ZA861351B - Substituted and unsubstituted 13-(alkoxy)methoxy derivatives of the avermectin aglycones - Google Patents

Substituted and unsubstituted 13-(alkoxy)methoxy derivatives of the avermectin aglycones

Info

Publication number: ZA861351B
Authority: ZA; South Africa
Prior art keywords: unsubstituted; alkoxy; substituted; methoxy derivatives; avermectin aglycones
Prior art date: 1985-02-25

Application number

ZA861351A

Other languages

English (en)

Inventor

Bruce O Linn

Helmut H Mrozik

Original Assignee

Merck & Co Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1985-02-25

Filing date

1986-02-24

Publication date

1986-10-29

1986-02-24 Application filed by Merck & Co Inc filed Critical Merck & Co Inc

1986-10-29 Publication of ZA861351B publication Critical patent/ZA861351B/xx

Links

239000005660 Abamectin Substances 0.000 title 1
RRZXIRBKKLTSOM-XPNPUAGNSA-N avermectin B1a Chemical compound C1=C[C@H](C)[C@@H]([C@@H](C)CC)O[C@]11O[C@H](C\C=C(C)\[C@@H](O[C@@H]2O[C@@H](C)[C@H](O[C@@H]3O[C@@H](C)[C@H](O)[C@@H](OC)C3)[C@@H](OC)C2)[C@@H](C)\C=C\C=C/2[C@]3([C@H](C(=O)O4)C=C(C)[C@@H](O)[C@H]3OC\2)O)C[C@H]4C1 RRZXIRBKKLTSOM-XPNPUAGNSA-N 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/22—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains four or more hetero rings
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/10—Anthelmintics

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Environmental Sciences (AREA)
Medicinal Chemistry (AREA)
Agronomy & Crop Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Tropical Medicine & Parasitology (AREA)
Plant Pathology (AREA)
Pest Control & Pesticides (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Wood Science & Technology (AREA)
Dentistry (AREA)
Zoology (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Saccharide Compounds (AREA)
Fodder In General (AREA)

ZA861351A 1985-02-25 1986-02-24 Substituted and unsubstituted 13-(alkoxy)methoxy derivatives of the avermectin aglycones ZA861351B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US06/705,254 US4587247A (en)	1985-02-25	1985-02-25	Substituted and unsubstituted 13-(alkoxy)methoxy derivatives of the avermectin aglycones, compositions and use

Publications (1)

Publication Number	Publication Date
ZA861351B true ZA861351B (en)	1986-10-29

Family

ID=24832670

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA861351A ZA861351B (en)	1985-02-25	1986-02-24	Substituted and unsubstituted 13-(alkoxy)methoxy derivatives of the avermectin aglycones

Country Status (9)

