ZA200102426B - Drugs for improving vesical excretory strength. - Google Patents

Drugs for improving vesical excretory strength. Download PDF

Info

Publication number
ZA200102426B
ZA200102426B ZA200102426A ZA200102426A ZA200102426B ZA 200102426 B ZA200102426 B ZA 200102426B ZA 200102426 A ZA200102426 A ZA 200102426A ZA 200102426 A ZA200102426 A ZA 200102426A ZA 200102426 B ZA200102426 B ZA 200102426B
Authority
ZA
South Africa
Prior art keywords
carbonyl
lower alkyl
alkyl
phenyl
carbamoyl
Prior art date
Application number
ZA200102426A
Other languages
English (en)
Inventor
Yuji Ishihara
Takayuki Doi
Hiroshi Nagabukuro
Yuji Ishichi
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Publication of ZA200102426B publication Critical patent/ZA200102426B/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/382—Heterocyclic compounds having sulfur as a ring hetero atom having six-membered rings, e.g. thioxanthenes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4525—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4535—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom, e.g. pizotifen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/473—Quinolines; Isoquinolines ortho- or peri-condensed with carbocyclic ring systems, e.g. acridines, phenanthridines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/30—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom
    • C07D211/32—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D273/00—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00
    • C07D273/02—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00 having two nitrogen atoms and only one oxygen atom
    • C07D273/06—Seven-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/06—Peri-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
ZA200102426A 1998-09-30 2001-03-23 Drugs for improving vesical excretory strength. ZA200102426B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP27667798 1998-09-30

Publications (1)

Publication Number Publication Date
ZA200102426B true ZA200102426B (en) 2001-09-25

Family

ID=17572787

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200102426A ZA200102426B (en) 1998-09-30 2001-03-23 Drugs for improving vesical excretory strength.

Country Status (12)

