AR003116A1 - Compuestos triciclicos utiles para inhibir la funcion de la proteina g y para el tratamiento de enfermedades proliferativas, composicion farmaceutica que los comprende y el uso de dichos compuestos para la manufactura de medicamentos - Google Patents
Compuestos triciclicos utiles para inhibir la funcion de la proteina g y para el tratamiento de enfermedades proliferativas, composicion farmaceutica que los comprende y el uso de dichos compuestos para la manufactura de medicamentosInfo
- Publication number
- AR003116A1 AR003116A1 ARP960102084A AR10208496A AR003116A1 AR 003116 A1 AR003116 A1 AR 003116A1 AR P960102084 A ARP960102084 A AR P960102084A AR 10208496 A AR10208496 A AR 10208496A AR 003116 A1 AR003116 A1 AR 003116A1
- Authority
- AR
- Argentina
- Prior art keywords
- compounds
- pharmaceutical composition
- medicines
- inhibit
- protein
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems
- C07D221/06—Ring systems of three rings
- C07D221/16—Ring systems of three rings containing carbocyclic rings other than six-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
Abstract
Se describen nuevos compuestos tricíclicos que tienen la fórmula (I) donde A, W, B, Z, X, R1 y R2 están definidos en la memoria descriptiva. También sedescribe una composición farmacéutica, que los comprende, útil para inhibir la función Ras yp or lo tanto para inhibir el desarrollo anormal de células yel uso de dichos compuestos para preparar medicamentos.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US41832395A | 1995-04-07 | 1995-04-07 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR003116A1 true AR003116A1 (es) | 1998-07-08 |
Family
ID=23657636
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP960102084A AR003116A1 (es) | 1995-04-07 | 1996-04-03 | Compuestos triciclicos utiles para inhibir la funcion de la proteina g y para el tratamiento de enfermedades proliferativas, composicion farmaceutica que los comprende y el uso de dichos compuestos para la manufactura de medicamentos |
Country Status (20)
Country | Link |
---|---|
EP (1) | EP0819121B1 (es) |
JP (1) | JP3038017B2 (es) |
KR (1) | KR100329877B1 (es) |
AR (1) | AR003116A1 (es) |
AT (1) | ATE363472T1 (es) |
AU (1) | AU719990B2 (es) |
BR (1) | BR9604787A (es) |
CA (1) | CA2217499C (es) |
CZ (1) | CZ316597A3 (es) |
DE (1) | DE69637105T2 (es) |
ES (1) | ES2288302T3 (es) |
HU (1) | HUP9800456A3 (es) |
IL (1) | IL117798A (es) |
MX (1) | MX9707665A (es) |
NO (1) | NO314082B1 (es) |
NZ (1) | NZ306665A (es) |
PL (1) | PL322689A1 (es) |
SK (1) | SK135597A3 (es) |
TW (1) | TW462968B (es) |
WO (1) | WO1996031478A1 (es) |
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ES2056214T3 (es) * | 1988-04-28 | 1994-10-01 | Schering Corp | Compuestos de benzopirido-piperidina, -piperidilideno y -piperazina, composiciones, metodos de preparacion y metodos de uso. |
ZA914764B (en) * | 1990-06-22 | 1992-03-25 | Schering Corp | Bis-benzo or benzopyrido cyclohepta piperidene,piperidylidene and piperazine compounds,compositions and methods of use |
AU8854091A (en) * | 1990-10-10 | 1992-05-20 | Schering Corporation | Bis-benzo cyclohepta piperidylidene, piperidine and piperazine compounds, compositions and methods of use |
DE69120430D1 (de) * | 1990-12-18 | 1996-07-25 | Wellcome Found | Mittel zur verstaerkung der wirkung von antitumoralen mittel und zur widerstandsbekaempfung von vielfachdrogen |
