ES2056214T3 - Compuestos de benzopirido-piperidina, -piperidilideno y -piperazina, composiciones, metodos de preparacion y metodos de uso. - Google Patents
Compuestos de benzopirido-piperidina, -piperidilideno y -piperazina, composiciones, metodos de preparacion y metodos de uso.Info
- Publication number
- ES2056214T3 ES2056214T3 ES89304169T ES89304169T ES2056214T3 ES 2056214 T3 ES2056214 T3 ES 2056214T3 ES 89304169 T ES89304169 T ES 89304169T ES 89304169 T ES89304169 T ES 89304169T ES 2056214 T3 ES2056214 T3 ES 2056214T3
- Authority
- ES
- Spain
- Prior art keywords
- methods
- piperidylidene
- piperidine
- benzopirid
- compositions
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
Abstract
NUEVOS COMPUESTOS DE BENZOPIRIDO PIPERIDINA, PIPERILIDENO Y PIPERAZINA DE LA FORMULA GENERALIZADA (I), QUE SON UTILES EN EL TRATAMIENTO DE ASMA, ALERGIA E INFLAMACION. NUEVAS COMPOSICIONES FARMACEUTICAS QUE CONTIENEN TALES COMPUESTOS Y PROCESOS PARA PRODUCIR LOS MISMOS.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US18760488A | 1988-04-28 | 1988-04-28 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2056214T3 true ES2056214T3 (es) | 1994-10-01 |
Family
ID=22689668
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES89304169T Expired - Lifetime ES2056214T3 (es) | 1988-04-28 | 1989-04-26 | Compuestos de benzopirido-piperidina, -piperidilideno y -piperazina, composiciones, metodos de preparacion y metodos de uso. |
Country Status (17)
Country | Link |
---|---|
EP (2) | EP0411048A1 (es) |
JP (1) | JPH0678315B2 (es) |
KR (1) | KR950004004B1 (es) |
AT (1) | ATE108453T1 (es) |
AU (1) | AU629835B2 (es) |
CA (1) | CA1341044C (es) |
DE (1) | DE68916699T2 (es) |
DK (1) | DK256890A (es) |
ES (1) | ES2056214T3 (es) |
FI (1) | FI96690C (es) |
IE (1) | IE64522B1 (es) |
IL (1) | IL90101A (es) |
MY (1) | MY106280A (es) |
NZ (1) | NZ228888A (es) |
OA (1) | OA09629A (es) |
WO (1) | WO1989010369A1 (es) |
ZA (1) | ZA893104B (es) |
Families Citing this family (38)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5665726A (en) * | 1986-10-31 | 1997-09-09 | Schering Corporation | Benzo[5,6]cycloheptapyridines, compositions and methods of use |
US5089496A (en) * | 1986-10-31 | 1992-02-18 | Schering Corporation | Benzo[5,6]cycloheptapyridine compounds, compositions and method of treating allergies |
CA2004211A1 (en) * | 1988-11-30 | 1990-05-31 | Masataka Syoji | Piperidine derivatives and hyportensives containing the same |
ZA914764B (en) * | 1990-06-22 | 1992-03-25 | Schering Corp | Bis-benzo or benzopyrido cyclohepta piperidene,piperidylidene and piperazine compounds,compositions and methods of use |
JPH089616B2 (ja) * | 1990-10-10 | 1996-01-31 | シェリング・コーポレーション | 置換されたイミダゾベンズアゼピン類およびイミダゾピリドアゼピン類 |
GB9109557D0 (en) * | 1991-05-02 | 1991-06-26 | Wellcome Found | Chemical compounds |
AU2028892A (en) * | 1991-05-23 | 1992-12-30 | Schering Corporation | Novel benzopyrido piperidylidene compounds, compositions, methods of manufacture and methods of use |
EP0524784A1 (en) * | 1991-07-23 | 1993-01-27 | Schering Corporation | Benzopyrido piperidylidene compounds as PAF antagonists |
