art keywords
- substituted
- group
- alkyl
- hydrogen
- phenyl
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D257/04—Five-membered rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4192—1,2,3-Triazoles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Addiction (AREA)
- Cardiology (AREA)
- Hematology (AREA)
- Hospice & Palliative Care (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Epidemiology (AREA)
- Anesthesiology (AREA)
- Child & Adolescent Psychology (AREA)
- Diabetes (AREA)
- Rheumatology (AREA)
- Obesity (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Se describen compuestos azol que contienen grupos carbamoilo y sales utiles para uso farmacéutico de los mismos. Los compuestos son anticonvulsivos efectivos que se utilizan en el tratamiento de trastornos del sistema nervioso central, en especial ansiedad, depresion, convulsion, epilepsia, migrana, trastorno bipolar, abuso, de drogas, hábito de fumar, ADHD, obesidad, trastorno del sueno, apoplejía, dolor neuropático, discapacidad cognitiva, neurodegeneracion y espasmo muscular. Se incluyen composiciones farmacéuticas que los contienen. Reivindicacion 1: Un azol que comprende un compuesto de la formula (1), donde G es un anillo seleccionado del grupo que consiste en piperonilo, indanilo, naftilo, fenilo y fenoximetilo, anillo que puede sustituirse con uno o más sustituyentes idénticos o diferentes seleccionados del grupo que consiste en hidrogeno, alquilo inferior C1-8, halogeno, alcoxi C1-8, tioalcoxi C1-8, hidroxi, perfluoroalquilo, fenoxi, fenilalquiloxi C1-8 o fenoxialquilo C1-8, donde el resto fenilo de fenoxi, fenoxialquilo, y fenilalquiloxi no se sustituye o se sustituye con amino, amino mono- di-sustituido con alquilo inferior C1-8, amido, sulfonamido, nitro, carboxilo o perfluoroalquilo C1-8; m es un numero entero de 0 a 6; Y se selecciona del grupo que consiste en hidrogeno, halogeno y alquilo inferior C1-8; n es un numero entero de 0 a 6; A es un grupo azol representado mediante la formula estructural (2) o (3) donde A1 se selecciona del grupo que consiste en un átomo de nitrogeno y CH; Q se selecciona del grupo que consiste en hidrogeno, perfluoroalquilo, halogeno, amino, alquilamino mono- o di-sustituido con alquilo inferior C1-8, amido, alquilo lineal o ramificado C1-8, cicloalquilo C3- 8, arilalquilo, morfolino, piperidino, pirrolidino, tioalcoxi C1-8, benciltio, tieinilo, aminoalquilo, hidroxialquilo, estirilo, carboxílico, piridinilo, fenilo no sustituido y fenilo sustituido con uno o más sustituyentes idénticos o diferentes seleccionados del grupo que consiste en hidrogeno, alquilo inferior C1-8, arilalquilo, halogeno, alcoxi C1-8, fenoxi, amino, amino mono- o di-sustituido con alquilo C1-8, nitro, hidroxi, tioalcoxi, furanilo, sulfonamido o perfluoroalquilo; R1 y R2 se seleccionan en forma independiente del grupo que consiste en hidrogeno, C(=O)NH2, alquilo inferior C1-8, fenilo no sustituido o sustituido, y fenilalquilo no sustituido o sustituido C1-8, o se toman junto con el nitrogeno al cual se encuentran unidos y forman