ES8702400A1 - Procedimiento para la obtencion de acidos 7-amino-1-ciclopropil-6,8-dihalogeno-1,4-dihidro-4-oxo-3-quinolincarboxilico - Google Patents

Procedimiento para la obtencion de acidos 7-amino-1-ciclopropil-6,8-dihalogeno-1,4-dihidro-4-oxo-3-quinolincarboxilico

Info

Publication number
ES8702400A1
ES8702400A1 ES553084A ES553084A ES8702400A1 ES 8702400 A1 ES8702400 A1 ES 8702400A1 ES 553084 A ES553084 A ES 553084A ES 553084 A ES553084 A ES 553084A ES 8702400 A1 ES8702400 A1 ES 8702400A1
Authority
ES
Spain
Prior art keywords
carbon atoms
amino
alkyl
fluorine
radical
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES553084A
Other languages
English (en)
Other versions
ES553084A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG filed Critical Bayer AG
Publication of ES553084A0 publication Critical patent/ES553084A0/es
Publication of ES8702400A1 publication Critical patent/ES8702400A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

3PROCEDIMIENTO PARA LA OBTENCION DE ACIDOS 7-AMINO-1-CICLOPROPIL-6,8-DIHALOGENO-1,4-DIHIDRO-4-OXO-3-QUINOLINCARBOXILICO. CONSISTE EN HACER REACCIONAR UN ACIDO 7-(1-PIPERAZINIL)-3-QUINOLINCARBOXILICO DE FORMULA (II) CON ACEPTORES DE MICAEL DE FORMULA B-CHFCH2, PARA OBTENER ACIDOS 7-AMINO-1-CICLOPROPIL-6,8-DIHALOGENO-1,4-DIHIDRO-4-OXO-3-QUINOLINCARBOXILICO DE FORMULA (I), DONDE X1 Y X2 PUEDEN SER IGUALES O DIFERENTES Y SIGNIFICAN CLORO O FLUOR, NO PUDIENDO SER SIN EMBARGO, SIMULTANEAMENTE FLUOR; Y R1 Y R2 CONSTITUYEN JUNTO CON EL ATOMO DE NITROGENO, CON EL QUE ESTAN ENLAZADOS, UN ANILLO HETEROCICLICO DE 5 O 6 MIEMBROS, QUE PUEDE CONTENER COMO MIEMBRO DEL ANILLO ADICIONAL LOS ATOMOS O GRUPOS -O-, -S-, -SO-, -N-R3 O -CO-N-R3 Y OTROS. TIENEN UTILIDAD COMO PRODUCTOS ACTIVOS DE MEDICAMENTOS POR SU EFECTO ANTIBACTERIANO.
ES553084A 1984-06-04 1986-03-17 Procedimiento para la obtencion de acidos 7-amino-1-ciclopropil-6,8-dihalogeno-1,4-dihidro-4-oxo-3-quinolincarboxilico Expired ES8702400A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19843420743 DE3420743A1 (de) 1984-06-04 1984-06-04 7-amino-1-cyclopropyl-6,8-dihalogen-1,4-dihydro-4-oxo-3-chinolincarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel

Publications (2)

Publication Number Publication Date
ES553084A0 ES553084A0 (es) 1987-01-01
ES8702400A1 true ES8702400A1 (es) 1987-01-01

Family

ID=6237565

Family Applications (3)

Application Number Title Priority Date Filing Date
ES543836A Expired ES8607277A1 (es) 1984-06-04 1985-06-03 Acidos 7-amino-1-ciclopropil-6,8-dihalogeno-1,4-dihidro-4- oxo-3-quinolincarboxilico
ES553084A Expired ES8702400A1 (es) 1984-06-04 1986-03-17 Procedimiento para la obtencion de acidos 7-amino-1-ciclopropil-6,8-dihalogeno-1,4-dihidro-4-oxo-3-quinolincarboxilico
ES553083A Expired ES8702907A1 (es) 1984-06-04 1986-03-17 Procedimiento para la obtencion de acidos 7-amino-1-ciclopropil-6,8-dihalogeno-1,4-dihidro-4-oxo-3-quinolincarboxilico

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES543836A Expired ES8607277A1 (es) 1984-06-04 1985-06-03 Acidos 7-amino-1-ciclopropil-6,8-dihalogeno-1,4-dihidro-4- oxo-3-quinolincarboxilico