JP2974529B2 (ja) * | 1992-02-20 | 1999-11-10 | 北陸製薬株式会社 | 両性型三環系化合物 |
WO1993020080A1 (en) * | 1992-03-27 | 1993-10-14 | Schering Corporation | Bridged bis-aryl carbinol derivatives, compositions and methods of use |
ES2089815T3 (es) * | 1992-03-27 | 1996-10-01 | Schering Corp | Derivados de bis-aril-carbinol sin enlaces de puente, composiciones y metodos de uso. |
US5574173A (en) * | 1993-12-06 | 1996-11-12 | Schering Corporation | Tricyclic derivatives, compositions and methods of use |
US5538986A (en) * | 1993-12-06 | 1996-07-23 | Schering Corporation | Tricyclic derivatives, compositions and methods of use |
US5464840A (en) * | 1993-12-06 | 1995-11-07 | Schering Corporation | Tricyclic derivatives, compositions and methods of use |
US6524832B1 (en) | 1994-02-04 | 2003-02-25 | Arch Development Corporation | DNA damaging agents in combination with tyrosine kinase inhibitors |
IL117798A (en) * | 1995-04-07 | 2001-11-25 | Schering Plough Corp | Tricyclic compounds useful for inhibiting the function of protein - G and for the treatment of malignant diseases, and pharmaceutical preparations containing them |
US5801175A (en) | 1995-04-07 | 1998-09-01 | Schering Corporation | Tricyclic compounds useful for inhibition of G-protein function and for treatment of proliferative diseases |
US6323206B1 (en) | 1996-07-12 | 2001-11-27 | Millennium Pharmaceuticals, Inc. | Chemokine receptor antagonists and methods of use therefor |
PE92098A1 (es) * | 1996-07-31 | 1998-12-31 | Schering Corp | N-cianoiminas triciclicas utiles como inhibidores de transferasa de proteina farnesilo |
CH688412A5 (de) * | 1997-03-11 | 1997-09-15 | Cilag Ag | Verfahren zur Herstellung von 1,4-disubstituierten Piperidinverbindungen. |
US6051582A (en) * | 1997-06-17 | 2000-04-18 | Schering Corporation | Compounds useful for inhibition of farnesyl protein transferase |
KR20010013828A (ko) * | 1997-06-17 | 2001-02-26 | 둘락 노먼 씨. | 파르네실 단백질 트랜스퍼라제의 억제에 유용한벤조(5,6)사이클로헵타(1,2b)피리딘 유도체 |
US5925648A (en) * | 1997-07-29 | 1999-07-20 | Schering Corporation | Tricyclic N-cyanoimines useful as inhibitors of a farnesyl-protein transferase |
US6632455B2 (en) | 1997-12-22 | 2003-10-14 | Schering Corporation | Molecular dispersion composition with enhanced bioavailability |
US6613905B1 (en) | 1998-01-21 | 2003-09-02 | Millennium Pharmaceuticals, Inc. | Chemokine receptor antagonists and methods of use therefor |
CA2318088A1 (en) | 1998-01-21 | 1999-07-29 | Yoshisuke Nakasato | Chemokine receptor antagonists and methods of use therefor |
CA2319077A1 (en) | 1998-01-21 | 1999-07-29 | Yoshisuke Nakasato | Chemokine receptor antagonists and methods of use therefor |
US6509346B2 (en) | 1998-01-21 | 2003-01-21 | Millennium Pharmaceuticals, Inc. | Chemokine receptor antagonists and methods of use therefor |
US7271176B2 (en) | 1998-09-04 | 2007-09-18 | Millennium Pharmaceuticals, Inc. | Chemokine receptor antagonists and methods of use thereof |
ATE347880T1 (de) * | 1998-10-20 | 2007-01-15 | Univ North Carolina | Methoden zum befeuchten der nasenschleimhaut |