Country Link
US (1) US20040116457A1 (fr)
EP (3) EP1891954A3 (fr)
KR (2) KR100648869B1 (fr)
CN (4) CN1768745A (fr)
AU (1) AU758802B2 (fr)
BR (1) BR9914163A (fr)
CA (1) CA2344894A1 (fr)
HU (1) HUP0104493A3 (fr)
NO (1) NO20011602L (fr)
NZ (1) NZ510685A (fr)
WO (1) WO2000018391A1 (fr)
ZA (1) ZA200102426B (fr)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7091218B1 (en) 1999-09-01 2006-08-15 Eisai Co., Ltd. 4-substituted piperidine compound
EP1300395B1 (fr) * 2000-06-21 2009-09-02 Eisai R&D Management Co., Ltd. Compose piperidine 4-substitue
KR20030032043A (ko) 2000-09-21 2003-04-23 다케다 야쿠힌 고교 가부시키가이샤 3환식 축합 복소환 유도체의 제조 방법
US7132547B2 (en) 2001-12-28 2006-11-07 Takeda Pharmaceutical Company Limited Preventives/remedies for urinary disturbance
WO2004071533A1 (fr) * 2003-02-14 2004-08-26 Takeda Pharmaceutical Company Limited Preparation pour administration topique
CA2531019A1 (fr) * 2003-06-30 2005-01-06 Takeda Pharmaceutical Company Limited Preventif/medicament pour perturbation urinaire
US8602987B2 (en) * 2005-10-18 2013-12-10 Pneumoflex Systems, Llc Techniques for evaluating stress urinary incontinence (SUI) using involuntary reflex cough test
US8690790B2 (en) * 2005-10-18 2014-04-08 Pneumoflex Systems, Llc Techniques for evaluating urinary stress incontinence
US8597184B2 (en) 2005-10-18 2013-12-03 Pneumoflex Systems, Llc Techniques for evaluating urinary stress incontinence and use of involuntary reflex cough as a medical diagnostic tool
US9028406B2 (en) * 2005-10-18 2015-05-12 Pneumoflex Systems, Llc Oral-esophageal-gastric device to diagnose reflux and/or emesis
US9011328B2 (en) * 2005-10-18 2015-04-21 Pneumoflex Systems, Llc Oral-esophageal-gastric device with esophageal cuff to reduce gastric reflux and/or emesis
PE20070702A1 (es) * 2005-11-02 2007-07-20 Takeda Pharmaceutical COMPUESTOS DERIVADOS DE (TRIFLUOROMETOXI-FENIL)-ETILAMINO COMO INHIBIDORES DE LA ACETILCOLINESTERASA Y ANTAGONISTAS DEL RECEPTOR DE ADRENALINA alfa1
EP1956970A4 (fr) * 2005-12-09 2010-01-13 Pneumoflex Systems Llc Pression induite par une contraction involontaire en tant qu'outil de diagnostic
US8597183B2 (en) 2005-12-09 2013-12-03 Pneumoflex Systems, Llc Involuntary contraction induced pressure as a medical diagnostic tool using involuntary reflex cough test
US7662831B2 (en) 2006-07-27 2010-02-16 Wyeth Llc Tetracyclic indoles as potassium channel modulators
KR100689873B1 (ko) * 2006-11-10 2007-03-12 이동언 케이블 트레이의 결합구조
WO2011101774A1 (fr) 2010-02-16 2011-08-25 Pfizer Inc. (r)-4-((4-((4-(tétrahydrofuran-3-yloxy)benzo[d]isoxazol-3-yloxy)méthyl) pipéridin-1-yl)méthyl)tétrahydro-2h-pyran-4-ole, agoniste partiel des récepteurs 5-ht4
JP5951625B2 (ja) 2010-11-24 2016-07-13 ザ・トラスティーズ・オブ・コランビア・ユニバーシティー・イン・ザ・シティー・オブ・ニューヨークＴｈｅ Ｔｒｕｓｔｅｅｓ Ｏｆ Ｃｏｌｕｍｂｉａ Ｕｎｉｖｅｒｓｉｔｙ Ｉｎ Ｔｈｅ Ｃｉｔｙ Ｏｆ Ｎｅｗ Ｙｏｒｋ 加齢性黄斑変性症およびシュタルガルト病の処置のための非レチノイドｒｂｐ４アンタゴニスト
CN102675206A (zh) * 2011-03-08 2012-09-19 中南大学 新型乙酰胆碱酯酶抑制剂的制备及其活性
US8669281B1 (en) 2013-03-14 2014-03-11 Alkermes Pharma Ireland Limited Prodrugs of fumarates and their use in treating various diseases
NZ741985A (en) 2013-03-14 2019-12-20 Alkermes Pharma Ireland Ltd Prodrugs of fumarates and their use in treating various diseases
KR101537400B1 (ko) * 2013-03-21 2015-07-17 중앙대학교 산학협력단 아세틸콜린을 포함하는 전립선 비대증 치료용 조성물
CA2940845C (fr) 2014-02-24 2019-09-24 Alkermes Pharma Ireland Limited Sulfonamide et promedicaments de fumarates de sulfinamide et leur utilisation dans le traitement de diverses maladies
CN104211638A (zh) * 2014-08-13 2014-12-17 李增 一种脂肪氨基取代的芸香碱类衍生物及其制备和作为抗阿尔兹海默症的药物中的应用
CN114652675A (zh) * 2020-12-23 2022-06-24 燃点(南京)生物医药科技有限公司 一种盐酸乌拉地尔注射液的制备方法