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES553083A Expired ES8702907A1 (es) 1984-06-04 1986-03-17 Procedimiento para la obtencion de acidos 7-amino-1-ciclopropil-6,8-dihalogeno-1,4-dihidro-4-oxo-3-quinolincarboxilico

Country Status (22)

Country Link
US (2) US5571812A (es)
EP (1) EP0167763B1 (es)
JP (1) JPS611667A (es)
KR (1) KR920005112B1 (es)
AR (1) AR243510A1 (es)
AT (1) ATE36155T1 (es)
AU (1) AU575651B2 (es)
DD (1) DD240012A5 (es)
DE (2) DE3420743A1 (es)
DK (2) DK164596C (es)
ES (3) ES8607277A1 (es)
FI (1) FI852203L (es)
GR (1) GR851316B (es)
HK (1) HK7291A (es)
HU (1) HU208821B (es)
IE (1) IE57815B1 (es)
IL (1) IL75369A (es)
NO (1) NO173546C (es)
NZ (1) NZ212272A (es)
PH (2) PH23577A (es)
PT (1) PT80578B (es)
ZA (1) ZA854167B (es)

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IE55898B1 (en) * 1982-09-09 1991-02-14 Warner Lambert Co Antibacterial agents
DE3420743A1 (de) * 1984-06-04 1985-12-05 Bayer Ag, 5090 Leverkusen 7-amino-1-cyclopropyl-6,8-dihalogen-1,4-dihydro-4-oxo-3-chinolincarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
US5468861A (en) * 1984-06-04 1995-11-21 Bayer Aktiengesellschaft 8-chloro-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid and alkyl esters thereof
IN162769B (es) * 1984-11-13 1988-07-09 Kyorin Seiyaku Kk
US4771054A (en) * 1985-01-23 1988-09-13 Warner-Lambert Company Antibacterial agents
JPS61205258A (ja) * 1985-03-08 1986-09-11 Kyorin Pharmaceut Co Ltd キノロンカルボン酸誘導体及びその製造方法
JPS61225181A (ja) * 1986-02-04 1986-10-06 Kyorin Pharmaceut Co Ltd キノロンカルボン酸誘導体及びその製造方法
JPH0635457B2 (ja) * 1985-06-28 1994-05-11 杏林製薬株式会社 ピリドンカルボン酸誘導体およびその製造方法
AU594983B2 (en) * 1985-10-29 1990-03-22 Dainippon Pharmaceutical Co. Ltd. Novel quinoline derivatives and processes for preparation thereof
JPS62246541A (ja) * 1986-01-20 1987-10-27 Kyorin Pharmaceut Co Ltd ベンゾイル酢酸エステル誘導体とその製造方法
US4788320A (en) * 1986-01-20 1988-11-29 Kyorin Pharmaceutical Co., Ltd. Benzoylacetic acid ester derivatives and process for their preparations
DE3705621C2 (de) * 1986-02-25 1997-01-09 Otsuka Pharma Co Ltd Heterocyclisch substituierte Chinoloncarbonsäurederivate
DE3606698A1 (de) * 1986-03-01 1987-09-03 Bayer Ag 7-(1-pyrrolidinyl)-chinoloncarbonsaeure -derivate
FI871419A (fi) * 1986-03-31 1987-10-01 Sankyo Co Kinolin-3-karboxylsyraderivat, deras framstaellning och anvaendning.
US4771055A (en) * 1986-07-28 1988-09-13 Warner-Lambert Company 7-[[3-(aminomethyl)-3-alkyl]-1-pyrrolidinyl]-quinoline-carboxylic acids
DE3635218A1 (de) * 1986-10-16 1988-04-21 Bayer Ag 7-amino-1-cyclopropyl-8-chlor-6-fluor-1,4-dihydro-4-oxo-3-chinolincarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
DE3641312A1 (de) * 1986-12-03 1988-06-09 Bayer Ag Verfahren zur herstellung von chinolincarbonsaeuren
DE3702393A1 (de) * 1987-01-28 1988-08-11 Bayer Ag 8-cyano-1-cyclopropyl-1,4-dihydro-4-oxo- 3-chinolincarbonsaeuren, verfahren zu ihrer herstellung und diese enthaltende antibakterielle mittel
