AR007767A1 - Nuevos derivados de acidos alfa-hidroxi, su preparacion y utilizacion de dichos derivados o fragmentos de los mismos como antagonistas de receptores de las endotelinas - Google Patents

Nuevos derivados de acidos alfa-hidroxi, su preparacion y utilizacion de dichos derivados o fragmentos de los mismos como antagonistas de receptores de las endotelinas

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Publication number
AR007767A1
AR007767A1 ARP970101460A ARP970101460A AR007767A1 AR 007767 A1 AR007767 A1 AR 007767A1 AR P970101460 A ARP970101460 A AR P970101460A AR P970101460 A ARP970101460 A AR P970101460A AR 007767 A1 AR007767 A1 AR 007767A1
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Argentina
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alkyl
alkoxy
group
derivatives
hydroxy
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ARP970101460A
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Abbott Gmbh & Co Kg
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Publication of AR007767A1 publication Critical patent/AR007767A1/es

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Abstract

Se trata de derivados de ácidos alfa-hidroxicarboxílicos de fórmula (I) donde R es un grupo de fórmula-CO-R1, en la cual R1 tiene los siguientessignificados: a) hidrógeno, b) un grupo succinilimidoxi; c) un grupo heteroaromático de 5m iembros ligados mediante un átomo de nitrógeno, tal comopirrolilo, pirazolilo, imidazolilo o triazolilo, opcionalmente sustituído por uno o dos átomos de halógeno o uno o dos grupos alquilo de 1 a 4 átomos decarbono o uno o dos grupos alcoxi de1 a 4 átomos de carbono; d) un grupo de fórmula (II) en el cual k vale 0, 1 y 2 y p es 1,2,3 y 4, y R9 es C1-C4-alquilo, C3-C7-cicloalquilo, C3-C6-alquenilo, C3-C6 alquinilo o fenilo eventualmente sustituído, con al menos uno de los siguientesradi cales: halógeno, nitro,ciano, C1-C4-alquilo, C1-C4 halogenoalquilo, hidroxi C1-C4-alcoxi, C1-C4- -alquiltio, mercapto, amino, C1-C4-alquilo, C1-C4 dialquilamino; e) R1 tambiénpuede ser un radical OR10, representando R10 alguno de lossiguientes : hidrógeno, el catión de un metal alcalino tal como litio, sodio, potasio, o elcatión de un metal alcalio-térreo tal como calcio, magnesio o bario como también ión alquilamonio o amonio fisiológiamente tolerable; C3-C8cicloalquiloC1 -C8-alquilo, CH2-fenilo, que puede estar sustituido por uno o más de los siguientes radicales: halógeno, nitro, ciano, C1-C4-alquilo, C1-C4-halogenoalquilo, hidroxi, C1-C4-alcoxi, C1-C4-alcoxi, mercapto, C1-C4-alquiltío amino, C1-C4 alquilamino, C1-C4-dialquilamino; un grupo C3-C6-alquenilo o ungrupo C3-C6-alquinilo, pudiendo por su parte estos grupos llevar de uno a cinco átomos de halógeno; R10 puede también ser un radical fenilo, que puede llevarde uno a cinco átomos dehalógeno y/o de u no a tres de los siguientes radicales: nitro, ciano, C1-C4-alquilo, C1-C4-halogenoalquilo, hidroxi, C1-C4-alcoxi,
ARP970101460A 1996-04-12 1997-04-11 Nuevos derivados de acidos alfa-hidroxi, su preparacion y utilizacion de dichos derivados o fragmentos de los mismos como antagonistas de receptores de las endotelinas AR007767A1 (es)

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Application Number Priority Date Filing Date Title
DE19614533A DE19614533A1 (de) 1996-04-12 1996-04-12 Neue alpha-Hydroxysäurederivate, ihre Herstellung und Verwendung

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AR007767A1 true AR007767A1 (es) 1999-11-24

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AR (1) AR007767A1 (es)
AT (1) ATE242770T1 (es)
AU (1) AU731579B2 (es)
BG (1) BG102868A (es)
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DE (2) DE19614533A1 (es)
HR (1) HRP970198A2 (es)
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UA (1) UA49884C2 (es)
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EP0892787A1 (de) 1999-01-27
NO984717L (no) 1998-10-09
ID16501A (id) 1997-10-02
DE19614533A1 (de) 1997-10-16
DE59710272D1 (de) 2003-07-17
CA2250757A1 (en) 1997-10-23
IL126350A0 (en) 1999-05-09
BR9708608A (pt) 1999-08-03
TR199802039T2 (xx) 1999-01-18
HRP970198A2 (en) 1998-04-30
NO984717D0 (no) 1998-10-09
NO311801B1 (no) 2002-01-28
AU731579B2 (en) 2001-04-05
US6686369B1 (en) 2004-02-03
SK134498A3 (en) 1999-03-12
HUP9901312A3 (en) 2000-06-28
NZ332096A (en) 2000-01-28
ATE242770T1 (de) 2003-06-15
PL329241A1 (en) 1999-03-15
UA49884C2 (uk) 2002-10-15
TW425383B (en) 2001-03-11
CO4900040A1 (es) 2000-03-27
ZA973097B (en) 1998-10-12
JP2000508326A (ja) 2000-07-04
KR20000005369A (ko) 2000-01-25
EP0892787B1 (de) 2003-06-11
HUP9901312A2 (hu) 1999-08-30
WO1997038981A1 (de) 1997-10-23

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