UA84718C2 - Бензимидазолы, которые содержат морфолинил, как ингибиторы репликации респираторно-синцитиального вируса - Google Patents

Бензимидазолы, которые содержат морфолинил, как ингибиторы репликации респираторно-синцитиального вируса

Info

Publication number
UA84718C2
UA84718C2 UAA200606224A UAA200606224A UA84718C2 UA 84718 C2 UA84718 C2 UA 84718C2 UA A200606224 A UAA200606224 A UA A200606224A UA A200606224 A UAA200606224 A UA A200606224A UA 84718 C2 UA84718 C2 UA 84718C2
Authority
UA
Ukraine
Prior art keywords
ris
hydrogen
substituted
calkyl
respiratory syncytial
Prior art date
Application number
UAA200606224A
Other languages
English (en)
Ukrainian (uk)
Inventor
Жан-Френсуа Бонфанти
Конраад Йозеф Лодевийк Андриес
Жером Мишель Клод Фортен
Филипп Мюллер
Фредерик Марк Морис Дубле
Кристоф Майер
Руди Эдмонд Виллебрордс
Том Валериус Йозефа Геверс
Филип Мария Марта Берн Тиммерман
Original Assignee
Тиботек Фармасьютикелз Лтд.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34704695&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=UA84718(C2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Тиботек Фармасьютикелз Лтд. filed Critical Тиботек Фармасьютикелз Лтд.
Publication of UA84718C2 publication Critical patent/UA84718C2/ru

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D235/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/30Nitrogen atoms not forming part of a nitro radical
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/41641,3-Diazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/41641,3-Diazoles
    • A61K31/41841,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
UAA200606224A 2003-12-18 2004-12-20 Бензимидазолы, которые содержат морфолинил, как ингибиторы репликации респираторно-синцитиального вируса UA84718C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP03104810 2003-12-18
US56718204P 2004-04-30 2004-04-30
EP04105312 2004-10-26

Publications (1)

Publication Number Publication Date
UA84718C2 true UA84718C2 (ru) 2008-11-25

Family

ID=34704695

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA200606224A UA84718C2 (ru) 2003-12-18 2004-12-20 Бензимидазолы, которые содержат морфолинил, как ингибиторы репликации респираторно-синцитиального вируса

Country Status (33)