EP0339406A1 (en) * 1988-04-19 1989-11-02 Hokuriku Pharmaceutical Co.,Ltd Quinoline-3-carboxylic acid derivatives, process for preparing the same, and composition exhibiting excellent antibacterial effect containing the same
US5262417A (en) * 1988-12-06 1993-11-16 The Upjohn Company Antibacterial quinolone compounds
JP2613139B2 (ja) * 1990-07-19 1997-05-21 エスエス製薬 株式会社 キノロンカルボン酸誘導体
US5137892A (en) * 1990-12-12 1992-08-11 Abbott Laboratories Quinoline, naphthyridine and pyridobenzoxazine derivatives
DE4120646A1 (de) * 1991-06-22 1992-12-24 Bayer Ag 7-isoindolinyl-chinolon- und naphthyridoncarbonsaeure-derivate
DE4121214A1 (de) * 1991-06-27 1993-01-14 Bayer Ag 7-azaisoindolinyl-chinolon- und -naphthyridoncarbonsaeure-derivate
US5221676A (en) * 1992-02-06 1993-06-22 Warner-Lambert Company 7-substituted quinolones and naphthyridones as antibacterial agents
WO1993024460A1 (fr) * 1992-05-26 1993-12-09 Ss Pharmaceutical Co., Ltd. Derive d'acides-5-aminoquinolonecarboxylique et agent antibacterien contenant ce derive comme ingredient actif
EP0596395B1 (de) * 1992-11-04 2000-06-28 Clariant GmbH Verfahren zur Herstellung fluorierter Benzile
CA2114981A1 (en) * 1993-02-09 1994-08-10 Kazumi Ogata Quinolonecarboxylic acid derivatives
DE4342186A1 (de) 1993-12-10 1995-06-14 Bayer Ag Eintopfverfahren zur Herstellung von 3-Chinoloncarbonsäurederivaten
WO2001062734A1 (fr) * 2000-02-25 2001-08-30 Daiichi Pharmaceutical Co., Ltd. Procede de production d'acides quinolonecarboxyliques et de leurs intermediaires
DE10026903A1 (de) * 2000-06-03 2002-01-10 Cpc Cellular Process Chemistry Verfahren zur Herstellung von Chinolon-3-carbonsäuren
WO2003064412A1 (en) * 2002-01-31 2003-08-07 Micro Science Tech Co., Ltd. Monomer with anti-microbial character, polymer using the same, and manufacturing method thereof
WO2004023527A2 (en) * 2002-09-05 2004-03-18 Nanosys, Inc. Nanostructure and nanocomposite based compositions and photovoltaic devices
WO2005026145A2 (en) * 2003-09-12 2005-03-24 Warner-Lambert Company Llc Quinolone antibacterial agents
DE102004035203A1 (de) 2004-07-21 2006-02-16 Bayer Healthcare Ag Substituierte Chinolone
US7576216B2 (en) * 2004-07-30 2009-08-18 Abbott Laboratories Preparation of pyridonecarboxylic acid antibacterials
EP2305666B1 (en) * 2004-07-30 2014-06-25 AbbVie Inc. Preparation of pyridonecarboxylic acid antibacterials
CA2603783C (en) * 2005-04-11 2014-11-18 Abbott Laboratories Pharmaceutical compositions having improved dissolution profiles for poorly soluble drugs
DE102006005861A1 (de) 2006-02-09 2007-08-23 Aicuris Gmbh & Co. Kg Substituierte Chinolone III
US20080139574A1 (en) 2006-11-30 2008-06-12 Cadila Healthcare Limited Novel quinoline derivatives
UA106556C2 (uk) * 2013-05-13 2014-09-10 Наталья Николаевна Деркач СПОСІБ ОДЕРЖАННЯ (1-ЦИКЛОПРОПІЛ-6-ФТОР-1,4-ДИГІДРО-8-МЕТОКСІ-7-[(4aS,7aS)-ОКТАГІДРО-6Н-ПІРОЛО[3,4-b]-4-ОКСО-3-ХІНОЛІНКАРБОНОВОЇ КИСЛОТИ

