CN105859709B - 二氢嘧啶衍生物的复合物及其在药物中的应用 - Google Patents
二氢嘧啶衍生物的复合物及其在药物中的应用 Download PDFInfo
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- CN105859709B CN105859709B CN201610071071.XA CN201610071071A CN105859709B CN 105859709 B CN105859709 B CN 105859709B CN 201610071071 A CN201610071071 A CN 201610071071A CN 105859709 B CN105859709 B CN 105859709B
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Virology (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Description
Claims (9)
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CN201510068258 | 2015-02-07 |
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CN201610071071.XA Active CN105859709B (zh) | 2015-02-07 | 2016-02-01 | 二氢嘧啶衍生物的复合物及其在药物中的应用 |
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RU (1) | RU2017127611A (zh) |
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EP3503894A1 (en) * | 2016-08-24 | 2019-07-03 | H. Hoffnabb-La Roche Ag | Combination therapy of an hbv capsid assembly inhibitor and a nucleos(t)ide analogue |
RU2647576C1 (ru) * | 2017-02-28 | 2018-03-16 | Васильевич Иващенко Александр | Циклобутил (S)-2-[[[(R)-2-(6-аминопурин-9-ил)-1-метил-этокси]метил-фенокси-фосфорил]амино]-пропаноаты, способ их получения и применения |
WO2021009509A1 (en) * | 2019-07-15 | 2021-01-21 | Johnson Matthey Public Limited Company | Amorphous umbralisib monotosylate |
CN110615797A (zh) * | 2019-10-11 | 2019-12-27 | 李丽丽 | 用于治疗乙型肝炎的化合物及其用途 |
CN112876493B (zh) * | 2019-11-29 | 2023-05-09 | 广东东阳光药业有限公司 | 含氮三环化合物的盐及其用途 |
CN112876492B (zh) * | 2019-11-29 | 2023-07-18 | 广东东阳光药业有限公司 | 含氮三环化合物的晶型及其用途 |
WO2023027162A1 (ja) * | 2021-08-27 | 2023-03-02 | 科研製薬株式会社 | 2-(4-エチルフェノキシ)-4'-メトキシ-3,3'-ビピリジンの結晶及びその製造方法 |
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JPS61271278A (ja) | 1985-05-20 | 1986-12-01 | イ− ア−ル スクイブ アンド サンズ インコ−ポレ−テツド | 2−置換チオまたはオキソ−4−アリ−ルまたはヘテロシクロ−5−カルボキシ−1,4−ジヒドロピリミジン |
GB8906168D0 (en) | 1989-03-17 | 1989-05-04 | Pfizer Ltd | Therapeutic agents |
SE9702563D0 (sv) | 1997-07-02 | 1997-07-02 | Astra Ab | Compounds |
SE9702564D0 (sv) | 1997-07-02 | 1997-07-02 | Astra Ab | New compounds |
DE19817265A1 (de) | 1998-04-18 | 1999-10-21 | Bayer Ag | Verwendung von Dihydropyrimidinen als Arzneimittel und neue Stoffe |
DE19817262A1 (de) | 1998-04-18 | 1999-10-21 | Bayer Ag | Neue 2-heterocyclisch substituierte Dihydropyrimidine |
DE19817264A1 (de) | 1998-04-18 | 1999-10-21 | Bayer Ag | Neue Dihydropyrimidine |
AU4289100A (en) | 1999-03-25 | 2000-10-16 | Bayer Aktiengesellschaft | Dihydropyrimidines and their use in the treatment of hepatitis |
DE10012549A1 (de) | 2000-03-15 | 2001-09-20 | Bayer Ag | Arzneimittel gegen virale Erkrankungen |
DE10012823A1 (de) * | 2000-03-16 | 2001-09-20 | Bayer Ag | Arzneimittel gegen virale Erkrankungen |
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KR20160077050A (ko) | 2013-11-19 | 2016-07-01 | 선샤인 레이크 파르마 컴퍼니 리미티드 | 다이하이드로피리미딘 화합물 및 이의 약제학적 용도 |
CN104650070B (zh) | 2013-11-25 | 2018-09-14 | 广东东阳光药业有限公司 | 二氢嘧啶类化合物及其在药物中的应用 |
BR112016020566B1 (pt) | 2014-03-07 | 2022-11-29 | F. Hoffmann-La Roche Ag | Novas heteroaril-diidro-pirimidinas fundidas na posição 6 para o tratamento e profilaxia da infecção pelo vírus da hepatite b |
ES2687606T3 (es) | 2014-05-30 | 2018-10-26 | Qilu Pharmaceutical Co., Ltd. | Derivado de bucle de dihidropirimido como inhibidor de HBV |
WO2016012470A1 (en) * | 2014-07-25 | 2016-01-28 | F. Hoffmann-La Roche Ag | New amorphous and crystalline forms of (3s)-4-[[(4r)-4-(2-chloro-4-fluoro-phenyl)-5-methoxycarbonyl-2-thiazol-2-yl-1, 4-dihydropyrimidin-6-yl]methyl]morpholine-3-carboxylic acid |
WO2016202721A1 (en) | 2015-06-16 | 2016-12-22 | F. Hoffmann-La Roche Ag | Salts of (s)-4-[(r)-6-(2-chloro-4-fluoro-phenyl)-5-methoxycarbonyl-2-thiazol-2-yl-3,6- dihydro-pyrimidin-4-ylmethyl]-morpholine-3-carboxylic acid, salt former and methods for preparing and using the same |
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2016
- 2016-02-01 TW TW105103178A patent/TW201629054A/zh unknown
- 2016-02-01 EP EP16746121.9A patent/EP3253751B1/en active Active
- 2016-02-01 JP JP2017538954A patent/JP2018504414A/ja active Pending
- 2016-02-01 CN CN201610069626.7A patent/CN105859708B/zh active Active
- 2016-02-01 CA CA2970838A patent/CA2970838A1/en not_active Abandoned
- 2016-02-01 RU RU2017127611A patent/RU2017127611A/ru unknown
- 2016-02-01 AU AU2016214799A patent/AU2016214799A1/en not_active Abandoned
- 2016-02-01 US US15/539,147 patent/US10098889B2/en active Active
- 2016-02-01 CN CN201610071071.XA patent/CN105859709B/zh active Active
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EP3253751A4 (en) | 2018-06-20 |
WO2016124126A1 (en) | 2016-08-11 |
CA2970838A1 (en) | 2016-08-11 |
TW201629054A (zh) | 2016-08-16 |
AU2016214799A1 (en) | 2017-06-15 |
US10098889B2 (en) | 2018-10-16 |
CN105859708B (zh) | 2020-01-21 |
EP3253751A1 (en) | 2017-12-13 |
EP3253751B1 (en) | 2020-12-09 |
CN105859708A (zh) | 2016-08-17 |
JP2018504414A (ja) | 2018-02-15 |
CN105859709A (zh) | 2016-08-17 |
RU2017127611A (ru) | 2019-03-07 |
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