un anillo imidazolico, de piperazina o fenil piperazina o un anillo de amina cíclica representado por la formula estructural (4), donde A2 se selecciona del grupo que consiste en un átomo de nitrogeno y un átomo de carbono; E y U se seleccionan en forma independiente del grupo que consiste en hidrogeno, hidroxi y O-carbamoilo o se toman juntos y forman oxo; W se selecciona de un anillo que consiste en piperonilo, indanilo, naftilo, tetrazolilo, triazolilo, piridilo y fenilo, anillo que puede sustituirse con uno o más sustituyentes idénticos o diferentes seleccionados del grupo que consiste en hidrogeno, alquilo inferior C1-8, halogeno, alcoxi C1-8, tioalcoxi C1-8, hidroxi, fenoxi, fenilalquiloxi C1-8, fenoxialquilo C1- 8, donde el resto fenilo de fenoxi, fenoxialquilo y fenilalquiloxi no se sustituye o se sustituye con amino, amono mono- o di-sustituido con alquilo C1-8, amido, sulfonamido, nitro, carboxilo, hidroxi o perfluoroalquilo C1-8; j es un numero entero de 0 a 4; y t es un numero entero de 0 a 4.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US67453005P | 2005-04-22 | 2005-04-22 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR053065A1 true AR053065A1 (es) | 2007-04-18 |
Family
ID=37115369
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP060101598A AR053065A1 (es) | 2005-04-22 | 2006-04-21 | Compuestos azolicos neuroterapeuticos y composiciones farmaceuticas que los contienen |
Country Status (21)
Country | Link |
---|---|
US (1) | US7598279B2 (es) |
EP (1) | EP1879873B1 (es) |
JP (1) | JP5035238B2 (es) |
KR (1) | KR101286499B1 (es) |
CN (1) | CN101228138B (es) |
AR (1) | AR053065A1 (es) |
AU (1) | AU2006237798B2 (es) |
BR (1) | BRPI0607529B8 (es) |
CA (1) | CA2606258C (es) |
DK (1) | DK1879873T3 (es) |
ES (1) | ES2441765T3 (es) |
FI (1) | FIC20210018I1 (es) |
MX (1) | MX2007013197A (es) |
MY (1) | MY148589A (es) |
NL (1) | NL301106I2 (es) |
PL (1) | PL1879873T3 (es) |
PT (1) | PT1879873E (es) |
RU (1) | RU2418792C2 (es) |
TW (1) | TWI398249B (es) |
WO (1) | WO2006112685A1 (es) |
ZA (1) | ZA200709994B (es) |
Families Citing this family (39)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7598279B2 (en) | 2005-04-22 | 2009-10-06 | Sk Holdings Co., Ltd. | Neurotherapeutic azole compounds |
CA2686547C (en) * | 2007-05-14 | 2015-12-08 | Sk Holdings Co., Ltd. | Novel carbamoyloxy aryl alkan arylpiperazine compound, pharmaceutical compositions comprising the compound and method for treating pain, anxiety and depression by administering the compound |
AU2008258599B2 (en) | 2007-06-05 | 2013-06-13 | Nsab, Filial Af Neurosearch Sweden Ab, Sverige | Disubstituted phenylpyrrolidines as modulators of cortical catecholaminergic neurotransmission |
JP5527668B2 (ja) * | 2008-06-05 | 2014-06-18 | エスケー バイオファーマスティカルズ カンパニー リミテッド | 3−置換プロパンアミン化合物 |
BRPI0924997B1 (pt) * | 2009-06-22 | 2024-01-16 | Sk Biopharmaceuticals Co., Ltd | Método para preparar um composto de éster do ácido 1-aril-2- tetrazoil etil carbâmico |
US8404461B2 (en) * | 2009-10-15 | 2013-03-26 | SK Biopharmaceutical Co. Ltd. | Method for preparation of carbamic acid (R)-1-aryl-2-tetrazolyl-ethyl ester |
