ZA200709851B - Inhibitors of VEGF receptor and HGF receptor signaling - Google Patents

Inhibitors of VEGF receptor and HGF receptor signaling

Info

Publication number
ZA200709851B
ZA200709851B ZA200709851A ZA200709851A ZA200709851B ZA 200709851 B ZA200709851 B ZA 200709851B ZA 200709851 A ZA200709851 A ZA 200709851A ZA 200709851 A ZA200709851 A ZA 200709851A ZA 200709851 B ZA200709851 B ZA 200709851B
Authority
ZA
South Africa
Prior art keywords
receptor
inhibitors
hgf
signaling
vegf
Prior art date
Application number
ZA200709851A
Other languages
English (en)
Inventor
Saavedra Oscar Mario
Zhan Lijie
Vaisburg Arkadii
Deziel Robert
Nancy Z Zhou
Claridge Stephen William
Raeppel Franck
Raeppel Stephane
Mannion Michael
Isakovic Ljubomir
Original Assignee
Methylgene Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Methylgene Inc filed Critical Methylgene Inc
Publication of ZA200709851B publication Critical patent/ZA200709851B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system having sulfur as a ring hetero atom, e.g. ticlopidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
ZA200709851A 2005-05-20 2007-11-15 Inhibitors of VEGF receptor and HGF receptor signaling ZA200709851B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US68303805P 2005-05-20 2005-05-20

Publications (1)

Publication Number Publication Date
ZA200709851B true ZA200709851B (en) 2009-08-26

Family

ID=38023642

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200709851A ZA200709851B (en) 2005-05-20 2007-11-15 Inhibitors of VEGF receptor and HGF receptor signaling

Country Status (15)