Country	Link
US (1)	US4587247A (xx)
EP (1)	EP0193347B1 (xx)
JP (2)	JP2509560B2 (xx)
AU (1)	AU574566B2 (xx)
DE (1)	DE3673664D1 (xx)
HK (1)	HK62691A (xx)
NZ (1)	NZ215186A (xx)
SG (1)	SG44991G (xx)
ZA (1)	ZA861351B (xx)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
HUT39739A (en) *	1984-12-04	1986-10-29	Ciba Geigy Ag	Process for production of derivatives of 13,3-milbemycin and medical preparatives containing thereof
GB2168345B (en) *	1984-12-14	1988-05-25	Ciba Geigy Ag	Pesticidal 13b-substituted milbemycin derivatives
DE3650265T2 (de) *	1985-09-13	1995-07-27	American Cyanamid Co	Makrolide Antibiotika und Verfahren zu deren Herstellung.
PH24180A (en) *	1986-03-12	1990-03-22	Glaxo Group Ltd	Macrolide compounds,pharmaceutical composition containing said compound and method of use thereof
EP0240274A3 (en) *	1986-04-03	1990-03-14	Merck & Co. Inc.	Avermectins as growth promotant agents
US5019589A (en) *	1986-09-12	1991-05-28	American Cyanamid Company	Δ23 -LL-F28249 compounds
US4918097A (en) *	1988-03-11	1990-04-17	Ciba-Geigy Corporation	Insecticides and parasiticides
GB8811037D0 (en) *	1988-05-10	1988-06-15	Glaxo Group Ltd	Chemical compounds
GB8917064D0 (en) *	1989-07-26	1989-09-13	Pfizer Ltd	Antiparasitic agent
US5030650A (en) *	1989-09-11	1991-07-09	American Cyanamid Company	13-halo-23-imino derivatives of LL-F28249 compounds and their use as endo- and ectoparasiticidal, insecticidal, acaricidal and nematocidal agents
US5055454A (en) *	1989-10-30	1991-10-08	Merck & Co., Inc.	13-epi-avermectin derivatives useful as antiparasitic agents
US5114930A (en) *	1990-05-14	1992-05-19	Merck & Co., Inc.	Avermectin derivatives with a spacer inserted between the disaccharide and the aglycone useful as antiparasitic agents
US5225338A (en) *	1990-09-24	1993-07-06	Merck & Co., Inc.	Microbial preparation of 13β-13-deoxy-22,23-dihydro avermectin-B1A/B1B aglycone
EP0530901A1 (en) *	1991-09-04	1993-03-10	Merck & Co. Inc.	13-beta-O-methoxymethyl-22,23-dihydro avermectin B1A/B1B aglycone
US5229415A (en) *	1992-03-24	1993-07-20	Merck & Co., Inc.	Alkylthio alkyl avermectins are active antiparasitic agents
US5602107A (en) *	1993-05-10	1997-02-11	Merck & Co., Inc.	Pour-on formulations consisting of gylcols, glycerides and avermectin compounds
PL174488B1 (pl) *	1993-05-10	1998-08-31	Merck & Co Inc	Preparat do zwalczania pasożytów zwierząt oraz sposób wytwarzania preparatu do zwalczania pasożytów zwierząt
NZ286586A (en) *	1993-05-10	1997-10-24	Merck & Co Inc	Avermectin formulation with polymer carrier, as a parasiticide
BR9406627A (pt) *	1993-05-26	1996-02-06	Commw Scient Ind Res Org	Composições antiparasiticas
US5436355A (en) *	1994-02-03	1995-07-25	Merck & Co., Inc.	Process for making avermectin/zein compositions
EP1849363A1 (en) *	2006-03-09	2007-10-31	Cheminova A/S	Synergistic combination of glutamate- and GABA-gated chloride agonist pesticide and at least one of Vitamin E or Niacin
US7919522B2 (en) *	2007-05-03	2011-04-05	Merial Limited	Compositions comprising C-13 alkoxyether macrolide compounds and phenylpyrazole compounds
ES2595499T3 (es) *	2007-05-03	2016-12-30	Merial, Inc.	Composiciones que comprenden compuestos de alcoxiéter macrólidos C-13 y compuestos de fenilpirazol
JP5740676B2 (ja) *	2013-10-17	2015-06-24	メリアルリミテッド	Ｃ−１３アルコキシエーテルマクロライド化合物及びフェニルピラゾール化合物を含む組成物
CN107337682B (zh) *	2016-11-22	2019-08-30	石家庄市兴柏生物工程有限公司	13-酰基化阿维菌素B2a苷元衍生物及其制备方法和用途

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3950360A (en) *	1972-06-08	1976-04-13	Sankyo Company Limited	Antibiotic substances
SE434277B (sv) *	1976-04-19	1984-07-16	Merck & Co Inc	Sett att framstella nya antihelmintiskt verkande foreningar genom odling av streptomyces avermitilis
US4134973A (en) *	1977-04-11	1979-01-16	Merck & Co., Inc.	Carbohydrate derivatives of milbemycin and processes therefor
US4093629A (en) *	1977-04-11	1978-06-06	Merck & Co., Inc.	Derivatives of antibiotic substance milbemycin and processes therefor
PH15982A (en) *	1977-10-03	1983-05-18	Merck & Co Inc	Selective hydrogenation producta of c-076 compounds and derivatives thereof
US4199569A (en) *	1977-10-03	1980-04-22	Merck & Co., Inc.	Selective hydrogenation products of C-076 compounds and derivatives thereof
US4201861A (en) *	1977-10-03	1980-05-06	Merck & Co., Inc.	Acyl derivatives of C-076 compounds
US4206205A (en) *	1977-10-03	1980-06-03	Merck & Co., Inc.	Monosaccharide and aglycone derivatives of C-076
US4171314A (en) *	1977-12-19	1979-10-16	Merck & Co., Inc.	13-Halo and 13-deoxy C-076 compounds
US4173571A (en) *	1977-12-19	1979-11-06	Merck & Co., Inc.	13-Halo and 13-deoxy derivatives of C-076 compounds
PH16612A (en) *	1977-12-19	1983-11-28	Merck & Co Inc	13-halo and 13-deoxy derivatives of c-076 compounds
US4200581A (en) *	1978-08-04	1980-04-29	Merck & Co., Inc.	Alkyl derivatives of C-076 compounds
US4579864A (en) *	1984-06-11	1986-04-01	Merck & Co., Inc.	Avermectin and milbemycin 13-keto, 13-imino and 13-amino derivatives
EP0180539A1 (de) *	1984-09-18	1986-05-07	Ciba-Geigy Ag	13-Halo- und 13-Hydroximilbemycine
HUT39739A (en) *	1984-12-04	1986-10-29	Ciba Geigy Ag	Process for production of derivatives of 13,3-milbemycin and medical preparatives containing thereof
GB2168345B (en) *	1984-12-14	1988-05-25	Ciba Geigy Ag	Pesticidal 13b-substituted milbemycin derivatives
FI860233A (fi) *	1985-01-22	1986-07-23	Ciba Geigy Ag	13 -alkyl-milbemycinderivat foer bekaempning av parasiter hos djur och vaexter.

