AR023308A1 - Uso de dihidropirimidinas para la preparacion de un medicamento, dihidropirimidinas, procedimiento para su produccion y preparados farmaceuticos que loscontienen. - Google Patents
Uso de dihidropirimidinas para la preparacion de un medicamento, dihidropirimidinas, procedimiento para su produccion y preparados farmaceuticos que loscontienen.Info
- Publication number
- AR023308A1 AR023308A1 ARP990101778A ARP990101778A AR023308A1 AR 023308 A1 AR023308 A1 AR 023308A1 AR P990101778 A ARP990101778 A AR P990101778A AR P990101778 A ARP990101778 A AR P990101778A AR 023308 A1 AR023308 A1 AR 023308A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- substituted
- hydroxyl
- phenyl
- halogen
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
Abstract
Uso de dihidropirimidinas de formula general 1 o bien de su forma mesomera (1a) en las cuales R1 representa fenilo, furilo, tienilo, triazolilo, piridilo,cicloalquilo C3-6 o representa restos de formulas 2, 3 o 4 estando los sistemas anulares indicados anteriormente eventualmente mono- o multisustituídos porsustituyentes iguales o distintos elegidos del grupo: halogeno, trifluorometilo, nitro, ciano, trifluorometoxi, carboxilo, hidroxilo, alcoxi (C1-6),alcoxicarbonilo (C1-6) y alquilo (C1-6) que, por su parte, puede estar sustituído por arilo con C6-10 o halogeno, y/o los sistemas anulares indicados estáneventualmente sustituídos por grupos de formula -S-R6, NR7R8, CO-NR9R10, SO2-CF3 y -A-CH2-R11, donde R6 significa fenilo que está eventualmente sustituído porhalogeno, R7, R8, R9 y R10 son iguales o distintos y significan hidrogeno, fenilo, fenilo sustituído por hidroxilo, hidroxilo, acilo (C1-6) o alquilo (C1-6)que, por su parte, puede estar sustituído por hidroxilo, alcoxicarbonilo (C1-6), fenilo o fenilo sustituído por hidroxilo, A significa un resto O, S, SO o SO2,R11 significa fenilo que está eventualmente mono- a multisustituído por sustituyentes iguales o distintos elegidos del grupo: halogeno, nitro, trifluorometilo,alquilo (C1-6) y alcoxi (C1-6), R2 representa un resto de formula -XR12 o -NR13R14, donde X significa un enlace u oxígeno, R12 significa hidrogeno,alcoxicarbonilo (C1-6) lineal o ramificado o un resto hidrocarburo (C1-8) lineal, ramificado o cíclico, saturado o insaturado que eventualmente contiene uno odos eslabones heteroátomos iguales o distintos del grupo O, CO, NH, -NH-alquilo (C1-4), -N-(alquilo (C1-4))2, S o SO2 y que está eventualmente sustituído porhalogeno, nitro, ciano, hidroxilo, arilo conC6-10 o arilalquilo con C6-10, heteroarilo o un grupo de formula -NR15R16, donde R15 y R16 son iguales o distintosy significan hidrogeno, bencilo o alquilo (C1-6), R13 y R14 son iguales o distintos y significan hidrogeno, alquilo (C1-6) o cicloalquilo con C3 a 6, R3representa hidrogeno, amino o representa un resto de formula 5, o representa formilo, ciano, alquiltío (C1-6) sustituído por hidroxilo, trifluorometilo o
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19817265A DE19817265A1 (de) | 1998-04-18 | 1998-04-18 | Verwendung von Dihydropyrimidinen als Arzneimittel und neue Stoffe |
Publications (1)
Publication Number | Publication Date |
---|---|
AR023308A1 true AR023308A1 (es) | 2002-09-04 |
Family
ID=7864973
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP990101778A AR023308A1 (es) | 1998-04-18 | 1999-04-16 | Uso de dihidropirimidinas para la preparacion de un medicamento, dihidropirimidinas, procedimiento para su produccion y preparados farmaceuticos que loscontienen. |
Country Status (12)
Country | Link |
---|---|
US (1) | US6436943B1 (es) |