Country Link
US (2) US7790729B2 (xx)
EP (1) EP1904504B1 (xx)
JP (1) JP5275792B2 (xx)
KR (1) KR101078968B1 (xx)
CN (1) CN101248080B (xx)
AU (1) AU2006313456B2 (xx)
BR (1) BRPI0610382A2 (xx)
CA (1) CA2608726C (xx)
DK (1) DK1904504T3 (xx)
ES (1) ES2473341T3 (xx)
IL (1) IL187422A0 (xx)
MX (1) MX2007014617A (xx)
NZ (1) NZ563774A (xx)
WO (1) WO2007054831A2 (xx)
ZA (1) ZA200709851B (xx)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7202363B2 (en) 2003-07-24 2007-04-10 Abbott Laboratories Thienopyridine and furopyridine kinase inhibitors
AU2005250285B2 (en) 2004-06-02 2011-08-18 Takeda Pharmaceutical Company Limited Fused heterocyclic compound
JP5096142B2 (ja) 2004-07-30 2012-12-12 メチルジーン インコーポレイテッド Ｖｅｇｆレセプターおよびｈｇｆレセプターシグナル伝達の阻害剤
AU2006229343A1 (en) * 2005-03-28 2006-10-05 Kirin Pharma Kabushiki Kaisha Thienopyridine derivative, or quinoline derivative, or quinazoline derivative, having c-Met autophosphorylation inhibiting potency
AR059246A1 (es) * 2006-01-30 2008-03-19 Array Biopharma Inc Compuestos heterobiciclicos de tiofeno y metodos de uso
CA2655128A1 (en) * 2006-06-08 2007-12-21 Array Biopharma Inc. Quinoline compounds and methods of use
CA2660758A1 (en) 2006-08-24 2008-02-27 Astrazeneca Ab Morpholino pyrimidine derivatives useful in the treatment of proliferative disorders
EA018708B1 (ru) 2007-07-09 2013-10-30 Астразенека Аб ПРОИЗВОДНЫЕ МОРФОЛИНОПИРИМИДИНА, ИСПОЛЬЗУЕМЫЕ ПРИ ЗАБОЛЕВАНИЯХ, СВЯЗАННЫХ С mTOR КИНАЗОЙ И/ИЛИ PI3K
AU2008293038B2 (en) 2007-08-29 2013-08-29 Mirati Therapeutics, Inc. Inhibitors of protein tyrosine kinase activity
EP2426108B1 (en) * 2007-08-29 2016-08-10 MethylGene Inc. Processes and intermediates for preparing fused heterocyclic kinase inhibitors
EP2332536A1 (en) * 2008-03-05 2011-06-15 MethylGene Inc. Inhibitors of protein tyrosine kinase activity
BRPI0920765A2 (pt) * 2008-10-29 2015-08-18 Deciphera Pharmaceuticals Llc Amidas de cilopropano e análogos que exibem atividades anticâncer e antiproliferativas
ES2524966T3 (es) 2008-12-05 2014-12-16 Abbvie Bahamas Ltd. Derivados de tieno[3,2-c]piridina como inhibidores de quinasas para uso en el tratamiento del cáncer
US9340555B2 (en) 2009-09-03 2016-05-17 Allergan, Inc. Compounds as tyrosine kinase modulators
MX2012002596A (es) 2009-09-03 2012-07-03 Allergan Inc Compuestos como moduladores de tirosina cinasas.
CA2796054A1 (en) * 2010-04-16 2011-10-20 Methylgene Inc. Inhibitors of protein tyrosine kinase activity and use thereof to treat ophthalmic disorders
SA111320519B1 (ar) 2010-06-11 2014-07-02 Astrazeneca Ab مركبات بيريميدينيل للاستخدام كمثبطات atr
US8664244B2 (en) 2010-09-12 2014-03-04 Advenchen Pharmaceuticals, LLC Compounds as c-Met kinase inhibitors
BR112013006016A2 (pt) 2010-09-15 2016-06-07 Hoffmann La Roche compostos de azabenzotiazol, composições e métodos de uso
CN102153579B (zh) * 2011-02-23 2013-05-29 兰州米诺生物科技有限公司 氮-叔丁氧羰基-1,2,5,6-四氢吡啶-4-硼酸频哪醇酯的合成方法
CN102827186A (zh) * 2011-06-16 2012-12-19 中国科学院上海药物研究所 一类吡啶并五元杂环衍生物及其制备方法和用途
CN103732596B (zh) 2011-07-08 2016-06-01 诺华股份有限公司 吡咯并嘧啶衍生物
WO2013012909A1 (en) 2011-07-20 2013-01-24 Abbott Laboratories Kinase inhibitor with improved aqueous solubility
WO2013111798A1 (ja) 2012-01-27 2013-08-01 国立大学法人 富山大学 セリンラセマーゼ阻害剤
GB2499666A (en) * 2012-02-27 2013-08-28 Nanyang Polytechnic Mcl-1 inhibitors for the treatment of conditions associated with proliferative disorders
CN104507930B (zh) * 2012-06-29 2017-10-10 贝达药业股份有限公司 作为c‑Met酪氨酸激酶抑制剂的新型稠合吡啶衍生物
TWI520962B (zh) * 2012-06-29 2016-02-11 As the c-Met tyrosine kinase inhibitors novel fused pyridine derivatives
JP6218848B2 (ja) * 2012-11-20 2017-10-25 プロキナーゼ ゲゼルシャフト ミット ベシュレンクテル ハフツング プロテインキナーゼ阻害剤としてのチオエーテル誘導体
CN103396417B (zh) * 2013-08-14 2015-02-04 冯子侠 新型羟肟酸衍生物及其医疗应用
CN106995452B (zh) * 2016-12-22 2018-03-16 湖北民族学院 一种噻吩并[3，2‑d]嘧啶类EGFR/ErbB2双靶点抑制剂及其制备方法和用途
CN113874015A (zh) 2018-12-21 2021-12-31 细胞基因公司 Ripk2的噻吩并吡啶抑制剂
US10702525B1 (en) 2019-09-04 2020-07-07 United Arab Emirates University Pyrimidine derivatives as anti-diabetic agents