KR101783633B1 (ko) | 2009-11-06 | 2017-10-10 | 에스케이바이오팜 주식회사 | 섬유근육통 증후군의 치료 방법 |
ES2447295T3 (es) | 2009-11-06 | 2014-03-11 | Sk Biopharmaceuticals Co., Ltd. | Métodos para el tratamiento del trastorno de déficit de atención/hiperactividad |
US8623913B2 (en) | 2010-06-30 | 2014-01-07 | Sk Biopharmaceuticals Co., Ltd. | Methods for treating restless legs syndrome |
US9610274B2 (en) | 2010-06-30 | 2017-04-04 | Sk Biopharmaceuticals Co., Ltd. | Methods for treating bipolar disorder |
AU2013202982C1 (en) * | 2012-01-06 | 2017-01-05 | Novartis Ag | Heterocyclic compounds and methods for their use |
US9630896B2 (en) | 2013-11-22 | 2017-04-25 | Tansna Therapeutics, Inc. | 2,5-dialkyl-4-H/halo/ether-phenol compounds |
TWI655179B (zh) * | 2014-02-28 | 2019-04-01 | 南韓商愛思開生物製藥股份有限公司 | 胺基羰基胺基甲酸酯化合物 |
ITUA20161941A1 (it) * | 2016-03-23 | 2017-09-23 | Univ Degli Studi Di Siena | Uso di derivati dell’acido 2-amminotiofen-3- carbossilico per il trattamento delle dipendenze da cibo |
KR102421006B1 (ko) | 2016-05-19 | 2022-07-14 | 에스케이바이오팜 주식회사 | 두통의 예방학적 치료를 위한 카바메이트 화합물의 용도 |
KR102489052B1 (ko) * | 2016-05-19 | 2023-01-16 | 에스케이바이오팜 주식회사 | 섬유근육통 또는 섬유근육통의 연관된 기능적 증후군을 예방 또는 치료하기 위한 카바메이트 화합물의 용도 |
KR102421013B1 (ko) * | 2016-05-19 | 2022-07-14 | 에스케이바이오팜 주식회사 | 삼차신경통을 예방 또는 치료하기 위한 카바메이트 화합물의 용도 |
CN110290788A (zh) * | 2016-12-14 | 2019-09-27 | 爱思开生物制药株式会社 | 氨基甲酸酯化合物用于预防、缓解或治疗双相障碍的用途 |
EP3556365A4 (en) * | 2016-12-14 | 2020-06-17 | SK Biopharmaceuticals Co., Ltd. | USE OF A CARBAMATE COMPOUND FOR THE PREVENTION, RELIEF OR TREATMENT OF A DEMYLINATING DISEASE |
WO2018111009A1 (ko) * | 2016-12-14 | 2018-06-21 | 에스케이바이오팜 주식회사 | 진전 또는 진전 증후군의 예방, 경감 또는 치료를 위한 카바메이트 화합물의 용도 |
WO2018111003A1 (ko) | 2016-12-14 | 2018-06-21 | 에스케이바이오팜 주식회사 | 가려움증의 예방, 경감 또는 치료를 위한 카바메이트 화합물의 용도 |
JP7090616B2 (ja) * | 2016-12-14 | 2022-06-24 | エスケー バイオファーマスティカルズ カンパニー リミテッド | カルバメート化合物を含む口腔内崩壊錠 |
BR112019011914A2 (pt) * | 2016-12-14 | 2019-11-05 | Sk Biopharmaceuticals Co Ltd | formulação líquida parenteral, composição injetável, e, método para preparar uma formulação líquida parenteral. |
CN111432814B (zh) * | 2017-11-14 | 2024-05-14 | 爱思开生物制药株式会社 | 用于减轻或治疗包括脆性X染色体综合征、Angelman综合征或Rett综合征的发育障碍的氨基甲酸酯化合物的用途 |
ES2973111T3 (es) | 2017-11-14 | 2024-06-18 | Sk Biopharmaceuticals Co Ltd | Uso de un compuesto de carbamato para prevenir o tratar enfermedades asociadas con el aumento de la corriente tardía de sodio |
WO2019098633A1 (ko) | 2017-11-14 | 2019-05-23 | 에스케이바이오팜 주식회사 | 내장통 또는 내장 질환에서 기인한 통증을 예방, 경감 또는 치료하기 위한 카바메이트 화합물의 용도 |
WO2019098632A1 (ko) | 2017-11-14 | 2019-05-23 | 에스케이바이오팜 주식회사 | 근긴장증의 예방, 경감 또는 치료를 위한 카바메이트 화합물의 용도 |
CN111432813B (zh) | 2017-11-14 | 2024-01-09 | 爱思开生物制药株式会社 | 用于预防、减轻、或治疗精神***症的包含氨基甲酸酯化合物的共混物 |
US20200352907A1 (en) * | 2017-11-14 | 2020-11-12 | Sk Biopharmaceuticals Co., Ltd. | Use Of Carbamate Compound For Preventing, Alleviating Or Treating Absence Seizure Or Epilepsy Showing Absence Seizure |
TWI826531B (zh) * | 2018-09-21 | 2023-12-21 | 南韓商愛思開生物製藥股份有限公司 | 具有㗁二唑之化合物及包含該化合物之醫藥組合物 |