EP (1) | EP1073642B1 (es) |
JP (1) | JP2002512233A (es) |
AR (1) | AR023308A1 (es) |
AU (1) | AU3813499A (es) |
CA (1) | CA2328733A1 (es) |
DE (2) | DE19817265A1 (es) |
ES (1) | ES2186354T3 (es) |
GT (1) | GT199900054A (es) |
PE (1) | PE20000426A1 (es) |
SV (1) | SV1999000048A (es) |
WO (1) | WO1999054312A1 (es) |
Families Citing this family (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU4289100A (en) * | 1999-03-25 | 2000-10-16 | Bayer Aktiengesellschaft | Dihydropyrimidines and their use in the treatment of hepatitis |
WO2000078730A1 (fr) * | 1999-06-23 | 2000-12-28 | Ajinomoto Co., Inc. | Nouveaux derives dihydropyrimidiniques |
WO2001045712A1 (de) * | 1999-12-22 | 2001-06-28 | Bayer Aktiengesellschaft | Arzneimittelkombinationen gegen virale erkrankungen |
DE10012549A1 (de) * | 2000-03-15 | 2001-09-20 | Bayer Ag | Arzneimittel gegen virale Erkrankungen |
DE10012824A1 (de) * | 2000-03-16 | 2001-09-20 | Bayer Ag | Arzneimittel gegen virale Erkrankungen |
DE10012823A1 (de) | 2000-03-16 | 2001-09-20 | Bayer Ag | Arzneimittel gegen virale Erkrankungen |
DE10013126A1 (de) * | 2000-03-17 | 2001-09-20 | Bayer Ag | Arzneimittel gegen virale Erkrankungen |
GB0017676D0 (en) | 2000-07-19 | 2000-09-06 | Angeletti P Ist Richerche Bio | Inhibitors of viral polymerase |
GB0201179D0 (en) * | 2002-01-18 | 2002-03-06 | Angeletti P Ist Richerche Bio | Therapeutic agents |
KR100502394B1 (ko) * | 2003-06-04 | 2005-07-19 | (주) 비엔씨바이오팜 | 2-[2-(4-모르포리노)에틸아미노]피리딘 유도체, 그제조방법 및 이를 포함하는 항바이러스용 약학적 조성물 |
KR100502395B1 (ko) * | 2003-06-04 | 2005-07-19 | (주) 비엔씨바이오팜 | 4-[4-(4-모르포리노)아닐리노]피리미딘 유도체, 그제조방법 및 이를 포함하는 항바이러스용 약학적 조성물. |
GB0313250D0 (en) * | 2003-06-09 | 2003-07-16 | Angeletti P Ist Richerche Bio | Therapeutic agents |
KR101173892B1 (ko) | 2007-06-18 | 2012-08-16 | 선샤인 레이크 파르마 컴퍼니 리미티드 | 브로모-페닐 치환된 티아졸릴 디하이드로피리미딘 |
AR067630A1 (es) | 2007-07-12 | 2009-10-21 | Novartis Ag | Soluciones farmaceuticas de telbivudina y metodo de tratamiento |
WO2013019967A1 (en) * | 2011-08-02 | 2013-02-07 | Scripps Research Institute, A Not-For-Profit Public Benefit Corporation Of California | Modulators of virus assembly as antiviral agents |
EP2812324B1 (en) | 2012-02-08 | 2021-09-01 | Sunovion Pharmaceuticals Inc. | Heteroaryl compounds and methods of use thereof |
US20130267517A1 (en) | 2012-03-31 | 2013-10-10 | Hoffmann-La Roche Inc. | Novel 4-methyl-dihydropyrimidines for the treatment and prophylaxis of hepatitis b virus infection |
SG11201408791TA (en) | 2012-08-24 | 2015-01-29 | Sunshine Lake Pharma Co Ltd | Dihydropyrimidine compounds and their application in pharmaceuticals |
PE20150776A1 (es) | 2012-09-10 | 2015-05-21 | Hoffmann La Roche | 6-aminoacido-heteroarildihidropirimidinas para el tratamiento y profilaxis de la infeccion del virus de la hepatitis b |
SG11201503475WA (en) * | 2012-11-09 | 2015-05-28 | Univ Indiana Res & Tech Corp | Alternative uses for hbv assembly effectors |
CN105188703A (zh) * | 2013-03-20 | 2015-12-23 | 美国印第安纳大学研究和技术公司 | 荧光-hap:用于细胞中的hbv核的诊断性染色剂 |
AU2014352404B2 (en) | 2013-11-19 | 2018-07-19 | Sunshine Lake Pharma Co., Ltd. | Dihydropyrimidine compounds and their application in pharmaceuticals |
CN104672223B (zh) | 2013-11-27 | 2018-03-13 | 广东东阳光药业有限公司 | 二氢嘧啶衍生物的制备方法及其中间体 |
RU2682672C2 (ru) | 2014-03-28 | 2019-03-20 | Саншайн Лейк Фарма Ко., Лтд. | Соединения дигидропиримидина и их применение в фармацевтических препаратах |
CN105859709B (zh) | 2015-02-07 | 2018-12-04 | 广东东阳光药业有限公司 | 二氢嘧啶衍生物的复合物及其在药物中的应用 |
EP3490607A4 (en) | 2016-07-29 | 2020-04-08 | Sunovion Pharmaceuticals Inc. | COMPOUNDS AND COMPOSITIONS, AND USES THEREOF |