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6107300A (en) 1996-03-27 2000-08-22 Dupont Pharmaceuticals Arylamino fused pyrimidines
CN1280580A (zh) 1997-11-11 2001-01-17 辉瑞产品公司 用作抗癌药的噻吩并嘧啶和噻吩并吡啶衍生物
US6232320B1 (en) 1998-06-04 2001-05-15 Abbott Laboratories Cell adhesion-inhibiting antiinflammatory compounds
SK18542000A3 (sk) 1998-06-04 2001-12-03 Abbott Laboratories Protizápalové zlúčeniny inhibujúce bunkovú adhéziu
EP1181296A1 (en) 1999-06-03 2002-02-27 Abbott Laboratories Cell adhesion-inhibiting antiinflammatory compounds
ATE277933T1 (de) 2000-06-06 2004-10-15 Pfizer Prod Inc Thiophenverbindungen zur verwendung als antikrebsmittel
US20020004511A1 (en) 2000-06-28 2002-01-10 Luzzio Michael Joseph Thiophene derivatives useful as anticancer agents
US6488261B1 (en) * 2001-02-21 2002-12-03 Jen-Chieh Lee Ball valve
GB0115109D0 (en) 2001-06-21 2001-08-15 Aventis Pharma Ltd Chemical compounds
WO2003000194A2 (en) 2001-06-21 2003-01-03 Pfizer Inc. Thienopyridine and thienopyrimidine anticancer agents
CN100415720C (zh) * 2001-06-22 2008-09-03 麒麟医药株式会社 喹啉衍生物和喹唑啉衍生物以及含有这些化合物的药物组合物
MXPA04008403A (es) 2002-03-01 2004-11-26 Pfizer Indolil-urea derivados de tienopiridinas utiles como agentes antiangiogenicos, y procedimientos para su uso.
US20030199525A1 (en) * 2002-03-21 2003-10-23 Hirst Gavin C. Kinase inhibitors
CL2003002287A1 (es) 2002-11-25 2005-01-14 Wyeth Corp COMPUESTOS DERIVADOS DE TIENO[3,2-b]-PIRIDINA-6-CARBONITRILOS Y TIENEO[2,3-b]-PIRIDINA-5-CARBONITRILOS, COMPOSICION FARMACEUTICA, PROCEDIMIENTO DE PREPARACION Y COMPUESTOS INTERMEDIARIOS, Y SU USO EN EL TRATAMIENTO DEL CANCER, APOPLEJIA, OSTEOPOROSIS
DE602004017479D1 (de) 2003-08-29 2008-12-11 Pfizer Als neue antiangiogene mittel geeignete thienopyridinphenylacetamide und derivate davon
US7581674B2 (en) 2003-11-21 2009-09-01 Charles Cohen Financial transaction system and method
AU2005207946A1 (en) 2004-01-23 2005-08-11 Amgen Inc. Quinoline quinazoline pyridine and pyrimidine counds and their use in the treatment of inflammation angiogenesis and cancer
US7459562B2 (en) 2004-04-23 2008-12-02 Bristol-Myers Squibb Company Monocyclic heterocycles as kinase inhibitors
TW200538453A (en) 2004-04-26 2005-12-01 Bristol Myers Squibb Co Bicyclic heterocycles as kinase inhibitors
WO2005121125A1 (en) * 2004-06-09 2005-12-22 Pfizer Inc. Ether-linked heteroaryl compounds
US7439246B2 (en) 2004-06-28 2008-10-21 Bristol-Myers Squibb Company Fused heterocyclic kinase inhibitors
US20050288290A1 (en) 2004-06-28 2005-12-29 Borzilleri Robert M Fused heterocyclic kinase inhibitors
WO2006014325A2 (en) 2004-07-02 2006-02-09 Exelixis, Inc. C-met modulators and method of use
SG156650A1 (en) 2004-07-16 2009-11-26 Sunesis Pharmaceuticals Inc Thienopyrimidines useful as aurora kinase inhibitors
JP5096142B2 (ja) 2004-07-30 2012-12-12 メチルジーン インコーポレイテッド Ｖｅｇｆレセプターおよびｈｇｆレセプターシグナル伝達の阻害剤
AU2006229343A1 (en) * 2005-03-28 2006-10-05 Kirin Pharma Kabushiki Kaisha Thienopyridine derivative, or quinoline derivative, or quinazoline derivative, having c-Met autophosphorylation inhibiting potency
JO2787B1 (en) 2005-04-27 2014-03-15 امجين إنك, Alternative amide derivatives and methods of use
ES2623221T3 (es) * 2005-05-20 2017-07-10 Methylgene Inc Inhibidores de la señalización del receptor de VEGF y del receptor de HGF
AR059246A1 (es) 2006-01-30 2008-03-19 Array Biopharma Inc Compuestos heterobiciclicos de tiofeno y metodos de uso

