AR016010A1 - UN COMPUESTO DERIVADO DE ACIDO SULFONHIDROXAMICO AROMATICO INHIBIDOR DE METALOPROTEASAS, COMPUESTO INTERMEDIARIO, PROCESO PARA FORMARLO, COMPOSICION FARMACEUTICA Y USO PARA EL TRATAMIENTO DE UN ANIMAL HUESPED MAMíFERO. - Google Patents

UN COMPUESTO DERIVADO DE ACIDO SULFONHIDROXAMICO AROMATICO INHIBIDOR DE METALOPROTEASAS, COMPUESTO INTERMEDIARIO, PROCESO PARA FORMARLO, COMPOSICION FARMACEUTICA Y USO PARA EL TRATAMIENTO DE UN ANIMAL HUESPED MAMíFERO.

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Publication number
AR016010A1
AR016010A1 ARP980105784A ARP980105784A AR016010A1 AR 016010 A1 AR016010 A1 AR 016010A1 AR P980105784 A ARP980105784 A AR P980105784A AR P980105784 A ARP980105784 A AR P980105784A AR 016010 A1 AR016010 A1 AR 016010A1
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AR
Argentina
Prior art keywords
alkyl
group
compound
sulfonhydroxamic
zero
Prior art date
Application number
ARP980105784A
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English (en)
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Searle & Co
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Application filed by Searle & Co filed Critical Searle & Co
Publication of AR016010A1 publication Critical patent/AR016010A1/es

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4166—1,3-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. phenytoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/421—1,3-Oxazoles, e.g. pemoline, trimethadione
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
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    • C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
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    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
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    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
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    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

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Abstract

Un compuesto derivado de ácido sulfonhidroxámico aromático, corresponde en estructura a la formula (II), o a una sal aceptable para uso farmacéuticodel mismo, donde: R14 es hidruro, un cation aceptable para uso farmacéutico o C(W)R15 donde W es O o Sy R15 se selecciona del grupo formado por un grupo C1-6-alquilo, arilo, C1-6-alcoxi, heteroaril-C1-6-alquilo, C3-8-cicloalquil-C1-6-alquilo, ariloxi, ar-C1-6-alcoxi, ar-C1-6-alquilo, heteroarilo y amino C1-6-alquilodonde el nitrogeno del aminoalquilo es (i) insustituido o (ii) sustituido con uno o dos sutituyentes independientemente seleccionados del grupo formado por unC1-6-alquilo, arilo, ar-C1-6-alquilo, C3-8-cicloalquilo-C1-6-alquilo, ar-C1-6-alcoxicarbonilo, C1-6-alcoxicarbonilo, y C1-6-alcanoílo radical, o (iii)donde el nitrogeno del grupo amino C1-6-alquilo y dos sustituyentes unidos al mismo forman un anillo heterociclo o heteroarilo de 5 a 8 miembros; m es cero, 1o 2; n es cero, 1 o 2; p es cero, 1 o 2; la suma de m + n + p = 1, 2, 3, 4; (a) uno de X, Y y Z se selecciona entre el grupo formado por C(O), N, O, S, S(O),S(O)2 y NS(O)2R7, y los restantes dos de X, Y y Z son CR8R9 y CR10R11 o (b) X y Z o Z e Y juntos constituyen un grupo que se selecciona del grupo formado porNR6C(O), NR6S(O), NR6S(O)2, NR6O, SS, NR6NR6 y OC(O), siendo los restantes uno de X, Y y Z CR8R9, o (c) n es cero y Z, Y y Z juntos constituyen un gruposeleccionado del grupo formado por (III).
ARP980105784A 1997-11-14 1998-11-13 UN COMPUESTO DERIVADO DE ACIDO SULFONHIDROXAMICO AROMATICO INHIBIDOR DE METALOPROTEASAS, COMPUESTO INTERMEDIARIO, PROCESO PARA FORMARLO, COMPOSICION FARMACEUTICA Y USO PARA EL TRATAMIENTO DE UN ANIMAL HUESPED MAMíFERO. AR016010A1 (es)

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