MX2021003203A (es) | 2018-09-21 | 2021-05-27 | Sk Biopharmaceuticals Co Ltd | Compuesto de carbamato y uso de la formulacion que comprende el mismo en prevenir, aliviar, o tratar trastorno de estres agudo o trastorno de estres post-traumatico. |
CN113242735A (zh) * | 2018-09-21 | 2021-08-10 | 爱思开生物制药株式会社 | 使用氨基甲酸酯化合物预防、缓解或治疗并发的癫痫发作 |
KR20210062029A (ko) | 2018-10-19 | 2021-05-28 | 에스케이바이오팜 주식회사 | 카바메이트 화합물의 당뇨병성 말초 신경병증 또는 화학요법 유발 말초 신경병증의 예방, 완화 또는 치료를 위한 용도 |
US10611737B1 (en) | 2019-10-24 | 2020-04-07 | Sk Biopharmaceuticals Co., Ltd. | Method for preparing aryl 2-tetrazol-2-yl ketone with improved selectivity |
KR20220104746A (ko) * | 2019-11-22 | 2022-07-26 | 에스케이바이오팜 주식회사 | 카바메이트 화합물을 포함하는 경구용 약제학적 조성물 및 그 제조방법 |
KR20230048032A (ko) | 2020-08-06 | 2023-04-10 | 에스케이바이오팜 주식회사 | 카바메이트 화합물을 포함하는 경구용 고형 제제 및 이의 제조방법 |
CN114317620B (zh) * | 2020-09-29 | 2024-02-02 | 上海医药工业研究院 | 一种(r)-2-(2-氯苯基)环氧乙烷的生物制备方法 |
CN115974799A (zh) * | 2021-10-14 | 2023-04-18 | 成都百裕制药股份有限公司 | 氨基甲酸酯取代的醇衍生物及其在医药上的应用 |
ES2931000B2 (es) * | 2022-07-14 | 2023-07-07 | Univ Madrid Complutense | Proceso para la preparación de cenobamato |
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US3415840A (en) | 1965-10-22 | 1968-12-10 | American Home Prod | Pyrazole-1-ethanol derivatives |
DK181988A (da) | 1988-03-30 | 1989-10-01 | Dumex Ltd As | Thiocarbamidsyreester til brug som terapeutikum samt praeparat til behandling af alkoholmisbrug |
DE60222552T2 (de) * | 2001-06-25 | 2008-06-26 | Sk Corp. | Carbamate von 2-heterozyklischen 1,2-ethandiolen |
US6770659B2 (en) * | 2002-08-26 | 2004-08-03 | Sk Corporation | Benzoyl piperidine compounds |
US7598279B2 (en) | 2005-04-22 | 2009-10-06 | Sk Holdings Co., Ltd. | Neurotherapeutic azole compounds |
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- 2006-04-21 KR KR1020077026985A patent/KR101286499B1/ko active IP Right Grant
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KR20080005437A (ko) | 2008-01-11 |
ZA200709994B (en) | 2008-11-26 |
TWI398249B (zh) | 2013-06-11 |
EP1879873B1 (en) | 2013-10-09 |
TW200722085A (en) | 2007-06-16 |
CA2606258C (en) | 2014-01-14 |
CA2606258A1 (en) | 2006-10-26 |
BRPI0607529B8 (pt) | 2021-05-25 |
KR101286499B1 (ko) | 2013-07-16 |
EP1879873A1 (en) | 2008-01-23 |
BRPI0607529A2 (pt) | 2009-09-15 |
CN101228138A (zh) | 2008-07-23 |
JP5035238B2 (ja) | 2012-09-26 |
RU2418792C2 (ru) | 2011-05-20 |
EP1879873A4 (en) | 2011-06-15 |
US20060258718A1 (en) | 2006-11-16 |
PL1879873T3 (pl) | 2014-03-31 |
MY148589A (en) | 2013-05-15 |
NL301106I2 (nl) | 2021-08-03 |
ES2441765T3 (es) | 2014-02-06 |
FIC20210018I1 (fi) | 2021-06-14 |
CN101228138B (zh) | 2012-11-21 |
DK1879873T3 (da) | 2013-12-09 |
US7598279B2 (en) | 2009-10-06 |
WO2006112685A1 (en) | 2006-10-26 |
AU2006237798B2 (en) | 2012-07-12 |
JP2008538557A (ja) | 2008-10-30 |
RU2007143073A (ru) | 2009-05-27 |
NL301106I1 (nl) | 2021-06-02 |
PT1879873E (pt) | 2014-01-03 |
AU2006237798A1 (en) | 2006-10-26 |
BRPI0607529B1 (pt) | 2021-05-18 |
MX2007013197A (es) | 2008-02-12 |
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