Also Published As

Publication number Publication date
EP1904504A2 (en) 2008-04-02
DK1904504T3 (da) 2014-06-23
CN101248080B (zh) 2012-09-05
US7790729B2 (en) 2010-09-07
BRPI0610382A2 (pt) 2010-06-15
JP2008540639A (ja) 2008-11-20
CA2608726A1 (en) 2007-05-18
MX2007014617A (es) 2008-02-11
US20100249145A1 (en) 2010-09-30
CN101248080A (zh) 2008-08-20
NZ563774A (en) 2010-04-30
ES2473341T3 (es) 2014-07-04
CA2608726C (en) 2013-07-09
WO2007054831A2 (en) 2007-05-18
AU2006313456B2 (en) 2011-06-23
AU2006313456A1 (en) 2007-05-18
US20060287343A1 (en) 2006-12-21
IL187422A0 (en) 2008-02-09
KR101078968B1 (ko) 2011-11-01
KR20080027782A (ko) 2008-03-28
JP5275792B2 (ja) 2013-08-28
EP1904504A4 (en) 2010-06-02
EP1904504B1 (en) 2014-03-19
WO2007054831A3 (en) 2007-10-04

Similar Documents

Publication Publication Date Title
IL187484A0 (en) Inhibitors of vegf receptor and hgf receptor signaling
IL187422A0 (en) Inhibitors of vegf receptor and hgf receptor signaling
IL180788A0 (en) Inhibitors of vegf receptor and hgf receptor signaling
HK1203527A1 (en) Vegf analogs and methods of use vegf
EP2083864A4 (en) ANTAGONISTS OF PCSK9
EP2083859A4 (en) ANTAGONISTS OF PCSK9
EP2083860A4 (en) PCSK9 ANTAGONISTS
EP2106261A4 (en) ANTAGONISTS OF PCSK9
IL227215A (en) Vegf antagonists
CY2013042I2 (el) Αναστολεις πυριδυλιου της σηματοδοτησης hedgehog
EP1976529A4 (en) COMBINATIONS OF ANG2 AND VEGF INHIBITORS
ZA200705009B (en) Anthranilamide pyridinureas as vegf receptor kinase inhibitors
GB0611154D0 (en) Novel receptor antagonists and their methods of use
ZA200705006B (en) Novel anthranilamide pyridinureas as VEGF receptor kinase inhibitors
GB0522899D0 (en) Verification of continuity
ZA200804082B (en) Compositions and methods for controlling tissue factor signaling specificity
EP1806147A4 (en) USE OF IMMUNOSUPPRESSIVE RECEPTOR
EP1778878A4 (en) METHOD AND COMPOSITIONS FOR DETECTING RHINOVIRES
EP1739047A4 (en) DAMPING DEVICE FOR ONE ELEVATOR
HK1103651A1 (en) Vegf inhibition vegf
ZA200804681B (en) Inhibitors of C-Met and uses thereof
ZA200710843B (en) Inhibitors of VEGF receptor and HGF receptor signaling
GB0601098D0 (en) Vegf variants
ITMO20040070A1 (it) Apparato segnalatore
DE112007002472A5 (de) Chockerseil und Chockerseilsystem