AR016010A1 - UN COMPUESTO DERIVADO DE ACIDO SULFONHIDROXAMICO AROMATICO INHIBIDOR DE METALOPROTEASAS, COMPUESTO INTERMEDIARIO, PROCESO PARA FORMARLO, COMPOSICION FARMACEUTICA Y USO PARA EL TRATAMIENTO DE UN ANIMAL HUESPED MAMíFERO. - Google Patents
UN COMPUESTO DERIVADO DE ACIDO SULFONHIDROXAMICO AROMATICO INHIBIDOR DE METALOPROTEASAS, COMPUESTO INTERMEDIARIO, PROCESO PARA FORMARLO, COMPOSICION FARMACEUTICA Y USO PARA EL TRATAMIENTO DE UN ANIMAL HUESPED MAMíFERO.Info
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- AR016010A1 AR016010A1 ARP980105784A ARP980105784A AR016010A1 AR 016010 A1 AR016010 A1 AR 016010A1 AR P980105784 A ARP980105784 A AR P980105784A AR P980105784 A ARP980105784 A AR P980105784A AR 016010 A1 AR016010 A1 AR 016010A1
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- Prior art keywords
- alkyl
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- compound
- sulfonhydroxamic
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- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4166—1,3-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. phenytoin
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- A61K31/42—Oxazoles
- A61K31/421—1,3-Oxazoles, e.g. pemoline, trimethadione
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- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/426—1,3-Thiazoles
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- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- Neurology (AREA)
- Orthopedic Medicine & Surgery (AREA)
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- Ophthalmology & Optometry (AREA)
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Hydrogenated Pyridines (AREA)
- Pyrane Compounds (AREA)
Abstract
Un compuesto derivado de ácido sulfonhidroxámico aromático, corresponde en estructura a la formula (II), o a una sal aceptable para uso farmacéuticodel mismo, donde: R14 es hidruro, un cation aceptable para uso farmacéutico o C(W)R15 donde W es O o Sy R15 se selecciona del grupo formado por un grupo C1-6-alquilo, arilo, C1-6-alcoxi, heteroaril-C1-6-alquilo, C3-8-cicloalquil-C1-6-alquilo, ariloxi, ar-C1-6-alcoxi, ar-C1-6-alquilo, heteroarilo y amino C1-6-alquilodonde el nitrogeno del aminoalquilo es (i) insustituido o (ii) sustituido con uno o dos sutituyentes independientemente seleccionados del grupo formado por unC1-6-alquilo, arilo, ar-C1-6-alquilo, C3-8-cicloalquilo-C1-6-alquilo, ar-C1-6-alcoxicarbonilo, C1-6-alcoxicarbonilo, y C1-6-alcanoílo radical, o (iii)donde el nitrogeno del grupo amino C1-6-alquilo y dos sustituyentes unidos al mismo forman un anillo heterociclo o heteroarilo de 5 a 8 miembros; m es cero, 1o 2; n es cero, 1 o 2; p es cero, 1 o 2; la suma de m + n + p = 1, 2, 3, 4; (a) uno de X, Y y Z se selecciona entre el grupo formado por C(O), N, O, S, S(O),S(O)2 y NS(O)2R7, y los restantes dos de X, Y y Z son CR8R9 y CR10R11 o (b) X y Z o Z e Y juntos constituyen un grupo que se selecciona del grupo formado porNR6C(O), NR6S(O), NR6S(O)2, NR6O, SS, NR6NR6 y OC(O), siendo los restantes uno de X, Y y Z CR8R9, o (c) n es cero y Z, Y y Z juntos constituyen un gruposeleccionado del grupo formado por (III).
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US6600797P | 1997-11-14 | 1997-11-14 |
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ARP980105784A AR016010A1 (es) | 1997-11-14 | 1998-11-13 | UN COMPUESTO DERIVADO DE ACIDO SULFONHIDROXAMICO AROMATICO INHIBIDOR DE METALOPROTEASAS, COMPUESTO INTERMEDIARIO, PROCESO PARA FORMARLO, COMPOSICION FARMACEUTICA Y USO PARA EL TRATAMIENTO DE UN ANIMAL HUESPED MAMíFERO. |
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US (3) | US6541489B1 (es) |
EP (1) | EP1042290A1 (es) |
JP (1) | JP2001523662A (es) |
CN (1) | CN1279669A (es) |
AR (1) | AR016010A1 (es) |
AU (1) | AU756150C (es) |
BR (1) | BR9814643A (es) |
CA (1) | CA2306460A1 (es) |
IL (1) | IL135106A0 (es) |
NO (1) | NO20002469L (es) |
NZ (1) | NZ503485A (es) |
PL (1) | PL341379A1 (es) |
RU (1) | RU2250105C2 (es) |
WO (1) | WO1999025687A1 (es) |
ZA (1) | ZA9810412B (es) |
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-
1998
- 1998-11-12 WO PCT/US1998/023242 patent/WO1999025687A1/en not_active Application Discontinuation
- 1998-11-12 US US09/554,082 patent/US6541489B1/en not_active Expired - Fee Related
- 1998-11-12 EP EP98957485A patent/EP1042290A1/en not_active Withdrawn
- 1998-11-12 AU AU13732/99A patent/AU756150C/en not_active Ceased
- 1998-11-12 CA CA002306460A patent/CA2306460A1/en not_active Abandoned
- 1998-11-12 CN CN98811130A patent/CN1279669A/zh active Pending
- 1998-11-12 BR BR9814643-2A patent/BR9814643A/pt not_active Application Discontinuation
- 1998-11-12 NZ NZ503485A patent/NZ503485A/en unknown
- 1998-11-12 JP JP2000521071A patent/JP2001523662A/ja not_active Withdrawn
- 1998-11-12 RU RU2000115948/15A patent/RU2250105C2/ru not_active IP Right Cessation
- 1998-11-12 PL PL98341379A patent/PL341379A1/xx unknown
- 1998-11-12 IL IL13510698A patent/IL135106A0/xx unknown
- 1998-11-13 AR ARP980105784A patent/AR016010A1/es unknown
- 1998-11-13 ZA ZA9810412A patent/ZA9810412B/xx unknown
-
2000
- 2000-05-12 NO NO20002469A patent/NO20002469L/no not_active Application Discontinuation
-
2003
- 2003-01-07 US US10/337,942 patent/US6890937B2/en not_active Expired - Fee Related
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2005
- 2005-01-28 US US11/046,645 patent/US20060084688A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
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ZA9810412B (en) | 1999-12-09 |
BR9814643A (pt) | 2000-10-03 |
US6541489B1 (en) | 2003-04-01 |
PL341379A1 (en) | 2001-04-09 |
US20060084688A1 (en) | 2006-04-20 |
AU1373299A (en) | 1999-06-07 |
IL135106A0 (en) | 2001-05-20 |
CN1279669A (zh) | 2001-01-10 |
US20040048852A1 (en) | 2004-03-11 |
NO20002469L (no) | 2000-07-12 |
WO1999025687A1 (en) | 1999-05-27 |
AU756150B2 (en) | 2003-01-02 |
US6890937B2 (en) | 2005-05-10 |
JP2001523662A (ja) | 2001-11-27 |
NZ503485A (en) | 2002-10-25 |
RU2250105C2 (ru) | 2005-04-20 |
EP1042290A1 (en) | 2000-10-11 |
CA2306460A1 (en) | 1999-05-27 |
NO20002469D0 (no) | 2000-05-12 |
AU756150C (en) | 2004-03-04 |
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