Country Link
US (2) US7449463B2 (ru)
EP (1) EP1697345B1 (ru)
JP (1) JP4951348B2 (ru)
KR (1) KR100967406B1 (ru)
CN (2) CN101412709B (ru)
AP (1) AP2150A (ru)
AR (1) AR046959A1 (ru)
AT (1) ATE388950T1 (ru)
AU (1) AU2004298460B2 (ru)
BR (1) BRPI0417268B8 (ru)
CA (1) CA2548668C (ru)
CY (1) CY1108142T1 (ru)
DE (1) DE602004012448T2 (ru)
DK (1) DK1697345T3 (ru)
EA (1) EA009876B1 (ru)
EG (1) EG25799A (ru)
ES (1) ES2303653T3 (ru)
HK (1) HK1130799A1 (ru)
HR (1) HRP20080245T3 (ru)
IL (1) IL175910A (ru)
ME (1) ME01042B (ru)
MX (1) MXPA06007112A (ru)
MY (1) MY143573A (ru)
NO (1) NO339314B1 (ru)
NZ (1) NZ547479A (ru)
PL (1) PL1697345T3 (ru)
PT (1) PT1697345E (ru)
RS (1) RS50584B (ru)
SI (1) SI1697345T1 (ru)
TW (1) TWI351401B (ru)
UA (1) UA84718C2 (ru)
WO (1) WO2005058871A1 (ru)
ZA (1) ZA200605894B (ru)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR046959A1 (es) * 2003-12-18 2006-01-04 Tibotec Pharm Ltd Morfolinilo que contiene bencimidazoles como inhibidores de la replicacion del virus sincitial respiratorio
TWI370820B (en) 2005-04-27 2012-08-21 Takeda Pharmaceutical Fused heterocyclic compounds
AU2006260970B2 (en) * 2005-06-20 2012-07-05 Janssen Sciences Ireland Uc Heterocyclylaminoalkyl substituted benzimidazoles
CA2612263C (en) * 2005-06-20 2015-04-14 Tibotec Pharmaceuticals Ltd. 1-(2-amino-3-(substituted alkyl)-3h-benzimidazolylmethyl)-3-subtituted-1,3-dihydro-benzoimidazol-2-ones with activity on respiratory syncytial virus
US20120148678A1 (en) 2010-12-08 2012-06-14 Advanced Technologies And Regenerative Medicine, Llc. Sustained release of poorly water soluble active compounds
KR102066297B1 (ko) 2011-10-14 2020-01-14 암비트 바이오사이언시즈 코포레이션 헤테로사이클릭 화합물 및 이의 유형 3 수용체 티로신 키나아제의 조절인자로서의 용도
UA119050C2 (uk) * 2013-11-11 2019-04-25 Ґілеад Саєнсиз, Інк. ПІРОЛО[1.2-f][1.2.4]ТРИАЗИНИ, ЯКІ ВИКОРИСТОВУЮТЬСЯ ДЛЯ ЛІКУВАННЯ РЕСПІРАТОРНО-СИНЦИТІАЛЬНИХ ВІРУСНИХ ІНФЕКЦІЙ
JO3637B1 (ar) * 2015-04-28 2020-08-27 Janssen Sciences Ireland Uc مركبات بيرازولو- وترايازولو- بيريميدين مضادة للفيروسات rsv
CA3027097C (en) 2016-05-10 2023-11-28 Georgia State University Research Foundation, Inc. Bicyclic fused pyrazole derivatives for the treatment of rsv
TW201815787A (zh) 2016-09-23 2018-05-01 美商基利科學股份有限公司 磷脂醯肌醇3-激酶抑制劑
TW201813963A (zh) 2016-09-23 2018-04-16 美商基利科學股份有限公司 磷脂醯肌醇3-激酶抑制劑
TW201825465A (zh) 2016-09-23 2018-07-16 美商基利科學股份有限公司 磷脂醯肌醇3-激酶抑制劑
CN109311897B (zh) 2017-03-20 2021-07-20 福马治疗股份有限公司 作为丙酮酸激酶(pkr)活化剂的吡咯并吡咯组合物
TW201932470A (zh) 2017-11-29 2019-08-16 愛爾蘭商健生科學愛爾蘭無限公司 具有抗rsv活性之吡唑并嘧啶
CA3087926A1 (en) 2018-01-31 2019-08-08 Janssen Sciences Ireland Unlimited Company Cycloalkyl substituted pyrazolopyrimidines having activity against rsv
KR20210005569A (ko) 2018-04-23 2021-01-14 얀센 사이언시즈 아일랜드 언리미티드 컴퍼니 Rsv에 대한 활성을 갖는 헤테로방향족 화합물
US20230055923A1 (en) 2018-09-19 2023-02-23 Forma Therapeutics, Inc. Activating pyruvate kinase r
US20200129485A1 (en) 2018-09-19 2020-04-30 Forma Therapeutics, Inc. Treating sickle cell disease with a pyruvate kinase r activating compound
GB201820751D0 (en) * 2018-12-19 2019-01-30 Bp Oil Int Methods for preparing intermediates
CA3147397A1 (en) 2019-07-22 2021-01-28 Lupin Limited Macrocyclic compounds as sting agonists and methods and uses thereof
JP7329239B2 (ja) 2019-09-20 2023-08-18 株式会社タマディック フライトシミュレーター
WO2023018560A1 (en) * 2021-08-13 2023-02-16 Georgia State University Research Foundation, Inc. Bicyclic fused pyrazole derivatives for the treatment of respiratory infections including rsv

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003503403A (ja) * 1999-06-28 2003-01-28 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ 呼吸合胞体ウイルス複製阻害剤
TR200103806T2 (tr) * 1999-06-28 2002-06-21 Janssen Pharmaceutica N. V. Solunum sistemi sinsitiyal virüsünün replikasyonunu inhibe edici maddeler.
DE60013836T2 (de) * 1999-06-28 2006-01-19 Janssen Pharmaceutica N.V. Replikationsinhibitoren des respiratorischen synzytialvirus
US8044073B2 (en) * 2003-12-18 2011-10-25 Tibotec Pharmaceuticals Aminobenzimidazoles and benzimidazoles as inhibitors of respiratory syncytial virus replication
AR046959A1 (es) * 2003-12-18 2006-01-04 Tibotec Pharm Ltd Morfolinilo que contiene bencimidazoles como inhibidores de la replicacion del virus sincitial respiratorio

