ZA954525B - Piperazine derivatives - Google Patents

Piperazine derivatives

Info

Publication number
ZA954525B
ZA954525B ZA954525A ZA954525A ZA954525B ZA 954525 B ZA954525 B ZA 954525B ZA 954525 A ZA954525 A ZA 954525A ZA 954525 A ZA954525 A ZA 954525A ZA 954525 B ZA954525 B ZA 954525B
Authority
ZA
South Africa
Prior art keywords
piperazine derivatives
hydrogen
compounds
halo
methyl
Prior art date
Application number
ZA954525A
Other languages
English (en)
Inventor
Christopher Ian Brightwell
Michael Gerhard Kelly
Original Assignee
Wyeth John & Brother Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth John & Brother Ltd filed Critical Wyeth John & Brother Ltd
Publication of ZA954525B publication Critical patent/ZA954525B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, ***e
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
  • Hydrogenated Pyridines (AREA)
ZA954525A 1994-06-03 1995-06-01 Piperazine derivatives ZA954525B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB9411099A GB9411099D0 (en) 1994-06-03 1994-06-03 Piperazine derivatives

Publications (1)

Publication Number Publication Date
ZA954525B true ZA954525B (en) 1996-12-02

Family

ID=10756114

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA954525A ZA954525B (en) 1994-06-03 1995-06-01 Piperazine derivatives

Country Status (25)

Country Link
US (1) US5723464A (fr)
EP (1) EP0763031B1 (fr)
JP (1) JPH10500989A (fr)
KR (1) KR100359393B1 (fr)
CN (2) CN1048985C (fr)
AT (1) ATE192744T1 (fr)
AU (1) AU680147B2 (fr)
BR (1) BR9507910A (fr)
CA (1) CA2191871C (fr)
CZ (1) CZ287381B6 (fr)
DE (1) DE69516867T2 (fr)
DK (1) DK0763031T3 (fr)
ES (1) ES2145275T3 (fr)
FI (1) FI114985B (fr)
GB (1) GB9411099D0 (fr)
GR (1) GR3033449T3 (fr)
HU (1) HUT76466A (fr)
IL (1) IL113967A (fr)
MX (1) MX9605915A (fr)
NZ (2) NZ331452A (fr)
PT (1) PT763031E (fr)
RU (1) RU2165933C2 (fr)
SK (1) SK281418B6 (fr)
WO (1) WO1995033743A1 (fr)
ZA (1) ZA954525B (fr)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU645681B2 (en) * 1991-05-02 1994-01-20 John Wyeth & Brother Limited Piperazine derivatives
ES2180638T3 (es) * 1994-06-03 2003-02-16 Wyeth John & Brother Ltd Nuevos procedimientos e intermediarios para la preparacion de derivados de piperazina.
CA2194984C (fr) * 1994-07-26 2002-07-02 John Eugene Macor Derives 4-indole utilises comme agonistes et antagonistes de la serotonine
US5486518A (en) * 1995-04-10 1996-01-23 American Home Products Corporation 4-indolylpiperazinyl derivatives
US5519025A (en) * 1995-04-10 1996-05-21 American Home Products Corporation 4-indolylpiperazinyl derivatives
IT1282705B1 (it) * 1996-02-28 1998-03-31 Recordati Chem Pharm Uso di antagonisti del recettore serotoninergico 5-ht|a per il trattamento dell'incontinenza urinaria
US5990114A (en) * 1996-02-28 1999-11-23 Recordati, S.A., Chemical And Pharmaceutical Company Use of 5-HT1A receptor antagonists for the treatment of urinary incontinence
DE19615232A1 (de) * 1996-04-18 1997-10-23 Merck Patent Gmbh Neue Carbamoylderivate und deren Verwendung als 5-HT ¶1¶¶A¶-Antagonisten
DE19725664A1 (de) 1997-06-18 1998-12-24 Merck Patent Gmbh 3-Benzylpiperidine
IT1293807B1 (it) * 1997-08-01 1999-03-10 Recordati Chem Pharm Derivati 1- (n-fenilaminoalchil) piperazinici sostituiti alla posizione 2 dell'anello fenilico
US6399614B1 (en) 1997-08-01 2002-06-04 Recordati S.A. Chemical And Pharmaceutical Company 1-(N-phenylaminoalkyl)piperazine derivatives substituted at position 2 of the phenyl ring
IT1293804B1 (it) 1997-08-01 1999-03-10 Recordati Chem Pharm Diarilalchilpiperazine attive sulle basse vie urinarie
US6271234B1 (en) 1997-08-01 2001-08-07 Recordati S.A., Chemical And Pharmaceutical Company 1,4-disubstituted piperazines
EP1000045A1 (fr) * 1997-08-01 2000-05-17 RECORDATI S.A. CHEMICAL and PHARMACEUTICAL COMPANY Piperazines 1,4-disubstituees
US6376494B1 (en) 1998-06-15 2002-04-23 American Home Products Corporation Cycloalkyl-substituted aryl-piperazines, piperidines and tetrahydropyridines as serotonergic agents
WO1999065887A1 (fr) * 1998-06-15 1999-12-23 American Home Products Corporation Tetrahydropyridines, piperidines et aryl-piperazines a substitution cycloalkyle, utilises en tant qu'agents serotoninergiques
US20060287335A1 (en) 2000-11-28 2006-12-21 Wyeth Serotonergic agents for treating sexual dysfunction
US20060223824A1 (en) 2000-11-28 2006-10-05 Wyeth Serotonergic agents
JPWO2002070482A1 (ja) * 2001-02-27 2004-07-02 鐘淵化学工業株式会社 光学活性ｎ−アリール−１−アミノ−２−プロパノール誘導体の製造法
AU2003220110B2 (en) 2002-03-12 2009-04-09 Wyeth Process for making chiral 1,4-disubstituted piperazines
US7091349B2 (en) 2002-03-12 2006-08-15 Wyeth Process for synthesizing N-aryl piperazines with chiral N′-1-[benzoyl(2-pyridyl)amino]-2-propane substitution
PT1483243E (pt) 2002-03-12 2007-06-27 Wyeth Corp Preparação do ácido n1- ( 2'-piridil )-1, 2-propanodiamino sulfâmico e as sua utilizações na síntese de piperazinas biologicamente activas.
US6713626B2 (en) * 2002-03-12 2004-03-30 Wyeth Process for synthesizing N-aryl piperazines with chiral N′-1-[benzoyl(2-pyridyl)amino]-2-propane substitution
US7361773B2 (en) 2002-03-12 2008-04-22 Wyeth Preparation of N1-(2'-pyridyl)-1,2-propanediamine sulfamic acid and its use in the synthesis of biologically active piperazines
US7179813B2 (en) * 2003-06-11 2007-02-20 Wyeth Bicyclic indolyl derivatives and methods for their use as serotonergic agents
CN100436448C (zh) * 2003-06-11 2008-11-26 惠氏公司 二环吲哚基衍生物以及其作为5-羟色胺能活性剂的应用
TW200800959A (en) 2005-06-10 2008-01-01 Wyeth Corp Piperazine-piperidine antagonists and agonists of the 5-HT1a receptor
WO2007146073A2 (fr) * 2006-06-09 2007-12-21 Wyeth Procédé destiné à renforcer la fonction cognitive
MX2016015610A (es) 2014-06-06 2017-07-13 Flexus Biosciences Inc Agentes inmunorreguladores.
UY36391A (es) 2014-11-05 2016-06-01 Flexus Biosciences Inc Compuestos moduladores de la enzima indolamina 2,3-dioxigenasa (ido1), sus métodos de síntesis y composiciones farmacèuticas que las contienen
EP3215141A4 (fr) 2014-11-05 2018-06-06 Flexus Biosciences, Inc. Agents immunorégulateurs
UY36390A (es) * 2014-11-05 2016-06-01 Flexus Biosciences Inc Compuestos moduladores de la enzima indolamina 2,3-dioxigenasa (ido), sus métodos de síntesis y composiciones farmacéuticas que los contienen