KR920014799A (ko) * | 1991-01-18 | 1992-08-25 | 나오가따 다이도 | 신규벤조[5,6]시클로헵타[1,2-b]피리딘 유도체 및 이를 함유하는 항알레르기제 |
JP2974529B2 (ja) * | 1992-02-20 | 1999-11-10 | 北陸製薬株式会社 | 両性型三環系化合物 |
IL111235A (en) * | 1993-10-15 | 2001-03-19 | Schering Plough Corp | Medicinal preparations for inhibiting protein G activity and for the treatment of malignant diseases, containing tricyclic compounds, some such new compounds and a process for the preparation of some of them |
IL111258A0 (en) * | 1993-10-15 | 1994-12-29 | Schering Corp | Tricyclic carbamate compounds useful for inhibition of g-protein function and for treatment of proliferative diseases |
WO1995010514A1 (en) * | 1993-10-15 | 1995-04-20 | Schering Corporation | Tricyclic sulfonamide compounds useful for inhibition of g-protein function and for treatment of proliferative diseases |
-
1996
- 1996-04-02 IL IL11779896A patent/IL117798A/en not_active IP Right Cessation
- 1996-04-03 WO PCT/US1996/004172 patent/WO1996031478A1/en active IP Right Grant
- 1996-04-03 NZ NZ306665A patent/NZ306665A/xx unknown
- 1996-04-03 HU HU9800456A patent/HUP9800456A3/hu unknown
- 1996-04-03 MX MX9707665A patent/MX9707665A/es not_active IP Right Cessation
- 1996-04-03 BR BR9604787A patent/BR9604787A/pt not_active Application Discontinuation
- 1996-04-03 SK SK1355-97A patent/SK135597A3/sk unknown
- 1996-04-03 CZ CZ973165A patent/CZ316597A3/cs unknown
- 1996-04-03 EP EP96912469A patent/EP0819121B1/en not_active Expired - Lifetime
- 1996-04-03 AT AT96912469T patent/ATE363472T1/de not_active IP Right Cessation
- 1996-04-03 DE DE69637105T patent/DE69637105T2/de not_active Expired - Lifetime
- 1996-04-03 AU AU55279/96A patent/AU719990B2/en not_active Ceased
- 1996-04-03 JP JP08530364A patent/JP3038017B2/ja not_active Expired - Fee Related
- 1996-04-03 ES ES96912469T patent/ES2288302T3/es not_active Expired - Lifetime
- 1996-04-03 KR KR1019970707063A patent/KR100329877B1/ko not_active IP Right Cessation
- 1996-04-03 CA CA002217499A patent/CA2217499C/en not_active Expired - Fee Related
- 1996-04-03 PL PL96322689A patent/PL322689A1/xx unknown
- 1996-04-03 AR ARP960102084A patent/AR003116A1/es not_active Application Discontinuation
- 1996-04-05 TW TW085103970A patent/TW462968B/zh not_active IP Right Cessation
-
1997
- 1997-10-06 NO NO19974610A patent/NO314082B1/no not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
CA2217499C (en) | 2004-03-30 |
IL117798A0 (en) | 1996-08-04 |
KR100329877B1 (ko) | 2002-08-28 |
IL117798A (en) | 2001-11-25 |
NO974610L (no) | 1997-12-08 |
HUP9800456A2 (hu) | 1999-06-28 |
SK135597A3 (en) | 1998-07-08 |
EP0819121B1 (en) | 2007-05-30 |
NO314082B1 (no) | 2003-01-27 |
JP3038017B2 (ja) | 2000-05-08 |
EP0819121A1 (en) | 1998-01-21 |
NZ306665A (en) | 2000-01-28 |
HUP9800456A3 (en) | 2000-04-28 |
AU719990B2 (en) | 2000-05-18 |
DE69637105T2 (de) | 2008-04-24 |
WO1996031478A1 (en) | 1996-10-10 |
TW462968B (en) | 2001-11-11 |
AU5527996A (en) | 1996-10-23 |
CA2217499A1 (en) | 1996-10-10 |
BR9604787A (pt) | 1998-07-07 |
DE69637105D1 (de) | 2007-07-12 |
ATE363472T1 (de) | 2007-06-15 |
NO974610D0 (no) | 1997-10-06 |
CZ316597A3 (cs) | 1998-03-18 |
MX9707665A (es) | 1997-11-29 |
PL322689A1 (en) | 1998-02-16 |
JPH10511981A (ja) | 1998-11-17 |
ES2288302T3 (es) | 2008-01-01 |
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