CN116514761A (zh) | 2016-07-29 | 2023-08-01 | 赛诺维信制药公司 | 化合物、组合物及其用途 |
CN110475775B (zh) * | 2017-03-31 | 2023-05-09 | 富士胶片株式会社 | 4-吡啶酮化合物或其盐、包含4-吡啶酮化合物的药物组合物及剂 |
SG11202000669VA (en) | 2017-08-02 | 2020-02-27 | Sunovion Pharmaceuticals Inc | Isochroman compounds and uses thereof |
CN108947996B (zh) * | 2018-07-12 | 2022-01-18 | 山东大学 | 二氢嘧啶-磺酰胺类衍生物及其制备方法与应用 |
KR20210139376A (ko) | 2019-03-14 | 2021-11-22 | 선오비온 파마슈티컬스 인코포레이티드 | 이소크로마닐 화합물의 염, 및 이의 결정성 형태, 제조방법, 치료 용도 및 약제학적 조성물 |
CN112778299B (zh) * | 2019-11-04 | 2023-07-14 | 江苏恒瑞医药股份有限公司 | 哌嗪脲基类衍生物、其制备方法及其在医药上的应用 |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
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CH550189A (de) | 1971-01-08 | 1974-06-14 | Ciba Geigy Ag | Verfahren zur herstellung von neuen dibenzo (b,f) thiepincarbonsaeuren. |
CH569043A5 (es) | 1973-01-23 | 1975-11-14 | Ciba Geigy Ag | |
DE3234684A1 (de) | 1982-09-18 | 1984-03-22 | Bayer Ag, 5090 Leverkusen | Neue dihydropyrimidine, verfahren zu ihrer herstellung sowie ihre verwendung in arzneimitteln |
US4698340A (en) | 1984-07-19 | 1987-10-06 | Fujisawa Pharmaceutical Co., Ltd. | Pyrimidine derivatives, processes for preparation thereof and composition containing the same |
US4727073A (en) | 1984-10-01 | 1988-02-23 | Fujisawa Pharmaceutical Co., Ltd. | Pyrimidine derivatives and composition of the same |
JPH07110132B2 (ja) | 1991-08-22 | 1995-11-22 | 日本モトローラ株式会社 | 電圧変換装置 |
JP3349781B2 (ja) | 1993-08-30 | 2002-11-25 | 富士通株式会社 | スイッチングレギュレータ電源装置 |
US5774319A (en) | 1993-10-27 | 1998-06-30 | Square D Company | Energy validation arrangement for a self-powered circuit interrupter |
US5638264A (en) | 1993-12-27 | 1997-06-10 | Hitachi, Ltd. | Parallelized power supply system providing uninterrupted operation |
JP3493840B2 (ja) | 1995-10-27 | 2004-02-03 | 松下電工株式会社 | 電源装置 |
SE9702564D0 (sv) * | 1997-07-02 | 1997-07-02 | Astra Ab | New compounds |
US5929615A (en) | 1998-09-22 | 1999-07-27 | Impala Linear Corporation | Step-up/step-down voltage regulator using an MOS synchronous rectifier |
-
1998
- 1998-04-18 DE DE19817265A patent/DE19817265A1/de not_active Withdrawn
-
1999
- 1999-04-07 WO PCT/EP1999/002346 patent/WO1999054312A1/de active IP Right Grant
- 1999-04-07 CA CA002328733A patent/CA2328733A1/en not_active Abandoned
- 1999-04-07 EP EP99920604A patent/EP1073642B1/de not_active Expired - Lifetime
- 1999-04-07 DE DE59903174T patent/DE59903174D1/de not_active Expired - Fee Related
- 1999-04-07 US US09/673,581 patent/US6436943B1/en not_active Expired - Fee Related
- 1999-04-07 ES ES99920604T patent/ES2186354T3/es not_active Expired - Lifetime
- 1999-04-07 JP JP2000544651A patent/JP2002512233A/ja active Pending
- 1999-04-07 AU AU38134/99A patent/AU3813499A/en not_active Abandoned
- 1999-04-15 PE PE1999000308A patent/PE20000426A1/es not_active Application Discontinuation
- 1999-04-16 GT GT199900054A patent/GT199900054A/es unknown
- 1999-04-16 SV SV1999000048A patent/SV1999000048A/es unknown
- 1999-04-16 AR ARP990101778A patent/AR023308A1/es unknown
Also Published As
Publication number | Publication date |
---|---|
JP2002512233A (ja) | 2002-04-23 |
PE20000426A1 (es) | 2000-06-25 |
US6436943B1 (en) | 2002-08-20 |
GT199900054A (es) | 2000-10-07 |
EP1073642A1 (de) | 2001-02-07 |
DE59903174D1 (de) | 2002-11-28 |
CA2328733A1 (en) | 1999-10-28 |
AU3813499A (en) | 1999-11-08 |
ES2186354T3 (es) | 2003-05-01 |
SV1999000048A (es) | 2000-07-04 |
EP1073642B1 (de) | 2002-10-23 |
WO1999054312A1 (de) | 1999-10-28 |
DE19817265A1 (de) | 1999-10-21 |
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