BR9604787A - Compostos tricíclicos utilizáveis para inibição de função de proteína g e para tratamento de doenças proliferativas - Google Patents

Compostos tricíclicos utilizáveis para inibição de função de proteína g e para tratamento de doenças proliferativas

Info

Publication number
BR9604787A
BR9604787A BR9604787A BR9604787A BR9604787A BR 9604787 A BR9604787 A BR 9604787A BR 9604787 A BR9604787 A BR 9604787A BR 9604787 A BR9604787 A BR 9604787A BR 9604787 A BR9604787 A BR 9604787A
Authority
BR
Brazil
Prior art keywords
inhibiting
proliferative diseases
protein function
tricyclic compounds
treating proliferative
Prior art date
Application number
BR9604787A
Other languages
English (en)
Inventor
Adriano Afonso
John J Baldwin
Ronald J Doll
Ge Li
Alan K Mallams
George F Njoroge
Dinanath F Rane
John C Reader
Randall R Rossman
Original Assignee
Pharmacopeia Inc
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacopeia Inc, Schering Corp filed Critical Pharmacopeia Inc
Publication of BR9604787A publication Critical patent/BR9604787A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/06—Ring systems of three rings
    • C07D221/16—Ring systems of three rings containing carbocyclic rings other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
BR9604787A 1995-04-07 1996-04-03 Compostos tricíclicos utilizáveis para inibição de função de proteína g e para tratamento de doenças proliferativas BR9604787A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US41832395A 1995-04-07 1995-04-07
PCT/US1996/004172 WO1996031478A1 (en) 1995-04-07 1996-04-03 Tricyclic compounds useful for inhibition of g-protein function and for treatment of proliferative diseases

Publications (1)

Publication Number Publication Date
BR9604787A true BR9604787A (pt) 1998-07-07

Family

ID=23657636

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9604787A BR9604787A (pt) 1995-04-07 1996-04-03 Compostos tricíclicos utilizáveis para inibição de função de proteína g e para tratamento de doenças proliferativas

Country Status (20)

Country Link
EP (1) EP0819121B1 (pt)
JP (1) JP3038017B2 (pt)
KR (1) KR100329877B1 (pt)
AR (1) AR003116A1 (pt)
AT (1) ATE363472T1 (pt)
AU (1) AU719990B2 (pt)
BR (1) BR9604787A (pt)
CA (1) CA2217499C (pt)
CZ (1) CZ316597A3 (pt)
DE (1) DE69637105T2 (pt)
ES (1) ES2288302T3 (pt)
HU (1) HUP9800456A3 (pt)
IL (1) IL117798A (pt)
MX (1) MX9707665A (pt)
NO (1) NO314082B1 (pt)
NZ (1) NZ306665A (pt)
PL (1) PL322689A1 (pt)
SK (1) SK135597A3 (pt)
TW (1) TW462968B (pt)
WO (1) WO1996031478A1 (pt)

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CA2174105C (en) * 1993-10-15 2002-02-12 W. Robert Bishop Tricyclic carbamate compounds useful for inhibition of g-protein function and for treatment of proliferative diseases
IL111235A (en) * 1993-10-15 2001-03-19 Schering Plough Corp Medicinal preparations for inhibiting protein G activity and for the treatment of malignant diseases, containing tricyclic compounds, some such new compounds and a process for the preparation of some of them
HUT76057A (en) * 1993-10-15 1997-06-30 Schering Corp Tricyclic sulfonamide compounds, pharmaceutical compositions containing them, which are useful for inhibition of g-protein function and for treatment of proliferative diseases and process for producing them

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KR100329877B1 (ko) 2002-08-28
CZ316597A3 (cs) 1998-03-18
CA2217499A1 (en) 1996-10-10
JPH10511981A (ja) 1998-11-17
AU719990B2 (en) 2000-05-18
DE69637105T2 (de) 2008-04-24
TW462968B (en) 2001-11-11
JP3038017B2 (ja) 2000-05-08
IL117798A (en) 2001-11-25
CA2217499C (en) 2004-03-30
AU5527996A (en) 1996-10-23
EP0819121A1 (en) 1998-01-21
NO974610L (no) 1997-12-08
HUP9800456A3 (en) 2000-04-28
PL322689A1 (en) 1998-02-16
ATE363472T1 (de) 2007-06-15
WO1996031478A1 (en) 1996-10-10
AR003116A1 (es) 1998-07-08
IL117798A0 (en) 1996-08-04
ES2288302T3 (es) 2008-01-01
HUP9800456A2 (hu) 1999-06-28
NZ306665A (en) 2000-01-28
DE69637105D1 (de) 2007-07-12
EP0819121B1 (en) 2007-05-30
NO974610D0 (no) 1997-10-06
MX9707665A (es) 1997-11-29
SK135597A3 (en) 1998-07-08
NO314082B1 (no) 2003-01-27

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