UY29301A1 - Derivados amida - Google Patents
Derivados amidaInfo
- Publication number
- UY29301A1 UY29301A1 UY29301A UY29301A UY29301A1 UY 29301 A1 UY29301 A1 UY 29301A1 UY 29301 A UY29301 A UY 29301A UY 29301 A UY29301 A UY 29301A UY 29301 A1 UY29301 A1 UY 29301A1
- Authority
- UY
- Uruguay
- Prior art keywords
- halogen
- trifluoromethyl
- alkyl
- amida
- derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
- A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/24—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Abstract
La invención se refiere a un compuesto de la fórmula I en donde m es 0-2 y cada R1 es un grupo tal como hidroxi, halógeno, trifluorometilo, heterociclilo y heterocicliloxi; R2 es halógeno, trifluorometilo o alquilo (1-6C); R3 es hidrógeno, halógeno o alquilo (1-6C); y R4 es cicloalquilo (3-6C); o sales farmacéuticamente aceptables del mismo, procesos para su preparación, composiciones farmacéuticas que lo contienen y su uso en el tratamiento de enfermedades o condiciones médicas mediadas por citoquinas.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0428326A GB0428326D0 (en) | 2004-12-24 | 2004-12-24 | Amide derivatives |
GB0507513A GB0507513D0 (en) | 2005-04-14 | 2005-04-14 | Amide derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
UY29301A1 true UY29301A1 (es) | 2006-07-31 |
Family
ID=35840517
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UY29301A UY29301A1 (es) | 2004-12-24 | 2005-12-22 | Derivados amida |
Country Status (21)
Country | Link |
---|---|
US (1) | US7786115B2 (es) |
EP (1) | EP1831174B1 (es) |
JP (1) | JP4937135B2 (es) |
KR (1) | KR20070095911A (es) |
CN (1) | CN102516170A (es) |
AR (1) | AR055017A1 (es) |
AT (1) | ATE500227T1 (es) |
AU (1) | AU2005317868B2 (es) |
BR (1) | BRPI0519287A2 (es) |
CA (1) | CA2589764A1 (es) |
DE (1) | DE602005026703D1 (es) |
HK (1) | HK1106245A1 (es) |
IL (1) | IL183657A (es) |
MX (1) | MX2007007424A (es) |
MY (1) | MY140868A (es) |
NO (1) | NO20073730L (es) |
NZ (1) | NZ555768A (es) |
RU (1) | RU2396259C2 (es) |
TW (1) | TWI364415B (es) |
UY (1) | UY29301A1 (es) |
WO (1) | WO2006067444A1 (es) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2929331B2 (ja) * | 1990-07-18 | 1999-08-03 | 丸善石油化学株式会社 | トラクションドライブ用流体 |
GB0324790D0 (en) | 2003-10-24 | 2003-11-26 | Astrazeneca Ab | Amide derivatives |
GB0504019D0 (en) * | 2005-02-26 | 2005-04-06 | Astrazeneca Ab | Amide derivatives |
GB0516570D0 (en) * | 2005-08-12 | 2005-09-21 | Astrazeneca Ab | Amide derivatives |
EP2035386A1 (en) * | 2006-06-19 | 2009-03-18 | AstraZeneca AB | Isoquinoline derivatives and their use as inhibitors of cytokine mediated diseases |
WO2008024961A1 (en) * | 2006-08-24 | 2008-02-28 | Serenex, Inc. | Dihydropyridazine, tetrahydropyridine, chromanone, and dihydronaphthalenone derivatives as heat-shock protein 90 inhibitors |
AR065810A1 (es) * | 2007-03-20 | 2009-07-01 | Celgene Corp | Derivados de isoindolina 4'-o-sustituidos,composiciones farmaceuticas que los comprenden y usos de los mismos en el tratamiento del cancer y en otros trastornos donde es necesario el control de la angiogenesis o la inhibicion de citoquinas, incluyendo tnf-alfa. |
TW200845988A (en) * | 2007-04-05 | 2008-12-01 | Astrazeneca Ab | New compounds and their uses 707 |
WO2009098144A1 (en) * | 2008-02-05 | 2009-08-13 | F. Hoffmann-La Roche Ag | Novel pyridinones and pyridazinones |
ATE494926T1 (de) | 2008-03-25 | 2011-01-15 | Affectis Pharmaceuticals Ag | Neuartige p2x7r-antagonisten und ihre verwendung |
AR073711A1 (es) * | 2008-10-01 | 2010-11-24 | Astrazeneca Ab | Derivados de isoquinolina |
US8299077B2 (en) * | 2009-03-02 | 2012-10-30 | Roche Palo Alto Llc | Inhibitors of Bruton's tyrosine kinase |
MX2011010810A (es) | 2009-04-14 | 2012-01-12 | Affectis Pharmaceuticals Ag | Nuevos antagonistas de p2x7r y su uso. |
WO2011010131A1 (en) | 2009-07-21 | 2011-01-27 | Astrazeneca Ab | Compositions comprising an oxoisoquinoline methylbenzamide and a polymer |
CN106866667B (zh) * | 2009-11-05 | 2019-11-15 | 圣母大学 | 咪唑并[1,2-a]吡啶类化合物及其合成及使用方法 |
EP2386541A1 (en) | 2010-05-14 | 2011-11-16 | Affectis Pharmaceuticals AG | Novel methods for the preparation of P2X7R antagonists |
WO2012110190A1 (en) | 2011-02-17 | 2012-08-23 | Affectis Pharmaceuticals Ag | Novel p2x7r antagonists and their use |
