DK0763031T3 - Piperazinderivater - Google Patents

Piperazinderivater

Info

Publication number
DK0763031T3
DK0763031T3 DK95921017T DK95921017T DK0763031T3 DK 0763031 T3 DK0763031 T3 DK 0763031T3 DK 95921017 T DK95921017 T DK 95921017T DK 95921017 T DK95921017 T DK 95921017T DK 0763031 T3 DK0763031 T3 DK 0763031T3
Authority
DK
Denmark
Prior art keywords
hydrogen
compounds
piperazine
halo
methyl
Prior art date
Application number
DK95921017T
Other languages
English (en)
Inventor
Christopher BRIGHTWELL
Michael Gerard Kelly
Original Assignee
Wyeth John & Brother Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth John & Brother Ltd filed Critical Wyeth John & Brother Ltd
Application granted granted Critical
Publication of DK0763031T3 publication Critical patent/DK0763031T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, ***e
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
DK95921017T 1994-06-03 1995-06-01 Piperazinderivater DK0763031T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9411099A GB9411099D0 (en) 1994-06-03 1994-06-03 Piperazine derivatives
PCT/GB1995/001263 WO1995033743A1 (en) 1994-06-03 1995-06-01 Piperazine derivatives as 5ht1a antagonists

Publications (1)

Publication Number Publication Date
DK0763031T3 true DK0763031T3 (da) 2000-08-14

Family

ID=10756114

Family Applications (1)

Application Number Title Priority Date Filing Date
DK95921017T DK0763031T3 (da) 1994-06-03 1995-06-01 Piperazinderivater

Country Status (25)

Country Link
US (1) US5723464A (da)
EP (1) EP0763031B1 (da)
JP (1) JPH10500989A (da)
KR (1) KR100359393B1 (da)
CN (2) CN1048985C (da)
AT (1) ATE192744T1 (da)
AU (1) AU680147B2 (da)
BR (1) BR9507910A (da)
CA (1) CA2191871C (da)
CZ (1) CZ287381B6 (da)
DE (1) DE69516867T2 (da)
DK (1) DK0763031T3 (da)
ES (1) ES2145275T3 (da)
FI (1) FI114985B (da)
GB (1) GB9411099D0 (da)
GR (1) GR3033449T3 (da)
HU (1) HUT76466A (da)
IL (1) IL113967A (da)
MX (1) MX9605915A (da)
NZ (2) NZ331452A (da)
PT (1) PT763031E (da)
RU (1) RU2165933C2 (da)
SK (1) SK281418B6 (da)
WO (1) WO1995033743A1 (da)
ZA (1) ZA954525B (da)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU645681B2 (en) * 1991-05-02 1994-01-20 John Wyeth & Brother Limited Piperazine derivatives
DK0763024T3 (da) * 1994-06-03 2002-12-02 Wyeth John & Brother Ltd Fremgangmåde og mellemprodukter til fremstilling af piperazinderivater
CA2194984C (en) * 1994-07-26 2002-07-02 John Eugene Macor 4-indole derivatives as serotonin agonists and antagonists
US5486518A (en) * 1995-04-10 1996-01-23 American Home Products Corporation 4-indolylpiperazinyl derivatives
US5519025A (en) * 1995-04-10 1996-05-21 American Home Products Corporation 4-indolylpiperazinyl derivatives
IT1282705B1 (it) * 1996-02-28 1998-03-31 Recordati Chem Pharm Uso di antagonisti del recettore serotoninergico 5-ht|a per il trattamento dell'incontinenza urinaria
US5990114A (en) * 1996-02-28 1999-11-23 Recordati, S.A., Chemical And Pharmaceutical Company Use of 5-HT1A receptor antagonists for the treatment of urinary incontinence
DE19615232A1 (de) * 1996-04-18 1997-10-23 Merck Patent Gmbh Neue Carbamoylderivate und deren Verwendung als 5-HT ¶1¶¶A¶-Antagonisten
DE19725664A1 (de) * 1997-06-18 1998-12-24 Merck Patent Gmbh 3-Benzylpiperidine
US6399614B1 (en) 1997-08-01 2002-06-04 Recordati S.A. Chemical And Pharmaceutical Company 1-(N-phenylaminoalkyl)piperazine derivatives substituted at position 2 of the phenyl ring
US6271234B1 (en) 1997-08-01 2001-08-07 Recordati S.A., Chemical And Pharmaceutical Company 1,4-disubstituted piperazines
JP2001512110A (ja) * 1997-08-01 2001-08-21 レコルダチ エッセ．ア．，ケミカル アンド ファーマシューティカル カンパニー １，４−ジ置換ピペラジン
IT1293807B1 (it) * 1997-08-01 1999-03-10 Recordati Chem Pharm Derivati 1- (n-fenilaminoalchil) piperazinici sostituiti alla posizione 2 dell'anello fenilico
IT1293804B1 (it) 1997-08-01 1999-03-10 Recordati Chem Pharm Diarilalchilpiperazine attive sulle basse vie urinarie
US6376494B1 (en) 1998-06-15 2002-04-23 American Home Products Corporation Cycloalkyl-substituted aryl-piperazines, piperidines and tetrahydropyridines as serotonergic agents
CN1312802A (zh) * 1998-06-15 2001-09-12 美国家用产品公司 作为5－羟色胺能药物的环烷基取代的芳基哌嗪、哌啶和四氢吡啶
US20060223824A1 (en) 2000-11-28 2006-10-05 Wyeth Serotonergic agents
US20060287335A1 (en) 2000-11-28 2006-12-21 Wyeth Serotonergic agents for treating sexual dysfunction
JPWO2002070482A1 (ja) * 2001-02-27 2004-07-02 鐘淵化学工業株式会社 光学活性ｎ−アリール−１−アミノ−２−プロパノール誘導体の製造法
CN101492383A (zh) 2002-03-12 2009-07-29 惠氏公司 制备手性1,4-二取代哌嗪的方法
US7091349B2 (en) 2002-03-12 2006-08-15 Wyeth Process for synthesizing N-aryl piperazines with chiral N′-1-[benzoyl(2-pyridyl)amino]-2-propane substitution
US7361773B2 (en) 2002-03-12 2008-04-22 Wyeth Preparation of N1-(2'-pyridyl)-1,2-propanediamine sulfamic acid and its use in the synthesis of biologically active piperazines
CN1982307A (zh) * 2002-03-12 2007-06-20 惠氏公司 合成手性n－芳基哌嗪的方法
SI1483243T1 (sl) 2002-03-12 2007-08-31 Wyeth Corp Priprava n1- (2'-piridil)-1,2-propandiamin sulfamske kisline in uporaba spojine za sintezo bioloĺ ko aktivnih piperazinov
US7179813B2 (en) * 2003-06-11 2007-02-20 Wyeth Bicyclic indolyl derivatives and methods for their use as serotonergic agents
CN100436448C (zh) * 2003-06-11 2008-11-26 惠氏公司 二环吲哚基衍生物以及其作为5-羟色胺能活性剂的应用
TW200800959A (en) 2005-06-10 2008-01-01 Wyeth Corp Piperazine-piperidine antagonists and agonists of the 5-HT1a receptor
US20080032965A1 (en) * 2006-06-09 2008-02-07 Hirst Warren D Method for enhancing cognitive function
CA2951259A1 (en) 2014-06-06 2015-12-10 Flexus Biosciences, Inc. Immunoregulatory agents
AR102537A1 (es) 2014-11-05 2017-03-08 Flexus Biosciences Inc Agentes inmunomoduladores
MX2017005462A (es) 2014-11-05 2017-07-28 Flexus Biosciences Inc Agentes inmunorreguladores.
UY36390A (es) 2014-11-05 2016-06-01 Flexus Biosciences Inc Compuestos moduladores de la enzima indolamina 2,3-dioxigenasa (ido), sus métodos de síntesis y composiciones farmacéuticas que los contienen

