PE20000426A1 - Uso de dihidropirimidinas como medicamento y nuevas sustancias - Google Patents

Uso de dihidropirimidinas como medicamento y nuevas sustancias

Info

Publication number
PE20000426A1
PE20000426A1 PE1999000308A PE00030899A PE20000426A1 PE 20000426 A1 PE20000426 A1 PE 20000426A1 PE 1999000308 A PE1999000308 A PE 1999000308A PE 00030899 A PE00030899 A PE 00030899A PE 20000426 A1 PE20000426 A1 PE 20000426A1
Authority
PE
Peru
Prior art keywords
alkyl
optionally substituted
phenyl
dihydropyrimidines
phenyl optionally
Prior art date
Application number
PE1999000308A
Other languages
English (en)
Inventor
Siegfried Goldmann
Jurgen Stoltefuss
Erwin Graef
Stefan Lottmann
Arnold Paessens
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of PE20000426A1 publication Critical patent/PE20000426A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)

Abstract

SE REFIERE AL USO DE DIHIDROPIRIMIDINAS DE FORMULA I COMO AGENTES ANTIVIRALES PARA EL TRATAMIENTO Y PROFILAXIS DE LA HEPATITIS B, DONDE R1 ES FENILO, FURILO, TIENILO, TRIAZOLILO, PIRIDILO, CICLOALQUILO C3-C6, GRUPO a, b, c OPCIONALMENTE SUSTITUIDO CON HALOGENO, TRIFLUOROMETILO, NITRO, CIANO, TRIFLUOROMETOXI, CARBOXILO, HIDROXILO, -S-R6, NR7R8, CONR9R10, SO2-CF3, -A-CH2-R11; R6 ES FENILO OPCIONALMENTE SUSTITUIDO POR HALOGENO; R7, R8, R9, R10 SON H, FENILO OPCIONALMENTE SUSTITUIDO POR HIDROXILO, ACILO C1-C6, ALQUILO C1-C6; A ES O, S, SO, SO2; R11 ES FENILO OPCIONALMENTE SUSTITUIDO CON HALOGENO, NITRO, TRIFLUOROMETILO, ALQUILO C1-C6, ALCOXI C1-C6; R2 ES -XR12, -NR13R14; X ES UN ENLACE, O; R12 ES H, ALCOXICARBONILO C1-C6, UN RESTO HIDROCARBONADO C1-C8; R13 Y R14 SON H, ALQUILO C1-C6, CICLOALQUILO C3-C6; R3 ES H, AMINO, -CH2-(OCH3)2, FORMILO, CIANO, ALQUILTIO C1-C6, O R3 ES FENILO OPCIONALMENTE SUSTITUIDO CON METOXI; R2 Y R3 FORMAN JUNTOS UN RESTO -O-CH2-; R4 ES H, ALQUILO C1-C4, ALQUENILO C2-C4, BENZOILO, ACILO C2-C6; R5 ES PIRIDILO, PIRIMIDILO, PIRAZINILO. TAMBIEN SE REFIERE A COMPUESTOS, ENTRE ELLOS UN COMPUESTO PREFERIDO DE FORMULA II Y A PROCEDIMIENTOS PARA LA PREPARACION
PE1999000308A 1998-04-18 1999-04-15 Uso de dihidropirimidinas como medicamento y nuevas sustancias PE20000426A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19817265A DE19817265A1 (de) 1998-04-18 1998-04-18 Verwendung von Dihydropyrimidinen als Arzneimittel und neue Stoffe

Publications (1)

Publication Number Publication Date
PE20000426A1 true PE20000426A1 (es) 2000-06-25

Family

ID=7864973

Family Applications (1)

Application Number Title Priority Date Filing Date
PE1999000308A PE20000426A1 (es) 1998-04-18 1999-04-15 Uso de dihidropirimidinas como medicamento y nuevas sustancias

Country Status (12)

Country Link
US (1) US6436943B1 (es)
EP (1) EP1073642B1 (es)
JP (1) JP2002512233A (es)
AR (1) AR023308A1 (es)
AU (1) AU3813499A (es)
CA (1) CA2328733A1 (es)
DE (2) DE19817265A1 (es)
ES (1) ES2186354T3 (es)
GT (1) GT199900054A (es)
PE (1) PE20000426A1 (es)
SV (1) SV1999000048A (es)
WO (1) WO1999054312A1 (es)