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AR223983A1 (es) * 1978-08-25 1981-10-15 Dainippon Pharmaceutical Co Un procedimiento para-preparar derivados de acido 6-halogeno-4-oxo-7-(1-piperazinil)-1,8-naftiridin-3-carboxilico
JPS5845426B2 (ja) * 1978-09-29 1983-10-08 杏林製薬株式会社 置換キノリンカルボン酸誘導体
JPS5630964A (en) * 1979-08-22 1981-03-28 Kyorin Pharmaceut Co Ltd Novel substituted quinolinecarboxylic acid and its preparation
DE3033157A1 (de) * 1980-09-03 1982-04-01 Bayer Ag, 5090 Leverkusen 7-amino-1-cyclopropyl-4-oxo-1,4-dihydro-naphthyridin-3-carbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
SE440354B (sv) * 1981-02-19 1985-07-29 Kyorin Seiyaku Kk Kinolinkarboxylsyraderivat
DE3248506A1 (de) * 1982-12-29 1984-07-05 Bayer Ag, 5090 Leverkusen 1-cyclopropyl-6-fluor-1,4-dihydro-4-oxo-7(alkyl-1-piperazinyl)-3-chinolincarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
DE3248507A1 (de) * 1982-12-29 1984-07-05 Bayer Ag, 5090 Leverkusen Mikrobizide mittel auf chinoloncarbonsaeure basis
DE3318145A1 (de) * 1983-05-18 1984-11-22 Bayer Ag, 5090 Leverkusen 7-amino-1-cyclopropyl-6,8-difluor-1,4-dihydro-4-oxo-3-chinolincarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
JPS60123837A (ja) * 1983-12-09 1985-07-02 Mitsubishi Paper Mills Ltd ハロゲン化銀写真乳剤
IL74244A (en) * 1984-02-17 1988-06-30 Warner Lambert Co Quinoline derivatives,their preparation and pharmaceutical compositions containing them
DE3420116A1 (de) * 1984-05-30 1985-12-05 Bayer Ag, 5090 Leverkusen Immunstimulierende mittel
DE3420743A1 (de) * 1984-06-04 1985-12-05 Bayer Ag, 5090 Leverkusen 7-amino-1-cyclopropyl-6,8-dihalogen-1,4-dihydro-4-oxo-3-chinolincarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
DE3420798A1 (de) * 1984-06-04 1985-12-05 Bayer Ag, 5090 Leverkusen 7-(3-aryl-l-piperazinyl)- sowie 7-(3-cyclohexyl-l-piperazinyl)-3-chinoloncarbonsaeuren
JPS60222448A (ja) * 1984-09-11 1985-11-07 Kyorin Pharmaceut Co Ltd アニリン類とその製造方法
US4771054A (en) * 1985-01-23 1988-09-13 Warner-Lambert Company Antibacterial agents
JPS61205258A (ja) * 1985-03-08 1986-09-11 Kyorin Pharmaceut Co Ltd キノロンカルボン酸誘導体及びその製造方法

Also Published As

Publication number Publication date
DE3564108D1 (en) 1988-09-08
DD240012A5 (de) 1986-10-15
NO173546B (no) 1993-09-20
PH23577A (en) 1989-09-11
DK164596B (da) 1992-07-20
DK164596C (da) 1992-12-07
PT80578B (pt) 1987-11-11
JPH0369343B2 (es) 1991-10-31
EP0167763A1 (de) 1986-01-15
IE57815B1 (en) 1993-04-21
AU4329385A (en) 1985-12-12
HK7291A (en) 1991-02-01
EP0167763B1 (de) 1988-08-03
KR920005112B1 (ko) 1992-06-26
ES553083A0 (es) 1987-01-16
IL75369A (en) 1988-10-31
AU575651B2 (en) 1988-08-04
FI852203L (fi) 1985-12-05
DK166276B (da) 1993-03-29
PT80578A (en) 1985-07-01
US5969141A (en) 1999-10-19
FI852203A0 (fi) 1985-05-31
HU910254D0 (en) 1991-08-28
IL75369A0 (en) 1985-09-29
ES8702907A1 (es) 1987-01-16
NZ212272A (en) 1988-05-30
ES8607277A1 (es) 1986-06-16
HUT38336A (en) 1986-05-28
JPS611667A (ja) 1986-01-07
ES553084A0 (es) 1987-01-01
AR243510A1 (es) 1993-08-31
KR860000281A (ko) 1986-01-27
ATE36155T1 (de) 1988-08-15
DK249885D0 (da) 1985-06-03
NO173546C (no) 1993-12-29
ES543836A0 (es) 1986-06-16
DK166276C (da) 1993-08-23
GR851316B (es) 1985-11-25
DK249885A (da) 1985-12-05
DE3420743A1 (de) 1985-12-05
HU208821B (en) 1994-01-28
NO852025L (no) 1985-12-05
US5571812A (en) 1996-11-05
IE851365L (en) 1985-12-04
DK159391D0 (da) 1991-09-12
DK159391A (da) 1991-09-12
ZA854167B (en) 1986-01-29
PH24947A (en) 1990-12-26

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