US6316462B1 (en) | 1999-04-09 | 2001-11-13 | Schering Corporation | Methods of inducing cancer cell death and tumor regression |
US6455554B1 (en) | 1999-06-07 | 2002-09-24 | Targacept, Inc. | Oxopyridinyl pharmaceutical compositions and methods for use |
EP1204664A1 (en) * | 1999-07-28 | 2002-05-15 | Millennium Pharmaceuticals, Inc. | Chemokine receptor antagonists and methods of use therefor |
EP1318994B1 (en) | 2000-09-20 | 2008-02-27 | Schering Corporation | Substituted imidazoles as dual histamine h1 and h3 agonists or antagonists |
EP1448566B3 (en) | 2001-11-21 | 2009-04-08 | Millennium Pharmaceuticals, Inc. | Chemokine receptor antagonists and methods of use thereof |
US7541365B2 (en) | 2001-11-21 | 2009-06-02 | Millennium Pharmaceuticals, Inc. | Chemokine receptor antagonists and methods of use therefor |
ES2211315B1 (es) | 2002-11-12 | 2005-10-16 | Almirall Prodesfarma, S.A. | Nuevos compuestos triciclicos. |
TWI291467B (en) | 2002-11-13 | 2007-12-21 | Millennium Pharm Inc | CCR1 antagonists and methods of use therefor |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4282233B1 (en) * | 1980-06-19 | 2000-09-05 | Schering Corp | Antihistaminic 11-(4-piperidylidene)-5h-benzoÄ5,6Ü-cyclohepta-Ä1,2Ü-pyridines |
HU194864B (en) * | 1984-02-15 | 1988-03-28 | Schering Corp | Process for production of 8-chlor-6,11-dihydro-11-(4-piperidilidene)-5h-benzo (5,6)-cyclo-hepta (1,2-b) pyridine and its salts |
EP0208855B1 (en) * | 1985-05-13 | 1991-03-06 | Schering Corporation | process for preparing piperidylidene dihydrodibenzo(a,d)cycloheptenes and aza derivatives thereof, compounds obtained by such process and the use of such compounds for preparing useful pharmaceutical compositions |
US4804666A (en) * | 1985-08-14 | 1989-02-14 | Schering Corporation | Antiallergic 6,11-dihydro-11-(4-piperidylidene)-5H-benzo(5,6)cyclohepta(1,2-B)pyridines |
US4826853A (en) * | 1986-10-31 | 1989-05-02 | Schering Corporation | 6,11-Dihydro-11-(N-substituted-4-piperidylidene)-5H-benzo(5,6)cyclohepta(1,2-B)pyridines and compositions and methods of use |
-
1989
- 1989-04-26 EP EP89905928A patent/EP0411048A1/en active Pending
- 1989-04-26 CA CA000597849A patent/CA1341044C/en not_active Expired - Fee Related
- 1989-04-26 ZA ZA893104A patent/ZA893104B/xx unknown
- 1989-04-26 NZ NZ228888A patent/NZ228888A/en unknown
- 1989-04-26 ES ES89304169T patent/ES2056214T3/es not_active Expired - Lifetime
- 1989-04-26 KR KR1019890702471A patent/KR950004004B1/ko not_active IP Right Cessation
- 1989-04-26 AT AT89304169T patent/ATE108453T1/de not_active IP Right Cessation
- 1989-04-26 AU AU37344/89A patent/AU629835B2/en not_active Ceased
- 1989-04-26 DE DE68916699T patent/DE68916699T2/de not_active Expired - Fee Related
- 1989-04-26 WO PCT/US1989/001688 patent/WO1989010369A1/en active IP Right Grant
- 1989-04-26 EP EP89304169A patent/EP0341860B1/en not_active Expired - Lifetime
- 1989-04-26 JP JP1505871A patent/JPH0678315B2/ja not_active Expired - Lifetime
- 1989-04-26 MY MYPI89000537A patent/MY106280A/en unknown
- 1989-04-27 IL IL9010189A patent/IL90101A/en not_active IP Right Cessation