1985
- 1985-02-25 US US06/705,254 patent/US4587247A/en not_active Expired - Lifetime
1986
- 1986-02-17 NZ NZ215186A patent/NZ215186A/xx unknown
- 1986-02-19 EP EP86301168A patent/EP0193347B1/en not_active Expired - Lifetime
- 1986-02-19 DE DE8686301168T patent/DE3673664D1/de not_active Expired - Fee Related
- 1986-02-24 ZA ZA861351A patent/ZA861351B/xx unknown
- 1986-02-24 AU AU54004/86A patent/AU574566B2/en not_active Ceased
- 1986-02-25 JP JP61038455A patent/JP2509560B2/ja not_active Expired - Lifetime
1991
- 1991-06-15 SG SG44991A patent/SG44991G/en unknown
- 1991-08-08 HK HK626/91A patent/HK62691A/xx not_active IP Right Cessation
1995
- 1995-08-30 JP JP7220965A patent/JP2647361B2/ja not_active Expired - Lifetime

Also Published As

Publication number	Publication date
AU574566B2 (en)	1988-07-07
EP0193347A2 (en)	1986-09-03
DE3673664D1 (de)	1990-10-04
NZ215186A (en)	1989-07-27
EP0193347A3 (en)	1986-10-29
JPS61200993A (ja)	1986-09-05
EP0193347B1 (en)	1990-08-29
JPH0873466A (ja)	1996-03-19
US4587247A (en)	1986-05-06
JP2647361B2 (ja)	1997-08-27
SG44991G (en)	1991-07-26
JP2509560B2 (ja)	1996-06-19
AU5400486A (en)	1986-08-28
HK62691A (en)	1991-08-16

Publication	Publication Date	Title
ZA861351B (en)	1986-10-29	Substituted and unsubstituted 13-(alkoxy)methoxy derivatives of the avermectin aglycones
NZ216980A (en)	1988-10-28	25-substituted avermectin derivatives
LV10314A (lv)	1994-10-20	Makrociklisko savienojumu iegusanas panemiens
AU572719B2 (en)	1988-05-12	Thiazolidinedione derivatives
GB8629758D0 (en)	1987-01-21	Naphthalenic derivatives
SE8600668L (sv)	1986-08-16	4-substituerade androstendionderivat och forfarande for deras framstellning
AU585375B2 (en)	1989-06-15	Fired hollow ceramic spheroids
FI864191A0 (fi)	1986-10-16	Karboxiamidderivat och deras framstaellning.
GB8624575D0 (en)	1986-11-19	Isothiazolone derivatives
EP0223744A3 (en)	1988-09-14	Flavone derivatives
DK139286A (da)	1986-10-03	Inden- og naphthalenderivater
NZ215917A (en)	1989-10-27	22-oh milbemycin derivatives and parasiticidal compositions
NZ216908A (en)	1989-06-28	Avermectin derivatives
IL80307A0 (en)	1987-01-30	Preparation of phenylpropanone derivatives
GB8628049D0 (en)	1986-12-31	Use of tetrahydrobenzothienylurea derivatives
NZ215918A (en)	1989-10-27	Milbemycin derivatives and parasiticidal compositions
NZ216910A (en)	1988-09-29	An avermectin derivative
GB2184442B (en)	1989-10-18	4-hydroxycoumarin derivatives
IL79438A0 (en)	1986-10-31	Preparation of 2-cyanoaminopyrimidine derivatives
GB8505786D0 (en)	1985-04-11	Macrolide derivatives
GB8623116D0 (en)	1986-10-29	4-one derivatives
GB8507595D0 (en)	1985-05-01	Thiazole derivatives
AR242386A1 (es)	1993-03-31	Procedimiento para la preparacion de los estereoisomeros trans de derivados de eburnamenina, opticamente activos.
LV5626A3 (lv)	1994-05-10	Avermektina atvasinajumu iegusanas panemiens
MX3230A (es)	1993-10-01	Derivados de avermectina y procedimeiento para su preparacion.