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8909209D0 (en) * 1989-04-22 1989-06-07 Wyeth John & Brother Ltd Piperazine derivatives
KR0173310B1 (ko) * 1989-04-22 1999-02-01 폴 에이 리쳐 피페라진 유도체
GB9021535D0 (en) * 1990-10-03 1990-11-14 Wyeth John & Brother Ltd Piperazine derivatives
AU645681B2 (en) * 1991-05-02 1994-01-20 John Wyeth & Brother Limited Piperazine derivatives
SE9201138D0 (sv) * 1992-04-09 1992-04-09 Astra Ab Novel phthalimidoalkylpiperazines
GB9300195D0 (en) * 1993-01-06 1993-03-03 Wyeth John & Brother Ltd Piperazine derivatives

Also Published As

Publication number Publication date
CN1093122C (zh) 2002-10-23
AU680147B2 (en) 1997-07-17
ATE192744T1 (de) 2000-05-15
RU2165933C2 (ru) 2001-04-27
CN1149873A (zh) 1997-05-14
DE69516867D1 (de) 2000-06-15
ZA954525B (en) 1996-12-02
CN1048985C (zh) 2000-02-02
DE69516867T2 (de) 2000-11-02
EP0763031B1 (en) 2000-05-10
FI964815A (fi) 1996-12-02
SK281418B6 (sk) 2001-03-12
KR970703333A (ko) 1997-07-03
WO1995033743A1 (en) 1995-12-14
GB9411099D0 (en) 1994-07-27
SK154196A3 (en) 1997-08-06
HUT76466A (en) 1997-09-29
NZ287498A (en) 1998-10-28
NZ331452A (en) 2000-01-28
CZ350796A3 (en) 1997-06-11
AU2623095A (en) 1996-01-04
ES2145275T3 (es) 2000-07-01
MX9605915A (es) 1997-12-31
FI964815A0 (fi) 1996-12-02
FI114985B (fi) 2005-02-15
GR3033449T3 (en) 2000-09-29
JPH10500989A (ja) 1998-01-27
IL113967A0 (en) 1995-10-31
CN1227841A (zh) 1999-09-08
EP0763031A1 (en) 1997-03-19
BR9507910A (pt) 1997-08-12
PT763031E (pt) 2000-10-31
IL113967A (en) 1999-03-12
KR100359393B1 (ko) 2003-01-24
HU9603315D0 (en) 1997-01-28
CA2191871C (en) 2004-09-21
CA2191871A1 (en) 1995-12-14
US5723464A (en) 1998-03-03
CZ287381B6 (en) 2000-11-15

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