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8909209D0 (en) * 1989-04-22 1989-06-07 Wyeth John & Brother Ltd Piperazine derivatives
DE69033100T2 (de) * 1989-04-22 2000-01-05 Wyeth John & Brother Ltd Piperazin-Derivate
GB9021535D0 (en) * 1990-10-03 1990-11-14 Wyeth John & Brother Ltd Piperazine derivatives
AU645681B2 (en) * 1991-05-02 1994-01-20 John Wyeth & Brother Limited Piperazine derivatives
SE9201138D0 (sv) * 1992-04-09 1992-04-09 Astra Ab Novel phthalimidoalkylpiperazines
GB9300195D0 (en) * 1993-01-06 1993-03-03 Wyeth John & Brother Ltd Piperazine derivatives

Also Published As

Publication number Publication date
US5723464A (en) 1998-03-03
CZ350796A3 (en) 1997-06-11
FI114985B (fi) 2005-02-15
KR970703333A (ko) 1997-07-03
RU2165933C2 (ru) 2001-04-27
EP0763031B1 (fr) 2000-05-10
ES2145275T3 (es) 2000-07-01
CA2191871A1 (fr) 1995-12-14
CN1227841A (zh) 1999-09-08
BR9507910A (pt) 1997-08-12
ATE192744T1 (de) 2000-05-15
HUT76466A (en) 1997-09-29
FI964815A (fi) 1996-12-02
IL113967A (en) 1999-03-12
AU2623095A (en) 1996-01-04
HU9603315D0 (en) 1997-01-28
CN1149873A (zh) 1997-05-14
DE69516867D1 (de) 2000-06-15
JPH10500989A (ja) 1998-01-27
IL113967A0 (en) 1995-10-31
NZ287498A (en) 1998-10-28
PT763031E (pt) 2000-10-31
GR3033449T3 (en) 2000-09-29
CN1093122C (zh) 2002-10-23
CA2191871C (fr) 2004-09-21
CZ287381B6 (en) 2000-11-15
DK0763031T3 (da) 2000-08-14
SK281418B6 (sk) 2001-03-12
DE69516867T2 (de) 2000-11-02
NZ331452A (en) 2000-01-28
WO1995033743A1 (fr) 1995-12-14
GB9411099D0 (en) 1994-07-27
SK154196A3 (en) 1997-08-06
FI964815A0 (fi) 1996-12-02
KR100359393B1 (ko) 2003-01-24
AU680147B2 (en) 1997-07-17
EP0763031A1 (fr) 1997-03-19
CN1048985C (zh) 2000-02-02
MX9605915A (es) 1997-12-31

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