Family Cites Families (87)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3238215A (en) 1963-10-17 1966-03-01 Sterling Drug Inc 1-[(3-, 2-, and 1-indolyl)-lower-alkyl-, lower-alkenyl-, and lower-alkynyl]piperidines
US3511836A (en) 1967-12-13 1970-05-12 Pfizer & Co C 2,4,6,7-tetra substituted quinazolines
BE755015A (fr) 1969-08-20 1971-02-01 Byk Gulden Lomberg Chem Fab Piperazinyl-alcoylamino-uraciles substitues par un groupe aryle, leurs ethers et thioethers, ainsi que leur procede de preparation
JPS536156B2 (fr) 1972-10-30 1978-03-04
NL175059C (nl) 1974-02-23 Boehringer Mannheim Gmbh Bereiding van bloeddrukverlagende stoffen en van preparaten die ze bevatten.
US4026894A (en) 1975-10-14 1977-05-31 Abbott Laboratories Antihypertensive agents
FR2334358A1 (fr) 1975-12-12 1977-07-08 Sogeras Nouveaux medicaments derives de l'indole
GB1591490A (en) 1977-08-04 1981-06-24 Abbott Lab 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-tetrahydrofuroyl)piperazine hydrochloride dihydrate
US4188390A (en) 1977-11-05 1980-02-12 Pfizer Inc. Antihypertensive 4-amino-2-[4-(1,4-benzodioxan-2-carbonyl) piperazin-1-yl or homopiperazin-1-yl]quinazolines
FR2421888A1 (fr) 1978-02-06 1979-11-02 Synthelabo Amides d'alkylene-diamines et leur application en therapeutique
IT1094076B (it) 1978-04-18 1985-07-26 Acraf Cicloalchiltriazoli
JPS56110665A (en) 1980-02-08 1981-09-01 Yamanouchi Pharmaceut Co Ltd Sulfamoyl-substituted phenetylamine derivative and its preparation
US4631286A (en) 1984-10-25 1986-12-23 Hoechst-Roussel Pharmaceuticals Inc. 9-amino-1,2,3,4-tetrahydroacridin-1-ol and related compounds
US5177082A (en) * 1985-11-05 1993-01-05 Yu Chao Mei Huperzines and analogs
DK623586A (da) 1985-12-27 1987-06-28 Eisai Co Ltd Piperidinderivater eller salte deraf og farmaceutiske kompositioner indeholdende forbindelserne
JPS63166881A (ja) 1986-12-29 1988-07-11 Sumitomo Pharmaceut Co Ltd アミノアザアクリジン誘導体
ES2056849T3 (es) 1987-04-23 1994-10-16 Hoechst Roussel Pharma Heteroalquilen-quinolinaminas condensadas, un procedimiento y productos intermedios para su preparacion y su uso como medicamentos.
FI95572C (fi) * 1987-06-22 1996-02-26 Eisai Co Ltd Menetelmä lääkeaineena käyttökelpoisen piperidiinijohdannaisten tai sen farmaseuttisen suolan valmistamiseksi
JP2832979B2 (ja) 1988-02-15 1998-12-09 武田薬品工業株式会社 不飽和カルボン酸アミド誘導体
US4868177A (en) 1988-11-09 1989-09-19 Hoechst-Roussel Pharmaceuticals, Inc. 1,2,3,4-tetrahydro-1,9-acridinediamines, pharmaceutical compositions and use
GB8827704D0 (en) 1988-11-28 1988-12-29 Fujisawa Pharmaceutical Co New acridine derivatives & processes for their production
JP2777159B2 (ja) 1988-12-22 1998-07-16 エーザイ株式会社 環状アミン誘導体を含有する医薬
JP2969359B2 (ja) 1989-01-13 1999-11-02 武田薬品工業株式会社 環状アミン化合物
JP2931986B2 (ja) 1989-02-17 1999-08-09 武田薬品工業株式会社 アラルキルアミン誘導体
JP2772814B2 (ja) 1989-03-04 1998-07-09 北陸製薬株式会社 記憶障害改善剤
IL93401A (en) * 1989-03-08 1994-08-26 Kali Chemie Pharma Gmbh H1 - Indole - 2 - Carboxylic acid 1, 7 - Consolidated N -) 1, 4 - Benzodiazepine - 3 - Il (amides, their preparation and drugs containing them