MX350121B (es) | 2011-03-18 | 2017-08-28 | Bayer Ip Gmbh | Derivados de n-(3-carbamoilfenil)-1h-pirazol-5-carboxamida y el uso de los mismos para el control de plagas de animales. |
WO2012163792A1 (en) | 2011-05-27 | 2012-12-06 | Affectis Pharmaceuticals Ag | Novel p2x7r antagonists and their use |
WO2012163456A1 (en) | 2011-05-27 | 2012-12-06 | Affectis Pharmaceuticals Ag | Novel p2x7r antagonists and their use |
WO2017003723A1 (en) | 2015-07-01 | 2017-01-05 | Crinetics Pharmaceuticals, Inc. | Somatostatin modulators and uses thereof |
US11028068B2 (en) | 2017-07-25 | 2021-06-08 | Crinetics Pharmaceuticals, Inc. | Somatostatin modulators and uses thereof |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5136461A (en) * | 1974-09-24 | 1976-03-27 | Grelan Pharmaceutical Co | 44 * 22 isokarubosuchiririiru * fuenirusakusanruinoseizoho |
JPS5143766A (en) * | 1974-10-09 | 1976-04-14 | Grelan Pharmaceutical Co | 44 * 22 * 3*44 jihidoroisokarubosuchiririiru * * fuenirusakusanruino seizoho |
PT590455E (pt) * | 1992-09-28 | 2001-04-30 | Hoechst Ag | 1(2h)-isoquinolinas substituidas anti-arritmicas e cardioprotectoras processo para a sua preparacao medicamento contendo estes compostos e sua utilizacao para a preparacao de um medicamento para o combate de falhas cardiacas |
KR100757282B1 (ko) * | 1999-03-17 | 2007-09-11 | 아스트라제네카 아베 | 아미드 유도체 |
JP2002220386A (ja) * | 2000-10-02 | 2002-08-09 | Tanabe Seiyaku Co Ltd | ベンジルアミン誘導体、その製法およびその合成中間体 |
GB0504019D0 (en) * | 2005-02-26 | 2005-04-06 | Astrazeneca Ab | Amide derivatives |
GB0516570D0 (en) | 2005-08-12 | 2005-09-21 | Astrazeneca Ab | Amide derivatives |
-
2005
- 2005-12-22 EP EP05823612A patent/EP1831174B1/en active Active
- 2005-12-22 NZ NZ555768A patent/NZ555768A/en not_active IP Right Cessation
- 2005-12-22 KR KR1020077014184A patent/KR20070095911A/ko not_active Application Discontinuation
- 2005-12-22 DE DE602005026703T patent/DE602005026703D1/de active Active
- 2005-12-22 BR BRPI0519287-0A patent/BRPI0519287A2/pt not_active IP Right Cessation
- 2005-12-22 US US11/793,781 patent/US7786115B2/en not_active Expired - Fee Related
- 2005-12-22 MX MX2007007424A patent/MX2007007424A/es active IP Right Grant
- 2005-12-22 MY MYPI20056172A patent/MY140868A/en unknown
- 2005-12-22 CN CN201110333201XA patent/CN102516170A/zh active Pending
- 2005-12-22 AU AU2005317868A patent/AU2005317868B2/en not_active Ceased
- 2005-12-22 WO PCT/GB2005/004984 patent/WO2006067444A1/en active Application Filing
- 2005-12-22 AR ARP050105493A patent/AR055017A1/es not_active Application Discontinuation
- 2005-12-22 AT AT05823612T patent/ATE500227T1/de not_active IP Right Cessation
- 2005-12-22 CA CA002589764A patent/CA2589764A1/en not_active Abandoned
- 2005-12-22 UY UY29301A patent/UY29301A1/es not_active Application Discontinuation
- 2005-12-22 RU RU2007130153/04A patent/RU2396259C2/ru not_active IP Right Cessation
- 2005-12-22 JP JP2007547641A patent/JP4937135B2/ja not_active Expired - Fee Related
- 2005-12-23 TW TW094146388A patent/TWI364415B/zh active
-
2007
- 2007-06-04 IL IL183657A patent/IL183657A/en not_active IP Right Cessation
- 2007-07-18 NO NO20073730A patent/NO20073730L/no not_active Application Discontinuation
-
2008
- 2008-01-08 HK HK08100175.9A patent/HK1106245A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
MX2007007424A (es) | 2007-07-17 |
KR20070095911A (ko) | 2007-10-01 |
MY140868A (en) | 2010-01-29 |
HK1106245A1 (en) | 2008-03-07 |
IL183657A (en) | 2012-10-31 |
CN102516170A (zh) | 2012-06-27 |
ATE500227T1 (de) | 2011-03-15 |
RU2396259C2 (ru) | 2010-08-10 |
JP2008525405A (ja) | 2008-07-17 |
AU2005317868A1 (en) | 2006-06-29 |
AU2005317868B2 (en) | 2009-06-04 |
RU2007130153A (ru) | 2009-02-20 |
AR055017A1 (es) | 2007-08-01 |
DE602005026703D1 (de) | 2011-04-14 |
WO2006067444A1 (en) | 2006-06-29 |
US7786115B2 (en) | 2010-08-31 |
EP1831174B1 (en) | 2011-03-02 |
EP1831174A1 (en) | 2007-09-12 |
JP4937135B2 (ja) | 2012-05-23 |
CA2589764A1 (en) | 2006-06-29 |
IL183657A0 (en) | 2007-09-20 |
NZ555768A (en) | 2009-12-24 |
NO20073730L (no) | 2007-09-10 |
TWI364415B (en) | 2012-05-21 |
BRPI0519287A2 (pt) | 2009-01-06 |
TW200635901A (en) | 2006-10-16 |
US20080146566A1 (en) | 2008-06-19 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
109 | Application deemed to be withdrawn |
Effective date: 20160606 |