Also Published As

Publication number Publication date
US20080280881A1 (en) 2008-11-13
ZA200605894B (en) 2008-01-08
TW200531972A (en) 2005-10-01
NO339314B1 (no) 2016-11-28
EP1697345A1 (en) 2006-09-06
CA2548668A1 (en) 2005-06-30
AP2006003640A0 (en) 2006-06-30
EP1697345B1 (en) 2008-03-12
US20070043022A1 (en) 2007-02-22
CN1894237A (zh) 2007-01-10
ME01042B (me) 2012-10-20
CN101412709B (zh) 2015-03-25
NZ547479A (en) 2009-03-31
AU2004298460A1 (en) 2005-06-30
JP4951348B2 (ja) 2012-06-13
DE602004012448D1 (de) 2008-04-24
PT1697345E (pt) 2008-06-12
US7449463B2 (en) 2008-11-11
PL1697345T3 (pl) 2008-08-29
HRP20080245T3 (en) 2008-07-31
AP2150A (en) 2010-09-04
AU2004298460B2 (en) 2009-03-19
AR046959A1 (es) 2006-01-04
CY1108142T1 (el) 2014-02-12
ATE388950T1 (de) 2008-03-15
MY143573A (en) 2011-05-31
WO2005058871A1 (en) 2005-06-30
ES2303653T3 (es) 2008-08-16
DK1697345T3 (da) 2008-06-23
EG25799A (en) 2012-08-06
MXPA06007112A (es) 2006-08-23
RS50584B (sr) 2010-05-07
BRPI0417268B8 (pt) 2021-05-25
TWI351401B (en) 2011-11-01
KR20070015507A (ko) 2007-02-05
IL175910A (en) 2013-08-29
BRPI0417268B1 (pt) 2018-10-23
HK1130799A1 (en) 2010-01-08
KR100967406B1 (ko) 2010-07-01
CA2548668C (en) 2011-09-20
EA009876B1 (ru) 2008-04-28
NO20063322L (no) 2006-09-18
BRPI0417268A (pt) 2007-03-13
IL175910A0 (en) 2006-10-05
US8883837B2 (en) 2014-11-11
SI1697345T1 (sl) 2008-08-31
EA200601178A1 (ru) 2006-10-27
DE602004012448T2 (de) 2009-03-26
JP2007514720A (ja) 2007-06-07
CN101412709A (zh) 2009-04-22

Similar Documents

Publication Publication Date Title
UA84718C2 (ru) Бензимидазолы, которые содержат морфолинил, как ингибиторы репликации респираторно-синцитиального вируса
IL260127B (en) mek inhibitors and methods of using them
SG170069A1 (en) Quinoline derivatives
TW200730502A (en) Isoquinoline aminopyrazole derivatives, their manufacture and use as pharmaceutical agents
TW200508214A (en) Novel compounds
TW200738659A (en) Novel compounds
MY148634A (en) Pyridazinone derivatives
MX2009002010A (es) Derivados de heteroarilo como inhibidores de la proteina cinasa.
NO20083207L (no) Inhibitorer av IAP
AU2003228770A8 (en) Substituted pyrazolopyrimidines
UA96277C2 (en) Benzimidazole derivatives
TW200639156A (en) New compounds
TW200716529A (en) New compounds II
WO2006057922A3 (en) Niacin receptor agonists, compositions containing such compounds and methods of treatment
WO2006125555A3 (de) Chinazolinone
TW200531688A (en) Novel pentafluorosulfanyl compounds, their manufacture and use as pharmaceutical agents
MY140235A (en) New benzimidazole derivatives
MY135850A (en) Ring-substituted diphenylazetidinones, process for their preparation, medicaments comprising these compounds and their use
TW200740781A (en) Novel compounds
MX2009006010A (es) Derivados de amina y su uso en enfermedades mediadas por el adrenoreceptor beta 2.
TW200719899A (en) Tricyclic azole derivatives, their manufacture and use as pharmaceutical agents
TW200720262A (en) Novel compounds ii
MX2008011769A (es) Derivados de ftalazinona pirazol, su fabricacion y uso como agentes farmaceuticos.
MX348127B (es) Derivados de quinazolinona como inhibidores del virus de la hepatitis c.
TW200637826A (en) Chemical compounds