JPH02291052A (ja) 1989-04-11 1990-11-30 Canon Inc 文字処理装置
JPH02296580A (ja) 1989-05-11 1990-12-07 Kubota Corp 自走式歩行型作業機
JP2861274B2 (ja) 1989-06-06 1999-02-24 武田薬品工業株式会社 アミノケトン誘導体
US4999358A (en) 1989-06-26 1991-03-12 Hoechst-Roussel Pharmaceuticals Inc. (1,2,3,4-tetrahydro-9-acridinimino)cyclohexane carboxylic acid and related compounds
US5109002A (en) 1989-09-08 1992-04-28 Du Pont Merck Pharmaceutical Company Antipsychotic 1-cycloalkylpiperidines
JPH03220189A (ja) 1989-11-29 1991-09-27 Ube Ind Ltd キノリン化合物
JP3054742B2 (ja) 1989-12-11 2000-06-19 武田薬品工業株式会社 アミノナフタレン化合物
TW197442B (fr) 1990-02-08 1993-01-01 Pfizer
JPH0418071A (ja) 1990-05-11 1992-01-22 Sumitomo Pharmaceut Co Ltd ビスピペリジン誘導体
JP3075566B2 (ja) 1990-05-15 2000-08-14 エーザイ株式会社 光学活性インダノン誘導体
JP2807577B2 (ja) 1990-06-15 1998-10-08 エーザイ株式会社 環状アミド誘導体
JP2660086B2 (ja) 1990-07-03 1997-10-08 明治製菓株式会社 脳及び心機能障害改善剤
JPH04134083A (ja) 1990-09-25 1992-05-07 Hodogaya Chem Co Ltd ４―アミノ―５，６，７，８―テトラヒドロチエノ〔２，３―ｂ〕キノリン誘導体
JPH0676401B2 (ja) 1990-10-19 1994-09-28 エスエス製薬株式会社 キノリン誘導体及びこれを含有する医薬
US5190951A (en) 1990-10-19 1993-03-02 Ss Pharmaceutical Co., Ltd. Quinoline derivatives
JPH04159225A (ja) 1990-10-24 1992-06-02 Tsumura & Co アセチルコリンエステラーゼ阻害剤
TW197435B (fr) 1990-11-22 1993-01-01 Takeda Pharm Industry Co Ltd
US5110815A (en) 1990-12-03 1992-05-05 Hoechst-Roussel Pharmaceuticals Inc. 5-amino-5,6,7,8-tetrahydroquinolines and related compounds and pharmaceutical use
FR2672888B1 (fr) 1991-02-14 1994-02-04 Fabre Medicament Pierre Nouvelles urees et thiourees, leur preparation et leur application en therapeutique.
US5155226A (en) 1991-02-19 1992-10-13 Hoechst-Roussel Pharmaceuticals Incorporated Method for the preparation of 9-amino-1,2,3,4-tetrahydroacridine
CA2195129C (fr) 1991-03-28 2002-09-10 Anabella Villalobos Intermediaires pour l'obtention de derives d'amines heterocycliques-cycliques, inhibiteurs de la cholinesterase
CA2108880A1 (fr) * 1991-05-14 1992-11-15 Ernir Snorrason Traitement du syndrome de fatigue avec des inhibiteurs de la cholinesterase
FR2677019B1 (fr) 1991-05-27 1994-11-25 Pf Medicament Nouvelles piperidines disubstituees-1,4, leur preparation et leur application en therapeutique.
US5106856A (en) 1991-06-07 1992-04-21 Hoechst-Roussel Pharmaceuticals Inc. [(Arylalkylpiperidin-4-yl)methyl]-2a,3,4,5-tetrahydro-1(2H)-acenaphthylen-1-ones and related compounds
FR2679555B1 (fr) 1991-07-25 1993-11-19 Fabre Medicament Pierre Nouveaux derives de l'uree, leur preparation et leur application en therapeutique.
CA2116117A1 (fr) 1991-08-22 1993-03-04 Hiroyuki Sueoka Compose de type benzisoxazole et son utilisation
JPH05320160A (ja) 1991-08-22 1993-12-03 Yoshitomi Pharmaceut Ind Ltd ベンゾイソオキサゾール化合物
JPH0559188A (ja) 1991-08-29 1993-03-09 Dainippon Ink & Chem Inc 塩素化ポリオレフイン樹脂水性分散液の製造方法
US5965574A (en) * 1996-08-13 1999-10-12 Chen; Yuhpyng Liang Heteroaryl amines as novel acetylcholinesterase inhibitors
TW263504B (fr) 1991-10-03 1995-11-21 Pfizer
SE9103752D0 (sv) 1991-12-18 1991-12-18 Astra Ab New compounds