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Publication number Priority date Publication date Assignee Title
AU4289100A (en) * 1999-03-25 2000-10-16 Bayer Aktiengesellschaft Dihydropyrimidines and their use in the treatment of hepatitis
AU5568400A (en) * 1999-06-23 2001-01-09 Ajinomoto Co., Inc. Novel dihydropyrimidine derivatives
WO2001045712A1 (de) * 1999-12-22 2001-06-28 Bayer Aktiengesellschaft Arzneimittelkombinationen gegen virale erkrankungen
DE10012549A1 (de) * 2000-03-15 2001-09-20 Bayer Ag Arzneimittel gegen virale Erkrankungen
DE10012823A1 (de) * 2000-03-16 2001-09-20 Bayer Ag Arzneimittel gegen virale Erkrankungen
DE10012824A1 (de) * 2000-03-16 2001-09-20 Bayer Ag Arzneimittel gegen virale Erkrankungen
DE10013126A1 (de) * 2000-03-17 2001-09-20 Bayer Ag Arzneimittel gegen virale Erkrankungen
GB0017676D0 (en) 2000-07-19 2000-09-06 Angeletti P Ist Richerche Bio Inhibitors of viral polymerase
GB0201179D0 (en) * 2002-01-18 2002-03-06 Angeletti P Ist Richerche Bio Therapeutic agents
KR100502394B1 (ko) * 2003-06-04 2005-07-19 (주) 비엔씨바이오팜 2-[2-(4-모르포리노)에틸아미노]피리딘 유도체, 그제조방법 및 이를 포함하는 항바이러스용 약학적 조성물
KR100502395B1 (ko) * 2003-06-04 2005-07-19 (주) 비엔씨바이오팜 4-[4-(4-모르포리노)아닐리노]피리미딘 유도체, 그제조방법 및 이를 포함하는 항바이러스용 약학적 조성물.
GB0313250D0 (en) * 2003-06-09 2003-07-16 Angeletti P Ist Richerche Bio Therapeutic agents
PT2514750E (pt) 2007-06-18 2014-01-23 Sunshine Lake Pharma Co Ltd Tiazolil dihidropirimidinas substituídas com bromo-fenilo
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AU2013305390C1 (en) 2012-08-24 2015-12-24 Ruyuan Wei Xiang Technology Co., Ltd. Dihydropyrimidine compounds and their application in pharmaceuticals
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US20150292045A1 (en) * 2012-11-09 2015-10-15 Indiana University Research And Technology Corporation Alternative uses for hbv assembly effectors
CA2907490A1 (en) * 2013-03-20 2014-09-25 Indiana University Research And Technology Corporation Fluorescent-hap: a diagnostic stain for hbv cores in cells
CA2920415A1 (en) 2013-11-19 2015-05-28 Sunshine Lake Pharma Co., Ltd. Dihydropyrimidine compounds and their application in pharmaceuticals
AU2014356984B2 (en) 2013-11-27 2018-01-04 Sunshine Lake Pharma Co., Ltd. Processes for preparing dihydropyrimidine derivatives and intermediates thereof
US9771358B2 (en) 2014-03-28 2017-09-26 Sunshine Lake Pharma Co., Ltd. Dihydropyrimidine compounds and their application in pharmaceuticals
AU2016214799A1 (en) 2015-02-07 2017-06-15 Sunshine Lake Pharma Co., Ltd. Complexes and salts of dihydropyrimidine derivatives and their application in pharmaceuticals
US10196403B2 (en) 2016-07-29 2019-02-05 Sunovion Pharmaceuticals Inc. Compounds and compositions and uses thereof
BR112019001407A2 (pt) 2016-07-29 2019-07-09 Pgi Drug Discovery Llc compostos e composições e usos dos mesmos
JP6813665B2 (ja) 2017-03-31 2021-01-13 富士フイルム株式会社 ４−ピリドン化合物またはその塩、それを含む医薬組成物および剤
JP7191085B2 (ja) 2017-08-02 2022-12-16 サノビオン ファーマシューティカルズ インク イソクロマン化合物およびその使用
CN108947996B (zh) * 2018-07-12 2022-01-18 山东大学 二氢嘧啶-磺酰胺类衍生物及其制备方法与应用
JP2022525169A (ja) 2019-03-14 2022-05-11 サノビオン ファーマシューティカルズ インク イソクロマニル化合物の塩およびその結晶体、ならびにそれらの製造方法、治療用途および医薬組成物
CN112778299B (zh) * 2019-11-04 2023-07-14 江苏恒瑞医药股份有限公司 哌嗪脲基类衍生物、其制备方法及其在医药上的应用

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Also Published As

Publication number Publication date
EP1073642B1 (de) 2002-10-23
AU3813499A (en) 1999-11-08
SV1999000048A (es) 2000-07-04
US6436943B1 (en) 2002-08-20
DE19817265A1 (de) 1999-10-21
ES2186354T3 (es) 2003-05-01
WO1999054312A1 (de) 1999-10-28
CA2328733A1 (en) 1999-10-28
JP2002512233A (ja) 2002-04-23
GT199900054A (es) 2000-10-07
DE59903174D1 (de) 2002-11-28
EP1073642A1 (de) 2001-02-07
AR023308A1 (es) 2002-09-04

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