- 1989-04-27 IE IE137989A patent/IE64522B1/en not_active IP Right Cessation
-
1990
- 1990-10-25 DK DK256890A patent/DK256890A/da not_active Application Discontinuation
- 1990-10-26 FI FI905280A patent/FI96690C/fi not_active IP Right Cessation
- 1990-10-26 OA OA59879A patent/OA09629A/en unknown
Also Published As
Publication number | Publication date |
---|---|
IE891379L (en) | 1989-10-28 |
NZ228888A (en) | 1991-12-23 |
FI96690B (fi) | 1996-04-30 |
DK256890A (da) | 1990-12-21 |
EP0341860A1 (en) | 1989-11-15 |
ZA893104B (en) | 1989-12-27 |
DE68916699D1 (de) | 1994-08-18 |
ATE108453T1 (de) | 1994-07-15 |
CA1341044C (en) | 2000-07-04 |
JPH0678315B2 (ja) | 1994-10-05 |
AU3734489A (en) | 1989-11-24 |
WO1989010369A1 (en) | 1989-11-02 |
IL90101A0 (en) | 1989-12-15 |
IL90101A (en) | 1996-11-14 |
MY106280A (en) | 1995-04-29 |
EP0341860B1 (en) | 1994-07-13 |
FI96690C (fi) | 1996-08-12 |
JPH03504012A (ja) | 1991-09-05 |
EP0411048A1 (en) | 1991-02-06 |
AU629835B2 (en) | 1992-10-15 |
OA09629A (en) | 1993-04-30 |
FI905280A0 (fi) | 1990-10-26 |
IE64522B1 (en) | 1995-08-09 |
KR900700486A (ko) | 1990-08-13 |
DK256890D0 (da) | 1990-10-25 |
DE68916699T2 (de) | 1994-12-01 |
KR950004004B1 (ko) | 1995-04-22 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ES2056214T3 (es) | Compuestos de benzopirido-piperidina, -piperidilideno y -piperazina, composiciones, metodos de preparacion y metodos de uso. | |
SE9904738D0 (sv) | Novel compounds | |
IL123293A (en) | Piperidine derivatives, their preparation and pharmaceutical compositions containing them | |
PL262105A1 (en) | The method of manufacture of new derivatives of benzimidazole | |
FI920023A0 (fi) | Heteroarylpiperazinfoereningar som antipsykotiska aemnen. | |
RU94038064A (ru) | Производные пиперазина и пиперидина, их применение в качестве противопсихотических средств, способ их получения фармацевтическая композиция | |
FI890311A (fi) | Kemiska foereningar. | |
FR2680507B1 (fr) | Nouvelles naphtylethylurees et naphtylethylthiourees, leur procede de preparation et les compositions pharmaceutiques qui les contiennent. | |
FI96309B (fi) | Menetelmä farmakologisesti arvokkaiden fuusioituneiden polysyklisten yhdisteiden valmistamiseksi | |
DK0587088T3 (da) | Substituerede cyclohexan-derivater, fremgangsmåde til deres fremstilling og anvendelsen af forbindelserne til behandling af sygdomme | |
NO971625L (no) | Nye peptider med immunomodulatoriske effekter | |
FI101376B1 (fi) | Menetelmä 3-bentsyyliamino-2-fenyylipiperidiinijohdannaisten valmistamiseksi | |
NO307464B1 (no) | Galantaminderivater, farmasøytisk sammensetning inneholdende samme samt deres anvendelse for fremstilling av medikamenter | |
ATE40369T1 (de) | Purinderivate. | |
NO904135D0 (no) | Fremgangsmaate for fremstilling av nye alkylpiperidiner. | |
DE59010865D1 (de) | N-substituierte naphthalimide, ihre herstellung und verwendung | |
DK0587048T3 (da) | Heteroarenylpiperaziner, en fremgangsmåde til deres fremstilling og deres anvendelse som lægemidler |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
Ref document number: 341860 Country of ref document: ES |