CA2126976A1 (fr) 1991-12-31 1993-07-08 Hisashi Takasugi Derives d'oxadiazole inhibiteurs de l'activite de l'acetylcholinesterase et agonistes muscariniques
JPH05239024A (ja) 1992-02-28 1993-09-17 Takeda Chem Ind Ltd 縮合複素環カルボン酸誘導体、その製造法、中間体および剤
GB9204958D0 (en) 1992-03-06 1992-04-22 Fujisawa Pharmaceutical Co Thiazole derivatives
JP3523887B2 (ja) 1992-03-09 2004-04-26 武田薬品工業株式会社 縮合複素環ケトン誘導体、その製造法、中間体および剤
TW218875B (fr) 1992-03-09 1994-01-11 Takeda Pharm Industry Co Ltd
TW226019B (fr) 1992-03-23 1994-07-01 Sankyo Co
JPH0641070A (ja) 1992-03-23 1994-02-15 Sankyo Co Ltd インドール誘導体
JPH0641125A (ja) 1992-03-26 1994-02-15 Yoshitomi Pharmaceut Ind Ltd ベンゾイソオキサゾール化合物およびその用途
JP3462234B2 (ja) 1992-04-24 2003-11-05 武田薬品工業株式会社 異項環化合物、その製造法、用途および合成中間体
ATE194982T1 (de) 1992-04-24 2000-08-15 Takeda Chemical Industries Ltd Benzoxazepin-derivate als cholinesterase- inhibitoren
JP3286056B2 (ja) 1993-01-18 2002-05-27 武田薬品工業株式会社 三環式縮合複素環誘導体、その製造法および用途
TW248556B (fr) * 1993-01-18 1995-06-01 Takeda Pharm Industry Co
JP3935199B2 (ja) * 1993-05-26 2007-06-20 シンテックス（ユー・エス・エイ）・インコーポレイテッド 新規１−フェニルアルカノン５−ｈｔ▲４▼レセプターリガンド類
SE9302080D0 (sv) 1993-06-16 1993-06-16 Ab Astra New compounds
ATE180780T1 (de) 1993-08-05 1999-06-15 Hoechst Marion Roussel Inc 2-(piperidin-4-yl, pyridin-4-yl und tetrahydropyridin-4-yl)-benzofuran-7-carbamat derivate, ihre herstellung und verwendung als acetylcholinesterase inhibitoren
US5620973A (en) 1993-11-30 1997-04-15 Takeda Chemical Industries, Ltd. Tetracyclic condensed heterocyclic compounds and their use
JPH07309835A (ja) 1993-11-30 1995-11-28 Takeda Chem Ind Ltd 四環式縮合複素環誘導体、その製造法および用途
US5864039A (en) * 1994-03-30 1999-01-26 Yoshitomi Pharmaceutical Industries, Ltd. Benzoic acid compounds and use thereof as medicaments
CN1125725A (zh) 1994-12-28 1996-07-03 中国科学院上海药物研究所 一类海克林碱衍生物及它的用途
JPH08245502A (ja) * 1995-03-08 1996-09-24 Mitsubishi Chem Corp 高純度テレフタル酸の製造方法
JPH08245583A (ja) * 1995-03-14 1996-09-24 Kyorin Pharmaceut Co Ltd 新規環状第四級アンモニウム塩およびその製造方法
JPH08245582A (ja) * 1995-03-14 1996-09-24 Kyorin Pharmaceut Co Ltd 新規環状第四級アンモニウム塩およびその製造方法
JPH0920755A (ja) * 1995-07-03 1997-01-21 Hokuriku Seiyaku Co Ltd 両性型三環系化合物
GB9514821D0 (en) * 1995-07-19 1995-09-20 Sod Conseils Rech Applic Galanthamine derivatives
GB9519267D0 (en) 1995-09-21 1995-11-22 Chiroscience Ltd Preparation of alkaloids
ES2100129B1 (es) 1995-10-11 1998-02-16 Medichem Sa Nuevos compuestos aminopiridinicos policiclicos inhibidores de acetilcolinesterasa, procedimiento para su preparacion y su utilizacion.
US5783584A (en) * 1995-12-11 1998-07-21 Mayo Foundation For Medical Education And Research THA analogs useful as cholinesterase inhibitors
JPH09268176A (ja) 1996-04-01 1997-10-14 Eisai Co Ltd アラルキルピペリジン誘導体
IL126003A0 (en) 1996-04-10 1999-04-11 Hoechst Marion Roussel Inc Spiro [cyclopent [b] indole-piperidines] and n-[phenyl-hydrazon intermediates for their preparation both being acetyl cholinesterase and mao inhibitors
AU8925998A (en) 1997-09-03 1999-03-22 Macro Hi-Tech Jv, Ltd. Huperzine a derivatives

Also Published As

Publication number Publication date
NO20011602L (no) 2001-05-22
WO2000018391A1 (fr) 2000-04-06
KR100639543B1 (ko) 2006-10-31
HUP0104493A2 (hu) 2002-04-29
NZ510685A (en) 2003-10-31
CN1328451A (zh) 2001-12-26
AU758802B2 (en) 2003-03-27
CA2344894A1 (fr) 2000-04-06
EP1118322A4 (fr) 2004-10-20
EP1891954A3 (fr) 2009-01-14
EP1118322A1 (fr) 2001-07-25
EP1604653A1 (fr) 2005-12-14
BR9914163A (pt) 2001-08-14
KR20060026972A (ko) 2006-03-24
CN1572299A (zh) 2005-02-02
KR20010085865A (ko) 2001-09-07
CN1535682A (zh) 2004-10-13
CN1163224C (zh) 2004-08-25
KR100648869B1 (ko) 2007-02-28
EP1891954A2 (fr) 2008-02-27
HUP0104493A3 (en) 2002-12-28
NO20011602D0 (no) 2001-03-29
CN1768745A (zh) 2006-05-10
AU5999599A (en) 2000-04-17
US20040116457A1 (en) 2004-06-17

Similar Documents

Publication Publication Date Title
ZA200102426B (en) Drugs for improving vesical excretory strength.
DE60020726T2 (de) Biaryletherderivate, die als inhibitoren der monoamin-wiederaufnahme nützlich sind
DE69915063T2 (de) Aminocyclohexylverbindungen und deren verwendung
DE60106607T2 (de) Substituierte 1-aminoalkyl-lactame und ihre verwendung als muscarinrezeptor antagonisten
CH616677A5 (fr)
US20020007064A1 (en) 1-Phenyl-4-benzylpiperazines dopamine receptor subtype specific ligands
JP2000507545A (ja) Ｃｎｓ損傷についての新規な治療
FR2823209A1 (fr) Nouvelles thiohydantoines et leur utilisation en therapeutique
SK1852004A3 (sk) Deriváty piperazínu s účinkami antagonistu receptora CCR1
KR101683222B1 (ko) 피페리딘 화합물, 이를 포함하는 약학적 조성물 및 그 용도
RU2005111589A (ru) Производные 1-пиридин-4-илмочевины
US6127554A (en) 2,4-bis[(4-amidino)phenyl]furans as anti-Pneumocystis carinii agents
HU223530B1 (hu) 4-Alkil-imidazol-származékok
JP2004507527A5 (fr)
BG63971B1 (bg) Окса- и тиа-диазоли като антагонисти на мускаринови рецептори
US20220008414A1 (en) Pharmaceutical composition comprising histone deacetylase 6 inhibitors
JP2574377B2 (ja) 睡眠改善剤
JPH021439A (ja) ジアミン化合物、その製法及び該化合物を含有する高血圧症及び炎症を治療するための医薬
JP3240143B2 (ja) 抗精神病薬としての環状ベンジルアミノ、ベンジルアミド及びベンジルイミド誘導体
AU679834B2 (en) Nitroxy group-containing benzylamine derivatives and their use for treating cardiovascular diseases, as well as increased intra-ocular pressure
US6476053B1 (en) Mycobacterial inhibitors
DE69911373T2 (de) Azetidincarboxamidderivate zur behandlung von zns-erkrankungen
JP5025266B2 (ja) ピペリジン誘導体又はその製薬学的に許容される塩
FR2567886A1 (fr) Derives 1-(2-pyrimidinyl)-piperazinyliques de 1-pyrrolidine-2-ones et leur application psychogeriatrique
US20060025456A1 (en) Saturated and unsaturated heteroarylcycloalkylmethyl amines as anti-depressants